Adaptation of metal and antibiotic resistant traits in novel β-Proteobacterium Achromobacter xylosoxidans BHW-15.

Abstract:

:Chromosomal co-existence of metal and antibiotic resistance genes in bacteria offers a new perspective to the bacterial resistance proliferation in contaminated environment. In this study, an arsenotrophic bacterium Achromobacter xylosoxidans BHW-15, isolated from Arsenic (As) contaminated tubewell water in the Bogra district of Bangladesh, was analyzed using high throughput Ion Torrent Personal Genome Machine (PGM) complete genome sequencing scheme to reveal its adaptive potentiality. The assembled draft genome of A. xylosoxidans BHW-15 was 6.3 Mbp containing 5,782 functional genes, 1,845 pseudo genes, and three incomplete phage signature regions. Comparative genome study suggested the bacterium to be a novel strain of A. xylosoxidans showing significant dissimilarity with other relevant strains in metal resistance gene islands. A total of 35 metal resistance genes along with arsenite-oxidizing aioSXBA, arsenate reducing arsRCDAB, and mercury resistance merRTPADE operonic gene cluster and 20 broad range antibiotic resistance genes including β-lactams, aminoglycosides, and multiple multidrug resistance (MDR) efflux gene complex with a tripartite system OM-IM-MFP were found co-existed within the genome. Genomic synteny analysis with reported arsenotrophic bacteria revealed the characteristic genetic organization of ars and mer operonic genes, rarely described in β-Proteobacteria. A transposon Tn21 and mobile element protein genes were also detected to the end of mer (mercury) operonic genes, possibly a carrier for the gene transposition. In vitro antibiotic susceptibility assay showed a broad range of resistance against antibiotics belonging to β-lactams, aminoglycosides, cephalosporins (1st, 2nd, and 3rd generations), monobactams and even macrolides, some of the resistome determinants were predicted during in silico analysis. KEGG functional orthology analysis revealed the potential of the bacterium to utilize multiple carbon sources including one carbon pool by folate, innate defense mechanism against multiple stress conditions, motility, a proper developed cell signaling and processing unit and secondary metabolism-combination of all exhibiting a robust feature of the cell in multiple stressed conditions. The complete genome of the strain BHW-15 stands as a genetic basis for the evolutionary adaptation of metal and the antibiotic coexistence phenomenon in an aquatic environment.

journal_name

PeerJ

journal_title

PeerJ

authors

Istiaq A,Shuvo MSR,Rahman KMJ,Siddique MA,Hossain MA,Sultana M

doi

10.7717/peerj.6537

subject

Has Abstract

pub_date

2019-03-13 00:00:00

pages

e6537

issn

2167-8359

pii

6537

journal_volume

7

pub_type

杂志文章

相关文献

PeerJ文献大全
  • Genetic divergence and fine scale population structure of the common bottlenose dolphin (Tursiops truncatus, Montagu) found in the Gulf of Guayaquil, Ecuador.

    abstract::The common bottlenose dolphin, Tursiops truncatus, is widely distributed along the western coast of South America. In Ecuador, a resident population of bottlenose dolphins inhabits the inner estuarine area of the Gulf of Guayaquil located in the southwestern part of the country and is under threat from different human...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4589

    authors: Bayas-Rea RLÁ,Félix F,Montufar R

    更新日期:2018-04-09 00:00:00

  • Identification of prognostic splicing factors and exploration of their potential regulatory mechanisms in pancreatic adenocarcinoma.

    abstract::Pancreatic adenocarcinoma (PAAD), the most common subtype of pancreatic cancer, is a highly lethal disease. In this study, we integrated the expression profiles of splicing factors (SFs) of PAAD from RNA-sequencing data to provide a comprehensive view of the clinical significance of SFs. A prognostic index (PI) based ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8380

    authors: Rong MH,Zhu ZH,Guan Y,Li MW,Zheng JS,Huang YQ,Wei DM,Li YM,Wu XJ,Bu HP,Peng HL,Wei XL,Li GS,Li MX,Chen MH,Huang SN

    更新日期:2020-02-11 00:00:00

  • Cross-cultural adaptation and validation of the Romanian International Knee Documentation Committee-subjective knee form.

    abstract:Aim:We aimed to translate and cross-culturally adapt the International Knee Documentation Committee-subjective knee form (IKDC) in Romanian. Method:The original (US) IKDC-subjective knee form was translated according to recommended guidelines. Validity was tested using Spearmans's correlation coefficient between score...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8448

    authors: Todor A,Vermesan D,Haragus H,Patrascu JM Jr,Timar B,Cosma DI

    更新日期:2020-02-03 00:00:00

  • The effect of climate change on the distribution of a tropical zoanthid (Palythoa caribaeorum) and its ecological implications.

