Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study.

Abstract:

Aim:The aim of present study was to determine the safety and efficacy of a new renal artery denervation system for treatment of hypertensive patients. Methods:Hypertensive patients with mean office systolic blood pressure ≥150mmHg and ≤180mmHg or an average of 24-hour ambulatory systolic blood pressure ≥145mmHg and ≤170mmHg after stopping hypertensive medications for 2 weeks or more were enrolled to undergo renal denervation (RDN) using a new RDN system. Changes in office blood pressure and mean 24-hour ambulatory blood pressure and safety were assessed after 6 months. Results:Fifteen patients underwent RDN and followed up for 6 months. At the 6-month follow-up, office systolic blood pressure decreased 11.5±9.9mmHg (P<0.01) and office diastolic blood pressure decreased 6.9±4.8mmHg (P<0.01); mean 24-hour ambulatory systolic blood pressure decreased 7.5±7.7mmHg (P<0.05) and mean 24-hour diastolic blood pressure decreased 3.3±4.7mmHg (P>0.05) compared to baseline values. There were no serious RDN-related adverse events during follow-up. Conclusion:Our results demonstrate that the new RDN system is safe and could significantly reduce blood pressure in hypertensive patients in the absence of antihypertensive medications. This trial is registered with ChiCTR1800017815.

journal_name

Int J Hypertens

authors

Li Y,Nawabi AQ,Feng Y,Dai Q,Ma G,Liu N

doi

10.1155/2019/7929706

subject

Has Abstract

pub_date

2019-02-14 00:00:00

pages

7929706

eissn

2090-0384

issn

2090-0392

journal_volume

2019

pub_type

杂志文章
  • Impact of Patient Beliefs on Blood Pressure Control in the General Population: Findings from the Population-Based STAAB Cohort Study.

    abstract::Background. Effective antihypertensive treatment depends on patient compliance regarding prescribed medications. We assessed the impact of beliefs related towards antihypertensive medication on blood pressure control in a population-based sample treated for hypertension. Methods. We used data from the Characteristics ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2019/9385397

    authors: Tiffe T,Morbach C,Rücker V,Gelbrich G,Wagner M,Faller H,Störk S,Heuschmann PU

    更新日期:2019-07-28 00:00:00

  • Associations of Short Sleep and Shift Work Status with Hypertension among Black and White Americans.

    abstract::Objective. The purpose of this study was to investigate whether short sleepers (<6 hrs) who worked the non-day-shift were at greater likelihood of reporting hypertension and if these associations varied by individuals' ethnicity. Methods. Analysis was based on the 2010 National Health Interview Survey (NHIS). A total ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2015/697275

    authors: Ceïde ME,Pandey A,Ravenell J,Donat M,Ogedegbe G,Jean-Louis G

    更新日期:2015-01-01 00:00:00

  • Hypertension, periodontal disease, and potassium intake in nonsmoking, nondrinker african women on no medication.

    abstract::The purpose of this cross-sectional study was to investigate the association of periodontitis and/or tooth loss with hypertension by excluding the common confounders. Eighty-one Tanzanian women who were aged 46-58 years, nonsmokers, nonalcoholic drinkers, and on no medication underwent clinical examination. Multiple-r...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.4061/2011/695719

    authors: Yamori M,Njelekela M,Mtabaji J,Yamori Y,Bessho K

    更新日期:2011-01-01 00:00:00

  • Cardiac-autonomic imbalance and baroreflex dysfunction in the renovascular Angiotensin-dependent hypertensive mouse.

    abstract::Mouse models provide powerful tools for studying the mechanisms underlying the dysfunction of the autonomic reflex control of cardiovascular function and those involved in cardiovascular diseases. The established murine model of two-kidney, one-clip (2K1C) angiotensin II-dependent hypertension represents a useful tool...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2012/968123

    authors: Campagnaro BP,Gava AL,Meyrelles SS,Vasquez EC

    更新日期:2012-01-01 00:00:00

  • Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload.

    abstract::Myocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts. According to the researches in recent years, myocardial fibrosis, as the pathological basis of various cardiovascular diseases, has been proven to be a co...

    journal_title:International journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1155/2020/3014693

    authors: Ding Y,Wang Y,Jia Q,Wang X,Lu Y,Zhang A,Lv S,Zhang J

    更新日期:2020-01-31 00:00:00

  • The brain Renin-Angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains.

