Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers Protection Against CVB3-Induced Viral Myocarditis.

abstract：:Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocat...

journal_title：Frontiers in cellular and infection microbiology

authors： Salcedo SP,Marchesini MI,Degos C,Terwagne M,Von Bargen K,Lepidi H,Herrmann CK,Santos Lacerda TL,Imbert PR,Pierre P,Alexopoulou L,Letesson JJ,Comerci DJ,Gorvel JP

更新日期：2013-07-08 00:00:00

abstract：:Clostridium difficile infections (CDI) are a major cause of antibiotic-associated diarrhea. It is hypothesized that CDI develops due to the antibiotic-induced disruption of the intestinal microbial community structure, which allows C. difficile to flourish. Here, we pre-treated weaned pigs with the antibiotics Clindam...

journal_title：Frontiers in cellular and infection microbiology

authors： Jurburg SD,Cornelissen JJBWJ,de Boer P,Smits MA,Rebel JMJ

更新日期：2019-08-06 00:00:00

abstract：:Non-encapsulated Streptococcus pneumoniae often possess two genes, aliB-like ORF 1 and aliB-like ORF 2, in place of capsule genes. AliB-like ORF 1 is thought to encode a substrate binding protein of an ABC transporter which binds peptide SETTFGRDFN, found in 50S ribosomal subunit protein L4 of Enterobacteriaceae. Here...

journal_title：Frontiers in cellular and infection microbiology

authors： Nasher F,Kwun MJ,Croucher NJ,Heller M,Hathaway LJ

更新日期：2019-09-10 00:00:00

abstract：:Human coronaviruses, which can cause a range of infectious diseases, have been studied for nearly 60 years. The field has gained renewed interest from researchers around the world due to the COVID-19 outbreak in late 2019. Despite a large amount of research, little is known about the knowledge structure and developing...

journal_title：Frontiers in cellular and infection microbiology

authors： Deng Z,Chen J,Wang T

更新日期：2020-09-23 00:00:00

abstract：:Ticks modulate their hosts' defense responses by secreting a biopharmacopiea of hundreds to thousands of proteins and bioactive chemicals into the feeding site (tick-host interface). These molecules and their functions evolved over millions of years as ticks adapted to blood-feeding, tick lineages diverged, and host-s...

journal_title：Frontiers in cellular and infection microbiology

authors： Mans BJ,Featherston J,de Castro MH,Pienaar R

更新日期：2017-09-25 00:00:00

abstract：:Iron is the most abundant transition metal in the human body and its bioavailability is stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to maintain homeostasis, to limit potential damage caused by iron toxicity under physiological conditions and to restrict access by p...

journal_title：Frontiers in cellular and infection microbiology

authors： Caza M,Kronstad JW

更新日期：2013-11-19 00:00:00

abstract：:The emerging relapsing fever spirochete Borrelia (B.) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spiroc...

journal_title：Frontiers in cellular and infection microbiology

authors： Nguyen NTT,Röttgerding F,Devraj G,Lin YP,Koenigs A,Kraiczy P

更新日期：2018-02-02 00:00:00

abstract：:Intraspecific differences in biological traits between Neospora caninum isolates have been widely described and associated with variations in virulence. However, the molecular basis underlying these differences has been poorly studied. We demonstrated previously that Nc-Spain7 and Nc-Spain1H, high- and low-virulence i...

journal_title：Frontiers in cellular and infection microbiology

authors： García-Sánchez M,Jiménez-Pelayo L,Horcajo P,Regidor-Cerrillo J,Collantes-Fernández E,Ortega-Mora LM

更新日期：2019-10-15 00:00:00

abstract：:Lipids are essential players in parasites pathogenesis. In particular, the highly phagocytic trophozoites of Entamoeba histolytica, the causative agent of amoebiasis, exhibit a dynamic membrane fusion and fission, in which lipids strongly participate; particularly during the overstated motility of the parasite to reac...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellanos-Castro S,Bolaños J,Orozco E

更新日期：2020-03-10 00:00:00

abstract：:MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of infections. We investigated the influence of miR-21 on macrophage responses during infection with Li...

journal_title：Frontiers in cellular and infection microbiology

authors： Johnston DGW,Kearney J,Zasłona Z,Williams MA,O'Neill LAJ,Corr SC

更新日期：2017-05-23 00:00:00

abstract：:Shigella is the major cause of bacillary dysentery world-wide. It is divided into four species, named S. flexneri, S. sonnei, S. dysenteriae, and S. boydii, which are distinct genomically and in their ability to cause disease. Shigellosis, the clinical presentation of Shigella infection, is characterized by watery dia...

journal_title：Frontiers in cellular and infection microbiology

authors： Mattock E,Blocker AJ

更新日期：2017-03-24 00:00:00

abstract：:Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic characterization by ...

