Impact of Radical Hysterectomy Versus Simple Hysterectomy on Survival of Patients with Stage 2 Endometrial Cancer: A Meta-analysis.

Abstract:

BACKGROUND:The strategy of radical surgery for stage 2 endometrial cancer (EC) remains controversial. This meta-analysis aimed to investigate the impact of radical hysterectomy (RH) versus simple hysterectomy (SH) on survival of patients with stage 2 EC. METHODS:A systematic review was conducted to identify studies comparing survival between RH and SH in International Federation of Gynecology and Obstetrics (FIGO) stage 2 EC patients by searching several databases to July 2018. Hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival and progression-free survival were pooled using Stata V.12.0. RESULTS:The study included 10 retrospective cohort studies enrolling 2866 patients. Patients who received RH did not show a significant survival benefit for either overall survival (pooled HR 0.92; 95% CI 0.72-1.16; P = 0.484) or progression-free survival (pooled HR 0.75; 95% CI 0.39-1.42; P = 0.378). The result remained consistent after it was balanced with possible impact from adjuvant radiotherapy (pooled HR 0.85; 95% CI 0.62-1.16; P = 0.300). In earlier studies that staged patients according to FIGO 1988, RH showed a 27% survival benefit (pooled HR 0.73; 95% CI 0.53-1.00; P = 0.050), whereas in newly published studies based on FIGO 2009 staging, it reversely showed increased risk of death (pooled HR 1.24; 95% CI 0.86-1.77; P = 0.245). However, no statistical significance was reached under either staging criterion. CONCLUSIONS:Based on the results of this meta-analysis, RH does not significantly improve survival in stage 2 EC. The choice of RH remains controversial and should be considered carefully in clinical practice. More qualified studies are needed to determine the best treatment strategy for stage 2 EC.

journal_name

Ann Surg Oncol

authors

Liu T,Tu H,Li Y,Liu Z,Liu G,Gu H

doi

10.1245/s10434-019-07472-y

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

2933-2942

issue

9

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-019-07472-y

journal_volume

26

pub_type

杂志文章,meta分析
  • Water: a simple solution for tumor spillage.

    abstract:BACKGROUND:Although often proposed as a means to reduce the harmful consequences of tumor spill, water lavage has yet to be systematically evaluated in relevant in vitro and in vivo models. This study evaluates the mechanisms and utility of a single water lavage to improve the sequelae of tumor spill during laparotomy....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1588-4

    authors: Ito F,Camoriano M,Seshadri M,Evans SS,Kane JM 3rd,Skitzki JJ

    更新日期:2011-08-01 00:00:00

  • Preoperative needle biopsy as a potential quality measure in breast cancer surgery.

    abstract::Preoperative needle diagnosis (PND) is being considered as a quality measure in breast cancer surgery. This criterion has not been thoroughly evaluated in the literature. The purpose of this study is to assess ease of access to these data and rate of compliance in a tertiary care center. We retrospectively reviewed al...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0188-4

    authors: Pocock B,Taback B,Klein L,Joseph KA,El-Tamer M

    更新日期:2009-05-01 00:00:00

  • Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer.

    abstract:BACKGROUND:The involvement of lipids in carcinogenic and developmental processes has been reported in some malignancies, but their roles in gastric cancer remain to be analyzed. In this study, we compared the lipid content of gastric cancer tissue and adjacent nonneoplastic mucosa using imaging mass spectrometry. METH...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4459-6

    authors: Uehara T,Kikuchi H,Miyazaki S,Iino I,Setoguchi T,Hiramatsu Y,Ohta M,Kamiya K,Morita Y,Tanaka H,Baba S,Hayasaka T,Setou M,Konno H

    更新日期:2016-02-01 00:00:00

  • Lymphatic drainage patterns from the treated breast.