    abstract::Mitochondrial dysfunction is implicated in many cardiovascular diseases, including hypertension, and may be associated with an overactive renin-angiotensin system (RAS). Angiotensin (Ang) II, a potent vasoconstrictor hormone of the RAS, also impairs baroreflex and mitochondrial function. Most deleterious cardiovascula...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2013/136028

    authors: Nautiyal M,Arnold AC,Chappell MC,Diz DI

    更新日期:2013-01-01 00:00:00

  • Associations between Ambulatory Blood Pressure Parameters and Cerebral White Matter Lesions.

    abstract::Silent cerebral white matter lesions (WMLs) are a common finding on magnetic resonance imaging of the brain in the elderly. However, in patients with hypertension, WMLs tend to occur earlier in life and appear to be more severe. There is a body of evidence that supports the idea that WMLs in asymptomatic hypertensive ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.4061/2011/478710

    authors: Sierra C

    更新日期:2011-01-01 00:00:00

  • Extreme Elevations in Blood Pressure and All-Cause Mortality in a Referred CKD Population: Results from the CRISIS Study.

    abstract::Hypertension frequently complicates chronic kidney disease (CKD), with studies showing clinical benefit from blood pressure lowering. Subgroups of patients with severe hypertension exist. We aimed to identify patients with the greatest mortality risk from uncontrolled hypertension to define the prevalence and phenotyp...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2013/597906

    authors: Ritchie J,Rainone F,Green D,Alderson H,Chiu D,Middleton R,O'Donoghue D,Kalra PA

    更新日期:2013-01-01 00:00:00

  • Management of High Blood Pressure in Those without Overt Cardiovascular Disease Utilising Absolute Risk Scores.

    abstract::Increasing blood pressure has a continuum of adverse risk for cardiovascular events. Traditionally this single measure was used to determine who to treat and how vigorously. However, estimating absolute risk rather than measurement of a single risk factor such as blood pressure is a superior method to identify who is ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.4061/2011/595791

    authors: Nelson MR

    更新日期:2011-01-01 00:00:00

  • Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels.

    abstract::Poor eating habits may represent cardiovascular risk factors since high intake of fat and saturated fatty acids contributes to dyslipidemia, obesity, diabetes mellitus, and hypertension. Thus, nutritional interventions are recognized as important strategies for primary prevention of hypertension and as adjuvants to ph...

    journal_title:International journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1155/2016/6791519

    authors: d'El-Rei J,Cunha AR,Trindade M,Neves MF

    更新日期:2016-01-01 00:00:00

  • Mobile Phone-Based Intervention in Hypertension Management.

    abstract::Hypertension is known as the major risk factor for cardiovascular mortality and morbidity. Antihypertensive agents are directed to prevent many of the harmful effects of elevated blood pressure, yet medication nonadherence hinders the effectiveness of these therapies. Nowadays the use of mobile phone has vastly spread...

    journal_title:International journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9021017

    authors: Andre N,Wibawanti R,Siswanto BB

    更新日期:2019-04-07 00:00:00

  • Qualitative Study of Barriers to Adherence to Antihypertensive Medication among Rural Women in India.

    abstract:Objective:There is poor adherence to antihypertensive therapies among women in India. To determine its socioeconomic barriers we performed a qualitative study on Indian rural women with hypertension. Methods:In-depth interviews with women having hypertension and presenting to outpatient department at a teaching hospit...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2019/5749648

    authors: Gupta S,Dhamija JP,Mohan I,Gupta R

    更新日期:2019-01-23 00:00:00

  • Correlation of Prehypertension with Left Ventricular Mass Assessed by Cardiac Magnetic Resonance Imaging.

    abstract::Introduction. The purpose of this observational cross-sectional study was to assess left ventricular mass (LVM) in prehypertensive individuals in comparison to normotensives and to determine if central blood pressure (BP) correlates better with LVM index (LVMI) than brachial BP. Methods and Result. Brachial and centra...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2015/742658

    authors: Mousa TM,Akinseye OA,Berekashvili K,Akinboboye OO

    更新日期:2015-01-01 00:00:00

  • Predictors of Hypertension in a Population of Undergraduate Students in Sierra Leone.

