Abstract:
:In this issue of Cancer Discovery, Auciello and colleagues find that in the pancreatic cancer microenvironment activated fibroblasts secrete specific lipids that provide a source of biomass production and signaling molecules for cancer cells, fueling their proliferation and migration. Targeting of this stromal-tumor metabolic cross-talk impairs pancreatic cancer progression and represents a new potential therapeutic opportunity.See related article by Auciello et al., p. 617.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Biffi G,Tuveson DAdoi
10.1158/2159-8290.CD-19-0273subject
Has Abstractpub_date
2019-05-01 00:00:00pages
578-580issue
5eissn
2159-8274issn
2159-8290pii
9/5/578journal_volume
9pub_type
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