Abstract:
BACKGROUND:Tenofovir disoproxil fumarate (TDF), a primary antiretroviral agent used to treat AIDS, triggers systematic bone loss. However, the effect of TDF on osteopenia or osteoporosis in the jaw remains unclear. TDF-induced bone loss in the jaw, if any, likely involves mandible-derived mesenchymal stem cells (MMSCs), which play a key role in jawbone metabolism. Probiotics prevent long bone loss, and could prove efficacious in treating TDF-induced mandibular bone loss. OBJECTIVES:To determine whether TDF triggers mandibular bone loss, elucidate the underlying mechanisms, and study the effect of Lactobacillus rhamnosus GG (LGG) on TDF-induced bone loss in the jaw. METHODS:Tenofovir disoproxil fumarate was administered orally daily and LGG semiweekly from eight weeks to the end of the study (LGG group) to male C57BL6/J mice. The mice were sacrificed, and body weight (BW) and serum Ca and P were measured. Mandibular histomorphometry was evaluated by micro-CT. MMSCs and LGG culture supernatants were isolated, and MMSC proliferation and ALP production when treated with different concentrations of LGG supernatant and/or TDF were measured. Relative abundance of osteogenic markers was assessed by qPCR. RESULTS:Orally administered LGG protected against bone mass loss and deterioration of bone microarchitecture and increased serum P levels. The BW of the TDF group was highest among the study groups. TDF partially impaired osteogenesis and proliferation of MMSCs. LGG culture supernatant rescued MMSC osteogenesis and proliferation, and osteogenic gene expression. CONCLUSIONS:Lactobacillus rhamnosus GG protected against tenofovir-induced mandibular bone loss in mice by rescuing MMSC proliferation and osteogenesis.
journal_name
J Oral Rehabiljournal_title
Journal of oral rehabilitationauthors
Liu H,Gu R,Li W,Xue J,Cong Z,Wei Q,Zhou Ydoi
10.1111/joor.12840subject
Has Abstractpub_date
2020-11-01 00:00:00pages
83-90eissn
0305-182Xissn
1365-2842journal_volume
47 Suppl 1pub_type
杂志文章abstract::Class V cavities were prepared on twelve extracted teeth and then filled with amalgam which was condensed in six cases by hand and six by mechanical means. SEM records were obtained before and after ultrasonic scaling of the restored area. They showed that such scaling had a deleterious effect on the surface of the am...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1984.tb00580.x
更新日期:1984-05-01 00:00:00
abstract::Oral food perception depends on somatosensory information that includes taste and can be modified by oral components and/or functions such as mastication. The purpose of this study was to describe the interplay between oral health, mastication and taste. A review according to the Preferred Reporting Items for Systemat...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章,评审
doi:10.1111/joor.12535
更新日期:2017-12-01 00:00:00
abstract::The localization of lymph capillaries and blood capillaries in the human temporomandibular joint (TMJ) discs was examined immunohistologically with anti-human collagen IV antibody and anti-human von Willebrand factor in 26 human TMJ samples. The 16 internal derangement cases were then compared with the 10 normal contr...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.1999.00402.x
更新日期:1999-07-01 00:00:00
abstract::The aim of this retrospective study was to record patients' satisfaction with fixed metal ceramic bridges and crowns made by dental students and to evaluate the functioning and condition of the bridges and crowns clinically and radiologically. Out of the 60 patients treated at the Institute of Dentistry during 1984-85...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.1997.00554.x
更新日期:1997-10-01 00:00:00
abstract::The purpose of this study was to evaluate the fracture strength of four different types of anterior 3-unit bridges after thermo-mechanical fatigue in a dual-axis chewing simulator. Sixty-four human maxillary incisors were prepared and 32 bridges fabricated. The four groups of eight bridges each were - (GC): AGC(R) gal...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.2001.00742.x
更新日期:2001-04-01 00:00:00
abstract::By means of videofluoroscopic recordings, chewing, swallowing and speech were monitored in nine patients with congenital and acquired maxillary defects. All of them were rehabilitated with a maxillary obturator prosthesis. The defective region was seldom used for chewing. No leakage between the obturator and surroundi...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1991.tb00069.x
更新日期:1991-11-01 00:00:00
abstract::It is well known that acid regurgitated from the stomach into the mouth will erode teeth. Conditions such as anorexia and bulimia nervosa, chronic alcoholism and gastric disturbances cause palatal dental erosion. The common factor in these conditions is the role played by the stomach and oesophagus in the acid movemen...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2842.1996.tb00855.x
