Abstract:
:Taking into consideration the progress in cancer treatment, an increase in the number of adult survivors of childhood cancer is expected. These survivors will have received treatment that predisposes them to late morbidity and increased risk of early mortality. The aim of this single-center retrospective cohort study was to describe the frequency and identify risk factors associated with late adverse events related to cancer treatment in survivors of childhood and adolescent cancer.Patients were recruited from 2010 to 2014. All possible late adverse effects identified, were classified according to CTCAE grading system version 4.0. The variables were characterized and stratified according to the presence or not of late effects. Odds ratio was used as a measure of association in bivariate analysis to identify characteristics associated with the late effects of treatment. Among 111 potentially eligible participants, 62 survivors met the inclusion criteria; 17 (27.4%) had abnormal test results observed in the systems: 8 (47%) in the endocrine and metabolic, 7 (41.2%) in the cardiovascular, 5 (29.4%) in the musculoskeletal, and 1 (5.9%) in auditory and renal systems. Frequency and severity of late adverse events were not affected by treatments employed; except for radiotherapy which was associated with a higher risk of late adverse effect occurrences.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Livinalli A,Silva MT,Lopes LCdoi
10.1097/MD.0000000000014921subject
Has Abstractpub_date
2019-03-01 00:00:00pages
e14921issue
12eissn
0025-7974issn
1536-5964pii
00005792-201903220-00039journal_volume
98pub_type
杂志文章,随机对照试验相关文献
MEDICINE文献大全abstract:BACKGROUND:Lactate dehydrogenase (LDH) as a hypoxia-regulator plays a vital role in alternative metabolic pathways of cancer cells. Numerous studies have assessed the prognostic value of elevated pretreatment LDH in malignant mesothelioma (MM). However, the results have been largely inconsistent. Hence, the aim of curr...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000005706
更新日期:2016-12-01 00:00:00
abstract::Pasteurella multocida, a small, gram-negative coccobacillus , is part of the normal oral flora of many animals, including the dog and cat. P. multocida is the etiologic agent in a variety of infectious disease syndromes. We have reported 34 cases of infection caused by P. multocida and have reviewed the English litera...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:
更新日期:1984-05-01 00:00:00
abstract:RATIONALE:Angioleiomyoma is an uncommon benign tumor that originates from the vascular smooth muscle cells and contains thick-walled vessels. It can appear anywhere in the body but more frequently in the extremities (especially in the lower limbs) and rarely invades the internal organs. PATIENT CONCERNS:A 52-year-old ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014661
更新日期:2019-03-01 00:00:00
abstract::The aim of this study was to investigate the relationship between textbook outcome and survival in patients with surgically treated colon cancer. A total of 804 surgical cases were enrolled between June 1, 2010 and December 31, 2014. Textbook outcome was defined as patients who had colon cancer surgery and met the six...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022447
更新日期:2020-10-02 00:00:00
abstract::Intracavitary application of brachytherapy (BT) sources followed by external beam radiation is essential for the local treatment of carcinoma of the cervix, postate, and nasopharynx. Dose distribution of external beam radiation plus BT can be challenging for the planning system because of their dose calculation by 2 d...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020760
更新日期:2020-07-17 00:00:00
abstract::Osteocalcin (OC) is an endocrine hormone that regulates glucose metabolism.The aim of this study was to investigate the relationship between serum OC levels and glucose metabolism after trauma.This was a retrospective study of trauma patients admitted to the Department of Emergency Medicine between October 2017 and Ap...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021901
更新日期:2020-09-04 00:00:00
abstract::Esophageal cancer is a common malignant tumor of the digestive system with a high incidence and a poor prognosis. At the present, CT-based radiomics is providing more and more valuable information. However, the heterogeneity of the study and the poor repeatability of the texture feature parameters have limited its wid...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021470
更新日期:2020-08-07 00:00:00