    abstract::Palythoa caribaeorum is a zoanthid often dominant in shallow rocky environments along the west coast of the Atlantic Ocean, from the tropics to the subtropics. This species has high environmental tolerance and is a good space competitor in reef environments. Considering current and future scenarios in the global clima...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4777

    authors: Durante LM,Cruz ICS,Lotufo TMC

    更新日期:2018-05-17 00:00:00

  • Association between maternal pre-delivery body mass index and offspring overweight/obesity at 1 and 2 years of age among residents of a suburb in Taiwan.

    abstract:Background:Overweight and obesity among children can cause metabolic syndrome in adulthood and are a significant public health issue. Some studies suggest that maternal pre-pregnancy body mass index (BMI) and excessive gestational weight gain during pregnancy are associated with overweight and obesity in offspring. How...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6473

    authors: Liu HK,Wu CY,Yang YN,Wu PL,He ZR,Yang SN,Tey SL

    更新日期:2019-02-25 00:00:00

  • Single nucleotide polymorphism of MTHFR rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease.

    abstract:Background:Methylenetetrahydrofolate reductase (MTHFR) is indispensable for the conversion of homocysteine (Hcy) to methionine. The single nucleotide polymorphism (SNP) of MTHFR gene (rs1801133, C667T) is correlated with decreased enzyme activity that eventually results in elevated plasma Hcy levels. Hyperhomocysteinem...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8627

    authors: Yuan H,Fu M,Yang X,Huang K,Ren X

    更新日期:2020-02-20 00:00:00

  • Variegated tropical landscapes conserve diverse dung beetle communities.

    abstract:BACKGROUND:Conserving biodiversity in tropical landscapes is a major challenge to scientists and conservationists. Current rates of deforestation, fragmentation, and land use intensification are producing variegated landscapes with undetermined values for the conservation of biological communities and ecosystem functio...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3125

    authors: Costa C,Oliveira VHF,Maciel R,Beiroz W,Korasaki V,Louzada J

    更新日期:2017-04-04 00:00:00

  • The fossil Osmundales (Royal Ferns)-a phylogenetic network analysis, revised taxonomy, and evolutionary classification of anatomically preserved trunks and rhizomes.

    abstract::The Osmundales (Royal Fern order) originated in the late Paleozoic and is the most ancient surviving lineage of leptosporangiate ferns. In contrast to its low diversity today (less than 20 species in six genera), it has the richest fossil record of any extant group of ferns. The structurally preserved trunks and rhizo...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3433

    authors: Bomfleur B,Grimm GW,McLoughlin S

    更新日期:2017-07-11 00:00:00

  • Chemical analysis and evaluation of antioxidant and antimicrobial activities of fruit fractions of Mauritia flexuosa L. f. (Arecaceae).

    abstract:Background:Fruit consumption is currently considered beyond the nutritional aspects because of the important roles in disease prevention and benefits to health. The objective of this study was to characterize the chemical profile and evaluate the antioxidant and antimicrobial properties of different fractions obtained ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5991

    authors: Nonato CFA,Leite DOD,Pereira RC,Boligon AA,Ribeiro-Filho J,Rodrigues FFG,da Costa JGM

    更新日期:2018-11-28 00:00:00

  • Agrichemicals and antibiotics in combination increase antibiotic resistance evolution.

    abstract::Antibiotic resistance in our pathogens is medicine's climate change: caused by human activity, and resulting in more extreme outcomes. Resistance emerges in microbial populations when antibiotics act on phenotypic variance within the population. This can arise from either genotypic diversity (resulting from a mutation...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5801

    authors: Kurenbach B,Hill AM,Godsoe W,van Hamelsveld S,Heinemann JA

    更新日期:2018-10-12 00:00:00

  • Structure and expression analysis of seven salt-related ERF genes of Populus.

    abstract::Ethylene response factors (ERFs) are plant-specific transcription factors (TFs) that play important roles in plant growth and stress defense and have received a great amount of attention in recent years. In this study, seven ERF genes related to abiotic stress tolerance and response were identified in plants of the Po...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10206

    authors: Huang J,Wang S,Wang X,Fan Y,Han Y

    更新日期:2020-10-20 00:00:00

  • Cave features, seasonality and subterranean distribution of non-obligate cave dwellers.

    abstract::Seasonality impacts species distributions through changes of the environmental conditions that affect the presence of individuals at a given place. Although the dynamics of cave microclimates are well known, only a few studies have evaluated the effects of such dynamics on non-strictly cave species. Here we assessed i...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3169

    authors: Lunghi E,Manenti R,Ficetola GF

    更新日期:2017-05-10 00:00:00

  • Elaborate cellulosome architecture of Acetivibrio cellulolyticus revealed by selective screening of cohesin-dockerin interactions.

