Late adverse effects related to treatment in a cohort of survivors of childhood and adolescent cancer.

Abstract:

:Taking into consideration the progress in cancer treatment, an increase in the number of adult survivors of childhood cancer is expected. These survivors will have received treatment that predisposes them to late morbidity and increased risk of early mortality. The aim of this single-center retrospective cohort study was to describe the frequency and identify risk factors associated with late adverse events related to cancer treatment in survivors of childhood and adolescent cancer.Patients were recruited from 2010 to 2014. All possible late adverse effects identified, were classified according to CTCAE grading system version 4.0. The variables were characterized and stratified according to the presence or not of late effects. Odds ratio was used as a measure of association in bivariate analysis to identify characteristics associated with the late effects of treatment. Among 111 potentially eligible participants, 62 survivors met the inclusion criteria; 17 (27.4%) had abnormal test results observed in the systems: 8 (47%) in the endocrine and metabolic, 7 (41.2%) in the cardiovascular, 5 (29.4%) in the musculoskeletal, and 1 (5.9%) in auditory and renal systems. Frequency and severity of late adverse events were not affected by treatments employed; except for radiotherapy which was associated with a higher risk of late adverse effect occurrences.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Livinalli A,Silva MT,Lopes LC

doi

10.1097/MD.0000000000014921

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

e14921

issue

12

eissn

0025-7974

issn

1536-5964

pii

00005792-201903220-00039

journal_volume

98

pub_type

杂志文章,随机对照试验

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