Abstract：
OBJECTIVE:There is very little literature surrounding the prophylactic use of zonisamide in cluster headaches. The study aims to evaluate the effectiveness of zonisamide for prophylaxis of cluster headache in patients with chronic or episodic cluster headache. BACKGROUND:Both chronic and episodic cluster headaches are debilitating disorders which are often refractory to multiple prophylactic medication regimens. There is a scarcity of research in this area, and current prophylactic options for patients are fairly limited, which is troublesome for affected patients. Zonisamide is an established antiepileptic with a multifactorial mechanism of action which has shown to be useful in other headache disorders such as migraine. METHODS:Twenty cluster headache patients, both episodic (n = 12; ICHD 3.1.1) and chronic (n = 8; ICHD 3.1.2), who had been or currently were treated with zonisamide, were retrospectively evaluated. Effectiveness of the medication was assessed and identified as headache remission or a reduction in severity or frequency of cluster headache of greater than 50%. Responder status, side effects, and dosage were recorded. RESULTS:Fourteen (70%) patients responded to zonisamide treatment, while 6 (30%) did not. Recorded effective plasma zonisamide levels ranged from 10.2 to 31.9 μg/mL. Of the 6 non-responders, 2 stopped the medication due to ineffectiveness, while 4 discontinued the medication secondary to intolerable side effects ranging from gastrointestinal upset to malaise. No more serious adverse events occurred. Eight patients total experienced weight loss/anorexia which many perceived as a positive effect; they lost an average of 10.5% of their body weight in the first 6 months of therapy. CONCLUSIONS:Zonisamide appears to be an effective prophylactic treatment for patients with chronic and episodic cluster headache disorders. Further research in this area is clearly warranted.
journal_name
Headachejournal_title
Headacheauthors
Limmer AL,Holland LC,Loftus BDdoi
10.1111/head.13546subject
Has Abstractpub_date
2019-06-01 00:00:00pages
924-929issue
6eissn
0017-8748issn
1526-4610journal_volume
59pub_type
杂志文章相关文献
HEADACHE文献大全abstract：:If you vomit with migraines, get full-blown migraines upon awakening, or want rapid relief without injections, consider a nasal spray. Options include triptans (zolmitriptan [Zomig] or sumatriptan [Imitrex]), DHE (Migranal), or an NSAID (Sprix). ...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/head.12045
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To describe the statuslike pattern of SUNCT (short-lasting unilateral neuralgiform pain with conjunctival injection and tearing) in two young women. BACKGROUND:SUNCT syndrome is a rare condition characterized by a short-lasting periocular pain associated with marked autonomic symptoms. Twenty-five cases have...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.2001.01151.x
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:To investigate the prevalence, clinical correlates, and treatment of migraine in bipolar disorder. BACKGROUND:The relationship between migraine and mood disorders has been of long-standing interest to researchers and clinicians. Although a strong association has been demonstrated consistently for migraine an...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.2003.03184.x
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To investigate the influence of different pharmacological treatments on the intensity dependence of auditory evoked cortical potentials in migraineurs. BACKGROUND:Between attacks, patients with migraine show abnormalities in cortical information processing and decreased brain mitochondrial energy reserve. Bo...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.2000.00005.x
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Though thyroid growths are considered to be a frequent cause of Horner's syndrome, concurrent headache attacks are not commonly seen. CASE:A 63-year-old woman presented with severe, daily occurring, unilateral headache attacks with ipsilateral Horner's syndrome. Magnetic resonance imaging arteriography show...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/head.12315
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To investigate the impact of coumarin therapy on migraine attack frequency. BACKGROUND:Sporadic case reports and clinical studies have described beneficial effects of coumarin therapy on migraine severity. DESIGN AND METHODS:A retrospective follow-up study based on a prescription database covering a populat...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.2001.01141.x
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy of celecoxib for treatment of withdrawal headache vs prednisone in patients with medication overuse headache (MOH). METHODS:In this prospective, double-blind, parallel-group clinical trial, 97 consecutive subjects with MOH were randomized (simple randomization using computer-generated...