    abstract::Cellulosic waste represents a significant and underutilized carbon source for the biofuel industry. Owing to the recalcitrance of crystalline cellulose to enzymatic degradation, it is necessary to design economical methods of liberating the fermentable sugars required for bioethanol production. One route towards unloc...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.636

    authors: Hamberg Y,Ruimy-Israeli V,Dassa B,Barak Y,Lamed R,Cameron K,Fontes CM,Bayer EA,Fried DB

    更新日期:2014-10-30 00:00:00

  • Ontogenetic foraging activity and feeding selectivity of the Brazilian endemic parrotfish Scarus zelindae.

    abstract::Parrotfish are fundamental species in controlling algal phase-shifts and ensuring the resilience of coral reefs. Nevertheless, little is known on their ecological role in the south-western Atlantic Ocean. The present study analysed the ontogenetic foraging activity and feeding selectivity of the Brazilian endemic parr...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2536

    authors: Pereira PH,Santos M,Lippi DL,Silva P

    更新日期:2016-10-12 00:00:00

  • Comments and corrections on 3D modeling studies of locomotor muscle moment arms in archosaurs.

    abstract::In a number of recent studies we used computer modeling to investigate the evolution of muscle leverage (moment arms) and function in extant and extinct archosaur lineages (crocodilians, dinosaurs including birds and pterosaurs). These studies sought to quantify the level of disparity and convergence in muscle moment ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1272

    authors: Bates K,Maidment SC,Schachner ER,Barrett PM

    更新日期:2015-10-08 00:00:00

  • Correction: Prevalence and correlates of psychological distress among diabetes mellitus adults in the Jilin province in China: a cross-sectional study.

    abstract::[This corrects the article DOI: 10.7717/peerj.2869.]. ...

    journal_title:PeerJ

    pub_type: 杂志文章,已发布勘误

    doi:10.7717/peerj.2869/correction-1

    authors: Qiu S,Sun H,Liu Y,Kanu JS,Li R,Yu Y,Huang X,Li B,Zhang X

    更新日期:2017-12-07 00:00:00

  • Lacosamide adjunctive therapy for partial-onset seizures: a meta-analysis.

    abstract::Background. The relative efficacy and safety of lacosamide as adjunctive therapy compared to other antiepileptic drugs has not been well established. Objective. To determine if lacosamide provides improved efficacy and safety, reduced length of hospital stay and improved quality of life compared with other anti-epilep...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.114

    authors: Sawh SC,Newman JJ,Deshpande S,Jones PM

    更新日期:2013-08-06 00:00:00

  • Nutritional assessment, phytochemical composition and antioxidant analysis of the pulp and seed of medjool date grown in Mexico.

    abstract::The aim of this study was the characterization of fatty acids, antioxidant activity, some physical properties, nutrient content, sugars, and minerals in the pulp and seeds of the date cultivar 'Medjool' (Phoenix dactylifera L.) grown in Mexico. The samples were obtained at maturity (Tamar) in the 2017 harvest season i...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6821

    authors: Salomón-Torres R,Ortiz-Uribe N,Valdez-Salas B,Rosas-González N,García-González C,Chávez D,Córdova-Guerrero I,Díaz-Rubio L,Haro-Vázquez MDP,Mijangos-Montiel JL,Morales-Maza A,Mahadevan P,Krueger R

    更新日期:2019-07-17 00:00:00

  • Self-centeredness and selflessness: happiness correlates and mediating psychological processes.

    abstract::The main objective of this research was to test central assumptions from the Self-centeredness/Selflessness Happiness Model. According to this model, while self-centered psychological functioning induces fluctuating happiness, authentic-durable happiness results from selflessness. Distinct mediating processes are supp...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3306

    authors: Dambrun M

    更新日期:2017-05-11 00:00:00

  • Comparative genomics of Synechococcus and proposal of the new genus Parasynechococcus.

    abstract::Synechococcus is among the most important contributors to global primary productivity. The genomes of several strains of this taxon have been previously sequenced in an effort to understand the physiology and ecology of these highly diverse microorganisms. Here we present a comparative study of Synechococcus genomes. ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1522

    authors: Coutinho F,Tschoeke DA,Thompson F,Thompson C

    更新日期:2016-01-14 00:00:00

  • The effect of voluntary head movements on postural kinetics in the standing cat.