更新日期:1996-05-01 00:00:00
abstract::The fracture strengths of stylized all-ceramic crowns manufactured using an yttrium-oxide-partially-stabilized (Y-TZP) zirconia ceramic core (Denzir) veneered with lithium disilicate glass-ceramics (IPS Empress 2 or IPS Eris) were evaluated. The Denzir cores were manufactured in two ways: either with different thickne...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2004.01284.x
更新日期:2004-07-01 00:00:00
abstract::Quality control is very important in relation to invasive and lengthy treatments, such as integrated orthodontic and surgical correction of dentofacial deformities. The aim of this cross-sectional study was to compare self-reported somatosensory disturbances and quantitative sensory testing (QST) findings between two ...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2010.02059.x
更新日期:2010-05-01 00:00:00
abstract::The purpose of this study was to clarify association between food mixing ability and activity of jaw-closing muscles during chewing of a wax cube. Twenty subjects with complete dentitions (mean age 24.1 years) were directed to chew a two-coloured paraffin wax cube for 10 strokes on preferred chewing side. Surface elec...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2008.01849.x
更新日期:2008-05-01 00:00:00
abstract::The present study investigated condylar position and joint morphology in adolescent patients and elucidated the possible association between the joint structure and condylar position, and craniofacial morphology. Sixty-five adolescent patients were selected as subjects and their tomograms and lateral cephalograms were...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.2003.01194.x
更新日期:2003-11-01 00:00:00
abstract::This article provides a review of somatosensory and motor pathways and processes involved in oral sensorimotor function and dysfunction. It reviews somatosensory processes in peripheral tissues, brainstem and higher brain centres such as thalamus and cerebral cortex, with a particular emphasis on nociceptive mechanism...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2842.2006.01623.x
更新日期:2006-04-01 00:00:00
abstract::This study examined the relationship between the subjective food intake of 30 food types and their objective bite force to identify the key food items within the 30 food types to achieve a greater depth of masticatory function in Korean adults. A sample of 308 (112 males and 196 females) adults over the age of 20 (ave...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2842.2008.01924.x
更新日期:2009-03-01 00:00:00
abstract::The absorption of gas during heating and melting of pure gold and of two dental gold alloys was studied by gas chromatography. The metals were melted by two methods, i.e. gas-torch and electric heating. The specimens were analysed regarding the content of hydrogen, oxygen and nitrogen. The amount of nitrogen was not m...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1982.tb00532.x
更新日期:1982-01-01 00:00:00
abstract::The relationship between isotonic jaw-opening and jaw-closing muscle function was studied using a newly developed apparatus which enables load and velocity to be detected simultaneously. The following results were obtained from 17 male adults (age range 22-32 years) without any occlusal dysfunction. (i) The force-velo...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1991.tb00045.x
更新日期:1991-03-01 00:00:00
abstract::The purpose of this study was to evaluate temporomandibular disorders (TMD) Axis I and II among Israeli-Jewish patients using the Hebrew version of the Research Diagnostic Criteria (RDC) for TMD and to compare the results with Swedish, United States, Asian and Israeli-Arab populations. The study consisted of 298 Israe...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2008.01898.x
更新日期:2009-01-01 00:00:00
abstract::Although tooth loss with age has been extensively investigated, there appears to be no literature on the relationship of age to remaining mandibular third molars. The study showed that as age increases so does the frequency of absent vertically erupted mandibular third molars. However, no correlation was found between...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.1997.00195.x
更新日期:1997-12-01 00:00:00
abstract::Idiopathic trigeminal neuralgia (ITN) is a chronic neuropathic pain that affects the masticatory system. The objective of this study was to identify orofacial pain and temporomandibular characteristics, including temporomandibular disorder (TMD), in a sample of 105 ITN patients treated with compression of the trigemin...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2006.01680.x
更新日期:2007-02-01 00:00:00
abstract::The objective of this study is to compare the effects of canine guidance (CG) and bilateral balanced occlusion (BBO) on denture satisfaction and kinesiographic parameters of complete denture wearers, by means of a cross-over trial. Fifty edentulous patients received new maxillary and mandibular complete dentures. Afte...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2842.2012.02299.x
