Abstract：
:Medulloblastoma (MB), the most common malignant paediatric brain tumour occurs in the cerebellum. Advances in molecular genomics have led to the identification of defined subgroups which are associated with distinct clinical prognoses. Despite this classification, standard therapies for all subgroups often leave children with life-long neurological deficits. New therapeutic approaches are therefore urgently needed to reduce current treatment toxicity and increase survival for patients. GD3 is a well-studied ganglioside which is known to have roles in the development of the cerebellum. Post-partum GD3 is not highly expressed in the brain. In some cancers however GD3 is highly expressed. In MB cells GD3 is largely acetylated to GD3A. GD3 is pro-apoptotic but GD3A can protect cells from apoptosis. Presence of these gangliosides has previously been shown to correlate with resistance to chemotherapy. Here we show that the GD3 acetylation pathway is dysregulated in MB and as a proof-of-principle we show that increased GD3 expression sensitises an MB cell line to etoposide.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mather RL,Loveson KF,Fillmore HLdoi
10.1038/s41598-019-44950-5subject
Has Abstractpub_date
2019-06-13 00:00:00pages
8609issue
1issn
2045-2322pii
10.1038/s41598-019-44950-5journal_volume
9pub_type
杂志文章abstract：:Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16219
更新日期：2015-11-18 00:00:00
abstract：:Nanofabrication has seen an increasing demand for applications in many fields of science and technology, but its production still requires relatively difficult, time-consuming, and expensive processes. Here we report a simple but very effective one dimensional (1D) nano-patterning technology that suggests a new nanofa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18892
更新日期：2016-01-04 00:00:00
abstract：:A number of human and animal in vitro or in vivo studies have investigated the relationship between dietary choline and betaine and cancer risk, suggesting that choline and betaine consumption may be protective for cancer. There are also a few epidemiologic studies exploring this relationship, however, with inconsiste...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep35547
更新日期：2016-10-19 00:00:00
abstract：:The d-band center model of Hammer and Nørskov is widely used in understanding and predicting catalytic activity on transition metal (TM) surfaces. Here, we demonstrate that this model is inadequate for capturing the complete catalytic activity of the magnetically polarized TM surfaces and propose its generalization. W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35916
更新日期：2016-11-03 00:00:00
abstract：:We evaluated changes in incidence, relative survival (RS), and conditional survival (CS) of head and neck squamous cell carcinoma (HNSCC), focusing on oral tongue squamous cell carcinoma (OTSCC). Data of 74 680 HNSCC patients from 1976 to 2015 were obtained from the Surveillance, Epidemiology, and End Results database...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64748-0
更新日期：2020-05-12 00:00:00
abstract：:The presence of hepatic steatosis (HS) is an important histological feature in a variety of liver disease. It is critical to assess HS accurately, particularly where it plays an integral part in defining the disease. Conventional methods of quantifying HS remain semi-quantitative, with potential limitations in precisi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39783-1
更新日期：2019-02-27 00:00:00
abstract：:Disseminated diseases of the central nervous system such as amyotrophic lateral sclerosis (ALS) require that therapeutic agents are delivered and distributed broadly. Intrathecal route is attractive in that respect, but to date there was no methodology available allowing for optimization of this technique to assure sa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34723-x
更新日期：2018-11-07 00:00:00
abstract：:Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, which have highly active membrane dynamics. Using new assays with femtomole sensitivity, we determined that whereas levels of phosphatidylinos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26978
更新日期：2016-06-01 00:00:00
abstract：:Poly(N-isopropylacrylamide) (PNIPAm) is widely used to fabricate cell sheet surfaces for cell culturing, however copolymer and interpenetrated polymer networks based on PNIPAm have been rarely explored in the context of tissue engineering. Many complex and expensive techniques have been employed to produce PNIPAm-base...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63228-9
更新日期：2020-04-09 00:00:00
abstract：:Desorption electrospray ionisation-mass spectrometry imaging (DESI-MSI) is a powerful imaging technique for the analysis of complex surfaces. However, the often highly complex nature of biological samples is particularly challenging for MSI approaches, as options to appropriately address molecular complexity are limit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36957-1
更新日期：2019-01-09 00:00:00
abstract：:The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been described, with different protein cargoes including the MA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44451
更新日期：2017-03-15 00:00:00
abstract：:Pseudoalteromonas haloplanktis TAC125 is among the most commonly studied bacteria adapted to cold environments. Aside from its ecological relevance, P. haloplanktis has a potential use for biotechnological applications. Due to its importance, we decided to take advantage of next generation sequencing (Illumina) and th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52832-z
更新日期：2019-11-11 00:00:00
abstract：:Bacterial global post-transcriptional regulators execute hundreds of interactions with targets that display varying molecular features while retaining specificity. Herein, we develop, validate, and apply a biophysical, statistical thermodynamic model of canonical target mRNA interactions with the CsrA global post-tran...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27474-2
