The effect of pharmacological inhibition of Serine Proteases on neuronal networks in vitro.

abstract：OBJECTIVES:The purpose of this study is to determine the prevalence and clinical impact of human papillomavirus (HPV) related laryngeal squamous cell carcinoma (LSCC). METHODS:A total of 106 LSCC patients who underwent primary surgical resection with or without adjuvant radiotherapy/chemoradiotherapy were enrolled ret...

journal_title：PeerJ

authors： Chen WC,Chuang HC,Lin YT,Huang CC,Chien CY

更新日期：2017-05-30 00:00:00

abstract：:Pueraria lobata (willd.) Ohwi is a consumable selenium-enriched plant used for medicinal purposes. The molecular response to selenium (Se) stimuli in P. lobata is currently unknown. We used RNA-Seq to identify potential genes involved in selenite metabolism and analyzed their expression profiles. We obtained a total o...

journal_title：PeerJ

authors： Guo K,Yao Y,Yang M,Li Y,Wu B,Lin X

更新日期：2020-03-24 00:00:00

abstract：:Global warming can significantly affect many aspects of the biology of animal species, including their thermal physiology and physiological performance. Thermal performance curves provide a heuristic model to evaluate the impacts of temperature on the ecophysiology of ectotherms. When integrated with other thermal bio...

journal_title：PeerJ

authors： Cabezas-Cartes F,Fernández JB,Duran F,Kubisch EL

更新日期：2019-08-09 00:00:00

abstract：:Barnacles and their allies (Thecostraca) are a biologically diverse, monophyletic crustacean group, which includes both intensely studied taxa, such as the acorn and stalked barnacles, as well as cryptic taxa, for example, Facetotecta. Recent efforts have clarified phylogenetic relationships in many different parts of...

journal_title：PeerJ

authors： Ewers-Saucedo C,Owen CL,Pérez-Losada M,Høeg JT,Glenner H,Chan BKK,Crandall KA

更新日期：2019-08-16 00:00:00

abstract：:Soil sickness is the progressive loss of soil quality due to continuous monocropping. The bacterial populations are critical to sustaining agroecosystems, but their responses to long-term peanut monocropping have not been determined. In this study, based on a previously constructed gradient of continuous monocropped p...

journal_title：PeerJ

authors： Chen M,Liu H,Yu S,Wang M,Pan L,Chen N,Wang T,Chi X,Du B

更新日期：2020-04-28 00:00:00

abstract：Aim:Historically, the distribution of Sandhill Cranes included much of North America and extending in summer into northeast Russia. In recent years, observations of sandhill cranes in Asia during the non-breeding period have been frequently reported. However, the distribution and abundance of sandhill cranes during the...

journal_title：PeerJ

authors： Gao L,Mi C,Guo Y

更新日期：2019-08-30 00:00:00

abstract：:Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals. In dogs, dilated cardiomyopathy is the second most common cardiac disease ...

journal_title：PeerJ

authors： Simpson S,Edwards J,Emes RD,Cobb MA,Mongan NP,Rutland CS

更新日期：2015-03-26 00:00:00

abstract：:Dung beetles of the subfamily Scarabaeinae are widely recognised as important providers of multiple ecosystem services and are currently experiencing revisions that have improved our understanding of higher-level relationships in the subfamily. However, the study of phylogenetic relationships at the level of genus or ...

journal_title：PeerJ

authors： Pardo-Diaz C,Lopera Toro A,Peña Tovar SA,Sarmiento-Garcés R,Sanchez Herrera M,Salazar C

更新日期：2019-08-05 00:00:00

abstract：:Almost all extant testudinids are highly associated with terrestrial habitats and the few tortoises with high affinity to aquatic environments are found within the genus Manouria. Manouria belongs to a clade which forms a sister taxon to all remaining tortoises and is suitable as a model for studying evolutionary tran...

journal_title：PeerJ

authors： Natchev N,Tzankov N,Werneburg I,Heiss E

更新日期：2015-08-11 00:00:00

abstract：Background:The influenza virus can cause seasonal infections with mild to severe symptoms, circulating worldwide, and it can affect people in any age group. Therefore, this infection is a serious public health problem that causes severe illness and death in high-risk populations. Every year, 0.5% of the world's populat...

