Toll-like receptors: A pathway alluding to cancer control.

Abstract:

:Toll-like receptors (TLRs) are usually expressed on immune cells such as macrophages, dendritic cells, mast cells, as well as on eosinophils and some epithelial cells. They play a central role in the recognition of harmful molecules that belong to invading microorganisms or internal damaged tissues, which lead to inflammation. Among the hallmarks of cancer, there is immune evasion and inflammation. Summing this with the discovery that a majority of cancers also seem to express TLRs, made researchers realize these receptors might also be linked with cancer progression. This review will cover some of the effects of TLR engagement in cancer cells that might induce the promotion or inhibition of cancer with mechanisms involved. The differences of TLR expression in cancer progression and its possible relation with patient prognosis, TLR genetic disorders found in cancer, and new strategies to cancer therapy will be discussed to target TLRs in cancer cells.

journal_name

J Cell Physiol

authors

Ayala-Cuellar AP,Cho J,Choi KC

doi

10.1002/jcp.28879

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

21707-21715

issue

12

eissn

0021-9541

issn

1097-4652

journal_volume

234

pub_type

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