Selection of a novel DNA aptamer against OFA/iLRP for targeted delivery of doxorubicin to AML cells.

abstract：:Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...

journal_title：Scientific reports

authors： Ledet MM,Harman RM,Fan JC,Schmitt-Matzen E,Diaz-Rubio ME,Zhang S,Van de Walle GR

更新日期：2020-11-25 00:00:00

abstract：:Perinatal piglet mortality is an important factor in pig production from economic and animal welfare perspectives; however, the statistical analysis of mortality is difficult because of its categorical nature. Recent studies have suggested that a binomial model for the survival of each specific piglet with a logit app...

journal_title：Scientific reports

authors： Varona L,Noguera JL,Casellas J,de Hijas MM,Rosas JP,Ibáñez-Escriche N

更新日期：2020-12-03 00:00:00

abstract：:Although gut microbiota and early life events are likely involved in the development of irritable bowel syndrome (IBS), it remains unclear how these factors interact in the pathophysiology of IBS. In the present study, using rats subjected to maternal separation (MS) as a model of IBS, we investigated interrelationshi...

journal_title：Scientific reports

authors： Fukui H,Oshima T,Tanaka Y,Oikawa Y,Makizaki Y,Ohno H,Tomita T,Watari J,Miwa H

更新日期：2018-08-17 00:00:00

abstract：:We developed a new concept of X- and γ-ray radiation semiconductor detectors based on a large area graphene/semi-insulating single crystal CdTe Schottky-type heterojunction. These two terminal electronic devices can be easily fabricated by forming a Van der Waals contact between large area chemical vapor deposited gra...

journal_title：Scientific reports

authors： Brus VV,Maslyanchuk OL,Solovan MM,Maryanchuk PD,Fodchuk I,Gnatyuk VA,Vakhnyak ND,Melnychuk SV,Aoki T

更新日期：2019-01-31 00:00:00

abstract：:The manifestation of cognitive and physical impairment in stroke patients before the acute event suggests accumulating subclinical vascular pathology in the brain. We investigated whether impairments in cognitive and physical functioning were associated with an increased stroke risk. Between 2002 and 2008, 8,519 strok...

journal_title：Scientific reports

authors： Heshmatollah A,Mutlu U,Koudstaal PJ,Ikram MA,Ikram MK

更新日期：2020-04-14 00:00:00

abstract：:Post-glycosylphosphatidylinositol (GPI) attachment to proteins 3, also known as PGAP3 or PERLD1 (PER1-like domain-containing protein 1), participates in the lipid remodeling process of glycosylphosphatidylinositol (GPI) anchor proteins during post-translational modification. Functional defect in PERLD1 was previously ...

journal_title：Scientific reports

authors： Sio YY,Anantharaman R,Lee SQE,Matta SA,Ng YT,Chew FT

更新日期：2020-01-20 00:00:00

abstract：:Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

journal_title：Scientific reports

authors： Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

更新日期：2015-03-13 00:00:00

abstract：:The extracellular matrix (ECM) impacts stem cell differentiation, but identifying formulations supportive of differentiation is challenging in 3D models. Prior efforts involving combinatorial ECM arrays seemed intuitively advantageous. We propose an alternative that suggests reducing sample size and technological burd...

journal_title：Scientific reports

authors： Jung JP,Hu D,Domian IJ,Ogle BM

更新日期：2015-12-21 00:00:00

abstract：:Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mut...

journal_title：Scientific reports

authors： Billingsley KJ,Lättekivi F,Planken A,Reimann E,Kurvits L,Kadastik-Eerme L,Kasterpalu KM,Bubb VJ,Quinn JP,Kõks S,Taba P

更新日期：2019-03-13 00:00:00

abstract：:Based on the polarization-sensitive absorption of graphene under conditions of total internal reflection, a novel optical sensor combining graphene and a microfluidic structure was constructed to achieve the sensitive real-time monitoring of refractive indexes. The atomic thickness and strong broadband absorption of g...

journal_title：Scientific reports

authors： Xing F,Liu ZB,Deng ZC,Kong XT,Yan XQ,Chen XD,Ye Q,Zhang CP,Chen YS,Tian JG

更新日期：2012-01-01 00:00:00

abstract：:The heterogeneity of metabolic reactions leads to a non-uniform distribution of temperature in different parts of the living cell. The demand to study normal functioning and pathological abnormalities of cellular processes requires the development of new visualization methods. Previously, we have shown that the 35-kDa...

journal_title：Scientific reports

authors： Maksimov EG,Yaroshevich IA,Tsoraev GV,Sluchanko NN,Slutskaya EA,Shamborant OG,Bobik TV,Friedrich T,Stepanov AV

