Abstract:
:Seven benzodiazepine-receptor ligands of the beta-carbolines' group were administered IP in Wistar rats from (1) a strain displaying spontaneous petit mal-like seizures (PMLS) characterized by spike and wave discharges (SWD) and, (2) a strain where no seizure is ever observed (NS). Five different types of effects were observed. (1) Injection of a full agonist (ZK 93 423) suppressed SWD in PMLS rats, in a dose-dependent manner, and induced marked sedation with alteration of EEG background activity; (2) Injection of partial agonists (ZK 95 962, ZK 91 296) suppressed SWD in PMLS rats without sedation; (3) Injection of low doses of a full inverse agonist (DMCM) significantly increased the total duration of SWD in PMLS rats and induced SWD in NS rats. Higher doses of DMCM induced convulsions in both strains; (4) Injection of partial inverse agonists (FG 7142, ZK 90 886) aggravated SWD in PMLS and induced SWD in NS rats. FG 7142 induced convulsions only in PMLS animals, whereas no convulsions were ever observed with ZK 90 886; (5) Injection of an antagonist (ZK 93 426) did not significantly modify SWD in PMLS rats. However, this compound was able to reverse both antiepileptic effects of agonists and epileptogenic effects of inverse agonists. These results suggest the involvement of the benzodiazepine-GABA receptor complex in the control of petit mal-like seizures in rats.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Marescaux C,Vergnes M,Jensen LH,Petersen E,Depaulis A,Micheletti G,Warter JMdoi
10.1016/0361-9230(87)90101-8subject
Has Abstractpub_date
1987-09-01 00:00:00pages
327-35issue
3eissn
0361-9230issn
1873-2747pii
0361-9230(87)90101-8journal_volume
19pub_type
杂志文章abstract::Reports from both this laboratory and others indicate that prenatal exposure of rats to cocaine can produce alterations in development, activity and responses to environmental stimuli. In order to determine a biochemical basis for these effects, radioligand receptor-binding assays for different monoaminergic receptors...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90261-h
更新日期:1991-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
abstract::Hoe 065 is a compound structurally related to the angiotensin converting enzyme inhibitors and capable of increasing central cholinergic activity. The effects of this compound were studied on alcohol intake and on the reduction in alcohol intake produced by abutapril, an angiotensin converting enzyme inhibitor. Hoe 06...
journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(85)90111-x
更新日期:1985-06-01 00:00:00
abstract::Reserpine depletes dopamine (DA) levels and increases tyrosine hydroxylase (TH) activity in the rat corpus striatum. TH is activated not only by enhancement of DA neuronal impulse flow, but also by cessation of impulse flow. To assist in the understanding of the relative contribution of impulse flow to the regulation ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(81)80037-8
更新日期:1981-02-01 00:00:00
abstract::Surgical removal of the olfactory bulbs (OB) was performed in mature male red-winged blackbirds, maintained under a short-day light regime. Bulbectomy caused hyperphagia, which was not accompanied by obesity. Bulbectomized (OBX) birds had incresaed thyroid follicular activity and had greater developed testes than sham...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(79)80011-8
更新日期:1979-05-01 00:00:00
abstract::Previously we have shown that systemic injection of adenosine antagonists can significantly improve cold tolerance in both rats and humans. However, it is not clear whether systemic administration of adenosine antagonist acts peripherally or centrally at the thermoregulatory site. To resolve this, theophylline (nonsel...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(90)90094-g
更新日期:1990-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90158-t
更新日期:1992-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2001-01-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/0361-9230(91)90147-c
更新日期:1991-09-01 00:00:00
abstract::beta-endorphin-like immunoreactivity was measured by radioimmunoassay in the brains of adult rats treated neonatally with beta-endorphin, naloxone, or vehicle. After treatment with beta-endorphin, the decreases observed in beta-endorphin-like immunoreactivity in the hypothalamus, pineal, midbrain, pons-medulla, hippoc...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(81)90118-0
更新日期:1981-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90223-5
更新日期:1984-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2020.01.020
更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0361-9230(99)00264-6
更新日期:2000-03-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.05.022
更新日期:2005-09-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(03)00188-6
更新日期:2003-09-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(85)90149-2
更新日期:1985-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(85)90008-5
更新日期:1985-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0361-9230(83)90097-7
更新日期:1983-03-01 00:00:00
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更新日期:1996-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.09.019
更新日期:2020-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90148-5
更新日期:1984-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2021.01.002
更新日期:2021-01-07 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90191-d
更新日期:1993-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(96)00350-4
更新日期:1997-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90068-0
更新日期:1983-01-01 00:00:00
abstract::To clarify the role of febrile temperatures on the immune system, rats were immunized with sheep erythrocytes and their core temperature was then changed by continuously cooling or heating the preoptic area for five days. Core temperatures of up to 2 degrees C above or below normal were associated with a high titre of...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90124-2
更新日期:1984-08-01 00:00:00