The Relationship Between Adverse Childhood Experiences and Health Care Use in the Manitoba IBD Cohort Study.

abstract：BACKGROUND:Drug concentration monitoring may be useful to guide therapeutic adjustments for anti-tumor necrosis factor agents in Crohn's disease. The relationship between serum adalimumab concentrations and clinical outcomes was assessed using data from CLinical Assessment of Adalimumab Safety and Efficacy Studied as I...

journal_title：Inflammatory bowel diseases

authors： Chiu YL,Rubin DT,Vermeire S,Louis E,Robinson AM,Lomax KG,Pollack PF,Paulson SK

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:High doses of mesalazine usually result in an inconvenient dosage schedule and reduced compliance. The goal of this trial was to compare the effects of mesalazine 4 g daily given as prolonged-release granules in packets of 1 g with that of prolonged-release tablets of 0.5 g. METHODS:Two hundred twenty-seven...

journal_title：Inflammatory bowel diseases

authors： Farup PG,Hinterleitner TA,Lukás M,Hébuterne X,Rachmilewitz D,Campieri M,Meier R,Keller R,Rathbone B,Oddsson E

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Unlike other anti-tumor necrosis factor alpha antibodies, golimumab does not deliver on its promise of effectiveness for treating patients with ulcerative colitis. We investigated the value of therapeutic drug monitoring for optimizing golimumab therapy. METHODS:We analyzed the golimumab pharmacokinetics da...

journal_title：Inflammatory bowel diseases

authors： Dreesen E,Kantasiripitak W,Detrez I,Stefanović S,Vermeire S,Ferrante M,Bouillon T,Drobne D,Gils A

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Mucosa-associated Escherichia coli are abundant in inflammatory bowel disease (IBD), but whether these bacteria gain intracellular access within the mucosa is uncertain. If E. coli does gain intracellular access, the contribution of bacterial pathogenicity to this requires further elucidation. This study aim...

journal_title：Inflammatory bowel diseases

authors： Elliott TR,Hudspith BN,Wu G,Cooley M,Parkes G,Quiñones B,Randall L,Mandrell RE,Fagerquist CK,Brostoff J,Rayment NB,Boussioutas A,Petrovska L,Sanderson JD

更新日期：2013-10-01 00:00:00

abstract：Background:In Crohn's disease (CD) a small bowel study-in addition to colonoscopy-is considered necessary for diagnosis/staging. In this study we re-examined the role of capsule endoscopy (CE), colonoscopy, imaging tests [magnetic resonance enterography/computed tomographic enterography (MRE/CTE)], and inflammatory mar...

journal_title：Inflammatory bowel diseases

authors： Sorrentino D,Nguyen VQ

更新日期：2018-06-08 00:00:00

abstract：BACKGROUND:Previous systematic cumulative analyses of the placebo arm in ulcerative colitis (UC) were limited by the wide heterogeneity in the scores and definitions of response. We aimed at estimating the placebo rates of remission, response, and mucosal healing (MH) in phase 2 and 3 randomized placebo-controlled tria...

journal_title：Inflammatory bowel diseases

authors： Macaluso FS,Maida M,Ventimiglia M,Renna S,Cottone M,Orlando A

更新日期：2019-05-04 00:00:00

abstract：:This review examines preclinical and clinical studies relevant to our understanding of how the bidirectional gut-brain axis influences the natural history of inflammatory bowel disease. Preclinical studies provide proof of concept that preexisting behavioral illness, such as depression, results in increased susceptibi...

journal_title：Inflammatory bowel diseases

authors： Collins SM

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:The consistency of endoscopic and histologic findings in patients with ulcerative colitis (UC) has not been elucidated. Choice of assessment may affect study outcomes. METHODS:Post hoc analyses were performed using data from 2 randomized, controlled multicenter trials: (1) SAG-26, mesalazine granules for in...

journal_title：Inflammatory bowel diseases

authors： Wolff S,Terheggen G,Mueller R,Greinwald R,Franklin J,Kruis W

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Experiential learning in medical education, as exemplified by objective structured clinical examinations (OSCEs), is a well-validated approach for improving trainee performance. Furthermore, the Accreditation Council for Graduate Medical Education has identified OSCEs as an ideal method for assessing the cor...

journal_title：Inflammatory bowel diseases

authors： Wolff MJ,Balzora S,Poles M,Zabar S,Mintah A,Wong L,Weinshel E,Malter LB

更新日期：2015-04-01 00:00:00

abstract：:Citrullination is a posttranslational modification of proteins mediated by a specific family of enzymes called peptidylarginine deiminases (PAD). Dysregulation of these enzymes is involved in the etiology of various diseases, from cancer to autoimmune disorders. In inflammatory bowel disease (IBD), data for a role of ...

