Elevated p21-activated kinase 2 activity results in anchorage-independent growth and resistance to anticancer drug-induced cell death.

abstract：:Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia. Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor...

journal_title：Neoplasia (New York, N.Y.)

authors： Tellier C,Desmet D,Petit L,Finet L,Graux C,Raes M,Feron O,Michiels C

更新日期：2015-01-01 00:00:00

abstract：:The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R. In human U87MG glioblastoma cells, AChE-R formed a triple complex wit...

journal_title：Neoplasia (New York, N.Y.)

authors： Perry C,Sklan EH,Soreq H

更新日期：2004-05-01 00:00:00

abstract：:The biologic plausibility of an association between type 2 diabetes mellitus (T2D) and lung cancer has received increasing attention, but the results of investigations remain largely inconclusive. In the present study we investigated the influence of the anti-diabetic drug metformin on the cytotoxic effects of EGFR ta...

journal_title：Neoplasia (New York, N.Y.)

authors： Xiao Z,Gaertner S,Morresi-Hauf A,Genzel R,Duell T,Ullrich A,Knyazev PG

更新日期：2017-05-01 00:00:00

abstract：:This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies, with a prevalence of <200,000 in the United States, which makes it an orphan disease (Basu et al., 2010).1 For functional purposes, NENs are divided into two grou...

journal_title：Neoplasia (New York, N.Y.)

authors： Oronsky B,Ma PC,Morgensztern D,Carter CA

更新日期：2017-12-01 00:00:00

abstract：:Although it is well known that nasopharyngeal carcinoma (NPC) is closely related with Epstein-Barr virus (EBV), few data are available about which and how EBV-expressed gene is involved in the carcinogenesis of human nasopharyngeal epithelial cells. EBV-encoded BARF1 (BamH I-A right frame 1) gene has been shown to be ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jiang R,Cabras G,Sheng W,Zeng Y,Ooka T

更新日期：2009-09-01 00:00:00

abstract：:The term mucositis is coined to describe the adverse effects of radiation and chemotherapy treatments. Mucositis is one of the most common adverse reactions encountered in radiation therapy for head and neck cancers, as well as in chemotherapy, in particular with drugs affecting DNA synthesis (S-phase-specific agents ...

journal_title：Neoplasia (New York, N.Y.)

authors： Naidu MU,Ramana GV,Rani PU,Mohan IK,Suman A,Roy P

更新日期：2004-09-01 00:00:00

abstract：:Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PanINs), the precursor lesions, are a potential target for chemoprevention. Targeting eicosanoid pathways is an obvious choice because 5-lipoxygenase (5-LOX) has been s...

journal_title：Neoplasia (New York, N.Y.)

authors： Hennig R,Kehl T,Noor S,Ding XZ,Rao SM,Bergmann F,Fürstenberger G,Büchler MW,Friess H,Krieg P,Adrian TE

更新日期：2007-11-01 00:00:00

abstract：:Treatment decisions in oncology are increasingly guided by information on the biologic characteristics of tumors. Currently, patient-specific information on tumor biology is obtained from the analysis of biopsy material. Positron emission tomography (PET) provides quantitative estimates of regional biochemistry and re...

journal_title：Neoplasia (New York, N.Y.)

authors： Mankoff DA,Dehdashti F,Shields AF

更新日期：2000-01-01 00:00:00

abstract：:During normal sympathetic nervous system (SNS) development, cells of the ganglionic lineage can malignantly transform and develop into the childhood tumor neuroblastoma. Hypoxia-inducible transcription factors (HIFs) mediate cellular responses during normal development and are central in the adaptation to oxygen short...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohlin S,Hamidian A,Påhlman S

更新日期：2013-03-01 00:00:00

abstract：:SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported. Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomita...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen S,Yang X,Yu M,Wang Z,Liu B,Liu M,Liu L,Ren M,Qi H,Zou J,Vucenik I,Zhu WG,Luo J

更新日期：2019-07-01 00:00:00

abstract：:PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1alpha, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanced (DCE) and diffusi...

journal_title：Neoplasia (New York, N.Y.)

authors： Jordan BF,Runquist M,Raghunand N,Baker A,Williams R,Kirkpatrick L,Powis G,Gillies RJ

更新日期：2005-05-01 00:00:00

abstract：:ET-743 (trabectedin; Yondelis) is approved in Europe for the treatment of soft tissue sarcomas. Emerging phase 1 and 2 clinical data have shown high response rates in myxoid liposarcoma in part owing to the inhibition of the FUS-CHOP transcription factor. In this report, we show that modulation of specific oncogenic t...

