Abstract:
Background/Aims:Nutrient-induced gut hormone release (eg, cholecystokinin [CCK]) and the modulation of gut motility (particularly pyloric stimulation) contribute to the regulation of acute energy intake. Non-caloric bitter compounds, including quinine, have recently been shown in cell-line and animal studies to stimulate the release of gastrointestinal hormones by activating bitter taste receptors expressed throughout the gastrointestinal tract, and thus, may potentially suppress energy intake without providing additional calories. This study aims to evaluate the effects of intraduodenally administered quinine on antropyloroduodenal pressures, plasma CCK and energy intake. Methods:Fourteen healthy, lean men (25 ± 5 years; BMI: 22.5 ± 2.0 kg/m2) received on 4 separate occasions, in randomized, double-blind fashion, 60-minute intraduodenal infusions of quinine hydrochloride at doses totaling 37.5 mg ("Q37.5"), 75 mg ("Q75") or 225 mg ("Q225"), or control (all 300 mOsmol). Antropyloroduodenal pressures (high-resolution manometry), plasma CCK (radioimmunoassay), and appetite perceptions/gastrointestinal symptoms (visual analog questionnaires) were measured. Ad libitum energy intake (buffet-meal) was quantified immediately post-infusion. Oral quinine taste-thresholds were assessed on a separate occasion using 3-alternative forced-choice procedure. Results:All participants detected quinine orally (detection-threshold: 0.19 ± 0.07 mmol/L). Intraduodenal quinine did not affect antral, pyloric or duodenal pressures, plasma CCK (pmol/L [peak]; control: 3.6 ± 0.4, Q37.5: 3.6 ± 0.4, Q75: 3.7 ± 0.3, Q225: 3.9 ± 0.4), appetite perceptions, gastrointestinal symptoms or energy intake (kcal; control: 1088 ± 90, Q37.5: 1057 ± 69, Q75: 1029 ±7 0, Q225: 1077 ± 88). Conclusions:Quinine, administered intraduodenally over 60 minutes, even at moderately high doses, but low infusion rates, does not modulate appetite-related gastrointestinal functions or energy intake.
journal_name
J Neurogastroenterol Motiljournal_title
Journal of neurogastroenterology and motilityauthors
Bitarafan V,Fitzgerald PCE,Little TJ,Meyerhof W,Wu T,Horowitz M,Feinle-Bisset Cdoi
10.5056/jnm19036subject
Has Abstractpub_date
2019-07-01 00:00:00pages
413-422issue
3eissn
2093-0879issn
2093-0887pii
jnm19036journal_volume
25pub_type
杂志文章abstract:Background/Aims:The Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed and validated as a tool for the diagnosis of gastroesophageal reflux disease (GERD) in patients with gastrointestinal symptoms. However, the GerdQ and the cutoff value for determining GERD has not been validated in Korea. Meth...
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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abstract:Background/Aims:Recent studies suggest that air pollution may play a role in gastrointestinal disorders. However, the effect of long-term exposure to air pollution on childhood irritable bowel syndrome (IBS) is unclear. Hence, we conducted a nationwide cohort study to investigate the association between long-term air p...
journal_title:Journal of neurogastroenterology and motility
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doi:10.5056/jnm18135
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abstract:BACKGROUND/AIMS:Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implant...
journal_title:Journal of neurogastroenterology and motility
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doi:10.5056/jnm15046
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abstract::The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has revealed that various alterations to the DNA methylation apparatus within both of these cell types can result in a variety of cellular phe...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章,评审
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.2.192
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm14020
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.3.306
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19062
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abstract:BACKGROUND/AIMS:Several motility disorders are associated with disruption of interstitial cells of Cajal (ICC), which provide important functions, such as pacemaker activity, mediation of neural inputs and responses to stretch in the gastrointestinal (GI) tract. Restoration of ICC networks may be therapeutic for GI mot...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm14026
更新日期:2014-07-31 00:00:00
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.3.317
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm20094
更新日期:2020-12-28 00:00:00
abstract::Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophagea...
journal_title:Journal of neurogastroenterology and motility
pub_type: 评审
doi:10.5056/jnm19081
更新日期:2019-10-30 00:00:00
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.4.389
更新日期:2010-10-01 00:00:00
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.4.495
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm17140
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.1.77
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.3.279
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15064
更新日期:2016-04-30 00:00:00
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journal_title:Journal of neurogastroenterology and motility
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