更新日期：2018-07-02 00:00:00
abstract：:Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system. However, the mechanisms underlying its tumor initiation, progression, and metastasis are not yet fully understood. The annexin A4 (ANXA4) gene is highly expressed in GBC tissues and may play an important role in the initiation and progr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31056
更新日期：2016-08-05 00:00:00
abstract：:High-carrier mobility semiconductors on insulators are essential for fabricating advanced thin-film transistors, allowing for three-dimensional integrated circuits or high-performance mobile terminals. We investigate the low-temperature (375-450 °C) solid-phase crystallization (SPC) of Ge on a glass substrate, focusin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17273-6
更新日期：2017-12-05 00:00:00
abstract：:Although poaching (illegal killing) is an important cause of death for large carnivores globally, the effect of lethal management policies on poaching is unknown for many populations. Two opposing hypotheses have been proposed: liberalizing killing may decrease poaching incidence ('tolerance hunting') or increase it (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70837-x
更新日期：2020-08-17 00:00:00
abstract：:A green, facile and tunable pair electrochemical process was developed for the synthesis of new benzenesulfonamide derivatives by using reductive controlled potential electrolysis of dinitrobenzene (DNB) in the presence of arylsulfinic acids (ASAs). In addition to the usual features associated with paired electrochemi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38544-4
更新日期：2019-03-14 00:00:00
abstract：:There is still much to understand about the brain's colour processing mechanisms and the transformation from cone-opponent representations to perceptual hues. Moreover, it is unclear which area(s) in the brain represent unique hues. We propose a hierarchical model inspired by the neuronal mechanisms in the brain for l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64969-3
更新日期：2020-05-22 00:00:00
abstract：:In this study, a model assisted strategy is developed to control the distribution of colloids in porous media in the framework of nanoremediation, an innovative environmental nanotechnology aimed at reclaiming contaminated aquifers. This approach is exemplified by the delivery of humic acid-stabilized iron oxide nanop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13423-y
更新日期：2017-10-11 00:00:00
abstract：:Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. HFMD outbreaks and reported cases have sharply increased in China since 2008. Epidemiological and clinical data of HFMD cases reported in Henan Province were collected from 2008 to 2013. Clinical specimens were obtained from a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08904
更新日期：2015-03-10 00:00:00
abstract：:CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26235-5
更新日期：2018-05-22 00:00:00
abstract：:Plants are constantly exposed to pathogens and environmental stresses. To minimize damage caused by these potentially harmful factors, plants respond by massive transcriptional reprogramming of various stress-related genes via major transcription factor families. One of the transcription factor families, WRKY, plays a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07981
更新日期：2015-01-23 00:00:00
abstract：:We address the impact of the spin-orbit (SO) coupling on the localization-delocalization-transition (LDT) in a spin-orbit coupled Bose-Einstein condensate in a bichromatic potential. We find that SO coupling significantly alters the threshold depth of the one of sublattices above which the lowest eigenstates transform...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31700
更新日期：2016-08-17 00:00:00
abstract：:Coupled networks are extremely fragile because a node failure of a network would trigger a cascade of failures on the entire system. Existing studies mainly focused on the cascading failures and the robustness of coupled networks when the networks suffer from attacks. In reality, it is necessary to recover the damaged...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08439
更新日期：2015-02-13 00:00:00
abstract：:This paper investigates the effects of temperature on an InGaP (GaInP) 55Fe X-ray photovoltaic cell prototype for a radioisotope microbattery (also called a nuclear microbattery). An In0.5Ga0.5P p-i-n (5 μm i-layer) mesa photodiode was illuminated by a standard 206 MBq 55Fe radioisotope X-ray source and characterised ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05181-8
更新日期：2017-07-10 00:00:00
abstract：:Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41697
更新日期：2017-01-31 00:00:00
abstract：:Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39688
更新日期：2017-01-03 00:00:00
abstract：:First-generation adenovirus vectors (FG AdVs) are widely used in basic studies and gene therapy. However, virus-associated (VA) RNAs that act as small-interference RNAs are indeed transcribed from the vector genome. These VA RNAs can trigger the innate immune response. Moreover, VA RNAs are processed to functional vir...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01136
更新日期：2013-01-01 00:00:00
abstract：:High salinity frequently causes inhibition and even failure in anaerobic digestion. To explore the impact of increasing NaCl concentrations on biogas production, and reveal the microbial community variations in response to high salinity stress, the Illumina high-throughput sequencing technology was employed. The resul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01298-y
更新日期：2017-04-25 00:00:00
abstract：:Cells regulate their intracellular mRNA levels by using specific ribonucleases. Oligoribonuclease (ORN) is a 3'-5' exoribonuclease for small RNA molecules, important in RNA degradation and re-utilisation. However, there is no structural information on the ligand-binding form of ORNs. In this study, the crystal structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39641-0
更新日期：2019-02-25 00:00:00
