Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention.

Abstract:

BACKGROUND:Worldwide, the progress in reducing neonatal mortality has been very slow. The rate of preterm birth has increased over the last 20 years in low-income and middle-income countries. Its association with increased mortality and morbidity is based on experimental studies and neonatal outcomes from countries with socioeconomic differences, which have considered implementing alternative healthcare strategies to prevent and reduce preterm births. METHODS:Currently, there is no widely effective strategy to prevent preterm birth. Pharmacological therapies are directed at inhibiting myometrial contractions to prolong parturition. Some drugs, medicinal plants and microorganisms possess myorelaxant, anti-inflammatory and immunomodulatory properties that have proved useful in preventing preterm birth associated with inflammation and infection. RESULTS:This review focuses on the existing literature regarding the use of different drugs, medicinal plants, and microorganisms that show promising benefits for the prevention of preterm birth associated with inflammation and infection. New alternative strategies involving the use of PDE-4 inhibitors, medicinal plants and probiotics could have a great impact on improving prenatal and neonatal outcomes and give babies the best start in life, ensuring lifelong health benefits. CONCLUSION:Despite promising results from well-documented cases, only a small number of these alternative strategies have been studied in clinical trials. The development of new drugs and the use of medicinal plants and probiotics for the treatment and/or prevention of preterm birth is an area of growing interest due to their potential therapeutic benefits in the field of gynecology and obstetrics.

journal_name

Curr Pharm Biotechnol

authors

Muñoz-Pérez VM,Ortiz MI,Cariño-Cortés R,Fernández-Martínez E,Rocha-Zavaleta L,Bautista-Ávila M

doi

10.2174/1389201020666190408112013

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

354-365

issue

5

eissn

1389-2010

issn

1873-4316

pii

CPB-EPUB-97881

journal_volume

20

pub_type

杂志文章,评审
  • Wound Healing Effect of Curcumin: A Review.

    abstract::Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have b...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:

    authors: Tejada S,Manayi A,Daglia M,Nabavi SF,Sureda A,Hajheydari Z,Gortzi O,Pazoki-Toroudi H,Nabavi SM

    更新日期:2016-07-21 00:00:00

  • TRP channels in the digestive system.

    abstract::Several of the 28 mammalian transient receptor potential (TRP) channel subunits are expressed throughout the alimentary canal where they play important roles in taste, chemo- and mechanosensation, thermoregulation, pain and hyperalgesia, mucosal function and homeostasis, control of motility by neurons, interstitial ce...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920111793937862

    authors: Holzer P

    更新日期:2011-01-01 00:00:00

  • Preparation and in vitro evaluation of α and β-amyrins loaded nanoemulsions.

    abstract::The triterpenes α- and β-amyrins display important pharmacological activities. As a result of their high hydrophobia, they present low water solubility and reflect poor oral bioavailability. Different techniques can be used for the improvement of amyrins solubility, one of them is the use of nanoemulsions. Therefore, ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201015666140317121647

    authors: Rodrigues IV,Seibert JB,Carneiro SP,de Souza GH,dos Santos OD,Lopes NP

    更新日期:2013-01-01 00:00:00

  • The Role of the Coagulase-negative Staphylococci (CoNS) in Infective Endocarditis; A Narrative Review from 2000 to 2020.

    abstract::Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, e...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201021666200423110359

    authors: Noshak MA,Rezaee MA,Hasani A,Mirzaii M

    更新日期:2020-01-01 00:00:00

  • Blood Brain Barrier Permeability Prediction Using Machine Learning Techniques: An Update.

    abstract::Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of permeability that allow a limited range of drug and compounds to pass through it. The BBB plays a vital role in maintaining balance between intracellular and extracellular environment for brain. Brain Capillary Endothelial Cells...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201020666190821145346

    authors: Saxena D,Sharma A,Siddiqui MH,Kumar R

    更新日期:2019-01-01 00:00:00

  • Targeting cells with MR imaging probes based on paramagnetic Gd(III) chelates.

    abstract::The low sensitivity is the major disadvantage of MRI as compared to PET. Therefore, amplification strategies are necessary for specific pathway labeling. This survey is aimed at exploring different routes to the entrapment of Gd(III) chelates in various type of cells at amounts sufficiently large to allow MRI visualiz...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201043376580

    authors: Aime S,Barge A,Cabella C,Crich SG,Gianolio E

    更新日期:2004-12-01 00:00:00

  • Peroxisome proliferator activated receptor α ligands as anticancer drugs targeting mitochondrial metabolism.

