Activation of β-catenin in Col2-expressing chondrocytes leads to osteoarthritis-like defects in hip joint.

abstract：:Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining s...

journal_title：Journal of cellular physiology

authors： Hong G,Kuek V,Shi J,Zhou L,Han X,He W,Tickner J,Qiu H,Wei Q,Xu J

更新日期：2018-11-01 00:00:00

abstract：:A new form of cell death has been observed. The death occurs at liquid-air interfaces when Tetrahymena cells are grown in a chemically defined medium (CDM) at low inocula. The cells die by lysis at the liquid-air interface (medium surface), which they reach due to negative gravitaxis as well as positive aerotaxis. Whe...

journal_title：Journal of cellular physiology

authors： Kristiansen TB,Hagemeister JJ,Grave M,Hellung-Larsen P

更新日期：1996-10-01 00:00:00

abstract：:Cultured hepatic stellate cells (HSCs), the cell type primarily involved in the progression of liver fibrosis, secrete insulin-like growth factor-I (IGF-I) and IGF binding protein (IGFBP) activity. IGF-I exerts a mitogenic effect on HSCs, thus potentially contributing to the fibrogenic process in an autocrine fashion....

journal_title：Journal of cellular physiology

authors： Gentilini A,Feliers D,Pinzani M,Woodruff K,Abboud S

更新日期：1998-02-01 00:00:00

abstract：:Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

journal_title：Journal of cellular physiology

authors： Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

更新日期：2017-02-01 00:00:00

abstract：:The clonal hematopoiesis when occurring without hematologic abnormalities is defined as clonal hematopoiesis of indeterminate potential (CHIP). Aging causes accumulation of somatic mutations, and hematopoietic stem cells (HSCs) can develop clonal expansion of different lineages by these mutations. CHIP has a correlati...

journal_title：Journal of cellular physiology

authors： Haybar H,Shahrabi S,Ghanavat M,Khodadi E

更新日期：2019-06-01 00:00:00

abstract：:Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor that was related to cancer development and metastasis dissemination on several types of tumors. However, it is not known the effect of SLPI on mammary and colon tumors. The aim of this study was to examine the effect of SLPI on mammary and co...

journal_title：Journal of cellular physiology

authors： Amiano NO,Costa MJ,Reiteri RM,Payés C,Guerrieri D,Tateosian NL,Sánchez ML,Maffia PC,Diament M,Karas R,Orqueda A,Rizzo M,Alaniz L,Mazzolini G,Klein S,Sallenave JM,Chuluyan HE

更新日期：2013-02-01 00:00:00

abstract：:The stromal cell-derived factor-1 (SDF-1)/CXC receptor 4 (CXCR4) axis has been shown to play a role in colorectal cancer progression. In addition, the protease urokinase-type plasminogen activator (uPA) is an important factor in tumor cell invasion and metastasis. However, the mechanism by which SDF-1 mediates uPA exp...

journal_title：Journal of cellular physiology

authors： Huang WS,Chin CC,Chen CN,Kuo YH,Chen TC,Yu HR,Tung SY,Shen CH,Hsieh YY,Guo SE,Shi CS,Liu TJ,Kuo HC

更新日期：2012-03-01 00:00:00

abstract：:Serine racemase (SR) is responsible for the biosynthesis of D-serine (D-Ser), an endogenous co-agonist for the glycine (Gly)-binding site on N-methyl-D-aspartate (NMDA) receptors, from L-Ser in the brain. We have previously demonstrated high expression of SR by chondrocytes in cartilage. In this study, we attempted to...

journal_title：Journal of cellular physiology

authors： Takarada T,Takahata Y,Iemata M,Hinoi E,Uno K,Hirai T,Yamamoto T,Yoneda Y

更新日期：2009-09-01 00:00:00

abstract：:A cloned human hepatoma cell line (Li-7A), possessing epidermal growth factor (EGF) receptors numbering in the range of 10-20 pmol/10(6) cells, was inhibited in its growth by EGF as well as an antagonist monoclonal antibody (MoAb) to the EGF receptor. The mode of action of the two ligands of EGF receptors appeared to ...

journal_title：Journal of cellular physiology

authors： Knowles AF

更新日期：1988-01-01 00:00:00

abstract：:Alternative splicing (AS) is critically associated with tumorigenesis and patient's prognosis. Here, we systematically analyzed survival-associated AS signatures in oral squamous cell carcinoma (OSCC) and evaluated their prognostic predictive values. Survival-related AS events were identified by univariate and multiva...