    abstract:INTRODUCTION:Lymphatic drainage patterns from the breast have been described in the past. Drainage may change after treatment of a breast or axilla, and this may have implications for lymphatic mapping. The aim of this study was to determine the lymphatic drainage patterns in breast cancer patients with a previously tr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0841-6

    authors: van der Ploeg IM,Oldenburg HS,Rutgers EJ,Baas-Vrancken Peeters MJ,Kroon BB,Valdés Olmos RA,Nieweg OE

    更新日期:2010-04-01 00:00:00

  • Cavity Shaving Reduces Involved Margins and Reinterventions Without Increasing Costs in Breast-Conserving Surgery: A Propensity Score-Matched Study.

    abstract:BACKGROUND:Currently, reinterventions for involved margins after breast-conserving surgery remain common. The aim of this study was to assess the capability of the cavity shave margins (CSM) technique to reduce positive margin rates and reoperations compared with simple lumpectomy (SL). The impact of CSM on the various...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5774-x

    authors: Corsi F,Sorrentino L,Bonzini M,Bossi D,Truffi M,Amadori R,Nebuloni M,Brillat B,Mazzucchelli S

    更新日期:2017-06-01 00:00:00

  • Sestamibi imaging for primary hyperparathyroidism: the impact of surgeon interpretation and radiologist volume.

    abstract:BACKGROUND:Preoperative localization is the first step towards minimally invasive targeted parathyroidectomy. While there are data emphasizing that surgeon experience optimizes operative outcomes, the role of the radiologist's experience in successful preoperative imaging is unclear. We hypothesized that the accuracy o...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2581-2

    authors: Zia S,Sippel RS,Chen H

    更新日期:2012-11-01 00:00:00

  • Multicenter institutional experience of surgically resected thymic epithelial tumors (TETs): an observational report on behalf of F.O.N.I.C.A.P. (Forza Operativa Nazionale Interdisciplinare Contro il Cancro del Polmone).

    abstract:BACKGROUND:This multicenter analysis evaluated patient outcome and clinical pathologic features of thymic epithelial tumors after complete surgical resection and adjuvant treatment. METHODS:Histologic classification and clinical staging were performed according to WHO classification and Masaoka staging system, respect...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-013-3018-2

    authors: Genestreti G,Ampollini L,Burgio MA,Rolli L,Sanna S,Scarpi E,Monti M,Burgio SL,Giannone L,Santo A,Mezzetti M,Casanova C,Buosi R,Rusca M,Amadori D,Gavelli G

    更新日期:2013-09-01 00:00:00

  • Nephrectomy during operative management of retroperitoneal sarcoma.

    abstract:BACKGROUND:Complete resection of a retroperitoneal sarcoma often requires removal of adjacent organs. In this study we evaluated the role of nephrectomy during operation for retroperitoneal sarcoma. METHODS:Between July 1982 and July 1995, 75 of the 371 (20%) patients who underwent resection of retroperitoneal sarcoma...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02305556

    authors: Russo P,Kim Y,Ravindran S,Huang W,Brennan MF

    更新日期:1997-07-01 00:00:00

  • Visceral obesity may affect oncologic outcome in patients with colorectal cancer.

    abstract:PURPOSE:Obesity is closely related to the development of colorectal cancer as well as other metabolic complications. We investigated the prognostic significance of visceral obesity and body mass index (BMI) in 161 resectable colorectal cancer patients. METHODS:Ratios of visceral fat area (VFA) to subcutaneous fat area...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9891-4

    authors: Moon HG,Ju YT,Jeong CY,Jung EJ,Lee YJ,Hong SC,Ha WS,Park ST,Choi SK

    更新日期:2008-07-01 00:00:00

  • Impact of Patient Age on the Postoperative Survival in Pancreatic Head Cancer.

