VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy.

Abstract:

:Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.

journal_name

Genet Mol Biol

authors

Silva RCD,Alves NMP,Pereira JJS,Coelho AVC,Arraes LC,Brandão LAC,Crovella S,Silva JA

doi

10.1590/1678-4685-GMB-2017-0289

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

351-356

issue

2

eissn

1415-4757

issn

1678-4685

pii

S1415-47572019005025102

journal_volume

42

pub_type

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