journal_title：Inflammatory bowel diseases

authors： Dragoni G,De Hertogh G,Vermeire S

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Patients with inflammatory bowel disease (IBD) have identified a need for more information about their disease. PURPOSE:To assess the effect of an educational intervention on health-related quality of life (HRQOL) in patients with IBD. METHODS:Consecutive ambulatory IBD patients were randomized to receive ...

journal_title：Inflammatory bowel diseases

authors： Borgaonkar MR,Townson G,Donnelly M,Irvine EJ

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Mucosal healing (MH) is associated with improved clinical outcomes in patients with Crohn's disease (CD) and ulcerative colitis (UC). MH as a target for treatment has been suggested, although there is little pediatric data. The goal of this study was to evaluate MH in clinical practice in pediatric patients ...

journal_title：Inflammatory bowel diseases

authors： Santha SL,Shankar PR,Pan A,Schoen B,Kugathasan S,Sauer CG

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a well-known complication of Crohn's disease (CD). Osteoprotegerin (OPG) concentration is elevated in patients with CD compared to healthy controls. Long-term infliximab (IFX) maintenance therapy improves the patients' bone mineral density. The effect of IFX on bone metabolism has not yet bee...

journal_title：Inflammatory bowel diseases

authors： Miheller P,Muzes G,Rácz K,Blázovits A,Lakatos P,Herszényi L,Tulassay Z

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:Studies aimed at establishing which characteristics of patients with ulcerative proctitis could be predictive of the extension of inflammation have failed to provide conclusive results. The aim of the study was to evaluate the prognostic role of clinical and therapeutic parameters in patients with proctitis....

journal_title：Inflammatory bowel diseases

authors： Pica R,Paoluzi OA,Iacopini F,Marcheggiano A,Crispino P,Rivera M,Bella A,Consolazio A,Paoluzi P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Vitamin A is an important regulator of the human immune system, especially in the gut. Recent studies have revealed that retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-beta-dependent conversion of naïve T cells into regulatory T (Treg) cells. Thus, RA...

journal_title：Inflammatory bowel diseases

authors： Wada Y,Hisamatsu T,Kamada N,Okamoto S,Hibi T

更新日期：2009-10-01 00:00:00

abstract：Background:Both muscle-related complaints and elevated serum creatine kinase (CK) levels have been reported in patients with inflammatory bowel disease (IBD) treated with infliximab (IFX), mainly as case reports. The aim of this study was to investigate the effect of IFX therapy on serum CK levels in a cohort of Greek ...

journal_title：Inflammatory bowel diseases

authors： Theodoraki E,Orfanoudaki E,Foteinogiannopoulou K,Koutroubakis IE

更新日期：2018-05-18 00:00:00

abstract：:Clinical and epidemiological studies have revealed that the incidence of colorectal cancer associated with ulcerative colitis increases with long-term chronic inflammation. Careful endoscopic observation and histological studies to check for dysplasia in the colon are important in detecting neoplasia. Current surveill...

journal_title：Inflammatory bowel diseases

authors： Matsumoto T,Iwao Y,Igarashi M,Watanabe K,Otsuka K,Watanabe T,Iizuka B,Hida N,Sada M,Chiba T,Kudo SE,Oshitani N,Nagawa H,Ajioka Y,Hibi T

更新日期：2008-02-01 00:00:00

abstract：:Lymphocyte migration is at the heart of chronic inflammatory ailments, including inflammatory bowel disease (IBD). Whereas naïve lymphocytes migrate to all secondary lymphoid organs, they are mostly excluded from nonlymphoid peripheral tissues. Upon activation, lymphocytes change their pattern of adhesion receptors an...

journal_title：Inflammatory bowel diseases

authors： Mora JR

更新日期：2008-02-01 00:00:00

abstract：:: We report our initial characterization of the immune system in C3H/HeJBir mice that spontaneously develop perianal ulceration. Analysis of lymphokine production by mucosal and systemic lymphoid cells obtained from these mice revealed higher levels of interleukin (IL)4 in supernatants of in vitro stimulated Peyer's p...

journal_title：Inflammatory bowel diseases

authors： Tonkonogy SL,Sartor BR

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:This study examines the resources utilization in patients with Crohn's disease (CD) during the year before (Y - 1) and after (Y + 1) starting treatment with adalimumab and the drug's efficiency. METHODS:Observational, multicenter, prospective cohort study of patients with CD naive to biological drugs. The p...

journal_title：Inflammatory bowel diseases

authors： Saro C,Ceballos D,Muñoz F,De la Coba C,Aguilar MD,Lázaro P,Iglesias-Flores E,Barreiro-de Acosta M,Hernández-Durán MD,Barrio J,Riestra S,Fernández Salazar L,EFICADEC Researchers Group.