    abstract:BACKGROUND:Some reports have stated that pancreatoduodenectomy for elderly patients have comparable morbidity and mortality to that of young patients. However, the long-term outcomes of these patients have not been fully evaluated, especially for pancreatic head cancer. METHODS:A total of 227 patients who underwent pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5994-0

    authors: Sugiura T,Okamura Y,Ito T,Yamamoto Y,Ashida R,Uesaka K

    更新日期:2017-10-01 00:00:00

  • Receptor Tyrosine Kinase Expression Predicts Response to Sunitinib in Breast Cancer.

    abstract:BACKGROUND:Preliminary data indicate that tyrosine kinase inhibitors (TKIs) function through rearranged during transfection (RET) in breast cancer. However, TKIs are not specific and can block several receptor tyrosine kinases (RTKs). This study used cell lines and primary breast cancer specimens to determine factors a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4597-x

    authors: Spanheimer PM,Lorenzen AW,De Andrade JP,Kulak MV,Carr JC,Woodfield GW,Sugg SL,Weigel RJ

    更新日期:2015-12-01 00:00:00

  • Risk of colorectal cancer in chronic kidney disease: a matched cohort study based on administrative data.

    abstract:BACKGROUND:The risk of colorectal cancer (CRC) in chronic kidney disease (CKD) patients relative to the general population is unknown. The aim of this population-based study was to investigate the risk of CRC in patients with CKD. METHODS:The study cohort included patients aged ≥18 years diagnosed with CKD between 200...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-013-3065-8

    authors: Wu MY,Chang TC,Chao TY,Huang MT,Lin HW

    更新日期:2013-11-01 00:00:00

  • Predictive Value of CD44 in Muscle-Invasive Bladder Cancer and Its Relationship with IL-6 Signaling.

    abstract:BACKGROUND:CD44, a cancer stem cell surface marker, is associated with treatment resistance and prognosis in some cancers. In the present study, we examined the predictive value of CD44 in muscle-invasive bladder cancer (MIBC). METHODS:We retrospectively analyzed the clinical outcomes of 105 MIBC patients and correlat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6706-0

    authors: Wu CT,Lin WY,Chen WC,Chen MF

    更新日期:2018-11-01 00:00:00

  • A Comparison of the LigaSure and harmonic scalpel in thyroid surgery: a single institution review.

    abstract:BACKGROUND:During the last few years, many surgeons have begun to utilize the LigaSure device or Harmonic scalpel to perform thyroid surgery. Several papers have demonstrated the benefits of these devices compared with traditional hand-tying techniques. The purpose of this study was to examine our institution's experie...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-010-1334-3

    authors: Zarebczan B,Mohanty D,Chen H

    更新日期:2011-01-01 00:00:00

  • Laparoscopic Segment 1 with Partial IVC Resection in Advanced Cirrhosis: How to Do It Safely.

    abstract:BACKGROUND:Laparoscopic versus open hepatocellular carcinoma (HCC) resection reduces morbidity without a compromise in oncologic safety.1-4 Moreover, in the subgroup of cirrhotic patients, a decreased risk of prolonged postoperative ascites and liver decompensation has been reported.5-7 METHODS: A 54-year-old homeless,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08122-z

    authors: Vega EA,Nicolaescu DC,Salehi O,Kozyreva O,Vellayappan U,Ricklan D,McCarty J,Fontan F,Pomposelli F,Conrad C

    更新日期:2020-04-01 00:00:00

  • ASO Author Reflections: Radiation Therapy in Soft Tissue Sarcoma: Who Benefits and How?

