Over-expression of SOX8 predicts poor prognosis in colorectal cancer: A retrospective study.

Abstract:

:Aberrant expression of SRY-box 8 (SOX8) is closely correlated with the development and progression of many types of cancers in human. Limited studies report the relationship between SOX8 expression and overall survival in colorectal cancer (CRC). This study aimed to collect the pathological tissues and clinical data in order to analyze the relationship between SOX8 expression and clinicopathological parameters and prognosis of CRC patients. Tissue microarrays were constructed from 424 primary CRC patients with clinicopathological information and follow-up data. Immunohistochemistry (IHC) was performed on tissue microarrays to explore the relationship between SOX8 expression and clinicopathological information and patient's prognosis. The expression of SOX8 was higher in CRC tissues than that in non-tumor adjacent tissues (NATs, P <.001). High expression of SOX8 was associated with tumor stage (P = .04) and shorter overall survival (OS) after operation of patients (P = .004). Subsequently, univariate COX analysis identified that high expression of SOX8 (P = .004), differentiation (P = .006), distant metastasis (P <.001), tumor stage (P = .003), and higher rate of lymph node metastasis (P <.001), all significantly predicted decrease in OS. Multivariate analysis demonstrated that distant metastasis (P <.001), high SOX8 expression, (P = .013) and lymph node metastasis (P <.001) were independent poor prognostic factors in CRC patients. This study showed that SOX8 is over-expressed in patients with high T stage, which affects the outcome of prognosis in CRC patients. High expression of SOX8 usually has a poor independent prognostic factor for CRC.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Wang Y,Yang W,Liu T,Bai G,Liu M,Wang W

doi

10.1097/MD.0000000000016237

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

e16237

issue

27

eissn

0025-7974

issn

1536-5964

pii

00005792-201907050-00055

journal_volume

98

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Infective endocarditis caused by slow-growing, fastidious, Gram-negative bacteria.

    abstract::In a review of endocarditis caused by fastidious, slow-growing gram-negative rods, similarities in the spectrum of disease overshadow differences among cases grouped by specific organisms. Cardiobacterium hominis, Actinobacillus actinomycetemcomitans and Haemophilus species usually seed previously damaged cardiac valv...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-197903000-00003

    authors: Ellner JJ,Rosenthal MS,Lerner PI,McHenry MC

    更新日期:1979-03-01 00:00:00

  • Are gastric hyperplastic polyps an additional manifestation in celiac disease?: Results from a retrospective study.

    abstract::Gastric polyps are frequently reported in patients undergoing upper endoscopic procedures. In this retrospective study, the association between hyperplastic polyps and celiac disease in Northern Sardinia was estimated.Age, gender, body mass index, and medications taken in the 2 preceding months, including proton-pump ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005923

    authors: Dore MP,Pes GM,Rocchi C,Loria MF,Soro S,Bassotti G

    更新日期:2017-02-01 00:00:00

  • Splenic abscess owing to cancer at the splenic flexure: A case report and comprehensive review.

    abstract:BACKGROUND:The cancer of the splenic flexure of the colon is a rare medical entity with severe morbidity because of its insidious onset. METHODS:We present the case of a 59-year-old male patient with dull left upper quadrant pain, leukocytosis, and anemia. A splenic abscess described as an air-fluid level with splenoc...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000004941

    authors: Awotar GK,Luo F,Zhao Z,Guan G,Ning S,Ren J,Liu Y,Wang G,Liu P

    更新日期:2016-09-01 00:00:00

  • Infective Endocarditis and Cancer Risk: A Population-Based Cohort Study.

    abstract::This study investigated the possible relationship between endocarditis and overall and individual cancer risk among study participants in Taiwan.We used data from the National Health Insurance program of Taiwan to conduct a population-based, observational, and retrospective cohort study. The case group consisted of 14...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003198

    authors: Sun LM,Wu JN,Lin CL,Day JD,Liang JA,Liou LR,Kao CH

    更新日期:2016-03-01 00:00:00

  • Confirmed cases of Neuroborreliosis with involvement of peripheral nervous system: Description of a cohort.

    abstract::The manifestations of borreliosis in the peripheral nervous system (PNS) remain poorly described. As the symptoms of neuroborreliosis can be reversed with timely introduction of antibiotics, early identification could avoid unnecessary axonal loss. Our aim was to describe the characteristics of confirmed neuroborrelio...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021986

    authors: Kaminsky AL,Maisonobe T,Lenglet T,Psimaras D,Debs R,Viala K

    更新日期:2020-10-02 00:00:00

  • Which neoadjuvant chemotherapy regimen should be recommended for patients with advanced nasopharyngeal carcinoma?: A network meta-analysis.