journal_title：Frontiers in cellular and infection microbiology

authors： Telatin V,Nicoli F,Frasson C,Menegotto N,Barbaro F,Castelli E,Erne E,Palù G,Caputo A

更新日期：2019-06-14 00:00:00

abstract：:Differentiation between mitis group streptococci (MGS) bacteria in routine laboratory tests has become important for obtaining accurate epidemiological information on the characteristics of MGS and understanding their clinical significance. The most reliable method of MGS species identification is multilocus sequence ...

journal_title：Frontiers in cellular and infection microbiology

authors： Imai K,Nemoto R,Kodana M,Tarumoto N,Sakai J,Kawamura T,Ikebuchi K,Mitsutake K,Murakami T,Maesaki S,Fujiwara T,Hayakawa S,Hoshino T,Seki M,Maeda T

更新日期：2020-01-30 00:00:00

abstract：:The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in murine macrophages infected with M. bovis. Using ex vivo and in ...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang J,Hussain T,Yue R,Liao Y,Li Q,Yao J,Song Y,Sun X,Wang N,Xu L,Sreevatsan S,Zhao D,Zhou X

更新日期：2018-07-10 00:00:00

abstract：:In this original study, we retrospectively reviewed the cases of nocardiosis diagnosed through culture and next-generation sequencing (NGS) methods between 2014 and 2018 in Huashan Hospital and found out that the latter way can not only improve the detection rate of Nocardia spp. but also greatly reduce the turnaround...

journal_title：Frontiers in cellular and infection microbiology

authors： Weng SS,Zhang HY,Ai JW,Gao Y,Liu YY,Xu B,Zhang WH

更新日期：2020-02-18 00:00:00

abstract：:Porphyromonas gingivalis is a major etiological agent in chronic and aggressive forms of periodontal disease. The organism is an asaccharolytic anaerobe and is a constituent of mixed species biofilms in a variety of microenvironments in the oral cavity. P. gingivalis expresses a range of virulence factors over which i...

journal_title：Frontiers in cellular and infection microbiology

authors： Hirano T,Beck DA,Demuth DR,Hackett M,Lamont RJ

更新日期：2012-06-12 00:00:00

abstract：:Chronic otitis media with effusion (COME) is a common childhood disease characterized by an accumulation of fluid behind the eardrum. COME often requires surgical intervention and can also lead to significant hearing loss and subsequent learning disabilities. Recent characterization of the middle ear fluid (MEF) micro...

journal_title：Frontiers in cellular and infection microbiology

authors： Kolbe AR,Castro-Nallar E,Preciado D,Pérez-Losada M

更新日期：2019-10-04 00:00:00

abstract：:Antifolate resistance is significant in Kenya and presumed to result from extensive use and cross-resistance between antifolate antimalarials and antibiotics, including cotrimoxazole/Bactrim used for HIV-1 chemotherapy. However, little is known about antifolate-resistant malaria in the context of newly diagnosed HIV-1...

journal_title：Frontiers in cellular and infection microbiology

authors： Torrevillas BK,Garrison SM,McKeeken AJ,Patel D,Van Leuven JT,Dizon NI,Rivas KI,Hathaway NJ,Bailey JA,Waitumbi JN,Kifude CM,Oyieko J,Stewart VA,Luckhart S

更新日期：2020-11-26 00:00:00

abstract：:Brucella is a facultative intracellular pathogen that causes zoonotic infection known as brucellosis which results in abortion and infertility in natural host. Humans, especially in low income countries, can acquire infection by direct contact with infected animal or by consumption of animal products and show high mor...

journal_title：Frontiers in cellular and infection microbiology

authors： Ahmed W,Zheng K,Liu ZF

更新日期：2016-03-15 00:00:00

abstract：:In the present study, we determined the in vitro characteristics and binding interactions of chicken PD-1 (chPD-1) and PD-L1 (chPD-L1) and developed a panel of specific monoclonal antibodies against the two proteins. ChPD-1 and chPD-L1 sequence identities and similarities were lower compared with those of humans and o...

journal_title：Frontiers in cellular and infection microbiology

authors： Reddy VRAP,Mwangi W,Sadigh Y,Nair V

更新日期：2019-12-19 00:00:00

abstract：:Group A Streptococcus (GAS), also called Streptococcus pyogenes, is a Gram-positive beta-hemolytic human pathogen which causes a wide range of mostly self-limiting but also several life-threatening diseases. Innate immune responses are fundamental for defense against GAS, yet their activation by pattern recognition re...

