Abstract:
:The structure, mechanism of action and copper stoichiometry of the transmembrane sensor domain of the plant ethylene receptor ETR1 and homologs have remained elusive, hampering the understanding on how the perception of the plant hormone ethylene is transformed into a downstream signal. We generated the first structural model of the transmembrane sensor domain of ETR1 by integrating ab initio structure prediction and coevolutionary information. To refine and independently validate the model, we determined protein-related copper stoichiometries on purified receptor preparations and explored the helix arrangement by tryptophan scanning mutagenesis. All-atom molecular dynamics simulations of the dimeric model reveal how ethylene can bind proximal to the copper ions in the receptor, illustrating the initial stages of the ethylene perception process.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Schott-Verdugo S,Müller L,Classen E,Gohlke H,Groth Gdoi
10.1038/s41598-019-45189-wsubject
Has Abstractpub_date
2019-06-20 00:00:00pages
8869issue
1issn
2045-2322pii
10.1038/s41598-019-45189-wjournal_volume
9pub_type
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