更新日期：2019-06-20 00:00:00

abstract：:Phenotypic plasticity describes the ability of a given genotype to produce distinct phenotypes in different environments. We use the temperature sensitivity of abdominal pigmentation in Drosophila melanogaster females as a model to analyse the effect of the environment on development. We reported previously that therm...

journal_title：Scientific reports

authors： Gibert JM,Mouchel-Vielh E,Peronnet F

更新日期：2017-02-23 00:00:00

abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...

journal_title：Scientific reports

authors： Brown L,Villegas JM,Elean M,Fadda S,Mozzi F,Saavedra L,Hebert EM

更新日期：2017-08-17 00:00:00

abstract：:Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer's disease. However, little is known about the association between fibrinogen a...

journal_title：Scientific reports

authors： Page MJ,Thomson GJA,Nunes JM,Engelbrecht AM,Nell TA,de Villiers WJS,de Beer MC,Engelbrecht L,Kell DB,Pretorius E

更新日期：2019-02-28 00:00:00

abstract：:A large retreat of sea-ice in the 'stormy' Atlantic Sector of the Arctic Ocean has become evident through a series of record minima for the winter maximum sea-ice extent since 2015. Results from the Norwegian young sea ICE (N-ICE2015) expedition, a five-month-long (Jan-Jun) drifting ice station in first and second yea...

journal_title：Scientific reports

authors： Graham RM,Itkin P,Meyer A,Sundfjord A,Spreen G,Smedsrud LH,Liston GE,Cheng B,Cohen L,Divine D,Fer I,Fransson A,Gerland S,Haapala J,Hudson SR,Johansson AM,King J,Merkouriadi I,Peterson AK,Provost C,Randelhoff A,R

更新日期：2019-06-25 00:00:00

abstract：:A large number of drugs are administered on different mucosal surfaces. However, due to the poor mucoadhesion of the current formulations, their bioavailability is often very low. The development of efficient mucoadhesive drug delivery systems is thus crucial for improving the performance of these drugs. The mucoadhes...

journal_title：Scientific reports

authors： Ouellette M,Masse F,Lefebvre-Demers M,Maestracci Q,Grenier P,Millar R,Bertrand N,Prieto M,Boisselier É

更新日期：2018-09-25 00:00:00

abstract：:Broadband acoustic absorbers with thin thickness are highly desired in practical situations such as architectural acoustics, yet it is still challenging to achieve high absorption by using structure with limited thickness. Here we report the theoretical optimal design, numerical simulation and experimental demonstrati...

journal_title：Scientific reports

authors： Gao YX,Lin YP,Zhu YF,Liang B,Yang J,Yang J,Cheng JC

更新日期：2020-07-01 00:00:00

abstract：:In this study, the anatomical and ultrastructural responses of Capsicum annuum to iron nanoparticles (Fe NPs) were determined. The results showed that the bio-effects of Fe NPs on plants could be positive or negative, depending on the additive concentrations. Low concentrations of Fe NPs were found to promote plant gr...

journal_title：Scientific reports

authors： Yuan J,Chen Y,Li H,Lu J,Zhao H,Liu M,Nechitaylo GS,Glushchenko NN

更新日期：2018-02-19 00:00:00

abstract：:We present a detailed study to resolve the discrepancy between the existing theoretically estimated oscillator strengths and the recently observed result from the X-ray free electron laser (XFEL) experiment performed at the Linac Coherent Light Source (LCLS) for the intensity ratio between two of the strongest emissio...

journal_title：Scientific reports

authors： Wu C,Gao X

更新日期：2019-05-16 00:00:00

abstract：:Transforming growth factor-β (TGF-β) signaling plays a key role in progression and metastasis of HCC. This study was undertaken to gain the proof of concept of a small-molecule inhibitor of TGF-β type I receptor kinase, EW-7197 as a potent anti-cancer therapy for HCC. We identified tissue inhibitors of metalloproteina...

journal_title：Scientific reports

authors： Park SA,Kim MJ,Park SY,Kim JS,Lim W,Nam JS,Yhong Sheen Y

更新日期：2015-11-09 00:00:00

abstract：:The dynamics of networks of neuronal cultures has been recently shown to be strongly dependent on the network geometry and in particular on their dimensionality. However, this phenomenon has been so far mostly unexplored from the theoretical point of view. Here we reveal the rich interplay between network geometry and...