journal_title：Headache
pub_type： 杂志文章,随机对照试验
doi：10.1111/head.12487
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To assess the effect of aspirin on platelet reactivity in migraineurs. BACKGROUND:Migraineurs, particularly women with aura and high monthly migraine frequency, are at risk for ischemic stroke and myocardial infarction (MI). High on-aspirin platelet reactivity (HAPR), or aspirin resistance, has been reported...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/j.1526-4610.2012.02143.x
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:To assess the relationship between the phenotype of the "visual snow" syndrome, comorbid migraine, and typical migraine aura on a clinical basis and using functional brain imaging. BACKGROUND:Patients with "visual snow" suffer from continuous TV-static-like tiny flickering dots in the entire visual field. Mo...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/head.12378
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of migraine and episodic tension-type headache (ETTH) among university students as well as its impact on academic performance and quality of life. BACKGROUND:Headache is a very common symptom in clinical practice. The reduced capacities due to migraine can be profound, and more st...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.2001.041007710.x
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Previous observational studies reported an increased prevalence of asthma in migraine patients. Whether triptans affect the asthma risk has not yet been explored in an epidemiological study. OBJECTIVE:To estimate the risk of newly diagnosed asthma in patients with a general practitioner-diagnosed migraine i...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/j.1526-4610.2007.01030.x
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To establish if criteria for the diagnosis of migraine change with age and to document the influence of age on the full spectrum of migraine features. Also to define the clinical spectrum and provide a prognostic profile of migraine stratified by age. BACKGROUND:Few studies have formally analyzed migraine ch...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/j.1526-4610.2006.00444.x
更新日期：2006-07-01 00:00:00
abstract：:This multicenter, double-blind, clinical study was designed to compare the efficacy and safety of alpha-dihydroergocryptine and flunarizine in the prophylaxis of migraine without aura. One hundred thirty-five patients fulfilling the diagnostic criteria of the International Headache Society were enrolled at five neurol...
journal_title：Headache
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1526-4610.1999.3906426.x
更新日期：1999-06-01 00:00:00
abstract：:Piroxicam beta-cyclodextrin has recently been observed to be equal to, or even possibly to be superior to, indomethacin (mainly with regard to side effects) in a single case of hemicrania continue. Piroxicam beta-cyclodextrin, 20 to 40 mg per day, was, accordingly, tried in six patients with chronic paroxysmal hemicra...
journal_title：Headache
pub_type： 临床试验,杂志文章
doi：10.1111/j.1526-4610.1995.hed3509549.x
更新日期：1995-10-01 00:00:00
abstract：OBJECTIVES:To determine the association between the severity of premenstrual (PMS) symptoms and headache outcome measures during natural menstrual cycles and after medical oophorectomy. BACKGROUND:Premenstrual syndrome may occur in 64% of those with pure menstrual migraine and 33% of those with menstrually related mig...
journal_title：Headache
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1526-4610.2006.00306.x
更新日期：2006-01-01 00:00:00
abstract：:We describe a patient with ophthalmoplegic migraine and right abducens nerve palsy, in whom serial magnetic resonance imaging showed a transient, gadolinium-enhancing lesion in the right lower pons, during both headache and the headache-free period. The enhancing linear lesion was felt to represent intraparenchymal fi...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.2002.02031.x
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVE:Previous attempts to develop a pragmatic human model for testing new anti-migraine drugs, have failed. Calcitonin gene-related peptide (CGRP) induces a mild headache in healthy volunteers and migraine-like headache in migraine patients. The induced headache must respond to already established migraine treatme...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/head.13747
更新日期：2020-04-01 00:00:00
abstract：:The history of post-traumatic headache begins in the middle of the 19th century, and its latest iteration has been defined in the International Headache Classification of 2004. Contrary to the latter, there are instances when mild head injury without symptoms or signs of concussion may evoke the pathophysiological cha...
