Abstract:
PURPOSE:To evaluate the diagnostic performance of coronary computed tomography angiography derived fractional flow reserve (CT-FFR) with invasive fractional flow reserve (FFR) in patients with coronary artery disease" before "with invasive fractional flow reserve serving as the reference standard. MATERIALS AND METHODS:CT-FFR values based on a machine learning algorithm (cFFRML) in 183 vessels of 136 patients from four centers were measured with invasive FFR as reference standard. The diagnostic performance from our multicenter study was combined into a meta-analysis following a literature search in Web of Science, PubMed, Cochrane library to identify studies comparing diagnostic performance of coronary computed tomography angiography (CCTA) and CT-FFR. Sensitivity, specificity, accuracy were analyzed on both per-vessel and per-patient basis for intermediate lesions and by algorithm. RESULTS:Our multicenter study demonstrated sensitivities, specificities, and accuracies of cFFRML and CCTA of 0.85, 0.94, 0.90, and 0.95, 0.28, 0.55 on a per-vessel basis, respectively. For our meta-analysis, pooled sensitivities, specificities, and accuracies of CT-FFR and CCTA were 0.85, 0.82, 0.82, and 0.85, 0.57, 0.65 with AUC of 0.86 (95%CI: 0.83˜0.89) and 0.83 (95%CI: 0.79˜0.86) on a per-vessel basis, respectively. The sensitivity, specificity and accuracy for intermediate lesions using cFFRML were 0.84, 0.92, and 0.89. No significant difference was found among different algorithms of CT-FFR (P < 0.001). CONSLUSION:This multicenter study with meta-analysis showed that CT-FFR had a high diagnostic accuracy in determining ischemia-specific lesions and intermediate lesions. There was no significant difference when comparing the combined diagnostic performance of different algorithms of CT-FFR with invasive FFR as the reference standard.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Tang CX,Wang YN,Zhou F,Schoepf UJ,Assen MV,Stroud RE,Li JH,Zhang XL,Lu MJ,Zhou CS,Zhang DM,Yi Y,Yan J,Lu GM,Xu L,Zhang LJdoi
10.1016/j.ejrad.2019.04.011subject
Has Abstractpub_date
2019-07-01 00:00:00pages
90-97eissn
0720-048Xissn
1872-7727pii
S0720-048X(19)30145-7journal_volume
116pub_type
杂志文章,meta分析,多中心研究abstract:PURPOSE:Lymphangioleiomyomatosis (LAM) is characterized by proliferation of smooth muscle tissue that causes bronchial obstruction and secondary cystic destruction of lung parenchyma. The aim of this study was to evaluate the typical distribution of cystic defects in LAM with quantitative volumetric chest computed tomo...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.12.019
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abstract:BACKGROUND:The production of a copy of the fracture or a deformity in a bone with a complex geometry can be one of the important applications of the integration between two modern computer-based technologies, reverse engineering (RE) and rapid prototyping (RP). METHODS:This article reviews recent development in this f...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2010.10.007
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abstract:OBJECTIVE:To compare the diagnostic performance between Prostate Imaging Reporting and Data System version 1(PI-RADS v1) and PI-RADS v2 for detection of prostate cancer (PCa). METHODS:A systematic literature search was performed from inception to September 31, 2018, in following databases MEDLINE, EMBASE, Cochrane Lib...
journal_title:European journal of radiology
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abstract:PURPOSE:To evaluate the effect of transarterial pulsed perfusion with 60 °C saline on vascular permeability of tumor tissue, as well as its hepatic and renal toxicity, in a rabbit VX2 liver model. MATERIALS AND METHODS:VX2 carcinomas were grown in rabbit livers, forty male New Zealand white tumor-bearing rabbits were ...
journal_title:European journal of radiology
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doi:10.1016/j.ejrad.2011.01.108
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abstract::The management of trauma patients has become a very relevant issue and one of the major challenges in the western countries. In the assessment of politrauma patients, since the last 2 decades, radiological imaging methods have been increasingly used in order to provide a quick and thorough survey of craniocerebral, ce...
journal_title:European journal of radiology
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pub_type: 杂志文章,多中心研究
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abstract::Today radiology is an essential step in the pathological analysis of breast biopsies. It is determinant at each stage of the management of non palpable lesions, clusters of microcalcifications and opacities, whether this concerns the needle biopsy or the surgical excision. Firstly, an X-ray is necessary to ensure that...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2004.11.016
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abstract:STUDY OBJECTIVES:to study the validity and observers consistency in the detection of lung cancer on the chest radiograph. MATERIALS AND METHODS:the chest radiographs of 100 clinical cases were interpreted by 14 observers. The radiographs were obtained from 30 patients with initially missed but histopathologically prov...
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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