journal_title：Frontiers in cellular and infection microbiology

authors： Fieber C,Kovarik P

更新日期：2014-10-02 00:00:00

abstract：:Cleavage and activation of hemagglutinin (HA) by trypsin-like proteases in influenza A virus (IAV) are essential prerequisites for its successful infection and spread. In host cells, some transmembrane serine proteases such as TMPRSS2, TMPRSS4 and HAT, along with plasmin in the bloodstream, have been reported to cleav...

journal_title：Frontiers in cellular and infection microbiology

authors： Hayashi H,Kubo Y,Izumida M,Takahashi E,Kido H,Sato K,Yamaya M,Nishimura H,Nakayama K,Matsuyama T

更新日期：2018-03-23 00:00:00

abstract：:Infections with parasites of the genus Leishmania lead to a rapid, but transient activation of natural killer (NK) cells. In mice activation of NK cells requires a toll-like-receptor 9-dependent stimulation of dendritic cells (DC) which is followed by the production of IL-12. Although NK cells appear to be non-essenti...

journal_title：Frontiers in cellular and infection microbiology

authors： Bogdan C

更新日期：2012-05-29 00:00:00

abstract：:Streptococcus pyogenes (Group A Streptococcus or GAS) is a hemolytic human pathogen associated with a wide variety of infections ranging from minor skin and throat infections to life-threatening invasive diseases. The cell wall of GAS consists of peptidoglycan sacculus decorated with a carbohydrate comprising a polyrh...

journal_title：Frontiers in cellular and infection microbiology

authors： Edgar RJ,Chen J,Kant S,Rechkina E,Rush JS,Forsberg LS,Jaehrig B,Azadi P,Tchesnokova V,Sokurenko EV,Zhu H,Korotkov KV,Pancholi V,Korotkova N

更新日期：2016-10-13 00:00:00

abstract：:The endosymbiotic origin of eukaryotes brought together two disparate genomes in the cell. Additionally, eukaryotic natural history has included other endosymbiotic events, phagotrophic consumption of organisms, and intimate interactions with viruses and endoparasites. These phenomena facilitated large-scale lateral g...

journal_title：Frontiers in cellular and infection microbiology

authors： Aravind L,Anantharaman V,Zhang D,de Souza RF,Iyer LM

更新日期：2012-06-29 00:00:00

abstract：:Rickettsia rickettsii is a tick-borne obligate intracellular bacterium that causes Rocky Mountain Spotted Fever (RMSF). In Brazil, two species of ticks in the genus Amblyomma, A. sculptum and A. aureolatum, are incriminated as vectors of this bacterium. Importantly, these two species present remarkable differences in ...

journal_title：Frontiers in cellular and infection microbiology

authors： Martins LA,Galletti MFBM,Ribeiro JM,Fujita A,Costa FB,Labruna MB,Daffre S,Fogaça AC

更新日期：2017-04-28 00:00:00

abstract：:Apicomplexan parasites, such as human malaria parasites, have complex lifecycles encompassing multiple and diverse environmental niches. Invading, replicating, and escaping from different cell types, along with exploiting each intracellular niche, necessitate large and dynamic changes in parasite morphology and cellul...

journal_title：Frontiers in cellular and infection microbiology

authors： Ferreira JL,Heincke D,Wichers JS,Liffner B,Wilson DW,Gilberger TW

更新日期：2021-01-08 00:00:00

abstract：:Chlamydiae are obligate intracellular pathogens of eukaryotes. The bacteria grow in an intracellular vesicle called an inclusion, the membrane of which is heavily modified by chlamydial proteins called Incs (Inclusion membrane proteins). Incs represent 7-10% of the genomes of Chlamydia and, given their localization at...

journal_title：Frontiers in cellular and infection microbiology

authors： Gauliard E,Ouellette SP,Rueden KJ,Ladant D

更新日期：2015-02-11 00:00:00

abstract：:Objectives: To evaluate metagenomic next-generation sequencing (mNGS) as a diagnostic tool in detecting pathogens from osteoarticular infection (OAI) samples. Methods: 130 samples of joint fluid, sonicate fluid, and tissue were prospectively collected from 92 patients with OAI. The performance of mNGS and microbiology...

journal_title：Frontiers in cellular and infection microbiology

authors： Huang ZD,Zhang ZJ,Yang B,Li WB,Zhang CJ,Fang XY,Zhang CF,Zhang WM,Lin JH

更新日期：2020-09-17 00:00:00

abstract：:Rift Valley fever (RVF) is endemic to sub-Saharan Africa, and has spread into Madagascar, Egypt, Saudi Arabia, and Yemen. Rift Valley fever virus (RVFV) of the family Bunyaviridae, genus Phlebovirus causes hemorrhagic fever, neurological disorders or blindness in humans, and high rate abortion and fetal malformation i...

journal_title：Frontiers in cellular and infection microbiology

authors： Indran SV,Ikegami T

更新日期：2012-10-26 00:00:00