Abstract:
BACKGROUND:In epileptic patients with motor disability, it's difficult to disentangle the effects of antiepileptic drugs (AEDs) on bone health from those provoked by impaired mobility. The aim of this study was to evaluate the effects of AEDs on bone mineral status by phalangeal quantitative ultrasound (QUS), a no-radiation and non-invasive method, in pediatric patients with motor impairment and epilepsy. METHODS:We enrolled 56 patients (31 females, 25 males) with epilepsy and motor impairment and 24 children with only motor disability (13 females, 11 males). Patients were stratified by Gross Motor Function Classification System Scale (GMFCS) in 4 groups: group A1 with epilepsy and mild motor impairment (GMFCS levels I-II), group A2 with only mild motor impairment, group B1 with epilepsy and severe motor impairment (GMFCS levels III-V), group B2 with only severe motor impairment. The bone mineral status was evaluated by QUS and amplitude-dependent speed of sound (AD-SoS) Z-score was calculated for each patient. RESULTS:The four groups showed no significant differences in age, gender and 25- hydroxyvitamin D levels. The group B1 had a statistically lower amplitude-dependent speed of sound Z-score as compared to group A2 (p<0.05). The multivariate analysis of independent factors revealed a significant correlation between amplitude-dependent speed of sound Z-score and Gross Motor Function Classification System levels (p=0.004). The mean Z-score value decreased by 0.53, increasing the motor impairment. CONCLUSIONS:The bone mineral status measured as AD-SoS strongly correlates with severity of motor disability evaluated by GMFCS as compared to antiepileptic therapy and 25-hydroxyvitamin D levels.
journal_name
Minerva Pediatrjournal_title
Minerva pediatricaauthors
Terrone G,Gragnaniello V,Esposito A,Del Puente A,Del Giudice Edoi
10.23736/S0026-4946.18.05235-0subject
Has Abstractpub_date
2019-05-23 00:00:00eissn
0026-4946issn
1827-1715pii
S0026-4946.18.05235-0pub_type
杂志文章abstract:AIM:Despite the availability of a number of pharmacological options, relief of allergic rhinitis (AR) symptoms, especially nasal obstruction, is often limited and local and systemic adverse reactions are not infrequent. The main aim of the present pilot study was to provide subjective and objective evidence of the clin...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2015-06-01 00:00:00
abstract::The management of neonatal fungal infections poses several challenges, including the fact that the choices of available agents are limited, given the paucity of data relating to the use of newer antifungal agents in the group of infants. The information summarized herein represents in part the consensus of a group of ...
journal_title:Minerva pediatrica
pub_type: 共识发展会议,杂志文章,评审
doi:
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The nutritional status of foster children, the quality of daily menus in group homes and the food security inside these organizations have been poorly studied. For this reason, the aim of this study was to investigate them. METHODS:A sample of 125 children, ranging in age from 0-17 years, among seven group ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.16.04802-7
更新日期:2020-12-01 00:00:00
abstract:AIM:Aim of this study is to evaluate anxiety and temperament characteristics in developmental age subjects who practised agonistic sport (individual or team sports) in comparison with a sample group of subjects who practice no agonistic sports. METHODS:Sixty subjects aged from 10 to 16 years were enrolled in the study...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract::Age of diagnosis and clinical pattern were studied in 97 celiac patients, diagnosed with jejunal biopsy, between 1976-1991. They were selected on the basis of clinical and laboratory patterns. The laboratory tests utilized were steatorrhea and xylose in the first years, while in recent years AGA, ARA and AEA were also...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::The association of congenital anal stenosis, or other anal and rectal malformation, sacral defect and a presacral mass is known as the Currarino syndrome described for the first time in 1981. Currarino et al. proposed that abnormal endoectodermal adhesions and notochordal defects in early fetal life may result in a fi...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the potential of dexfenfluramine (dF) for reducing cardiovascular risk factors and improving compliance towards diet in a group of young patients hospitalized for essential obesity of high degree (BMI > or = 35). METHODS:103 adolescents (mean age 15.4 +/- 0.2) partic...