journal_title：Neoplasia (New York, N.Y.)

authors： Grohar PJ,Griffin LB,Yeung C,Chen QR,Pommier Y,Khanna C,Khan J,Helman LJ

更新日期：2011-02-01 00:00:00

abstract：:Mutation of the PARK2 gene can promote both Parkinson's Disease and cancer, yet the underlying mechanisms of how PARK2 controls cellular physiology is incompletely understood. Here, we show that the PARK2 tumor suppressor controls the apoptotic regulator BCL-XL and modulates programmed cell death. Analysis of approxim...

journal_title：Neoplasia (New York, N.Y.)

authors： Gong Y,Schumacher SE,Wu WH,Tang F,Beroukhim R,Chan TA

更新日期：2017-02-01 00:00:00

abstract：:BUB1 (budding uninhibited by benzimidazoles-1) is required for efficient TGF-β signaling, through its role in stabilizing the TGFBR1 and TGFBR2 complex. Here we demonstrate that TGFBR2 phosphorylates BUB1 at Serine-318, which is conserved in primates. S318 phosphorylation abrogates the interaction of BUB1 with TGFBR1 ...

journal_title：Neoplasia (New York, N.Y.)

authors： Nyati S,Gregg BS,Xu J,Young G,Kimmel L,Nyati MK,Ray D,Speers C,Rehemtulla A

更新日期：2020-04-01 00:00:00

abstract：:One of the challenges of tailored antiangiogenic therapy is the ability to adequately monitor the angiogenic activity of a malignancy in response to treatment. The α(v)β(3) integrin, highly overexpressed on newly formed tumor vessels, has been successfully used as a target for Arg-Gly-Asp (RGD)-functionalized nanopart...

journal_title：Neoplasia (New York, N.Y.)

authors： Jarzyna PA,Deddens LH,Kann BH,Ramachandran S,Calcagno C,Chen W,Gianella A,Dijkhuizen RM,Griffioen AW,Fayad ZA,Mulder WJ

更新日期：2012-10-01 00:00:00

abstract：:With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely understood. Three of the recently approved ADCs contain payloads exh...

journal_title：Neoplasia (New York, N.Y.)

authors： Khera E,Cilliers C,Smith MD,Ganno ML,Lai KC,Keating TA,Kopp A,Nessler I,Abu-Yousif AO,Thurber GM

更新日期：2021-02-01 00:00:00

abstract：:The sequence of genomic alterations acquired by cancer cells during tumor progression and metastasis is poorly understood. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that integrates cytoskeleton remodeling, mitogenic signaling and cell survival. FAK has previously been reported to undergo nuclear lo...

journal_title：Neoplasia (New York, N.Y.)

authors： Constanzo JD,Tang KJ,Rindhe S,Melegari M,Liu H,Tang X,Rodriguez-Canales J,Wistuba I,Scaglioni PP

更新日期：2016-05-01 00:00:00

abstract：:Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) incidence is increasing at a near epidemic rate. We investigated whether the mammalian (or mechanistic) target of rapamycin (mTOR) inhibitor, rapamycin, can be used as a concurrent agent to standard-of-care cisplatin/radiation therapy (CR...

journal_title：Neoplasia (New York, N.Y.)

authors： Coppock JD,Wieking BG,Molinolo AA,Gutkind JS,Miskimins WK,Lee JH

更新日期：2013-06-01 00:00:00

abstract：:The ZNF198- FGFR1 fusion gene arises as a result of the t(8;13)(p11;q12) in the 8p11 myeloproliferative syndrome. To determine the transforming properties of this chimeric protein we transfected ZNF198-FGFR1 into the interleukin (IL)-3 dependent cell line Ba/F3. Growth factor independent subclones were obtained in whi...

journal_title：Neoplasia (New York, N.Y.)

authors： Smedley D,Demiroglu A,Abdul-Rauf M,Heath C,Cooper C,Shipley J,Cross NC

更新日期：1999-10-01 00:00:00

abstract：:In this study, a new compound, 4-(N)-docosahexaenoyl 2', 2'-difluorodeoxycytidine (DHA-dFdC), was synthesized and characterized. Its antitumor activity was evaluated in cell culture and in mouse models of pancreatic cancer. DHA-dFdC is a poorly soluble, pale yellow waxy solid, with a molecular mass of 573.3Da and a me...

journal_title：Neoplasia (New York, N.Y.)

authors： Naguib YW,Lansakara-P D,Lashinger LM,Rodriguez BL,Valdes S,Niu M,Aldayel AM,Peng L,Hursting SD,Cui Z