journal_title：Journal of cellular physiology

authors： Zhang S,Wu X,Diao P,Wang C,Wang D,Li S,Wang Y,Cheng J

更新日期：2020-05-01 00:00:00

abstract：:Incubation of alveolar macrophages or hepatocytes in media in which Na+ is replaced by K+ ("isotonic-K buffer") inhibited the movement of internalized ligand from late endosomes to lysosomes (Ward et al.: Journal of Cell Biology 110:1013-1022, 1990). In this study we investigate the mechanism responsible for the isoto...

journal_title：Journal of cellular physiology

authors： Ward DM,Hackenyos DP,Davis-Kaplan S,Kaplan J

更新日期：1990-12-01 00:00:00

abstract：:The growth-regulated vimentin gene contains a functional double AP-1 binding site formed by two nearly perfect inverted repeats. We present evidence for down-regulation of vimentin expression by the retinoic acid receptor (RAR) in two mesodermally derived cell types. By mutation analysis we prove that the double conse...

journal_title：Journal of cellular physiology

authors： Van de Klundert FA,Jansen HJ,Bloemendal H

更新日期：1995-07-01 00:00:00

abstract：:The herbicide 2,4,5 trichlorophenoxy acetic acid (245T) at concentrations from 0.5 to 0.9 mM, was found to inhibit respiration and then growth in exponentially growing cultures of Tetrahymena pyriformis. Cell division was stopped for periods up to 60 minutes after which the cells recovered and division resumed. Recove...

journal_title：Journal of cellular physiology

authors： Silberstein GB,Hooper AB

更新日期：1975-04-01 00:00:00

abstract：:During embryonic and early postnatal development, the chick leg muscle cells undergo a series of changes in their electrical responses in the following sequence: passive response, plateau response, plateau plus spike response and spike response. This suggests that the electrogenetic mechanism of muscles matures during...

journal_title：Journal of cellular physiology

authors： Kano M

更新日期：1975-12-01 00:00:00

abstract：:Adiponectin, one of the adipose-derived hormone with metabolic activity, has been reported to conversely affect angiogenesis of endothelial cells in vitro. The previous study in animal models has demonstrated that adiponectin has a protective role in retinal vascular injury following pathological stimuli. However, cli...

journal_title：Journal of cellular physiology

authors： Li R,Du J,Yao Y,Yao G,Wang X

更新日期：2019-11-01 00:00:00

abstract：:Colon cancer stem cells (CCSCs) stand for a critical subpopulation of colon cancer cells that possess self-renewal and multilineage differentiation potentials and drive tumorigenicity. Due to their impact on treatment tolerance, CCSCs have been a hot research topic in the past few years. We have previously reported th...

journal_title：Journal of cellular physiology

authors： Ma X,Liu J,Li J,Li Y,Le VM,Li S,Liang X,Liu L,Liu J

更新日期：2019-12-01 00:00:00

abstract：:It has been established that syndecan-1 is an important modulator of events relevant to acute tissue repair and chronic injury responses. The current studies were designed to examine syndecan-1 expression during atherosclerotic lesion formation and whether angiotensin II influences syndecan-1 expression in macrophages...

journal_title：Journal of cellular physiology

authors： Wang W,Haller CA,Wen J,Wang P,Chaikof EL

更新日期：2008-03-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been associated with lung cancer (LC), one of the most common cancers, but the underlying molecular mechanisms of the specific correlation with LC carcinogenesis remain unveiled. Quantitative real-time polymerase chain reaction was applied to examine the level of circZNF609. LC cells were...

journal_title：Journal of cellular physiology

authors： Liu S,Yang N,Jiang X,Wang J,Dong J,Gao Y

更新日期：2021-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) have spurred considerable interest in numerous tumors. We aimed to investigate the clinical, prognostic, and diagnostic roles of circRNAs in human lung cancer. We systematically searched PubMed, Web of Science, EMBASE, Scopus, CBM, and the Cochrane Library databases up to July 24, 2018. Eligib...

journal_title：Journal of cellular physiology

authors： Huang X,Zhang W,Shao Z

更新日期：2019-08-01 00:00:00

abstract：:In fertilized echinoderm eggs, the male and female pronuclei fuse to form the diploid nucleus even in the presence of aphidicolin, a specific inhibitor of eukaryotic DNA polymerase-alpha. The subsequent first cleavage is independent of chromosomes but dependent on spindle and amphiaster. The fate of DNA originally exi...

journal_title：Journal of cellular physiology

authors： Yamada H,Hirai S,Ikegami S,Kawarada Y,Okuhara E,Nagano H

更新日期：1985-07-01 00:00:00

abstract：:P2Y(2) receptor expression is increased in intestinal epithelial cells (IECs) during inflammatory bowel diseases (IBDs). In this context, P2Y(2) stimulates PGE(2) release by IECs, suggesting a role in wound healing. For this study, we have used the non-cancerous IEC-6 cell line. IEC-6 cell migration was determined usi...