abstract:BACKGROUND:Lots of previous reports have suggested a potential association of atopic dermatitis (AD) with stroke and myocardial infarction (MI). However, the result is still controversial, Consequently, we conducted this meta-analysis to estimate the relationship of AD with Stroke and MI. METHODS:PubMed, Embase, and W...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013512
更新日期:2018-12-01 00:00:00
abstract::Few case series provide a current, comprehensive, and detailed description of splenic infarction (SI), an uncommon condition.Retrospective chart review complemented by imaging evaluation and patient follow-up.All adult patients with a confirmed diagnosis of acute SI discharged over 10 years from a single academic cent...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001363
更新日期:2015-09-01 00:00:00
abstract::The annual number of cases of culture-proven extrapulmonary tuberculosis (TB) at our hospital increased from 47 cases in 1983 to 113 cases in 1988. At least 43% (199) of 464 consecutive patients with extrapulmonary TB during this 6-year period were infected with the human immunodeficiency virus (HIV); since HIV serolo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199111000-00004
更新日期:1991-11-01 00:00:00
abstract::Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) have been suggested to influence the occurrence and progression of cancer through altering the expression and biological function of miRNAs. The aim of this study was to investigate whether the potential functional SNPs in MIR196A2 promoter had effect on the...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000173
更新日期:2014-11-01 00:00:00
abstract::To assess the prevalence and causes of visual impairment (VI) in the elderly Chinese rural population in Shaanxi Province.A population-based, cross-sectional study design was used to determine the extent of VI in Chinese people over the age of 50 years in Shaanxi Province. Visual acuity and best-corrected visual acuit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020109
更新日期:2020-05-01 00:00:00
abstract::The aim of this study was to compare preoperative dual-time point F-fluorodeoxyglucose (FDG) uptake pattern with intraoperative 5-aminolevulinic acid (5-ALA) fluorescence in high-grade gliomas. In addition, we assessed for possible associations with a pathologic parameter (Ki-67 index).Thirty-one patients with high-gr...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014397
更新日期:2019-02-01 00:00:00
abstract::This retrospective study evaluated the effect of neuromuscular electrical stimulation (NMES) for the treatment of endometriosis-associated pain (EAP).A total of 154 patients with EAP were included and were divided into 2 groups in this retrospective study. Eighty-three patients were assigned a treatment group, and und...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011266
更新日期:2018-06-01 00:00:00
abstract::Previous studies have reported that intraoperative dexmedetomidine has morphine-sparing effects in patient-controlled analgesia (PCA). The present study was designed to investigate the possible sex differences in the morphine-sparing effects of intraoperative dexmedetomidine following general anesthesia. A total of 22...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000003619
更新日期:2016-05-01 00:00:00
abstract::Massive blood transfusion (MBT) is a relatively common complication of cardiac surgery, which is independently associated with severe postoperative adverse events. However, the value of using rapid thrombotomography (r-TEG) to predict MBT in perioperative period of cardiac surgery has not been explored. This study aim...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021833
更新日期:2020-09-11 00:00:00
abstract::The aims of this study were to investigate the incidence and risk factors for oral candidiasis in patients receiving radiotherapy for head and neck cancer, and to determine the influence of topical steroid therapy on the development of oral candidiasis.We conducted a retrospective study of 300 patients receiving radio...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013073
更新日期:2018-11-01 00:00:00
abstract:RATIONALE:Hepatic ectopic pregnancy is an extremely rare ectopic pregnancy. This study aimed to report a case of primary hepatic pregnancy in a patient with polycystic syndrome. PATIENT CONCERNS:A 30-year-old woman presented with vaginal bleeding after 63 days of amenorrhea. DIAGNOSIS:The patient was initially diagno...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019649
更新日期:2020-03-01 00:00:00
abstract::The most serious complications of the central nervous system that occur after venomous snake bite are intracranial hemorrhage and ischemic stroke.We present a rarely seen central nervous system complication, acute demyelinating encephalomyelitis, after a treated Deinagkistrodon's viper bite.On April 5, 2015, a 50-year...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005310
