Abstract：
OBJECTIVE:To study the incidence of postoperative systemic inflammatory response syndrome (SIRS) following different antibiotic prophylaxis (ABP) regimens in retrograde intrarenal surgery (RIRS). PATIENTS AND METHODS:Single-centre, randomised, controlled trial (August 2014-September 2017) including 426 patients with renal stones with preoperative sterile urine managed by RIRS (ClinicalTrials.gov NCT02304822). Different ciprofloxacin-based ABP regimens were used and included a zero dose, single dose (30 min before surgery) or two doses (first dose at 30 min before RIRS and additional dose within 6 h after RIRS). The incidence of SIRS was compared using intention-to-treat (ITT) and per-protocol (PP) analyses. RESULTS:Each group enrolled 142 patients. In the ITT analysis, a zero dose of ABP was statistically similar to the two ABP regimes for the incidence of SIRS (9.9% vs single dose 4.9%, P = 0.112; vs two doses 4.2%, P = 0.062). There were also no relevant differences across groups in the PP analysis; no urosepsis was recorded. In subgroup analysis with stratification by stone area, the three regimens all had a low and similar incidence of SIRS for stones of ≤200 mm2 in the ITT analysis with a sufficient power value (5.4% vs 6.2% vs 3.6%, P = 0.945 vs single dose and P = 0.553 vs two doses). However, there was a greater chance of SIRS in patients who received no ABP with stones of >200 mm2 (18% vs single dose 4.3%, P = 0.036; vs two doses 5.5%, P = 0.044). Similar trends were seen in the PP analysis. CONCLUSIONS:For patients with preoperative sterile urine, ABP is not strongly recommended in patients with stones of ≤200 mm2 , but for stones >200 mm2 single-dose ABP is still required.
journal_name
BJU Intjournal_title
BJU internationalauthors
Zhao Z,Fan J,Sun H,Zhong W,Zhu W,Liu Y,Wu W,de la Rosette J,Del Pilar Laguna Pes M,Zeng Gdoi
10.1111/bju.14832subject
Has Abstractpub_date
2019-09-01 00:00:00pages
496-503issue
3eissn
1464-4096issn
1464-410Xjournal_volume
124pub_type
杂志文章,随机对照试验abstract：OBJECTIVES:To analyze pathological and short-term oncological outcomes in men undergoing open and minimally-invasive radical prostatectomy (MIRP) for high-risk prostate cancer (HRPC; prostate-specific antigen level [PSA] >20 ng/mL, ≥ cT2c, Gleason score 8-10) in a contemporaneous series. PATIENTS AND METHODS:In total,...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2012.11757.x
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:To determine the safety, efficacy and pharmacokinetics of tolterodine in children with an overactive bladder. PATIENTS AND METHODS:Thirty-three children (20 boys and 13 girls, aged 5-10 years) with an overactive bladder and symptoms of urgency, frequency and/or urge incontinence were enrolled in an open, dos...
journal_title：BJU international
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1046/j.1464-410x.2001.00084.x
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between International Continence Society categories of lower urinary tract symptoms (LUTS; storage, voiding, and postmicturition) and individual LUTS (associated with decreased sexual activity and sexual satisfaction in men) with erectile dysfunction (ED), ejaculatory dysfunction (...
journal_title：BJU international
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1464-410X.2009.08447.x
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To review a series of children with anterior urethral valves and diverticula, to elucidate the pathophysiology and optimal management of this entity. PATIENTS AND METHODS:Nine cases (all boys; 1963 to 2003) were reviewed retrospectively. RESULTS:Seven of nine boys had bulbar diverticula. Continuity between ...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2004.04854.x
更新日期：2004-08-01 00:00:00
abstract：:To assess the evidence for the concept that the androgen receptor of prostate cancer (PCa) cells becomes saturated when testosterone values exceed castrate levels, so that testosterone administration in hypogonadal men with untreated PCa does not stimulate tumour growth. To propose basic criteria for administration of...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1111/j.1464-410X.2011.10193.x
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To report the management of urachal anomalies using a robotically assisted approach. PATIENTS AND METHODS:Between January 2005 and February 2006, five patients (mean age 51 years, range 24-68) were diagnosed with urachal anomalies. Two basic robot-assisted surgical approaches were used for excising the urach...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2006.06430.x
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To study scrotal microvascularization and apply the findings to the design of reliable skin flaps for reconstructive surgery of complex urethral or panurethral stenoses. MATERIALS AND METHODS:In 15 cryopreserved male cadavers, scrotal skin vascularization was explored using macro- and microdissections, and t...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2008.08167.x
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVES:To retrospectively review hypogonadal men receiving testosterone replacement therapy (TRT), and evaluate the changes in prostate-specific antigen (PSA) levels over an extended period, and thus evaluate the occurrence of prostate cancer, as a primary concern in treating late-onset hypogonadism (LOH) is the po...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2008.08240.x
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To determine the changes in body composition, muscle function and energy expenditure after radical cystectomy (RC). PATIENTS AND METHODS:Eleven consecutive men (median age 66 years, range 44-79) who had a RC over a 1-year period had measurements made of their total body protein, by neutron-activation analysi...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2007.07337.x
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To determine whether an indwelling catheter on free drainage provides a constantly low intravesical pressure in patients with a neuropathic bladder. PATIENTS AND METHODS:Thirty patients with complete spinal-cord injury (SCI) whose bladders were managed exclusively with an indwelling catheter were assessed ur...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.1999.00933.x
更新日期：1999-03-01 00:00:00
abstract：OBJECTIVES:To compare, in a retrospective study, pathological specimens of prostate cancer detected in additional areas of a 12-core biopsy with tumours detected using traditional sextant biopsy. PATIENTS AND METHODS:The study included 27 patients who had undergone radical prostatectomy (RP) for prostate cancer. Prost...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.2000.00558.x
更新日期：2000-04-01 00:00:00
abstract：UNLABELLED:Study Type--Therapy (practise pattern survey) Level of Evidence 3b. What's known on the subject? and What does the study add? Congenital penile deviation has become a relatively frequent finding due to a greater awareness of the problem among patients and physicians. Since the first surgical correction for c...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2012.11350.x
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To critically review published data on the urogynaecological aspects of female sexual dysfunction (FSD), as FSD is a developing multidisciplinary issue associated with several biological, medical and psychological factors. METHODS:The reported prevalence of FSD is 19-50% and women with lower urinary tract sy...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1111/j.1464-410X.2007.07442.x
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core tran...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.12517
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To develop a rat model of erectile dysfunction (ED) after cavernous nerve injury. MATERIALS AND METHODS:Given the great similarity between the anatomical structure of the cavernous nerve in rats and humans, 24 rats underwent dissections and the cavernous nerves were identified with the aid of an operating mi...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2008.07760.x
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:• To investigate the oncological efficacy of retroperitoneal laparoscopic radical nephrectomy (RLRN) compared with transperitoneal laparoscopic radical nephrectomy (TLRN) for the management of clear-cell renal cell carcinoma (RCC). PATIENTS AND METHODS:• With emphasis on survival and disease recurrence, a re...