journal_title:Minerva pediatrica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-03-01 00:00:00
abstract:AIM:Childhood leukaemia treatment contains multiple chemotherapeutic agents in high doses that can cause severe toxic effects on heart and other vital organs. In this respect patients taking cancer chemotherapy are followed for these adverse effects. Echocardiographic myocardial performance index (MPI) was reported as ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::The past 10 years have seen a return of rickets. Clinical and/or biochemical signs of vitamin D deficiency are still found in some children and adolescents, mainly during the winter. Sunlight exposure is able to prevent vitamin D deficiency and rickets but the dramatic influence of changes in solar ultraviolet-B radia...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:
更新日期:1992-11-01 00:00:00
abstract::Gilbert's syndrome is a genetically controlled non-hemolytic unconjugated hyperbilirubinemia, caused by reduced activity of UDP-glucoroniltransferase 1, an enzyme critical in bilirubin metabolism. Several molecular configurations may be implicated in a Gilbert's phenotype. Familial mediterranean fever (FMF) is an inhe...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2008-08-01 00:00:00
abstract::The Authors describe an uncommon case of growth retardation; the clinical and radiological elements that the Authors to a diagnosis of spondyloepiphyseal dysplasia (SED) are noted; they compare this to other diagnosis of different types of growth retardation, they underline the necessity of taking these rare types int...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Asthma is a condition characterised by airways inflammation and bronchial hyperresponsiveness to specific and aspecific spasmogens associated with reversible airways obstruction. The bronchomotor tone is the result of an interaction between neurotransmitter release and local mediators. The efferent neurohumoral pathwa...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:To document the evolution of cranial asymmetries in infants with signs of nonsynostotic occipital plagiocephaly (NSOP) who were undergo to many functional manual therapy treatments (in addition to the standard positioning recommendations) as well as to determine the feasibility of this methodology to conduct...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.17.04838-1
更新日期:2017-10-25 00:00:00
abstract::The dominant cause of mortality, morbidity and hospitalization worldwide is cardiac complications, and are the major public health problem in adult populations. The worldwide research is being focused on the idea that cardiovascular disease is an early life pathological state. Early unfavorable exposures, acting in di...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4946.16.04713-7
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Inflammation may represent a common underlying mechanism in a wide range of diseases, including neuropsychiatric disorders. Cytokine involvement has been investigated in some studies on patients with childhood neuropsychiatric diseases. The aim of this study was to determine whether cytokines are involved in...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2016-12-22 00:00:00
abstract::The onset of puberty may be late - in the latter part of the predicted normal range or truly delayed - beyond this range. The latest age to start is usually regarded as 13 years in girls and 14 years in boys. There may also be a delayed completion of puberty, 16 years in girls and 17 years in boys. The initial approac...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.20.05968-X
更新日期:2020-12-01 00:00:00
abstract:AIM:In the last few years we noted an increasing number of children with celiac disease with negative serum anti-gliadin antibodies (AGA) a useful serologic test to monitor compliance to gluten-free diet. The aim of this study was to verify diagnostic accuracy of AGA and compare clinical characteristics of AGA-negative...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract::In a short girl with celiac disease and Hashimoto's thyroiditis (HT), suspicion of an associated pituitary lesion was suggested by the finding of a thyroid function pattern that was not compatible with HT-related hypothyroidism (low FT4 with normal TSH). This case report reinforces the view that the finding of a norma...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Aim of study was to ascertain the possible presence of congenital dysplasia of the hip in infants (CDH) in the population immigrated from countries where the problem is surely neglected from the local health service and estimate its incidence. Moreover to observe the impact of the CDH problem on the parents ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::The Authors report a case of two pre-term monocorial twins affected by HSV-1 infection (Herpes Simplex Virus type 1), with generalized sepsis and involvement of the central nervous system (CNS), born by mother with primary infection who presented a typical vesicular eruption a week before delivery. As the HSV-1 was a ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::The nailfold capillaroscopy allows to study the microcirculation: for its simple and rapid execution it can be used also in children. We examined the nailfold capillaroscopy features in childhood and valued the maturation of microcirculation in connection to age and presented some pathologic patterns. We studied nailf...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::The lipidaemic profile has been evaluated in a series of 603 healthy children aged 13-14, within a programme for the prevention of atherosclerotic disease commenced in November 1980 at Health Unit 66 of the Region of Piedmont. Hyperlipaemia is among the environmental risk factors for ATS and more than any of the other...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract::Personal experience of a series of mycoplasma-induced pneumoniae is reported. The importance of early diagnosis for the purpose of speedy target antibiotic therapy is reiterated. Stress is laid on the absence of complications in all patients studied. ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:In the last years thalassemic patients gained a good improvement in prognosis and life style. However, short stature and hypogonadism are still frequent endocrine problems in this population. METHODS:In a group of eleven thalassemic males (14-18 years old), the spontaneous nocturnal endocrine patterns of LH...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:This study aims to explore the correlation between nutrient level and pneumonia via the analysis and intervention of nutrient levels in pediatric patients with pneumonia. METHODS:Nutrient deficient children with pneumonia were randomized into intervention and non-intervention groups, and healthy children wi...
journal_title:Minerva pediatrica
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2016-02-01 00:00:00
abstract::Celiac disease (CD) is one of the most common immune-mediated diseases with a worldwide prevalence of around 1%, although a couple of decades ago the disease was thought to be very rare. CD is characterized by an inadequate inflammatory response to gluten in genetically susceptible individuals. In this inflammatory re...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:
更新日期:2012-06-01 00:00:00
abstract::Sixty patients (31 male and 29 female) with thalassemia major, aged between 6 and 26 years, 18 of which were splenectomized, were observed in this study evaluating the oro-maxillo-facial alterations and correlating them to transfusion indexes, serum ferritin levels, splenectomy and age. For each patient a haematologic...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Eosinophilic esophagitis (EoE) is a chronic disease characterized by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation (≥15 eosinophils/high power field). In the last ten years, several epidemiological studies showed a significant increase in the incidence and prevalence of EoE, especi...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.20.05913-7
更新日期:2020-10-01 00:00:00
abstract:AIM:The aim of this study was to assess the impact and the peculiarities of cerebral palsy (CP) in children discharged from our neonatal intensive care unit (NICU) from January 1998 to April 2004. METHODS:A total of 2 303 children were discharged from our NICU during this period and 1 912 were followed up for 1 year t...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Specific learning disabilities are disorders that affect the instrumental skills of academic learning, leaving intact the general intellectual functioning. It is possible to distinguish: dyslexia, dysorthography, dysgraphia, and dyscalculia. The diagnosis is made according to DSMV. The aim of this study is t...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.18.05036-3
更新日期:2018-04-12 00:00:00