Abstract:
:Gap junction (GJ) channels in invertebrates have been used to understand cell-to-cell communication in vertebrates. GJs are a common form of intercellular communication channels which connect the cytoplasm of adjacent cells. Dysregulation and structural alteration of the gap junction-mediated communication have been proven to be associated with a myriad of symptoms and tissue-specific pathologies. Animal models relying on the invertebrate nervous system have exposed a relationship between GJs and the formation of electrical synapses during embryogenesis and adulthood. The modulation of GJs as a therapeutic and clinical tool may eventually provide an alternative for treating tissue formation-related diseases and cell propagation. This review concerns the similarities between Hirudo medicinalis innexins and human connexins from nucleotide and protein sequence level perspectives. It also sets forth evidence of computational techniques applied to the study of proteins, sequences, and molecular dynamics. Furthermore, we propose machine learning techniques as a method that could be used to study protein structure, gap junction inhibition, metabolism, and drug development.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sánchez A,Castro C,Flores DL,Gutiérrez E,Baldi Pdoi
10.3390/ijms20102476subject
Has Abstractpub_date
2019-05-19 00:00:00issue
10issn
1422-0067pii
ijms20102476journal_volume
20pub_type
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更新日期:2018-05-07 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms19113470
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更新日期:2018-07-13 00:00:00
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