Abstract：
:Chenopodium quinoa Wild is a "pseudocereal" grain which attracts a lot of attention in the scientific community as it has a positive effect on health. Here, we investigate the presence of biologically active O-prenylated phenylpropanoids in the ethanol extract of commercially available quinoa seeds. We claim that 4'-Geranyloxyferulic acid (GOFA) was the only phytochemical product found that belongs to quinoa's group secondary metabolites. We studied the changes in the oxidative and inflammatory status of the cellular environment in HCT 116 cell line processed with quinoa extract and its component GOFA; the implementation was done through the analysis of the antioxidant enzymes (SOD and CAT), the pro-inflammatory components (iNOS, IL-6 and TNF-α), and the products of intermediary metabolism (ONOO-, O2-). Moreover, the l-arginine uptake was proposed as a target of the tested compounds. We demonstrated that the GOFA, through a decrease of the CAT-2B expression, leads to a reduction of the l-arginine uptake, downregulating the harmful iNOS and restoring the altered redox state. These results propose a new molecular target involved in the reduction of the critical inflammatory process responsible for the cancer progression.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Franceschelli S,Gatta DMP,Pesce M,Ferrone A,Quiles JL,Genovese S,Epifano F,Fiorito S,Taddeo VA,Patruno A,Grilli A,Felaco M,Speranza Ldoi
10.3390/ijms20133262subject
Has Abstractpub_date
2019-07-02 00:00:00issue
13issn
1422-0067pii
ijms20133262journal_volume
20pub_type
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