更新日期:2012-08-01 00:00:00
abstract::Edentulous conditions and use of complete dentures alter the function of jaw muscles, which is presumably reflected in the myosin heavy chain (MyHC) isoform composition. This study is the first dealing with MyHC isoforms expression in edentulous persons with the aim to clarify to which extent the decreased functional ...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2012.02294.x
更新日期:2012-08-01 00:00:00
abstract::This in vitro study evaluates the degradation of repaired denture bases upon immersion in a simulated oral fluid. Denture base materials (Luciton 199), after being repaired by Repair Material and Triad, using three different joint surface designs (butt, round and 45 degrees bevel), were immersed onto 99.5 vol.% ethano...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.2000.00513.x
更新日期:2000-03-01 00:00:00
abstract::The aim of this study was to evaluate the effect of oscillating forces upon the flow of five dental cements. A laboratory investigation was carried out using a crown and die. It showed that the application of oscillating forces improved the flow of the tested dental cements when combined with low static loads and wide...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.1999.00459.x
更新日期:1999-11-01 00:00:00
abstract::Due to the difference in open circuit potential (OCP) versus SCE for Aristaloy amalgam (-969 mV) and Dispersalloy amalgam (-549 mV) in Ringer's solution at 25 degrees C, a galvanic cell was created with Dispersalloy amalgam as cathode and Aristaloy amalgam as anode. The galvanic corrosion current was studied as a func...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1977.tb00959.x
更新日期:1977-01-01 00:00:00
abstract::Resonance frequency (RF) analysis is a non-invasive, objective and sensitive technique developed for implantology where it measures the stability of the implant in osteotomy site. Although many studies were performed by the previous electronic version of RF analyzer, a very limited number of studies were carried out w...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2009.01990.x
更新日期:2009-10-01 00:00:00
abstract::Ion exchange has been shown to increase the fracture strength of not only industrial glasses but also dental porcelains. Tuf-Coat, an ion exchange material, has been introduced as a simple method to strengthen dental porcelain restorations. Our experimental investigation aims to evaluate the effect of the ion exchange...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2004.01367.x
更新日期:2005-01-01 00:00:00
abstract::The aim was to validate self-perceived oral health with salivary IgG as an inflammatory parameter in children with type 1 diabetes. Unstimulated whole saliva samples were collected from 36 children with well controlled and 12 with poorly controlled type 1 diabetes and 40 non-diabetic children (Controls). Salivary flow...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.2008.01895.x
更新日期:2009-01-01 00:00:00
abstract::As one of the dental differentiations in The Netherlands, temporomandibular disorders (TMD) focuses on the diagnosis and treatment of pain and dysfunction of the masticatory system. Bruxism (i.e. tooth clenching and/or grinding) is thought to play an important aetiological role in TMD. Among others, bruxism may result...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.0305-182X.2003.01244.x
更新日期:2004-03-01 00:00:00
abstract::Previous studies support the view that the oral medium is a dynamic system composed of several elements, among which are restorations in teeth. The author believes that the evolution in time of a restoration can be non-lineal and that it has an irregular and chaotic behaviour. To investigate the theory, the author stu...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1046/j.1365-2842.1997.00457.x
更新日期:1997-01-01 00:00:00
abstract::Intermaxillary elastics are commonly used in orthodontic treatment, yet the exact mechanism by which they effect tooth movement has been unclear. A photoelastic model was produced to stimulate this type of therapy in examples of Class II and III malocclusions. In the open situation, inter-arch activity precipitated oc...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1978.tb01209.x
更新日期:1978-04-01 00:00:00
abstract::This study aimed to assess possible fluoride uptake by cavity walls following a single application of Duraphat around class V or I amalgam restorations which were inserted in seventeen human premolars in vitro and in vivo. Six cavities were lined with one layer of Copalite before insertion of the restorations. After a...
journal_title:Journal of oral rehabilitation
pub_type: 杂志文章
doi:10.1111/j.1365-2842.1980.tb00433.x
更新日期:1980-03-01 00:00:00