    abstract::We report on the first survey of hypertension in undergraduates in Sierra Leone. Levels of hypertension (12%) and obesity (4%) appear low compared to the general population but given the rapid increase of both and the expectation that many graduates will enter the formal employment sector and a sedentary lifestyle, th...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2017/8196362

    authors: Lebbie A,Wadsworth R,Saidu J,Bangura C

    更新日期:2017-01-01 00:00:00

  • Prevalence and Associated Factors of Hypertension: A Community-Based Cross-Sectional Study in Municipalities of Kathmandu, Nepal.

    abstract::Objective. This study aimed to assess the prevalence and associated factors of hypertension in newly declared municipalities of Kathmandu, Nepal. Design, Settings, and Participants. This was a community-based cross-sectional study conducted in the municipalities of Kathmandu District, Nepal, between January and July 2...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2016/1656938

    authors: Dhungana RR,Pandey AR,Bista B,Joshi S,Devkota S

    更新日期:2016-01-01 00:00:00

  • Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3.

    abstract::The human renin gene has been widely known to be involved in essential hypertension (EH) pathogenesis. Genetic variant C-5434T of REN enhancer contributed to renin gene transcription and serum renin regulation. However, the mechanism associated with the transcription level changes remains unknown, and only a few repor...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2015/486961

    authors: Maslahah I,Rohman MS,Widodo N,Endharti AT,Utomo D

    更新日期:2015-01-01 00:00:00

  • Role of the rostral ventrolateral medulla in the arterial hypertension in chronic renal failure.

    abstract::Sympathetic activation in chronic renal failure (CRF) is a major mechanism leading to the progression of renal disease and hypertension. In the present study, we tested the hypothesis that in CRF increased reactive oxygen species (ROS) production in the RVLM mediated by enhanced circulating Angiotensin II (Ang II) is ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.4061/2010/219358

    authors: Dugaich AP,Oliveira-Sales EB,Abreu NP,Boim MA,Bergamaschi CT,Campos RR

    更新日期:2011-01-04 00:00:00

  • Roles of Brain Angiotensin II in Cognitive Function and Dementia.

    abstract::The brain renin-angiotensin system (RAS) has been highlighted as having a pathological role in stroke, dementia, and neurodegenerative disease. Particularly, in dementia, epidemiological studies indicate a preventive effect of RAS blockade on cognitive impairment in Alzheimer disease (AD). Moreover, basic experiments ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2012/169649

    authors: Mogi M,Iwanami J,Horiuchi M

    更新日期:2012-01-01 00:00:00

  • Vascular dysfunction as target organ damage in animal models of hypertension.

    abstract::Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species. Endothelial function is usually evaluated by measuring the vasodilation induced by the local NO production stim...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2012/187526

    authors: Neves MF,Kasal DA,Cunha AR,Medeiros F

    更新日期:2012-01-01 00:00:00

  • High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening.

    abstract::Primary aldosteronism is a main cause of secondary hypertension which can be effectively treated. The screening test for primary aldosteronism is benefit for minimizing damage to the patient. In the previous retrospective study, we obtained the optimal cutoff value of aldosterone-to-renin ratio detected by chemilumine...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2020/3934212

    authors: Lin W,Li Y,Chen D,Yao Z,Xu H,Chen Y,Xiao J,Feng P,Gan W

    更新日期:2020-08-27 00:00:00

  • Immunohistochemical Localization of AT1a, AT1b, and AT2 Angiotensin II Receptor Subtypes in the Rat Adrenal, Pituitary, and Brain with a Perspective Commentary.

    abstract::Angiotensin II increases blood pressure and stimulates thirst and sodium appetite in the brain. It also stimulates secretion of aldosterone from the adrenal zona glomerulosa and epinephrine from the adrenal medulla. The rat has 3 subtypes of angiotensin II receptors: AT1a, AT1b, and AT2. mRNAs for all three subtypes o...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2013/175428

    authors: Premer C,Lamondin C,Mitzey A,Speth RC,Brownfield MS

    更新日期:2013-01-01 00:00:00

  • Methylenetetrahydrofolate Reductase C677T Gene Polymorphism as a Risk Factor for Hypertension in a Rural Population.

