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Low-risk gestational trophoblastic neoplasia outcome after treatment with VMP regimen from 2005 to 2017.

Abstract：

OBJECTIVE:To evaluate the efficacy and toxicity of VMP regimen applied to the patients with low-risk gestational trophoblastic neoplasia (LR-GTN) treated in Anhui provincial hospital. MATERIALS AND METHODS:Between 2005 and 2017, 87 patients with low-risk gestational trophoblastic neoplasia received VMP regimen, consisted of vincristine (VCR), methotrexate (MTX) and platinum (cisplatin, carboplatin or nedaplatin), 68 of whom received VMP as their first-line chemotherapy, and 19 methotrexate-failed patients received VMP regimen as their second-line chemotherapy. The staging and scoring system was based on International Federation of Gynecology and Obstetrics (FIGO 2000) criteria. We describe and analyze their baseline characteristics, remission/resistance/recurrence rates, adverse reactions and prognosis. RESULTS:The first-line VMP protocol can achieve an 83.8% remission rate and it tended to develop resistance when the pretreatment β-hCG reaches 7503.5 IU/L, and can achieve complete remission with FAV and EMA-CO as the salvage regimen. Among the 19 methotrexate-failed patients, 2 of whom were yet resistant to VMP regimen, followed by several courses of salvage chemotherapy such as FAV and EMP, and achieved 89.5% remission rate in second-line VMP group. Resistance to this regimen was obviously related with higher pre-treatment HCG whether used as primary or salvage treatment. Severe myelosuppression (grade 3 or 4) was shown in 4 (5.9%) of 68 cases, of which none was grade 4. CONCLUSION:For patients diagnosed with LR-GTN VMP regimen was a safe and effective treatment with a high rate of remission.

journal_name

Taiwan J Obstet Gynecol

journal_title

Taiwanese journal of obstetrics & gynecology

authors

Zhu CC,Liu HY,Wei Y,Shen Z,Qian LL,Song WG,Wang J,Wu DB,Zhang XF,Zhou Y

doi

10.1016/j.tjog.2019.03.008

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

332-337

issue

3

eissn

1028-4559

issn

1875-6263

pii

S1028-4559(19)30069-5

journal_volume

58

pub_type

杂志文章

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