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The kinesin family (KIF) is reported to be aberrantly expressed and significantly correlated with survival outcomes in patients with various cancers. This meta-analysis was carried out to quantitatively evaluate the prognostic values of partial KIF members in cancer patients. METHODS:Two well-known KIF memb...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018040
更新日期:2019-11-01 00:00:00
abstract::Simple bone cysts (SBCs) are benign bone tumors. However, the treatment of SBCs remains controversial because of their healing rate and the invasiveness of surgery. The purpose of the present study was to evaluate the treatment of SBCs using a cannulated hydroxyapatite (HA) pin.A total of 43 patients (35 males, 8 fema...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001027
更新日期:2015-06-01 00:00:00
abstract::Chronic alcohol consumption may lead to progressive cardiac dysfunction. The aim of this study was to evaluate the feasibility of using real-time 3-dimensional echocardiography (3DE) on assessing left ventricular (LV) function in chronic alcoholics.We classified 92 male alcoholics into mild, moderate, and severe group...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006033
更新日期:2017-02-01 00:00:00
abstract:RATIONALE:Migraine is a recurrent, disabling neurovascular headache disorder. The patient's quality of life can be severely impaired by migraine attacks. Stellate ganglion block (SGB) can be used to relieve pain in the head, neck, and upper extremities. In the present cases, we performed SGB in 2 patients with migraine...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020023
更新日期:2020-05-01 00:00:00
abstract:RATIONALE:Adolescent wrist trauma can cause epiphyseal dysplasia and even distal radius deformity malunion. At present, there is no uniform treatment standard for the malunion of the distal radius of adolescents. Osteotomy and autologous bone grafting are currently one of the effective ways to treat the disease. We tre...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022535
更新日期:2020-10-02 00:00:00
abstract:RATIONALE:Filling materials for partial defect of the breast have rarely been developed because of safety and durability. PATIENT CONCERNS:Two female patients (ages, 53 and 50 years) with breast cancer underwent partial mastectomy with sentinel lymph node biopsy. DIAGNOSIS:Core needle biopsy revealed an invasive duct...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021217
更新日期:2020-07-31 00:00:00
abstract::This study aims to investigate major complications or symptoms of pregnant women, causes of maternal near-miss, and issues that are relevant to severe maternal disease.A retrospective analysis was performed in the "maternal individual investigation form," which included all critical maternity patients admitted to the ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011748
更新日期:2018-08-01 00:00:00
abstract:INTRODUCTION:Chemotherapy-induced peripheral neuropathy (CIPN) occurs in approximately 30% to 40% of patients who receive chemotherapy; however, standardized treatment for CIPN has not yet been developed. Acupuncture is widely used to treat CIPN in Korea, but its efficacy has not been investigated. The purpose of this ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015098
更新日期:2019-04-01 00:00:00
abstract:BACKGROUNDS:A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the result is still controversial and no consensus has been reached. Therefore, we performed a meta-analysis to evaluate the prognostic role of serum LDH in osteosarcom...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000010741
更新日期:2018-05-01 00:00:00
abstract:BACKGROUNDS:Diabetic kidney disease (DKD) is 1 of the common microvascular complications of diabetes, and the therapeutic effect of modern medicine on DKD is limited. At present, patented Chinese medicine Qizhijiangtang (QZJT) capsule has been widely used in the treatment of DKD. We aim to systematically assess the eff...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021923
更新日期:2020-08-21 00:00:00
abstract:BACKGROUND:Pneumonia is the second leading cause of death in children worldwide after preterm birth and certification. Bacteria, viruses, mycoplasma, and other microorganisms are known to be the main causes of pneumonia, of which bacterial pathogenic factors account for 12.5% of cases. The invention and application of ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023217
更新日期:2020-12-11 00:00:00