Abstract:
:Multiple lines of evidence suggest that functionally intact cerebello-hippocampal interactions are required for appropriate spatial processing. However, how the cerebellum anatomically and physiologically engages with the hippocampus to sustain such communication remains unknown. Using rabies virus as a retrograde transneuronal tracer in mice, we reveal that the dorsal hippocampus receives input from topographically restricted and disparate regions of the cerebellum. By simultaneously recording local field potential from both the dorsal hippocampus and anatomically connected cerebellar regions, we additionally suggest that the two structures interact, in a behaviorally dynamic manner, through subregion-specific synchronization of neuronal oscillations in the 6-12 Hz frequency range. Together, these results reveal a novel neural network macro-architecture through which we can understand how a brain region classically associated with motor control, the cerebellum, may influence hippocampal neuronal activity and related functions, such as spatial navigation.
journal_name
Elifejournal_title
eLifeauthors
Watson TC,Obiang P,Torres-Herraez A,Watilliaux A,Coulon P,Rochefort C,Rondi-Reig Ldoi
10.7554/eLife.41896subject
Has Abstractpub_date
2019-06-17 00:00:00issn
2050-084Xpii
41896journal_volume
8pub_type
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