Author Correction: Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells.

abstract：:Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural functions1,2; however, the precise circuit computations remain unknown. One potentially unifying model by which dopamine may underlie a diversity of functions is by modulating the signal-to-noise ratio in subpopulations of mPFC ...

journal_title：Nature

authors： Vander Weele CM,Siciliano CA,Matthews GA,Namburi P,Izadmehr EM,Espinel IC,Nieh EH,Schut EHS,Padilla-Coreano N,Burgos-Robles A,Chang CJ,Kimchi EY,Beyeler A,Wichmann R,Wildes CP,Tye KM

更新日期：2018-11-01 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...

journal_title：Nature

authors： Pijnappel WW,Esch D,Baltissen MP,Wu G,Mischerikow N,Bergsma AJ,van der Wal E,Han DW,Bruch Hv,Moritz S,Lijnzaad P,Altelaar AF,Sameith K,Zaehres H,Heck AJ,Holstege FC,Schöler HR,Timmers HT

更新日期：2013-03-28 00:00:00

abstract：:The biosynthesis of many of the complement proteins by cells of the monocyte-macrophage series has been established. Studies on these cells using radiolabelled amino acids demonstrated synthesis of precursor proteins (pro-complement), and the native complement protein similar in size to that found in the plasma. Howev...

journal_title：Nature

authors： Ooi YM,Ooi BS

更新日期：1982-07-22 00:00:00

abstract：: ...

journal_title：Nature

authors： Payne D

更新日期：2018-11-01 00:00:00

abstract：:Protein chains coil into alpha-helices and beta-sheet structures. Knowing the timescales and mechanism of formation of these basic structural elements is essential for understanding how proteins fold. For the past 40 years, alpha-helix formation has been extensively investigated in synthetic and natural peptides, incl...

journal_title：Nature

authors： Muñoz V,Thompson PA,Hofrichter J,Eaton WA

更新日期：1997-11-13 00:00:00

abstract：:Streptococcus pneumoniae, the pneumococcus, is the most common cause of sepsis and meningitis. Multiple-antibiotic-resistant strains are widespread, and vancomycin is the antibiotic of last resort. Emergence of vancomycin resistance in this community-acquired bacterium would be catastrophic. Antibiotic tolerance, the ...

journal_title：Nature

authors： Novak R,Henriques B,Charpentier E,Normark S,Tuomanen E

更新日期：1999-06-10 00:00:00

abstract：:Constructing agents with planning capabilities has long been one of the main challenges in the pursuit of artificial intelligence. Tree-based planning methods have enjoyed huge success in challenging domains, such as chess1 and Go2, where a perfect simulator is available. However, in real-world problems, the dynamics ...

journal_title：Nature

authors： Schrittwieser J,Antonoglou I,Hubert T,Simonyan K,Sifre L,Schmitt S,Guez A,Lockhart E,Hassabis D,Graepel T,Lillicrap T,Silver D

更新日期：2020-12-01 00:00:00

abstract：:Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in their biochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme conc...

journal_title：Nature

authors： Alon U,Surette MG,Barkai N,Leibler S

更新日期：1999-01-14 00:00:00

abstract：:The editing of RNA in trypanosomatid mitochondria involves the insertion and occasional deletion of uridine residues within coding regions of maxicircle messenger RNA transcripts. The extent to which the transcripts of homologous genes undergo editing differs in different species. In some, entire genes are edited (pan...

journal_title：Nature

authors： Maslov DA,Avila HA,Lake JA,Simpson L

更新日期：1994-03-24 00:00:00

abstract：:Salmonella enterica serovar Typhi (S. Typhi) differs from most other salmonellae in that it causes a life-threatening systemic infection known as typhoid fever. The molecular bases for its unique clinical presentation are unknown. Here we find that the systemic administration of typhoid toxin, a unique virulence facto...

journal_title：Nature

authors： Song J,Gao X,Galán JE

更新日期：2013-07-18 00:00:00

abstract：:The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and...

journal_title：Nature

authors： Carmeliet P

更新日期：2005-12-15 00:00:00

abstract：:Simple mathematical models of the transmission dynamics of HIV that incorporate demographic and epidemiological processes to assess the potential impact of AIDS on human population growth and structure in developing countries suggest that AIDS is capable of changing population growth rates from positive to negative va...

journal_title：Nature

authors： Anderson RM,May RM,McLean AR

更新日期：1988-03-17 00:00:00

abstract：:Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...

journal_title：Nature

authors： Hilton GC,Martinis JM,Wollman DA,Irwin KD,Dulcie LL,Gerber D,Gillevet PM,Twerenbold D

更新日期：1998-02-12 00:00:00

abstract：:Knowledge of the three-dimensional structures of proteins and other biological macromolecules often aids understanding of how they perform complicated tasks in the cell. Because many such tasks involve the cleavage or formation of chemical bonds, structural characterization at the atomic level is most useful. Developm...

journal_title：Nature

authors： Fernandez-Leiro R,Scheres SH

更新日期：2016-09-15 00:00:00

abstract：:Regulation of messenger RNA translation is central to eukaryotic gene expression control. Regulatory inputs are specified by them RNA untranslated regions (UTRs) and often target translation initiation. Initiation involves binding of the 40S ribosomal small subunit (SSU) and associated eukaryotic initiation factors (e...

journal_title：Nature

authors： Archer SK,Shirokikh NE,Beilharz TH,Preiss T

更新日期：2016-07-28 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2019-01-01 00:00:00

abstract：:Large mammals, including humans, save much of the energy needed for running by means of elastic structures in their legs and feet. Kinetic and potential energy removed from the body in the first half of the stance phase is stored briefly as elastic strain energy and then returned in the second half by elastic recoil. ...

