The Importance of Being an Antagonist as Well as Persistent.

Abstract:

:The current work by Jain et al. (S. Jain, A. M. Chang, M. Singh, J. S. McLean, et al., J Bacteriol 201:e00683-18, 2019, https://doi.org/10.1128/JB.00683-18) reports the cloning of the lipid A deacylase gene of Porphyromonas gingivalis and the phenotypic characterization of the enzyme. Attempts to clone the gene and thus provide proof of the existence of this enzyme had gone on for 2 decades. The enzyme is central to the bacterium's ability to modify and tailor the structure of its lipid A, changing a lipid A that is a moderate Toll-like receptor 4 (TLR4) agonist to an antagonist or silencer and thereby potentially changing the course of infection.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Progulske-Fox A

doi

10.1128/JB.00146-19

subject

Has Abstract

pub_date

2019-05-08 00:00:00

issue

11

eissn

0021-9193

issn

1098-5530

pii

JB.00146-19

journal_volume

201

pub_type

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