    abstract::Tumor cells show metabolic features distinctive from normal tissues, with characteristically enhanced aerobic glycolysis, glutaminolysis and lipid synthesis. Peroxisome proliferator activated receptor α (PPAR α) is activated by nutrients (fatty acids and their derivatives) and influences these metabolic pathways actin...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201011314030009

    authors: Grabacka M,Pierzchalska M,Reiss K

    更新日期:2013-01-01 00:00:00

  • A Study on Ecotoxicological Effects of Nano-copper Oxide Particles to Portunus Trituberculatus.

    abstract::As an important nano-material, nano-copper oxide particles (CuO-ENPs) harbor a vast range of characteristics, including electronic correlation effect, thermal stability, catalytic activity, sterilization and other properties. At present, the mechanism of ecotoxicological effects of CuO-ENPs is not yet clear, and has b...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201021666201229111251

    authors: Li T,Hu H,Yang C,Zhang B,Ma L

    更新日期:2020-12-28 00:00:00

  • Natural Products Mediated Regulation of Oxidative Stress and DNA Damage in Ultraviolet Exposed Skin Cells.

    abstract::Data obtained through high-throughput technologies have gradually revealed that a unique stratified epithelial architecture of human skin along with the antioxidant-response pathways provided vital defensive mechanisms against UV radiation. However, it is noteworthy that skin is a major target for toxic insult by UV r...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201016666150731111308

    authors: Farooqi AA,Li RN,Huang HW,Ismail M,Yuan SS,Wang HM,Liu JR,Tang JY,Chang HW

    更新日期:2015-01-01 00:00:00

  • Immunogenicity assessment of therapeutic proteins and peptides.

    abstract::Assessment of immunogenicity is a major aspect in evaluating the safety of biological therapeutic proteins. It is important to evaluate the immunogenic potential of the biologics in an appropriate fashion using clearly defined strategy and clinical trials. The studies must include the appropriate risk assessment proce...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920109788488860

    authors: Kaliyaperumal A,Jing S

    更新日期:2009-06-01 00:00:00

  • Ecofriendly Ethyl Cellulose Microsponges of Citronella Oil: Preparation, Characterization and Evaluation of Cytotoxicity and Larvicidal assay.

    abstract:BACKGROUND:Citronella Oil (CO) was used by the Indian army as mosquito repellant to repel mosquitoes at the beginning of the 20th century and later in 1948, it was registered in the USA for commercial purposes. Due to its ecofriendly nature, CO possesses immense potential as a mosquito repellent. METHODS:Citronella oi...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201020666191120124314

    authors: Sharma R,Kumar N,Singh SP,Kumar S,Rao R

    更新日期:2020-01-01 00:00:00

  • Cisplatin Changes Expression of SEMA3B in Endometrial Cancer.

    abstract:BACKGROUND:Semaphorin 3B (SEMA3B) is characterized as a strong suppressing factor of the proliferation of cancerous cells and also by its anti-angiogenic effect. However, the knowledge on the changes in the expression profile of SEMA3B under the influence of cisplatin in endometrial cancer remains fragmented. The aim o...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201021666200514215839

    authors: Peszek W,Kras P,Grabarek BO,Boroń D,Oplawski M

    更新日期:2020-01-01 00:00:00

  • New developments of clinical trial in immunotherapy for Alzheimer's disease.

    abstract::Active or passive immunotherapy is expected to slow or stop the pathological process of Alzheimer's disease (AD). Immunotherapy for AD has demonstrated that targeting beta-amyloid (Aβ) or tau protein with vaccines or antibodies can reduce AD pathologies. Active anti-Aβ immunization for AD includes using AN1792 and sec...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920101606150407112319

    authors: Yang C,Xiao S

    更新日期:2015-01-01 00:00:00

  • Effectiveness of Bacteriophage Therapy in Field Conditions and Possible Future Applications.