更新日期：2015-07-01 00:00:00

abstract：:Inflammatory bowel diseases are chronic intestinal inflammatory diseases thought to reflect a dysregulated immune response. Although antibody-based inhibition of tumor necrosis factor-α (TNF-α) has provided relief to many inflammatory bowel diseases patients, these therapies are either ineffective in a patient subset ...

journal_title：Inflammatory bowel diseases

authors： Collins CB,Strassheim D,Aherne CM,Yeckes AR,Jedlicka P,de Zoeten EF

更新日期：2014-04-01 00:00:00

abstract：:Anorexia, malnutrition, altered body composition and development of mesenteric obesity are well known features of inflammatory bowel disease (IBD). Recent data suggest that dysregulation of protein secretion by white adipose tissue is involved in these manifestations of patients with IBD. Adipocytes are recently recog...

journal_title：Inflammatory bowel diseases

authors： Karmiris K,Koutroubakis IE,Kouroumalis EA

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Previous decision analyses of inflam matory bowel diseases (IBD) have used decision trees and Markov chains. Occasionally IBD patients present with medical problems that are difficult or even impossible to phrase in terms of such established decision tools. This article aims to introduce modeling by a time-d...

journal_title：Inflammatory bowel diseases

authors： Sonnenberg A,Gavin MW

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:A North American genome-wide single nucleotide polymorphism (SNP) association study identified IL23R as a novel inflammatory bowel disease (IBD) susceptibility gene. Association was reported with multiple risk variants in the centromeric portion of IL23R in 3 large independent cohorts. The aims of this study...

journal_title：Inflammatory bowel diseases

authors： Cummings JR,Ahmad T,Geremia A,Beckly J,Cooney R,Hancock L,Pathan S,Guo C,Cardon LR,Jewell DP

更新日期：2007-09-01 00:00:00

abstract：:Colitis-associated colorectal neoplasia (CRN) is a well-known complication of chronic inflammation of the colon either with ulcerative colitis (UC) or colonic Crohn's disease (CD). Studies have shown that inflammatory bowel disease (IBD) patients have an overall higher risk for colorectal dysplasia and cancer compared...

journal_title：Inflammatory bowel diseases

authors： Gaidos JK,Bickston SJ

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is increasingly diagnosed in ethnic and racial minorities. Ileal pouch-anal anastomosis (IPAA) has become the treatment of choice for ulcerative colitis (UC) patients requiring surgery. Few studies have characterized the natural history of IPAA and the pouch outcomes in the H...

journal_title：Inflammatory bowel diseases

authors： Lian L,Moore L,Wu XJ,He XS,Lan P,Shen B

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Evaluating structural damage using imaging is essential for the evaluation of small intestinal Crohn's disease (CD), but it is limited by potential interobserver variation. We compared the agreement of enterography-based bowel damage measurements collected by experienced radiologists and a semi-automated ima...

journal_title：Inflammatory bowel diseases

authors： Stidham RW,Enchakalody B,Waljee AK,Higgins PDR,Wang SC,Su GL,Wasnik AP,Al-Hawary M

更新日期：2020-04-11 00:00:00

abstract：:This review summarizes the current phenotypic classifications of inflammatory bowel disease (IBD) and outlines their implications for diagnosis, therapy, prognosis, clinical trial design, and genotype-phenotype correlations. ...

journal_title：Inflammatory bowel diseases

authors： Walfish A,Sachar D

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Anxiety is linked with adverse health-related outcomes and increased health-seeking behaviors among patients with chronic illness. Yet, this relationship has received little attention in pediatric inflammatory bowel disease. The aim of this study was to examine whether anxiety symptoms predicted youth at inc...

journal_title：Inflammatory bowel diseases

authors： Reigada LC,Satpute A,Hoogendoorn CJ,Cohen BH,Lai J,Bao R,Dubinsky MC,Benkov KJ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:There has been a remarkable increase in the incidence of Crohn's disease (CD) among Arabs in recent years. We conducted this study to determine the clinical epidemiology of CD in Kuwait. METHODS:Sociodemographic and clinical information was collected for a continuous series of 206 Arab patients with CD and ...

journal_title：Inflammatory bowel diseases

authors： Siddique I,Alazmi W,Al-Ali J,Al-Fadli A,Alateeqi N,Memon A,Hasan F

更新日期：2012-09-01 00:00:00