    abstract:Background:Although the postural instability accompanying bilateral vestibular loss in human and quadrupeds during lateral head movements are well-known, it is still unclear whether or not lateral head turns would indeed activate the postural control system to maintain balance. This study aimed to examine the kinetic p...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8186

    authors: Song Y,Wang M,Baker JS,Gu Y

    更新日期:2019-12-12 00:00:00

  • In silico analysis of maize HDACs with an emphasis on their response to biotic and abiotic stresses.

    abstract::Histone deacetylases (HDACs) are key epigenetic factors in regulating chromatin structure and gene expression in multiple aspects of plant growth, development, and response to abiotic or biotic stresses. Many studies on systematic analysis and molecular function of HDACs in Arabidopsis and rice have been conducted. Ho...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8539

    authors: Zhang K,Yu L,Pang X,Cao H,Si H,Zang J,Xing J,Dong J

    更新日期:2020-02-12 00:00:00

  • Tweet success? Scientific communication correlates with increased citations in Ecology and Conservation.

    abstract::Science communication is seen as critical for the disciplines of ecology and conservation, where research products are often used to shape policy and decision making. Scientists are increasing their online media communication, via social media and news. Such media engagement has been thought to influence or predict tr...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4564

    authors: Lamb CT,Gilbert SL,Ford AT

    更新日期:2018-04-12 00:00:00

  • Maxent-directed field surveys identify new populations of narrowly endemic habitat specialists.

    abstract:BACKGROUND:Rare or narrowly endemic organisms are difficult to monitor and conserve when their total distribution and habitat preferences are incompletely known. One method employed in determining distributions of these organisms is species distribution modeling (SDM). METHODS:Using two species of narrowly endemic bur...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3632

    authors: Rhoden CM,Peterman WE,Taylor CA

    更新日期:2017-07-31 00:00:00

  • A new iguanodontian (Dinosauria: Ornithopoda) from the Early Cretaceous of Mongolia.

    abstract::We describe a new iguanodontian ornithopod, Choyrodon barsboldi gen. et sp. nov. from the Albian-aged Khuren Dukh Formation of Mongolia based on several partial skeletons interpreted to represent a subadult growth stage based on osteohistological features. This new taxon is diagnosed by many autapomorphies of the maxi...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5300

    authors: Gates TA,Tsogtbaatar K,Zanno LE,Chinzorig T,Watabe M

    更新日期:2018-08-03 00:00:00

  • Utilizing mutual information for detecting rare and common variants associated with a categorical trait.

    abstract::Background. Genome-wide association studies have succeeded in detecting novel common variants which associate with complex diseases. As a result of the fast changes in next generation sequencing technology, a large number of sequencing data are generated, which offers great opportunities to identify rare variants that...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2139

    authors: Sun L,Wang C,Hu YQ

    更新日期:2016-06-16 00:00:00

  • The effects of set volume during isolated lumbar extension resistance training in recreationally trained males.

    abstract::Background/Aim. Exercise designed to condition the lumbar extensor musculature is often included in resistance training (RT) programs. It is suggested that deconditioning of this musculature may be linked to low back pain. Thus effective means of conditioning these muscles are of interest to pursue. Evidence suggests ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.878

    authors: Steele J,Fitzpatrick A,Bruce-Low S,Fisher J

    更新日期:2015-03-31 00:00:00

  • A systematic review of the direct and indirect effects of herbivory on plant reproduction mediated by pollination.

    abstract:Background:Plant reproduction is influenced by the net outcome of plant-herbivore and plant-pollinator interactions. While both herbivore impacts and pollinator impacts on plant reproduction have been widely studied, few studies examine them in concert. Methodology:Here, we review the contemporary literature that exam...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9049

    authors: Haas SM,Lortie CJ

    更新日期:2020-06-08 00:00:00

  • Using signals associated with safety in avoidance learning: computational model of sex differences.

    abstract::Avoidance behavior involves learning responses that prevent upcoming aversive events; these responses typically extinguish when the aversive events stop materializing. Stimuli that signal safety from aversive events can paradoxically inhibit extinction of avoidance behavior. In animals, males and females process safet...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1081

    authors: Radell ML,Beck KD,Pang KC,Myers CE

    更新日期:2015-07-14 00:00:00

  • Diversity, host-specificity and stability of sponge-associated fungal communities of co-occurring sponges.

    abstract::Fungi play a critical role in a range of ecosystems; however, their interactions and functions in marine hosts, and particular sponges, is poorly understood. Here we assess the fungal community composition of three co-occurring sponges (Cymbastela concentrica, Scopalina sp., Tedania anhelans) and the surrounding seawa...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4965

    authors: Nguyen MTHD,Thomas T

    更新日期:2018-06-04 00:00:00