journal_title：Journal of cellular physiology

authors： Degagné E,Degrandmaison J,Grbic DM,Vinette V,Arguin G,Gendron FP

更新日期：2013-01-01 00:00:00

abstract：:Modeling breast cancer in the mouse has helped to better define the heterogeneity of human breast cancer. In the recent past, it has become evident that some limitations have restricted the potential benefits that can be achieved with this approach. In this review, we highlight some key points that should be taken int...

journal_title：Journal of cellular physiology

authors： Caligiuri I,Rizzolio F,Boffo S,Giordano A,Toffoli G

更新日期：2012-08-01 00:00:00

abstract：:Invasion of tumor cells is the primary cause of therapeutic failure in the treatment of malignant chondrosarcomas. Glial cell-derived neurotrophic factor (GDNF) plays a crucial role in migration and metastasis of human cancer cells. Integrins are the major adhesive molecules in mammalian cells. Here we found that GDNF...

journal_title：Journal of cellular physiology

authors： Su CM,Lu DY,Hsu CJ,Chen HT,Huang CY,Yang WH,Su YC,Yang SN,Fong YC,Tseng WP,Tang CH

更新日期：2009-08-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is the major cause of back pain. Notch signaling is activated in annulus fibrosus (AF) and nucleus pulposus (NP) tissues of degenerated IVDs, and induced by IL1-β and TNF-α in NP cells. However, the role of Notch activatin in the pathogenesis of IVD degeneration is largely unknow...

journal_title：Journal of cellular physiology

authors： Zheng Y,Liu C,Ni L,Liu Z,Mirando AJ,Lin J,Saijilafu,Chen D,Hilton MJ,Li B,Chen J

更新日期：2018-07-01 00:00:00

abstract：:Rat embryo fibroblasts were grown in medium containing 14C-leucine and 3H-thymidine. After a 24-hour chase in nonlabeled medium, cultures were placed in either fresh growth medium or medium containing 10-20 microgram/ml cycloheximide. Cell monolayers were processed at daily intervals for three days. Four hours prior t...

journal_title：Journal of cellular physiology

authors： Amenta JS,Sargus MJ,Baccino FM

更新日期：1978-12-01 00:00:00

abstract：:Glucose and tumor necrosis factor-alpha (TNFalpha) concentrations are elevated in diabetes. Both of these factors correlate with diabetic vasculopathy and endothelial cell apoptosis, yet their combined effects have not been measured. We have previously shown that the angiogenic growth factor fibroblast growth factor-2...

journal_title：Journal of cellular physiology

authors： Clyne AM,Zhu H,Edelman ER

更新日期：2008-10-01 00:00:00

abstract：:Quercetin has potentially beneficial effects on disease prevention, including cancer. An intriguing issue regarding the mechanisms of action of quercetin is the ability of this drug to modulate estrogen receptor (ER) activities. In a previous study, we demonstrated that quercetin elicited apoptosis through an ERα-depe...

journal_title：Journal of cellular physiology

authors： Bulzomi P,Galluzzo P,Bolli A,Leone S,Acconcia F,Marino M

更新日期：2012-05-01 00:00:00

abstract：:Retinoic acid (RA) reduced growth, fibronectin, and retinoic acid receptor (RAR alpha) in NIH 3T3 cells but not in cells transformed by the Ha-ras oncogene. RA lowered RAR alpha transcript and protein, increased RAR beta transcripts, and had no effect on RAR gamma. H-ras transformation downregulated RAR expression and...

journal_title：Journal of cellular physiology

authors： De Luca LM,Scita G,Takatsuka J

更新日期：1997-11-01 00:00:00

abstract：:Interleukin (IL)-37 diminishes a variety of inflammatory responses through ligation to its receptor IL-1R8/Sigirr. Sigirr is a Toll like receptor/IL-1R family member. We have shown that Sigirr is not stable in response to IL-37 treatment. IL-37-induced Sigirr degradation is mediated by the ubiquitin-proteasome system,...

journal_title：Journal of cellular physiology

authors： Li L,Wei J,Suber TL,Ye Q,Miao J,Li S,Taleb SJ,Tran KC,Tamaskar AS,Zhao J,Zhao Y

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:Elevated microsatellite alteration at selected tetranucleotide repeats (EMAST) is a type of microsatellite instability that occurs in ∼60% of colorectal cancers (CRCs) and associated with MSH3 dysfunction. A 5-fluorouracil (5-FU)-related cytotoxicity is attenuated in MSH3-deficient colon cancer cells. Report...

journal_title：Journal of cellular physiology

authors： Mohammadpour S,Goodarzi HR,Jafarinia M,Porhoseingholi MA,Nazemalhosseini-Mojarad E

更新日期：2020-04-01 00:00:00