journal_title：PeerJ

authors： Silva T,S Salomon P,Hamerski L,Walter J,B Menezes R,Siqueira JE,Santos A,Santos JAM,Ferme N,Guimarães T,O Fistarol G,I Hargreaves P,Thompson C,Thompson F,Souza TM,Siqueira M,Miranda M

更新日期：2018-10-26 00:00:00

abstract：:Objective. We hypothesized that a significant percentage of patients who are referred to the Emergency Department (ED) after calling their primary care physician's (PCP) office receive such instructions without the input of a physician. Methods. We enrolled a convenience sample of stable adults at an inner-city ED. Pa...

journal_title：PeerJ

authors： Hill R,Gest A,Smith C,Guardiola JH,Apolinario M,Ha J,Gonzalez JR,Richman PB

更新日期：2016-03-28 00:00:00

abstract：:Lead (Pb) is a ubiquitous pollutant which poses serious threats to plants, animals and humans once entered into the food chain via contaminated industrial effluents on their discharge into the surface of water bodies and/or geological materials. This study aimed to examine and compare the biosorption potential of natu...

journal_title：PeerJ

authors： Shah GM,Nasir M,Imran M,Bakhat HF,Rabbani F,Sajjad M,Umer Farooq AB,Ahmad S,Song L

更新日期：2018-09-28 00:00:00

abstract：:In highly biodiverse systems, such as coral reefs, prey species are faced with predatory threats from numerous species. Recognition of predators can be innate, or learned, and can help increase the chance of survival. Research suggests that parental exposure to increased predatory threats can affect the development, b...

journal_title：PeerJ

authors： Atherton JA,McCormick MI

更新日期：2020-06-18 00:00:00

abstract：:Helicobacter pylori is a human pathogenic bacterium with a high genomic plasticity. Although the functional CRISPR-Cas system has not been found in its genome, CRISPR-like loci have been recently identified. In this work, 53 genomes from different geographical areas are analyzed for the search and analysis of variabil...

journal_title：PeerJ

authors： García-Zea JA,de la Herrán R,Robles Rodríguez F,Navajas-Pérez R,Ruiz Rejón C

更新日期：2019-01-11 00:00:00

abstract：Background:Yunnanolepidoids constitute either the most basal consecutive segments or the most primitive clade of antiarchs, a highly diversified jawed vertebrate group from the Silurian and Early Devonian periods. Although the general morphology of yunnanolepidoids is well established, their endocranial features remain...

journal_title：PeerJ

authors： Wang Y,Zhu M

更新日期：2018-05-28 00:00:00

abstract：:Wild greens can contribute to the human diet as an important source of essential nutrients and drugs. Since environmental factors, including soil properties, may affect the chemical composition of plants, it is necessary among others to assess various habitats in terms of their usefulness for wild plant harvesting and...

journal_title：PeerJ

authors： Bosiacka B,Myśliwy M,Bosiacki M

更新日期：2020-11-24 00:00:00

abstract：:While there have been increasing numbers of reports of human-wolf conflict in China during recent years, little is known about the nature of this conflict. In this study, we used questionnaires and semi-structured interviews to investigate local villagers' perceptions of wolves in Jiuzhaigou County, western China. We ...

journal_title：PeerJ

authors： Xu Y,Yang B,Dou L

更新日期：2015-06-09 00:00:00

abstract：BACKGROUND:Motion sickness may be caused by a sensory conflict between the visual and the vestibular systems. Scopolamine, known to be the most effective therapy to control the vegetative symptoms of motion sickness, acts on the vestibular nucleus and potentially the vestibulospinal pathway, which may affect balance an...

journal_title：PeerJ

authors： Bestaven E,Kambrun C,Guehl D,Cazalets JR,Guillaud E

更新日期：2016-05-05 00:00:00

abstract：:Pseudogymnoascus destructans (Pd), the causative agent of white-nose syndrome in bats (WNS), has led to dramatic declines of bat populations in eastern North America. In the spring of 2016, WNS was first detected at several locations in Washington State, USA, which has prompted the need for large scale surveillance ef...

journal_title：PeerJ

authors： Urbina J,Chestnut T,Schwalm D,Allen J,Levi T

更新日期：2020-01-20 00:00:00

abstract：INTRODUCTION:Early detection of social anxiety and loneliness might be useful to prevent substantial impairment in personal relationships. Understanding the way people use smartphones can be beneficial for implementing an early detection of social anxiety and loneliness. This paper examines different types of smartphon...