    abstract:BACKGROUND:The clinical application has widespread disagreement on the different regimens of neoadjuvant chemotherapy (NCT) in the treatment of locoregionally advanced nasopharyngeal carcinoma (NPC). We conducted a network meta-analysis (NMA) to evaluate the efficacy of the different NCT regimens in the treatment of NP...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000011978

    authors: Yuan C,Xu XH,Luo SW,Wang L,Sun M,Ni LH,Xu L,Wang XL,Zeng G

    更新日期:2018-08-01 00:00:00

  • Barbed versus conventional 2-layer continuous running sutures for laparoscopic vaginal cuff closure.

    abstract::We compared results using unidirectional barbed sutures and conventional sutures for vaginal cuff closure during total laparoscopic hysterectomy (TLH).The electronic medical records and surgical videos of 170 patients who underwent TLH between January 2013 and March 2015 at Uijeong-bu St. Mary's Hospital of Catholic U...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004981

    authors: Kim JH,Byun SW,Song JY,Kim YH,Lee HJ,Park TC,Lee KH,Hur SY,Park JS,Lee SJ

    更新日期:2016-09-01 00:00:00

  • Protein-losing enteropathy secondary to nonocclusive mesenteric ischemia: A case report.

    abstract:RATIONALE:Nonocclusive mesenteric ischemia (NOMI) is a life-threatening disorder; prompt diagnosis is vital. Surgical treatment is often required, but some cases can be treated conservatively. We herein report an extremely rare case wherein protein-losing enteropathy (PLE) developed after conservative treatment of NOMI...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013403

    authors: Shima T,Ozeki M,Kinoshita T,Honda K,Inoue H,Morita S

    更新日期:2018-11-01 00:00:00

  • Association of Glutathione S-Transferase M1 null genotype with inflammatory bowel diseases: A systematic review and meta-analysis.

    abstract:BACKGROUND:Ulcerative colitis (UC) and Crohn disease (CD) are the 2 main types of inflammatory bowel diseases (IBDs). Several studies have been conducted to investigate the association of Glutathione S-Transferase M1 (GSTM1) null genotype with UC and CD, but the results are inconsistent. Here, we performed a meta-analy...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000017722

    authors: Zhou YJ,Zhao BL,Qian Z,Xu Y,Ding YQ

    更新日期:2019-11-01 00:00:00

  • Multimodality magnetic resonance imaging for the diagnosis of high-flow priapism following a straddle injury: A case report.

    abstract:RATIONALE:Priapism is a common urologic emergency, but high-flow penile priapism (HFP) caused by trauma is very rare. Therefore, HFP diagnosis and treatment are still not standardized. PATIENT CONCERNS:A 29-year-old man was admitted to the urology department of our hospital on August 01, 2019, due to "persistent penil...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022618

    authors: Zhu P,Fan S,Xiang J

    更新日期:2020-10-09 00:00:00

  • Necessity of harvesting at least 25 lymph nodes in patients with stage N2-N3 resectable gastric cancer: a 10-year, single-institution cohort study.

    abstract::A minimum of 15 lymph nodes (LNs) has been recommended as an adequate number for radical gastrectomy for gastric cancer (GC). This study aimed to investigate whether the harvesting of at least 25 LNs was a better criterion for stage N2-3 GC based on the 10-year experience of a high-volume hospital. A total of 1363 pat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000620

    authors: Chen HN,Chen XZ,Zhang WH,Chen XL,Yang K,Liu JP,Zhang B,Chen ZX,Chen JP,Zhou ZG,Hu JK

    更新日期:2015-03-01 00:00:00

  • Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma.

    abstract::Alpha-fetoprotein (AFP), Lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are widely used as tumor markers for the diagnosis of hepatocellular carcinoma (HCC). This study compared the diagnostic values of AFP, AFP-L3, and PIVKA-II individ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005811

    authors: Park SJ,Jang JY,Jeong SW,Cho YK,Lee SH,Kim SG,Cha SW,Kim YS,Cho YD,Kim HS,Kim BS,Park S,Bang HI

    更新日期:2017-03-01 00:00:00

  • Uterus-like mass in the right broad ligament: A case report.

    abstract:RATIONALE:Uterus-like masses (ULMs) are rare benign lesions that resemble the uterus. PATIENT CONCERNS:Here, we describe the case of a woman with a ULM in the right broad ligament. A 51-year-old woman with a 2-month history of irregular vaginal bleeding was found to have a mass in the right broad ligament. Imaging stu...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017246

    authors: Liu L,Yang H,Zhang SP

    更新日期:2019-09-01 00:00:00

  • Delayed intracranial subdural empyema following burr hole drainage: Case series and literature review.