    abstract::Hypertension remains a public health burden despite advances in its management. Hence, the search for further risk stratification tools and prevention and new treatment approaches continues. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with hypertension. Interestingly, riboflavin, as a ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2020/4267246

    authors: Candrasatria RM,Adiarto S,Sukmawan R

    更新日期:2020-02-13 00:00:00

  • Sociodemographic risk factors of diabetes and hypertension prevalence in republic of Korea.

    abstract::This study examined the relationships between SES and diabetes and hypertension for Korean adults using the Korean National Health and Nutritional Examination Survey. To handle the four dummy dependent variables: Diabetes and Hypertension, Diabetes alone, Hypertension alone, and Diabetes or Hypertension, four differen...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.4061/2010/410794

    authors: Min H,Chang J,Balkrishnan R

    更新日期:2010-06-21 00:00:00

  • High Prevalence of Hypertension in Ethiopian and Non-Ethiopian HIV-Infected Adults.

    abstract:Objectives:Prevalence of hypertension has not been studied in the Ethiopian HIV-infected population, which represents 60% of the patients in our AIDS unit. Our aim was to identify risk factors and characterize the prevalence of hypertension in the population monitored at our unit. Methods:A retrospective chart review ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2018/8637101

    authors: Korem M,Wallach T,Bursztyn M,Maayan S,Olshtain-Pops K

    更新日期:2018-01-29 00:00:00

  • Heme oxygenase-1 induction and organic nitrate therapy: beneficial effects on endothelial dysfunction, nitrate tolerance, and vascular oxidative stress.

    abstract::Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction, and chronic congestive heart failure. A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2012/842632

    authors: Daiber A,Oelze M,Wenzel P,Bollmann F,Pautz A,Kleinert H

    更新日期:2012-01-01 00:00:00

  • High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease.

    abstract:Background:Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether ANGPTL3 levels can be used to predict the future occurrence of maj...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2020/2980954

    authors: Chen MC,Hsu BG,Lee CJ,Wang JH

    更新日期:2020-03-27 00:00:00

  • Endothelial activation microparticles and inflammation status improve with exercise training in african americans.

    abstract::African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2013/538017

    authors: Babbitt DM,Diaz KM,Feairheller DL,Sturgeon KM,Perkins AM,Veerabhadrappa P,Williamson ST,Kretzschmar J,Ling C,Lee H,Grimm H,Thakkar SR,Crabbe DL,Kashem MA,Brown MD

    更新日期:2013-01-01 00:00:00

  • Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients.

    abstract::The aim of this study was to establish whether an independent relationship exists between CD4 count and hypertension and if this relationship is modified or confounded by the body mass index (BMI). Methods. A secondary data analysis of a cross-sectional study on 200 HIV/AIDS patients at a referral hospital in Cameroon...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2018/1691474

    authors: Dimala CA,Kadia BM,Kemah BL,Tindong M,Choukem SP

    更新日期:2018-01-22 00:00:00

  • Prevalence of hypertension and diabetes and coexistence of chronic kidney disease and cardiovascular risk in the population of the republic of moldova.

    abstract::In 2005, the International Society of Nephrology (ISN) established the Global Outreach Program (GO) aimed at building a capacity for detecting and managing chronic kidney disease and its complications in low- and middle-income countries. Here we report data from the 2006-2007 screening program (1025 subjects from the ...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.1155/2012/951734

    authors: Codreanu I,Sali V,Gaibu S,Suveica L,Popa S,Perico N,Ene-Iordache B,Carminati S,Feehally J,Remuzzi G

    更新日期:2012-01-01 00:00:00

  • Metabolic syndrome in italian obese children and adolescents: stronger association with central fat depot than with insulin sensitivity and birth weight.

    abstract::Aim. To evaluate whether body fat distribution, birth weight, and family history for diabetes (FHD) were associated with metabolic syndrome (MetS) in children and adolescents. Methods. A total of 439 Italian obese children and adolescents (5-18 years) were enrolled. Subjects were divided into 2 groups: prepubertal and...

    journal_title:International journal of hypertension

    pub_type: 杂志文章

    doi:10.4061/2011/257168

    authors: Brufani C,Fintini D,Giordano U,Tozzi AE,Barbetti F,Cappa M

    更新日期:2011-02-22 00:00:00