journal_title：BJU international
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1464-410X.2010.09636.x
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist (M3 SRA), from an analysis of pooled data from three phase III, multicentre, double-blind clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:After a 4-week washout/run-...
journal_title：BJU international
pub_type： 杂志文章,meta分析
doi：10.1111/j.1464-410X.2005.05454.x
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To report on the failure of thalidomide to inhibit tumour growth in an animal model of human renal cell carcinoma (RCC). MATERIALS AND METHODS:An orthotopic xenograft model of human RCC was used in which tumour cells were implanted in the left kidney of male 'severe combined immunodeficient' mice. Thalidomid...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.2002.02666.x
更新日期：2002-04-01 00:00:00
abstract：:The purpose of this study is to evaluate accuracy of magnetic resonance imaging (MRI) for local staging of bladder cancer for four clinical scenarios (T-stage thresholds) considered against current standards for clinical staging and secondarily to identify sources for variability in accuracy. Systematic review of pati...
journal_title：BJU international
pub_type： 杂志文章,meta分析
doi：10.1111/bju.14366
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:To analyse functional outcomes and complication rates of artificial urinary sphincter (AUS) implantation with a distal bulbar double cuff (DC) for the treatment of stress urinary incontinence (SUI) in men with and without a history of external beam radiotherapy (RT). PATIENTS AND METHODS:Data of all patient...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.14882
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To investigate the high circumcision rate in South Korea and its rapid increase in the short period since its introduction. SUBJECTS AND METHODS:From January to December 2000, 5434 South Korean males (or their parents) aged 0-92 years were interviewed in detail about their circumcision status, their age at c...
journal_title：BJU international
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the long-term results of salvage cystectomy after interstitial radiotherapy (IRT) and external beam radiotherapy (EBRT) for transitional cell carcinoma, and to assess the morbidity and functional results of the different urinary diversions used. PATIENTS AND METHODS:The records of 27 patients tre...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2004.05034.x
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To assess, in a repeat audit of a regional lithotripsy service, whether changes implemented after a regional audit in 1994 (which showed disappointing results from shock wave lithotripsy, attributable to both poor patient selection and an inadequate fixed-site lithotripter) have had any effect. PATIENTS AND ...
journal_title：BJU international
pub_type： 杂志文章,多中心研究
doi：10.1046/j.1464-410x.2002.02674.x
更新日期：2002-05-01 00:00:00
abstract：UNLABELLED:What's known on the subject? and What does the study add? Elderly patients have more years to compound comorbidities and it has previously been shown that comorbidity is an important predictor of overall survival in patients with bladder cancer, including those treated with radical cystectomy (RC). Other stu...
journal_title：BJU international
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1464-410X.2012.11180.x
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To determine whether Thr(307)-Asn(680) and Ala(307)-Ser(680) polymorphisms of the follicle-stimulating hormone receptor (FSH-R) gene are associated with male infertility, semen quality, and reproductive hormones. PATIENTS AND METHODS:The FSH-R polymorphisms at codons 680 and 307 were analysed by restriction-...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2010.09890.x
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To assess the relationship between glycogen content in bladder detrusor tissue and historical bladder function in a guinea-pig model of partial bladder outlet obstruction (PBOO). MATERIALS AND METHODS:In male immature guinea pigs PBOO was created with a silver ring around the proximal urethra; a control grou...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2007.07046.x
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To report a simplified and effective method for substratification of M1 castrate-resistant prostate cancer (CRPC) by correlating progression-free (PFS) and overall survival (OS) with simple quantification of skeletal metastases. PATIENTS AND METHODS:In all, 561 men with M1 CRPC were studied longitudinally. I...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.12717
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG). PATIENTS AND METHODS:Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) resu...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2012.10968.x
更新日期：2012-11-01 00:00:00
abstract：UNLABELLED:Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Erectile dysfunction is a recognized complication of radical prostatectomy. Androgen deprivation therapy adversely impacts sexual function. Our study shows that the preoperative use of androgen de...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2011.10728.x
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that benign prostatic hyperplasia (BPH) robotic surgery with aquablation would have a more pronounced benefit in certain patient subgroups, such as men with more challenging anatomies (e.g. large prostates, large middle lobes) and men with moderate BPH. METHODS:We conducted prespecifie...
journal_title：BJU international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/bju.14426
更新日期：2019-04-01 00:00:00