    abstract:RATIONALE:A subdural empyema (SDE) following burr hole drainage of a chronic subdural hematoma (CSDH) can be difficult to distinguish from a recurrence of the CSDH, especially when imaging data is limited to a computed tomography (CT) scan. PATIENTS CONCERNS:All patients underwent burr hole drainage of the CSDH at fir...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010664

    authors: Kim YS,Joo SP,Song DJ,Kim SH,Kim TS

    更新日期:2018-05-01 00:00:00

  • Costs of Physician-Hospital Integration.

    abstract::Given that the enactment of the Patient Protection and Affordable Care Act of 2010 is expected to generate forces toward physician-hospital integration, this study examined an understudied, albeit important, area of costs incurred in physician-hospital integration. Such costs were analyzed through 24 semi-structured i...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001762

    authors: Cho NE

    更新日期:2015-10-01 00:00:00

  • A case report of a child with sepsis induced multiorgan failure and massive complement consumption treated with a short course of Eculizumab: A case of crosstalk between coagulation and complement?

    abstract:RATIONALE:This article describes a child with a life-threatening multiorgan failure with disseminated intravascular coagulation (DIC) and massive complement consumption. To our knowledge this therapeutic approach was for the first time effectively applied in a pediatric patient. PATIENT CONCERNS:A 14-month-old boy was...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014105

    authors: Galic S,Csuka D,Prohászka Z,Turudic D,Dzepina P,Milosevic D

    更新日期:2019-01-01 00:00:00

  • Endobronchial Hamartoma Subtotally Occluding the Right Main Bronchus and Mimicking Bronchial Carcinoid Tumor.

    abstract::Hamartomas are very rarely identified as an endobronchial lesion. Herein, we describe a peculiar case of a 55-year-old woman with persistent cough and increasing dyspnea and radiological detection of a solid lesion subtotally occluding the main right bronchus. Despite the radiological and radiometabolic (18-fluoro-2-d...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003369

    authors: Lococo F,Galeone C,Lasagni L,Carbonelli C,Tagliavini E,Piro R,Zucchi L,Sgarbi G

    更新日期:2016-04-01 00:00:00

  • CA125 is a potential biomarker to predict surgically incurable gastric and cardia cancer: A retrospective study.

    abstract::Preoperative evaluation of the curability of gastric and cardia cancer is important to avoid risks of unnecessary surgery. Our previous study has reported several clinical parameters associated with incurable gastric surgery. In this study, we aimed to evaluate the correlation between CA125 and the curability of gastr...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005297

    authors: Luo T,Chen W,Wang L,Zhao H

    更新日期:2016-12-01 00:00:00

  • Histoplasmosis among human immunodeficiency virus-infected people in Europe: report of 4 cases and review of the literature.

    abstract::We reviewed the clinical, microbiologic, and outcome characteristics of 72 patients with human immunodeficiency virus (HIV)-associated histoplasmosis (4 newly described) reported in Europe over 20 years (1984-2004). Seven cases (9.7%) were acquired in Europe (autochthonous), whereas the majority involved a history of ...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.md.0000199934.38120.d4

    authors: Antinori S,Magni C,Nebuloni M,Parravicini C,Corbellino M,Sollima S,Galimberti L,Ridolfo AL,Wheat LJ

    更新日期:2006-01-01 00:00:00

  • A Case Report of Locked-in Syndrome Due to Bilateral Vertebral Artery Dissection After Cervical Spine Manipulation Treated by Arterial Embolectomy.

    abstract::Cervical spine manipulation (CSM) is a commonly spinal manipulative therapies for the relief of cervical spine-related conditions worldwide, but its use remains controversial. CSM may carry the potential for serious neurovascular complications, primarily due to vertebral artery dissection (VAD) and subsequent vertebro...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002693

    authors: Ke JQ,Yin B,Fu FW,Shao SM,Lin Y,Dong QQ,Wang XT,Zheng GQ

    更新日期:2016-02-01 00:00:00

  • Mannitol-induced acute renal failure.

    abstract::Mannitol is widely used to reduce intracranial pressure and is protective against ischemic and nephrotoxic acute renal failure. However, the capacity of this seemingly innocuous agent to produce acute renal failure is not well recognized. We report herein the clinical course of 8 cases of mannitol-induced acute renal ...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00005792-199005000-00003

    authors: Dorman HR,Sondheimer JH,Cadnapaphornchai P

    更新日期:1990-05-01 00:00:00

  • Causes and prognosis of chronic intestinal pseudo-obstruction in 48 subjects: A 10-year retrospective case series.

    abstract::The aim of the study was to evaluate the prognosis and survival of pediatric subjects with chronic intestinal pseudo-obstruction (CIPO) and investigate the independent risk factors affecting their prognosis.This was a retrospective case series of all pediatric subjects suffering from CIPO and treated at the Pediatric ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012150

    authors: Lu W,Xiao Y,Huang J,Lu L,Tao Y,Yan W,Cao Y,Cai W

    更新日期:2018-09-01 00:00:00

  • Sonography-guided trigger point injections in abdominal myofascial pain syndrome.