journal_title：Headache
pub_type： 历史文章,杂志文章
doi：10.1111/j.1526-4610.2009.01462.x
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:To determine the pain intensity of cluster headache through a large survey by comparing it to other painful disorders. Furthermore, to investigate the relationship between maximal pain, autonomic, and other clinical symptoms, as well as demographic attributes of cluster headache. BACKGROUND:The pain of clust...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/head.14021
更新日期：2020-12-18 00:00:00
abstract：:We describe a patient with atypical headache as the only presenting symptom of spontaneous triple cervical artery dissection. As the patient suffered from arterial hypertension, a causative relation between headache and arterial hypertension was initially taken into consideration. However, four-vessel arteriography di...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.2001.01090.x
更新日期：2001-05-01 00:00:00
abstract：:To date, there have been no reports on the use of propranolol in electroconvulsive therapy (ECT)-induced migraine; we describe a 32-year-old woman who was successfully treated with propranolol for this condition. Over a course of ECT, the patient developed increasingly severe migraine which was refractory to treatment...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.2001.111006092.x
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Many children suffering from chronic headache and migraine present with comorbid functional disability, including physical, social, emotional, and academic activities. For children severely impaired by headache, intensive interdisciplinary pain rehabilitation treatment (IIPT) can improve functioning. However...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/head.13389
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between a serotonin (5-HT) transporter gene polymorphism and migraines in Koreans. BACKGROUND:The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HT...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/j.1526-4610.2005.05187.x
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Zonisamide, a sulfonamide analog, is an antiepileptic drug with mechanisms of action similar to topiramate. Because of its pharmacodynamic and pharmacokinetics profiles, zonisamide is also potentially suitable for migraine prevention. METHODS:Tolerability and effectiveness of zonisamide for migraine prophyl...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/j.1526-4610.2010.01842.x
更新日期：2011-02-01 00:00:00
abstract：:This paper describes the development and validation of a migraine-specific quality-of-life instrument that is capable of measuring health-related quality-of-life impairments attributed to migraine. Item selection, item reduction, and pretesting and finalization of items during the instrument development phase resulted...
journal_title：Headache
pub_type： 杂志文章
doi：10.1046/j.1526-4610.1998.3804295.x
更新日期：1998-04-01 00:00:00
abstract：OBJECTIVES:To assess and compare the prevalence of migraine in patients with restless legs syndrome (RLS) and matched controls. BACKGROUND:Recent studies have suggested an association between migraine and RLS. Our work is the first case-control study on this subject performed in an RLS population. METHODS:A case-cont...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/head.12382
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Recurrent headache sufferers are often fearful of pain, which disrupts thought processes, interferes with daily activities, and may maintain headache-related disability through avoidance and associated negative reinforcement. OBJECTIVE:The aim of this cross-sectional study was to (1) examine differences in ...
journal_title：Headache
pub_type： 杂志文章
doi：10.1111/head.12561
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Fast relief of migraine pain, associated symptoms, and migraine-related disability are priorities in the acute treatment of migraine. Efforts to improve the pharmacokinetic profiles of acute migraine treatments with the aim of providing faster relief include the development of non-oral routes of administrati...
journal_title：Headache
pub_type： 杂志文章,随机对照试验
doi：10.1111/head.13165
更新日期：2017-11-01 00:00:00
abstract：:Spontaneous intracranial hypotension typically results from spontaneous cerebrospinal fluid (CSF) leak, often at spine level and only rarely from skull base. Once considered rare, it is now diagnosed far more commonly than before and is recognized as an important cause of headaches. CSF leak leads to loss of CSF volum...
journal_title：Headache
pub_type： 杂志文章,评审
doi：10.1111/head.12149
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:To explore the effects of olmesartan on frequency and severity of migraine attacks in patients with comorbid hypertension and prehypertension. BACKGROUND:A randomized, double-blind, placebo-controlled, crossover study with a total of 60 patients has demonstrated the efficacy and safety of the angiotensin II ...
journal_title：Headache
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1526-4610.2006.00382.x
更新日期：2006-03-01 00:00:00