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6970-z

    authors: Albertsmeier M,Roeder F,Angele MK

    更新日期:2018-12-01 00:00:00

  • Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms.

    abstract:BACKGROUND:Peritoneal carcinomatosis (PC) in the setting of mucinous appendiceal neoplasms is characterized by the intraperitoneal accumulation of mucinous ascites and mucin-secreting epithelial cells that leads to progressive compression of intra-abdominal organs, morbidity, and eventual death. We assessed postoperati...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2241-6

    authors: Austin F,Mavanur A,Sathaiah M,Steel J,Lenzner D,Ramalingam L,Holtzman M,Ahrendt S,Pingpank J,Zeh HJ,Bartlett DL,Choudry HA

    更新日期:2012-05-01 00:00:00

  • Fertility Preservation for the Young Breast Cancer Patient.

    abstract:BACKGROUND:The American Society of Clinical Oncology (ASCO) guidelines include incorporation of fertility preservation guidelines in the care of breast oncology patients. This study aimed to examine the baseline knowledge and preferences concerning fertility preservation among women of childbearing age with newly diagn...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5036-8

    authors: Goldfarb SB,Kamer SA,Oppong BA,Eaton A,Patil S,Junqueira MJ,Olcese C,Kelvin JF,Gemignani ML

    更新日期:2016-05-01 00:00:00

  • Predictive factors of level IIb lymph node metastasis in patients with papillary thyroid carcinoma.

    abstract:BACKGROUND:The extent of neck dissection (ND) appropriate for necks yielding clinical evidence of metastases of papillary thyroid carcinoma (PTC) is controversial. The need for level IIb lymph node (LN) dissection is particularly uncertain in view of its association with postoperative shoulder dysfunction. In the prese...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0367-y

    authors: Koo BS,Yoon YH,Kim JM,Choi EC,Lim YC

    更新日期:2009-05-01 00:00:00

  • Keynote Address at the American Society of Breast Surgeons 18th Annual Meeting : Current and Future Application of Intraoperative Radiotherapy (IORT) in the Curative and Palliative Treatment of Breast Cancer.

    abstract::Intraoperative radiotherapy (IORT) is increasingly used worldwide. Breast cancer is the most rapidly growing indication for IORT, approaching 70-80% of cases in most centers. This report reviews the theoretical background and clinical use of IORT for primary and metastasized breast cancer. There are established applic...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5942-z

    authors: Wenz F

    更新日期:2017-10-01 00:00:00

  • Clinical presentation of patients with a thyroid follicular neoplasm: are there preoperative predictors of malignancy?

    abstract:BACKGROUND:Studies examining differences in presentation of patients with benign [follicular adenoma (FA)] and malignant follicular thyroid neoplasms [follicular thyroid carcinoma (FTC) or follicular variant papillary thyroid carcinoma (FVPTC)] include only one or two of these subtypes, and none has considered clinical...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4324-z

    authors: Najafian A,Olson MT,Schneider EB,Zeiger MA

    更新日期:2015-09-01 00:00:00

  • Is head and neck melanoma different from trunk and extremity melanomas with respect to sentinel lymph node status and clinical outcome?

    abstract:BACKGROUND:Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN) positivity and/or survival. This study was conducted to evaluate and compare the effect of the anatomic locations of primary melanoma on long-term clinical outco...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2977-7

    authors: Fadaki N,Li R,Parrett B,Sanders G,Thummala S,Martineau L,Cardona-Huerta S,Miranda S,Cheng ST,Miller JR 3rd,Singer M,Cleaver JE,Kashani-Sabet M,Leong SP

    更新日期:2013-09-01 00:00:00

  • XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Adaptor proteins, with multimodular structures, can participate in the regulation of various cellular functions. A novel adaptor protein XB130 has been implicated as a substrate and regulator of tyrosine kinase-mediated signaling and in controlling cell proliferation and apoptosis in thyroid and lung cancer ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2474-4

    authors: Shiozaki A,Kosuga T,Ichikawa D,Komatsu S,Fujiwara H,Okamoto K,Iitaka D,Nakashima S,Shimizu H,Ishimoto T,Kitagawa M,Nakou Y,Kishimoto M,Liu M,Otsuji E

    更新日期:2013-09-01 00:00:00

  • An outcome study of breast reconstruction: presurgical identification of risk factors for complications.