    abstract::Even though chronic abdominal pain is 1 of the most common reasons for hospital visits, diagnostic testing is often time-consuming and treatment is inadequate. Abdominal myofascial pain syndrome (AMPS) is usually not included as a differential diagnosis, but it should be considered in cases of chronic abdominal pain. ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023408

    authors: Rhim HC,Cha JH,Cha J,Kim DH

    更新日期:2020-12-04 00:00:00

  • Comparison of oral versus intravenous tranexamic acid in total knee and hip arthroplasty: A GRADE analysis and meta-analysis.

    abstract:BACKGROUND:The efficacy and safety of oral tranexamic acid (TXA) remain controversial because of the small number of clinical studies. The aim of the present study was to compare the efficacy and safety of oral TXA with intravenous TXA in patients undergoing total hip arthroplasty and total knee arthroplasty in a syste...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000022999

    authors: Sun C,Zhang X,Chen L,Deng J,Ma Q,Cai X,Yang H

    更新日期:2020-10-30 00:00:00

  • Pemetrexed-carboplatin with intercalated icotinib in the treatment of patient with advanced EGFR wild-type lung adenocarcinoma: A case report.

    abstract:RATIONALE:Tyrosine kinase inhibitors (TKIs) are known to have greater efficacy in epidermal growth factor receptor (EGFR) mutation nonsmall cell lung cancer (NSCLC). However, about 10% of EGFR wild-type (wt) patients respond to TKIs. PATIENT CONCERNS:Several strategies to increase the efficacy of TKIs in wt NSCLC are ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007732

    authors: Xu T,Wu H,Jin S,Min H,Zhang Z,Shu Y,Wen W,Guo R

    更新日期:2017-08-01 00:00:00

  • Comparison of postoperative coagulation profiles and outcome for sugammadex versus pyridostigmine in 992 living donors after living-donor hepatectomy.

    abstract::Donor safety is the major concern in living donor liver transplantation, although hepatic resection may be associated with postoperative coagulopathy. Recently, the use of sugammadex has been gradually increased, but sugammadex is known to prolong prothrombin time (PT) and activated partial thromboplastin time (aPTT)....

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010129

    authors: Moon YJ,Kim SH,Kim JW,Lee YK,Jun IG,Hwang GS

    更新日期:2018-03-01 00:00:00

  • Current evidence of acupuncture for symptoms related to breast cancer survivors: A PRISMA-compliant systematic review of clinical studies in Korea.

    abstract:BACKGROUND:Breast cancer survivors experience various symptoms associated with their cancer interventions, and the benefits of acupuncture for these symptoms have been evaluated in clinical trials worldwide. The purpose of this review was to discuss the current status of clinical research regarding the use of acupunctu...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000011793

    authors: Kim TH,Kang JW,Lee MS

    更新日期:2018-08-01 00:00:00

  • Treating an intramuscular abscess following toothpick injury in a diabetic patient: A case report and literature review (CARE Complaint).

    abstract:RATIONALE:Toothpick puncture (TPP) is a penetrating injury that can result in bringing pathogens to the deep space. Such penetrating wounds are typically of pinpoint size with initial symptoms appearing subtle. Consequently, the injury itself is often neglected by patients, or is not detected during physical examinatio...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018159

    authors: Cheng YC,Liu PY,Hu SY

    更新日期:2019-11-01 00:00:00

  • Percutaneous pinning after prolonged skeletal traction with the hip in a flexed position for unstable slipped capital femoral epiphysis: A case series of 11 patients.

    abstract:BACKGROUND:Unstable slipped capital femoral epiphysis (SCFE) has a relatively high risk of avascular necrosis of the femoral head. Standard treatment for unstable SCFE is still controversial. We reviewed unstable SCFE case series treated with the standardized protocol, which consisted of percutaneous pinning after prol...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006662

    authors: Matsushita M,Mishima K,Iwata K,Hattori T,Ishiguro N,Kitoh H

    更新日期:2017-05-01 00:00:00

  • Risk factors for heart valve calcification in chronic kidney disease.

    abstract::Cardiovascular disease (CVD) is a common cause of death in patients with chronic kidney disease (CKD). Aortic and mitral valve calcification (AVC and MVC, respectively) are critical indicators of CVD and all-cause mortality in CKD patients.We conducted a single center retrospective study of Chinese inpatients with CKD...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009804

    authors: Rong S,Qiu X,Jin X,Shang M,Huang Y,Tang Z,Yuan W

    更新日期:2018-02-01 00:00:00