Gap Junction Channels of Innexins and Connexins: Relations and Computational Perspectives.

Abstract:

:Gap junction (GJ) channels in invertebrates have been used to understand cell-to-cell communication in vertebrates. GJs are a common form of intercellular communication channels which connect the cytoplasm of adjacent cells. Dysregulation and structural alteration of the gap junction-mediated communication have been proven to be associated with a myriad of symptoms and tissue-specific pathologies. Animal models relying on the invertebrate nervous system have exposed a relationship between GJs and the formation of electrical synapses during embryogenesis and adulthood. The modulation of GJs as a therapeutic and clinical tool may eventually provide an alternative for treating tissue formation-related diseases and cell propagation. This review concerns the similarities between Hirudo medicinalis innexins and human connexins from nucleotide and protein sequence level perspectives. It also sets forth evidence of computational techniques applied to the study of proteins, sequences, and molecular dynamics. Furthermore, we propose machine learning techniques as a method that could be used to study protein structure, gap junction inhibition, metabolism, and drug development.

journal_name

Int J Mol Sci

authors

Sánchez A,Castro C,Flores DL,Gutiérrez E,Baldi P

doi

10.3390/ijms20102476

subject

Has Abstract

pub_date

2019-05-19 00:00:00

issue

10

issn

1422-0067

pii

ijms20102476

journal_volume

20

pub_type

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