    abstract:BACKGROUND:Bacteriophages are viruses, which are obligate parasites of specific bacteria for the completion of their lifecycle. Bacteriophages could be the possible alternative to antibioticresistant bacterial diseases. With this objective, extensive research in different fields is published which are discussed in this...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201021666191217111156

    authors: Adhikari N,Acharya KP

    更新日期:2020-01-01 00:00:00

  • Green and Simple Synthesis of Silver Nanoparticles by Aqueous Extract of Perovskia abrotanoides: Characterization, Optimization and Antimicrobial Activity.

    abstract:BACKGROUND:Herein, we report the biosynthesis procedure to prepare silver nanoparticles as reduction and capping agents with the aqueous plant extract of Perovskia abrotanoides. METHODS:The therapeutic application of silver nanoparticles entirely depends on the size and shape of the nanoparticles therefore, their cont...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201020666190618121218

    authors: Mirsadeghi S,Koudehi MF,Rajabi HR,Pourmortazavi SM

    更新日期:2020-01-01 00:00:00

  • Status of Selinum spp. L. a Himalayan Medicinal Plant in India: A Review of Its Pharmacology, Phytochemistry and Traditional Uses.

    abstract::There is a growing trend of herbal medicines in India as well as other parts of the world. The use of herbal medicines alone or alongside prescription drugs for disease management is quite common now. We hereby carry out a review of dominant species of Selinum mainly S. vaginatum C.B. Clarke and S. wallichianum (DC.) ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201020666181227150829

    authors: Srivastava RP,Dixit P,Singh L,Verma PC,Saxena G

    更新日期:2018-01-01 00:00:00

  • Use of transgenic mouse models to understand the origins of familial pulmonary fibrosis.

    abstract::Pulmonary fibrosis is an unremitting degenerative lung disease that has an associated high mortality. The major pathological features include the growth of fibroblasts, emergence of myofibroblasts and their production of extracellular matrix that distorts the peripheral lung tissue and impairs respiratory function. Ef...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920111798281045

    authors: Glasser SW,Senft AP

    更新日期:2011-09-01 00:00:00

  • Optimization on Fc for Improvement of Stability and Aggregation Resistance.

    abstract::Fc-based therapeutics including therapeutic full-size monoclonal antibodies (mAbs) and Fcfusion proteins represent fastest-growing market in biopharmaceutical industrial. However, one major challenge during development of Fc-based therapeutics is how to maintain their efficacy in clinic use. Many factors may lead to f...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201017666161117145312

    authors: Chen X,Zeng F,Huang T,Cheng L,Liu H,Gong R

    更新日期:2016-01-01 00:00:00

  • Vaccines against Clostridium perfringens alpha-toxin.

    abstract::Clostridium perfringens alpha-toxin is thought to be an important agent in gas gangrene, which is a lifethreatening infection with fever, pain, edema, myonecrosis, and gas production. The toxin (370 residues) is composed of an N-terminal domain (1-250 residues, N-domain) in which the catalytic site is found and a C-te...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201014666131226124348

    authors: Nagahama M

    更新日期:2013-01-01 00:00:00

  • Potential Use of Pentoxifylline in Cancer Therapy.

    abstract:BACKGROUND:Pentoxifylline (PTX) is a drug commonly used in the treatment of intermittent claudication. However, numerous research groups report that PTX also may potentially be used in the anticancer therapy following one of the main trends in the nowadays medicine - combined anticancer therapy. SCOPE OF REVIEW:The re...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201019666180528084641

    authors: Golunski G,Woziwodzka A,Piosik J

    更新日期:2018-01-01 00:00:00

  • Monitoring molecular, functional and morphologic aspects of bone metastases using non-invasive imaging.

    abstract::Bone is among the most common locations of metastasis and therefore represents an important clinical target for diagnostic follow-up in cancer patients. In the pathogenesis of bone metastases, disseminated tumor cells proliferating in bone interact with the local microenvironment stimulating or inhibiting osteoclast a...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920112799436285

    authors: Bauerle T,Komljenovic D,Semmler W

    更新日期:2012-03-01 00:00:00

  • Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake.

    abstract::Chronic inflammation and oxidative stress increase with advancing age and appear to be involved in the pathogenesis of coronary heart disease, the leading cause of death worldwide. There is a need for animal models that reflect the increases in pro-inflammatory cytokines and oxidative damage observed during aging in h...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/138920110793262006

    authors: Schiborr C,Eckert GP,Weissenberger J,Müller WE,Schwamm D,Grune T,Rimbach G,Frank J

