Sulfur: the heart of nitric oxide-dependent redox signalling.

Abstract:

:Nitric oxide (NO), more benign than its more reactive and damaging related molecules, reactive oxygen species (ROS), is perfectly suited for duties as a redox signalling molecule. A key route for NO bioactivity is through S-nitrosation, the addition of an NO moiety to a protein Cys thiol (-SH). This redox-based, post-translational modification (PTM) can modify protein function analogous to more well established PTMs such as phosphorylation, for example by modulating enzyme activity, localization, or protein-protein interactions. At the heart of the underpinning chemistry associated with this PTM is sulfur. The emerging evidence suggests that S-nitrosation is integral to a myriad of plant biological processes embedded in both development and environmental relations. However, a role for S-nitrosation is perhaps most well established in plant-pathogen interactions.

journal_name

J Exp Bot

authors

Umbreen S,Lubega J,Loake GJ

doi

10.1093/jxb/erz135

subject

Has Abstract

pub_date

2019-08-19 00:00:00

pages

4279-4286

issue

16

eissn

0022-0957

issn

1460-2431

pii

5419863

journal_volume

70

pub_type

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