journal_title：Nature

authors： Ker RF,Bennett MB,Bibby SR,Kester RC,Alexander RM

更新日期：1987-01-08 00:00:00

abstract：:A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and...

journal_title：Nature

authors： Chumakov I,Rigault P,Guillou S,Ougen P,Billaut A,Guasconi G,Gervy P,LeGall I,Soularue P,Grinas L

更新日期：1992-10-01 00:00:00

abstract：:Limiting the increase of CO2 in the atmosphere is one of the largest challenges of our generation1. Because carbon capture and storage is one of the few viable technologies that can mitigate current CO2 emissions2, much effort is focused on developing solid adsorbents that can efficiently capture CO2 from flue gases e...

journal_title：Nature

authors： Boyd PG,Chidambaram A,García-Díez E,Ireland CP,Daff TD,Bounds R,Gładysiak A,Schouwink P,Moosavi SM,Maroto-Valer MM,Reimer JA,Navarro JAR,Woo TK,Garcia S,Stylianou KC,Smit B

更新日期：2019-12-01 00:00:00

abstract：:Milankovitch proposed that summer insolation at mid-latitudes in the Northern Hemisphere directly causes the ice-age climate cycles. This would imply that times of ice-sheet collapse should correspond to peaks in Northern Hemisphere June insolation. But the penultimate deglaciation has proved controversial because Jun...

journal_title：Nature

authors： Henderson GM,Slowey NC

更新日期：2000-03-02 00:00:00

abstract：:T-lymphocyte co-recognition of antigen and major histocompatibility complex (MHC)-encoded molecules (such as murine Ia molecules) is thought to be mediated by a single cell-surface receptor, although the molecular mechanism by which this occurs is controversial (reviewed in ref. 1). One possibility is that the antigen...

journal_title：Nature

authors： Ashwell JD,Schwartz RH

更新日期：1986-03-13 00:00:00

abstract：:Gene targeting in embryonic stem cells has become the principal technology for manipulation of the mouse genome, offering unrivalled accuracy in allele design and access to conditional mutagenesis. To bring these advantages to the wider research community, large-scale mouse knockout programmes are producing a permanen...

journal_title：Nature

authors： Skarnes WC,Rosen B,West AP,Koutsourakis M,Bushell W,Iyer V,Mujica AO,Thomas M,Harrow J,Cox T,Jackson D,Severin J,Biggs P,Fu J,Nefedov M,de Jong PJ,Stewart AF,Bradley A

更新日期：2011-06-15 00:00:00

abstract：:Protecting the world's freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts f...

journal_title：Nature

authors： Vörösmarty CJ,McIntyre PB,Gessner MO,Dudgeon D,Prusevich A,Green P,Glidden S,Bunn SE,Sullivan CA,Liermann CR,Davies PM

更新日期：2010-09-30 00:00:00

abstract：:Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcome...

journal_title：Nature

authors： Ishizuka JJ,Manguso RT,Cheruiyot CK,Bi K,Panda A,Iracheta-Vellve A,Miller BC,Du PP,Yates KB,Dubrot J,Buchumenski I,Comstock DE,Brown FD,Ayer A,Kohnle IC,Pope HW,Zimmer MD,Sen DR,Lane-Reticker SK,Robitschek EJ,Grif

更新日期：2019-01-01 00:00:00

abstract：:The maternal gene bicoid (bcd) determines pattern in the anterior half of the Drosophila embryo. It is reported here that the injection of bcd mutant embryos with messenger RNAs that encode proteins consisting of heterologous acidic transcriptional activating sequences fused to the DNA-binding portion of the bcd gene ...

journal_title：Nature

authors： Driever W,Ma J,Nüsslein-Volhard C,Ptashne M

更新日期：1989-11-09 00:00:00

abstract：:Many-body systems in nature exhibit complexity and self-organization arising from seemingly simple laws. For example, the long-range Coulomb interaction between electrical charges has a simple form, yet is responsible for a plethora of bound states in matter, ranging from the hydrogen atom to complex biochemical struc...

journal_title：Nature

authors： Kaindl RA,Carnahan MA,Hägele D,Lövenich R,Chemla DS

更新日期：2003-06-12 00:00:00

abstract：:Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during an immune response. The reaction is initiated by cytosine deamination by the activation-induced deaminase (AID) and completed by error-prone processing of the resulting uracils by mismatch and base excision rep...

journal_title：Nature

authors： Liu M,Duke JL,Richter DJ,Vinuesa CG,Goodnow CC,Kleinstein SH,Schatz DG

更新日期：2008-02-14 00:00:00

abstract：:Interactions between animal viruses and antiviral antisera may exceptionally result in an apparent increase in viral infectivity. Halstead and coworkers demonstrated enhanced replication of dengue virus (a Flavivirus, family Togaviridae) in human or simian peripheral blood leucocytes carrying Fc receptors at subneutra...

journal_title：Nature

authors： Peiris JS,Porterfield JS

更新日期：1979-11-29 00:00:00

abstract：:Many animals rely on an internal heading representation when navigating in varied environments1-10. How this representation is linked to the sensory cues that define different surroundings is unclear. In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure known as the elli...

journal_title：Nature

authors： Kim SS,Hermundstad AM,Romani S,Abbott LF,Jayaraman V

更新日期：2019-12-01 00:00:00

abstract：:In Fig. 3d this Letter, the R2 value should have been '0.19' instead of '0.66'; this has been corrected online. ...

journal_title：Nature

authors： Hoyt JR,Langwig KE,White JP,Kaarakka HM,Redell JA,Kurta A,DePue JE,Scullon WH,Parise KL,Foster JT,Frick WF,Kilpatrick AM

更新日期：2019-02-01 00:00:00