    更新日期:2010-12-01 00:00:00

  • Raman molecular imaging of cells and tissues: towards functional diagnostic imaging without labeling.

    abstract::Raman spectroscopy has long been used as a powerful tool for chemical composition analyses. Raman scattering light measurement has the advantage of being able to examine biomolecules in a nondestructive and non-labeling manner. However, molecular imaging of cells and tissues by using Raman microscopy had been hampered...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:

    authors: Harada Y,Takamatsu T

    更新日期:2013-01-01 00:00:00

  • Molecular and Pharmaceutical Aspects of Novel Methods and Materials for the Prevention of Tooth Structure Loss.

    abstract::In the past decade, a range of dental products have appeared which make advertising claims around preventing mineral loss or repairing mineral loss. This review examines the requirements for effective protection of tooth structure, and the evidence around technologies now available for preventing tooth structure loss ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/1389201017666161207163851

    authors: Walsh LJ

    更新日期:2017-01-01 00:00:00

  • Development of a STAT5 phosphorylation assay as a rapid bioassay to assess interleukin-7 potency.

    abstract::Interleukin (IL)-7 is a cytokine inducing the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway. As a consequence of IL-7 activating this pathway, STAT5 is phosphorylated. In pharmaceutical quality control, the potency of biopharmaceuticals is commonly assessed by proliferation assays....

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/138920111798357294

    authors: Zumpe C,Engel K,Wiedemann N,Metzger AU,Pischetsrieder M,Bachmann CL

    更新日期:2011-10-01 00:00:00

  • Transforming viral sequences to A (H1N1) flu diagnosis: the current status and future prospects of rtPCR based assays.

    abstract::A variety of technologies can be used in the detection of contagious pathogens. In the early stage of an outbreak of a new infectious disease, rtPCR is advantageous over many other assays. The rtPCR can be developed either using low fidelity DNA polymerase or high fidelity DNA polymerase. The application of high fidel...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920110790725339

    authors: Li K,Xiao L,Liu C,Zhang J,Sirois P

    更新日期:2010-01-01 00:00:00

  • Imaging adoptive cell transfer based cancer immunotherapy.

    abstract::The prospect of mobilizing the power of the immune system in the fight against cancer has fascinated generations of immunologists. After decades of sporadic successes scattered amongst frequent failures, the field of tumor immunology is now poised to take advantage of a greatly improved understanding of the molecular ...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920110792246528

    authors: Rabinovich BA,Radu CG

    更新日期:2010-09-01 00:00:00

  • Evaluation of Paclitaxel Effects in The Pattern of Expression of Survival and Apoptotic Genes Regulators in HeLa Cells.

    abstract::We aim to determine the regulation of apoptosis by paclitaxel-induced and understand cancer dynamics to treatment targets for HeLa cells by identifying decrease/increase genes expression on HeLa cells. In this study, the anti-tumor effects of Paclitaxel (PAC) on HeLa cells have been studied in order to determine the c...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201017666160914190550

    authors: Serbes U,Ozsoylemez OD,Ozcan G

    更新日期:2016-01-01 00:00:00

  • Efficient expression and purification of recombinant therapeutic protein candidates, human midkine and pleiotrophin.

    abstract::Midkine is a heparin-binding growth factor that promotes cell growth, survival, and migration. Externally added midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction in the mouse. Preclinical testing of this protein is in progress. Externally added pleiotrophin, a member o...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章

    doi:10.2174/1389201014666131226114919

    authors: Murasugi A

    更新日期:2013-01-01 00:00:00

  • Application of Serial Analysis of Gene Expression in cancer research.

    abstract::It is now widely believed that tumors originate from normal cells as a result of accumulated genetic/epigenetic changes. These alterations affect the signaling pathways at transcriptional and post-transcriptional level that drive cells into uncontrolled cell division, growth, and migration. Recent advancement of molec...

    journal_title:Current pharmaceutical biotechnology

    pub_type: 杂志文章,评审

    doi:10.2174/138920108785915102

    authors: Yamashita T,Honda M,Kaneko S

    更新日期:2008-10-01 00:00:00