Abstract:
:Introduction: Even with the currently recommended chemotherapeutic and immunotherapeutic treatment, the five year survival rate for advanced nonsquamous and squamous NSCLC without oncogenic drivers remains poor. However, several different chemo-immunotherapy combinations are presently being investigated - with favorable results- in order to increase the PFS and OS rates of these patients. Areas covered: Therefore, this paper aims to discuss the most promising trials investigating chemo-immunotherapy combinations and their present and future impact on advanced NSCLC treatment paradigms. Expert opinion: First line chemo-immunotherapy combinations are starting to and will certainly revolutionize the current paradigm of metastatic non small cell lung cancer treatment due to their superior performances - both in terms of PFS and OS - when compared to the actual standard of care platinum based chemotherapy. However, these associations are not devoid of problems, in fact, combining immunotherapy with chemotherapy obviously leads to enhanced treatment-related toxicities and to higher discontinuation rates; therefore these treatments should be administered carefully.
journal_name
Expert Rev Anticancer Therjournal_title
Expert review of anticancer therapyauthors
Rocco D,Della Gravara L,Battiloro C,Gridelli Cdoi
10.1080/14737140.2019.1631800subject
Has Abstractpub_date
2019-07-01 00:00:00pages
561-568issue
7eissn
1473-7140issn
1744-8328journal_volume
19pub_type
杂志文章,评审abstract::The Second European Lung Cancer Conference was held in Geneva, Switzerland from 28 April to 1 May 2010, under the cosponsorship of the International Association for the Study of Lung Cancer and the European Society for Medical Oncology. The main topics included: tobacco control, which represents a crucial challenge fo...
journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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journal_title:Expert review of anticancer therapy
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