Abstract:
:Synthetic food preservatives like sodium acetate (SA), sodium benzoate (SB), potassium sorbate (PS) and Butyl paraben (BP) have been widely used in food and pharmacy industries. One of the toxicological aspects of food additives is evaluation of their interaction with serum proteins such as albumin. These additives interaction with human serum albumin (HSA) can exert considerable effect on the absorption, distribution, metabolism and toxicity of chemical compounds. It should be noticed that the aforementioned food preservatives intake increase mainly in the presence of glucose may lead to complex formation of SA, SB, PS and BP with HSA and accelerate the development of variety disease such as cancer, diabetes, multiple sclerosis, brain damage, nausea and cardiac disease. Therefore, to understand the mechanisms of aforementioned food additives interaction and conformational changes of proteins, we aim to review various studies that investigated albumin interaction with these additives using several procedures.
journal_name
Food Chemjournal_title
Food chemistryauthors
Mohammadzadeh-Aghdash H,Akbari N,Esazadeh K,Ezzati Nazhad Dolatabadi Jdoi
10.1016/j.foodchem.2019.04.119subject
Has Abstractpub_date
2019-09-30 00:00:00pages
491-498eissn
0308-8146issn
1873-7072pii
S0308-8146(19)30791-5journal_volume
293pub_type
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