Anatomical and physiological foundations of cerebello-hippocampal interaction.

Abstract:

:Multiple lines of evidence suggest that functionally intact cerebello-hippocampal interactions are required for appropriate spatial processing. However, how the cerebellum anatomically and physiologically engages with the hippocampus to sustain such communication remains unknown. Using rabies virus as a retrograde transneuronal tracer in mice, we reveal that the dorsal hippocampus receives input from topographically restricted and disparate regions of the cerebellum. By simultaneously recording local field potential from both the dorsal hippocampus and anatomically connected cerebellar regions, we additionally suggest that the two structures interact, in a behaviorally dynamic manner, through subregion-specific synchronization of neuronal oscillations in the 6-12 Hz frequency range. Together, these results reveal a novel neural network macro-architecture through which we can understand how a brain region classically associated with motor control, the cerebellum, may influence hippocampal neuronal activity and related functions, such as spatial navigation.

journal_name

Elife

journal_title

eLife

authors

Watson TC,Obiang P,Torres-Herraez A,Watilliaux A,Coulon P,Rochefort C,Rondi-Reig L

doi

10.7554/eLife.41896

subject

Has Abstract

pub_date

2019-06-17 00:00:00

issn

2050-084X

pii

41896

journal_volume

8

pub_type

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