    abstract:BACKGROUND:Breast reconstruction following mastectomy has been shown to have a salutary effect on the overall psychological well-being of women being treated for breast cancer. Unfortunately, however, not every patient is an ideal candidate for reconstruction. Complications stemming from reconstructive surgery can caus...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-001-0586-3

    authors: Lin KY,Johns FR,Gibson J,Long M,Drake DB,Moore MM

    更新日期:2001-08-01 00:00:00

  • A look into the ductoscope: its role in pathologic nipple discharge.

    abstract:OBJECTIVE:Mammary ductoscopy allows direct visualization of the ductal system and a method for directed excision and pathologic diagnosis. We reviewed our experience with mammary ductoscopy in the evaluation of pathologic nipple discharge. METHODS:We reviewed all patients who underwent ductoscopy for pathologic nipple...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1962-2

    authors: Fisher CS,Margenthaler JA

    更新日期:2011-10-01 00:00:00

  • Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric Cancer.

    abstract:BACKGROUND:Identification of gastric cancer-related molecules is necessary to elucidate the pathological mechanisms of this heterogeneous disease. The purpose of this study was to identify novel genes associated with aggressive phenotypes of gastric cancer. METHODS:Global expression profiling was conducted using tissu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-07149-y

    authors: Uno Y,Kanda M,Miwa T,Umeda S,Tanaka H,Tanaka C,Kobayashi D,Suenaga M,Hattori N,Hayashi M,Yamada S,Nakayama G,Fujiwara M,Kodera Y

    更新日期:2019-03-01 00:00:00

  • Cytoreduction and hyperthermic intraperitoneal chemoperfusion in women with heavily pretreated recurrent ovarian cancer.

    abstract:BACKGROUND:Limited data are available on the use of cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (HIPEC) in patients with recurrent stage III ovarian cancer. METHODS:Patients with recurrent, heavily pretreated ovarian cancer were enrolled onto a phase II multimodal protocol consisting of exte...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0878-6

    authors: Ceelen WP,Van Nieuwenhove Y,Van Belle S,Denys H,Pattyn P

    更新日期:2012-07-01 00:00:00

  • Desmoplastic melanoma: is there a role for sentinel lymph node biopsy?

    abstract:BACKGROUND:The utility of sentinel lymph node biopsy (SLNB) for desmoplastic melanoma (DM) is debated. We describe a large single-institution experience with SLNB for DM to determine clinicopathologic factors predictive of SLN metastasis. METHODS:Retrospective review identified 205 patients with DM who underwent SLNB ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2883-z

    authors: Han D,Zager JS,Yu D,Zhao X,Walls B,Marzban SS,Rao NG,Sondak VK,Messina JL

    更新日期:2013-07-01 00:00:00

  • Radiofrequency ablation for eradication of renal tumor in a rabbit model by using a cooled-tip electrode technique.

    abstract:BACKGROUND:Radiofrequency ablation (RFA) has emerged as a potential alternative for surgery in clinical oncology. This animal experiment was conducted to evaluate the feasibility of RFA in the treatment of renal tumor. METHODS:Eighteen rabbits with renal implantation of VX2 tumors were divided into two groups. Group A...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-001-0651-y

    authors: Miao Y,Ni Y,Bosmans H,Yu J,Vaninbroukx J,Dymarkowski S,Zhang H,Marchal G

    更新日期:2001-09-01 00:00:00

  • Rapid genetic diagnosis with the transcription-reverse transcription concerted reaction system for cancer micrometastasis.

    abstract:BACKGROUND:Detection of cancer micrometastases is required for improvement of cancer therapy. The aim of this study was to establish a rapid and practical genetic assay to detect micrometastasis in gastric cancer and to assess its clinical significance with respect to prognosis. METHODS:A novel RNA amplification syste...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2004.12.043

    authors: Ishii T,Fujiwara Y,Ohnaka S,Hayashi T,Taniguchi H,Takiguchi S,Yasuda T,Yano M,Monden M

    更新日期:2004-08-01 00:00:00