journal_title：PeerJ

authors： Gao Y,Li A,Zhu T,Liu X,Liu X

更新日期：2016-07-12 00:00:00

abstract：Background:During their long evolution, Synechocystis sp. PCC6803 developed a remarkable capacity to acclimate to diverse environmental conditions. In this study, Raman spectroscopy and Raman chemometrics tools (RametrixTM) were employed to investigate the phenotypic changes in response to external stressors and correl...

journal_title：PeerJ

authors： Tanniche I,Collakova E,Denbow C,Senger RS

更新日期：2020-03-30 00:00:00

abstract：Background:The ongoing change in climate is predicted to exert unprecedented effects on Earth's biodiversity at all levels of organization. Biological conservation is important to prevent biodiversity loss, especially for species facing a high risk of extinction. Understanding the past responses of species to climate c...

journal_title：PeerJ

authors： Bai Y,Wei X,Li X

更新日期：2018-01-16 00:00:00

abstract：:Liver fibrosis often appears in chronic liver disease, with extracellular matrix (ECM) deposition as the main feature. Due to the presence of the liver-gut axis, the destruction of intestinal homeostasis is often accompanied by the development of liver fibrosis. The inconsistent ecological environment of different int...

journal_title：PeerJ

authors： Wan S,Huang C,Wang A,Zhu X

更新日期：2020-04-24 00:00:00

abstract：Background:Nurses are often the first to activate the chain of survival when a cardiorespiratory arrest happens. That is why it is crucial that they keep their knowledge and skills up-to-date and their attitudes to resuscitation are very important. The main aim of this study was to analyse whether the level of theoreti...

journal_title：PeerJ

authors： Tíscar-González V,Blanco-Blanco J,Gea-Sánchez M,Rodriguez Molinuevo A,Moreno-Casbas T

更新日期：2019-02-07 00:00:00

abstract：Background:The need for read-based phasing arises with advances in sequencing technologies. The minimum error correction (MEC) approach is the primary trend to resolve haplotypes by reducing conflicts in a single nucleotide polymorphism-fragment matrix. However, it is frequently observed that the solution with the opti...

journal_title：PeerJ

authors： Lin YY,Wu PC,Chen PL,Oyang YJ,Chen CY

更新日期：2018-10-30 00:00:00

abstract：:The knowledge on the spatial distribution of soil available water capacity at a regional or national extent is essential, as soil water capacity is a component of the water and energy balances in the terrestrial ecosystem. It controls the evapotranspiration rate, and has a major impact on climate. This paper demonstra...

journal_title：PeerJ

authors： Hong SY,Minasny B,Han KH,Kim Y,Lee K

更新日期：2013-04-23 00:00:00

abstract：Background:Cytoplasmic male sterility (CMS) is a common phenotype in higher plants, that is often associated with rearrangements in mitochondrial DNA (mtDNA), and is widely used to produce hybrid seeds in a variety of valuable crop species. Investigation of the CMS phenomenon promotes understanding of fundamental issue...

journal_title：PeerJ

authors： Makarenko MS,Kornienko IV,Azarin KV,Usatov AV,Logacheva MD,Markin NV,Gavrilova VA

更新日期：2018-07-23 00:00:00

abstract：:We examine heritability estimation of an ordinal trait for osteoarthritis, using a population of pig-tailed macaques from the Washington National Primate Research Center (WaNPRC). This estimation is non-trivial, as the data consist of ordinal measurements on 16 intervertebral spaces throughout each macaque's spinal co...

journal_title：PeerJ

authors： Chi PB,Duncan AE,Kramer PA,Minin VN

更新日期：2014-05-01 00:00:00

abstract：:The present study evaluated the level of support and satisfaction among parents of stillborn babies in Australian hospitals. One-hundred and eighty-nine mothers and fathers completed an online survey designed by the researcher based on the guidelines designed by the Perinatal Society of Australia and New Zealand. Supp...

journal_title：PeerJ

authors： Basile ML,Thorsteinsson EB

更新日期：2015-06-25 00:00:00

abstract：:Osteogenic cells form mineralized matrices in vitro, as well as in vivo. The formation and shape of the mineralized matrices are highly regulated by the cells. In vitro formation of mineralized matrices by osteogenic cells can be a model for in vivo osteogenesis. In this study, using a three-dimensional (3D) collagen ...

journal_title：PeerJ

authors： Kihara T,Umezu C,Sawada K,Furutani Y

更新日期：2019-10-23 00:00:00