journal_title：Scientific reports

authors： Millán AP,Torres JJ,Bianconi G

更新日期：2018-07-02 00:00:00

abstract：:The effect of substitution of Nb by Mo in Nb40Ti30Ni30 was investigated with respect to microstructural features and hydrogen dissolution, diffusion and permeation. As-cast Nb40-xMoxTi30Ni30 (x = 0, 5, 10) alloys consist of primary bcc-Nb phase and binary eutectic (bcc-Nb + B2-TiNi). The substitution of Nb by Mo reduc...

journal_title：Scientific reports

authors： Li X,Liang X,Liu D,Chen R,Huang F,Wang R,Rettenmayr M,Su Y,Guo J,Fu H

更新日期：2017-03-16 00:00:00

abstract：:Campylobacter hyointestinalis is a member of an emerging group of zoonotic Campylobacter spp. that are increasingly identified in both gastric and non-gastric disease in humans. Here, we discovered C. hyointestinalis in three separate classes of New Zealand ruminant livestock; cattle, sheep and deer. To investigate th...

journal_title：Scientific reports

authors： Wilkinson DA,O'Donnell AJ,Akhter RN,Fayaz A,Mack HJ,Rogers LE,Biggs PJ,French NP,Midwinter AC

更新日期：2018-02-05 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) is an evolutionarily conserved peptidyl dipeptidase. Mammalian ACE converts angiotensin I to the active vasoconstrictor angiotensin II, thus playing a critical role for homeostasis of the renin-angiotensin system. In Drosophila, the ACE homolog Ance is expressed in specific regions ...

journal_title：Scientific reports

authors： Kim AR,Choi EB,Kim MY,Choi KW

更新日期：2017-10-13 00:00:00

abstract：:Diamond attracts considerable attention as a versatile and technologically useful material. For many demanding applications, such as recently emerged quantum optics and sensing, it is important to develop new routes for fabrication of diamond containing defects with specific optical, electronic and magnetic properties...

journal_title：Scientific reports

authors： Palyanov YN,Kupriyanov IN,Borzdov YM,Surovtsev NV

更新日期：2015-10-05 00:00:00

abstract：:Fibroblast growth factor (FGF) 23 is a phosphaturic hormone that directly targets cardiac myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myocyte growth and the development of left ventricular hypertrophy (LVH) in rodents. Serum FGF23 levels are highly elevated in patients with chronic kidney disease ...

journal_title：Scientific reports

authors： Grabner A,Schramm K,Silswal N,Hendrix M,Yanucil C,Czaya B,Singh S,Wolf M,Hermann S,Stypmann J,Di Marco GS,Brand M,Wacker MJ,Faul C

更新日期：2017-05-16 00:00:00

abstract：:Tumorigenesis is driven by genetic alterations that perturb the signaling networks regulating proliferation or cell death. In order to block tumor growth, one has to precisely know how these signaling pathways function and interplay. Here, we identified the transcription factor Ets21C as a pivotal regulator of tumor g...

journal_title：Scientific reports

authors： Toggweiler J,Willecke M,Basler K

更新日期：2016-10-07 00:00:00

abstract：:The kidney is a high-energy demand organ rich in mitochondria especially renal tubular cells. Emerging evidence suggests that mitochondrial dysfunction, redox imbalance and kidney injury are interconnected. Artemether has biological effects by targeting mitochondria and exhibits potential therapeutic value for kidney ...

journal_title：Scientific reports

authors： Han P,Cai Y,Wang Y,Weng W,Chen Y,Wang M,Zhan H,Yu X,Wang T,Shao M,Sun H

更新日期：2021-01-14 00:00:00

abstract：:This study was conducted to investigate prognosis and survival of patients undergoing distal subtotal gastrectomy with D2 and D2+ lymphadenectomy for patients with locally advanced gastric cancer. Overall survival rates of 416 patients with locally advanced gastric cancer were compared between D2 and D2+ lymphadenecto...

journal_title：Scientific reports

authors： Zhang CD,Shen MY,Zhang JK,Ning FL,Zhou BS,Dai DQ

更新日期：2015-11-25 00:00:00

abstract：:The liver has a variety of functions for maintaining homeostasis, and hepatocytes play a major role. In contrast with the high regenerative capacity of mature hepatocytes (MHs) in vivo, they have not been successfully expanded ex vivo. Here we demonstrate that CD44-positive cells sorted from small hepatocyte (SH) colo...

journal_title：Scientific reports

authors： Ishii M,Kino J,Ichinohe N,Tanimizu N,Ninomiya T,Suzuki H,Mizuguchi T,Hirata K,Mitaka T

更新日期：2017-04-11 00:00:00