更新日期：2016-01-01 00:00:00

abstract：:Endothelin (ET) 1 is important in the growth of prostate cancer cells through the activation of the endothelin A (ET(A)) receptor. ET receptor blockade is a new therapeutic target in treating advanced prostate cancer. This study investigates the impact of the combination of the ET(A) antagonist atrasentan (ABT-627) an...

journal_title：Neoplasia (New York, N.Y.)

authors： Akhavan A,McHugh KH,Guruli G,Bies RR,Zamboni WC,Strychor SA,Nelson JB,Pflug BR

更新日期：2006-09-01 00:00:00

abstract：:Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity and might influence the prognosis of UUT-TCC. We examined the as...

journal_title：Neoplasia (New York, N.Y.)

authors： Sasaki M,Sakano S,Okayama N,Akao J,Hara T,Kawai Y,Ohmi C,Hinoda Y,Naito K

更新日期：2008-03-01 00:00:00

abstract：:Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts, plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal niche. Similarly, prostate cancer (PCa) cells express the annexin II receptor and seem to use the stem cell niche for homing to the bo...

journal_title：Neoplasia (New York, N.Y.)

authors： Shiozawa Y,Pedersen EA,Patel LR,Ziegler AM,Havens AM,Jung Y,Wang J,Zalucha S,Loberg RD,Pienta KJ,Taichman RS

更新日期：2010-02-01 00:00:00

abstract：:It has long been a puzzle in cancer treatment that despite the initial appearance of apoptosis, the process could be reversed in some cancer cells and often results in more aggressive tumors and metastasis. The mechanism for this recurrence is yet unknown. Here we report that human mammary carcinoma cells induced to u...

journal_title：Neoplasia (New York, N.Y.)

authors： Xu Y,So C,Lam HM,Fung MC,Tsang SY

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Inflammatory breast cancer (IBC) is arguably the deadliest form of breast cancer due to its rapid onset and highly invasive nature. IBC carries 5- and 10-year disease-free survival rates of ~45% and <20%, respectively. Multiple studies demonstrate that in comparison with conventional breast cancer, IBC has a un...

journal_title：Neoplasia (New York, N.Y.)

authors： Joglekar-Javadekar M,Van Laere S,Bourne M,Moalwi M,Finetti P,Vermeulen PB,Birnbaum D,Dirix LY,Ueno N,Carter M,Rains J,Ramachandran A,Bertucci F,van Golen KL

更新日期：2017-07-01 00:00:00

abstract：:We present an in vivo fluorescence microscopic evaluation of intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6 (NPe6) in an intradermal mouse EMT6 tumor model. Although the identification of favorable photophysical and pharmacological properties has led to the development of new photosensitizers...

journal_title：Neoplasia (New York, N.Y.)

authors： Mitra S,Foster TH

更新日期：2008-05-01 00:00:00

abstract：:Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase activity and immortal...

journal_title：Neoplasia (New York, N.Y.)

authors： Yi X,White DM,Aisner DL,Baur JA,Wright WE,Shay JW

更新日期：2000-09-01 00:00:00

abstract：:Alveolar soft part sarcoma is an extremely rare soft tissue sarcoma with poor prognosis. It is characterized by the unbalanced recurrent chromosomal translocation der(17)t(X;17)(p11;q25), resulting in the generation of an ASPL-TFE3 fusion gene. ASPL-TFE3 oncoprotein functions as an aberrant transcriptional factor and ...

journal_title：Neoplasia (New York, N.Y.)

authors： Ishiguro N,Yoshida H

更新日期：2016-10-01 00:00:00

abstract：:The cancer stem cell paradigm postulates that dysregulated tissue-specific stem cells or progenitor cells are precursors for cancer biogenesis. Consequently, identifying cancer stem cells is crucial to our understanding of cancer progression and for the development of novel therapeutic agents. In this study, we demons...

journal_title：Neoplasia (New York, N.Y.)

authors： Vesuna F,Lisok A,Kimble B,Raman V

更新日期：2009-12-01 00:00:00

abstract：:Inhibitors of histone deacetylases have been shown to enhance the sensitivity of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand TRAIL-mediated cytotoxicity. Valproic acid (VA), a commonly used antiepileptic agent whose pharmacokinetics and toxicity profiles are well described, is a histone dea...

journal_title：Neoplasia (New York, N.Y.)

authors： Ziauddin MF,Yeow WS,Maxhimer JB,Baras A,Chua A,Reddy RM,Tsai W,Cole GW Jr,Schrump DS,Nguyen DM

更新日期：2006-06-01 00:00:00