Abstract:
Background/Aims:Current evidence suggests the presence of motility or functional abnormalities in one area of the gastrointestinal tract increases the likelihood of abnormalities in others. However, the relationship of gastroparesis to chronic constipation (slow transit constipation and dyssynergic defecation) has been incompletely evaluated. Methods:We retrospectively reviewed the records of all patients with chronic dyspeptic symptoms and constipation who underwent both a solid gastric emptying scintigraphy and a high-resolution anorectal manometry at our institution since January 2012. When available, X-ray defecography and radiopaque marker colonic transit studies were also reviewed. Based on the gastric emptying results, patients were classified as gastroparesis or dyspepsia with normal gastric emptying (control group). Differences in anorectal and colonic findings were then compared between groups. Results:Two hundred and six patients met the inclusion criteria. Patients with gastroparesis had higher prevalence of slow transit constipation by radiopaque marker study compared to those with normal emptying (64.7% vs 28.1%, P = 0.013). Additionally, patients with gastroparesis had higher rates of rectocele (88.9% vs 60.0%, P = 0.008) and intussusception (44.4% vs 12.0%, P = 0.001) compared to patients with normal emptying. There was no difference in the rate of dyssynergic defecation between those with gastroparesis vs normal emptying (41.1% vs 42.1%, P = 0.880), and no differences in anorectal manometry findings. Conclusions:Patients with gastroparesis had a higher rate of slow transit constipation, but equal rates of dyssynergic defecation compared to patients with normal gastric emptying. These findings argue for investigation of possible delayed colonic transit in patients with gastroparesis and vice versa.
journal_name
J Neurogastroenterol Motiljournal_title
Journal of neurogastroenterology and motilityauthors
Zikos TA,Kamal AN,Neshatian L,Triadafilopoulos G,Clarke JO,Nandwani M,Nguyen LAdoi
10.5056/jnm18206subject
Has Abstractpub_date
2019-04-30 00:00:00pages
267-275issue
2eissn
2093-0879issn
2093-0887pii
jnm18206journal_volume
25pub_type
杂志文章abstract:BACKGROUND/AIMS:To draw a normative database of laryngopharynx pH profile in Chinese subjects. METHODS:Normal volunteers were recruited from "www.Ganji.com" and People's hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm13138
更新日期:2014-07-31 00:00:00
abstract:Background/Aims:Probiotics are expected to modify the composition of gut microbiota. We aimed to investigate the changes in the composition and diversity of gut microbiota by the administration of probiotics in healthy individuals. Methods:Twelve healthy volunteers with age range of 30-42 years provided baseline fecal...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm17140
更新日期:2018-07-30 00:00:00
abstract:BACKGROUND/AIMS:Transient lower esophageal sphincter relaxation (TLESR) is the main mechanism of gastroesophageal reflux disease (GERD). The aim of this study was to investigate the characteristics of transient lower esophageal sphincter movement in patients with or without gastroesophageal reflux by high-resolution ma...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.3.332
更新日期:2013-07-01 00:00:00
abstract::Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophagea...
journal_title:Journal of neurogastroenterology and motility
pub_type: 评审
doi:10.5056/jnm19081
更新日期:2019-10-30 00:00:00
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journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.1.35
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:Antispasmodics including otilonium bromide (OB) are recommended to treat irritable bowel syndrome (IBS). However, reports about OB experience in Asia is sparse. The purpose of present study was to provide the efficacy of OB in treating Asian IBS patients. METHODS:Overall, 117 IBS patients meeting Rome ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.4.402
更新日期:2011-10-01 00:00:00
abstract::In predisposed individuals with long standing gastroesophageal reflux disease (GERD), esophageal squamous mucosa can transform into columnar mucosa with intestinal metaplasia, commonly called Barrett's esophagus (BE). Barrett's mucosa can develop dysplasia, which can be a precursor for esophageal adenocarcinoma (EAC)....
journal_title:Journal of neurogastroenterology and motility
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更新日期:2019-04-30 00:00:00
abstract:BACKGROUND/AIMS:The marketing of newer agents for treatment of constipation and irritable bowel syndrome with constipation (IBS-C) emphasize improvements in abdominal pain. However, it is not clear whether this observation reflects a unique visceral analgesic effect of these agents or is a general feature of effective ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15171
更新日期:2016-01-31 00:00:00
abstract:BACKGROUND/AIMS:Functional gastrointestinal disorders (FGIDs), diagnosed by symptom-based criteria due to lack of biomarkers, need translatedvalidated questionnaires in different languages. As Bengali, the mother tongue of Bangladesh and eastern India, is the seventh most spoken language in the world, we translated and...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15129
更新日期:2016-04-30 00:00:00
abstract:BACKGROUND/AIMS:Proton pump inhibitors (PPIs) which are the most effective agents for the treatment of gastroesophageal reflux disease (GERD), have been known to delay gastric emptying. Mosapride has been used as prokinetics by accelerating gastric emptying. We evaluated the efficacy of mosapride to prevent PPI-induced...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.4.495
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND/AIMS:Researches on the potential risk factors for the development of erosive esophagitis have been conducted extensively, however, the results are conflicting. The aim of this multicenter study was to identify the prevalence rate and risk factors of erosive esophagitis and their interactions with residency s...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.1.70
更新日期:2013-01-01 00:00:00
abstract:Background/Aims:Lipopolysaccharide (LPS) is the key factor inducing mucosal and systemic inflammation in various intestinal and parenteral diseases, which could initially disrupt the epithelial barrier function. EphrinA1/ephA2 is speculated to increase the epithelial permeability for its "repulsive interaction" between...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19095
更新日期:2020-07-30 00:00:00
abstract:Background/Aims:Integrated relaxation pressure (IRP) is defined as the average minimum esophagogastric junction (EGJ) pressure for 4 seconds of relaxation (contiguous or noncontiguous) within 10 seconds of swallowing. The durability of IRP values during successive swallows in the supine position remains to be elucidate...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm20139
更新日期:2021-01-28 00:00:00
abstract:Background/Aims:Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1), a determinant of cholinergic signaling capacity, modulates intestinal motility associated with s...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18040
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). METHODS:Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swa...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.4.399
更新日期:2012-10-01 00:00:00
abstract:Background/Aims:The Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed and validated as a tool for the diagnosis of gastroesophageal reflux disease (GERD) in patients with gastrointestinal symptoms. However, the GerdQ and the cutoff value for determining GERD has not been validated in Korea. Meth...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm18133
更新日期:2019-01-31 00:00:00
abstract::The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has revealed that various alterations to the DNA methylation apparatus within both of these cell types can result in a variety of cellular phe...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章,评审
doi:10.5056/jnm19077
更新日期:2019-07-01 00:00:00
abstract::An increase in intracellular Ca(2+) is the primary trigger of contraction of gastrointestinal (GI) smooth muscles. However, increasing the Ca(2+) sensitivity of the myofilaments by elevating myosin light chain phosphorylation also plays an essential role. Inhibiting myosin light chain phosphatase activity with protein...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章,评审
doi:10.5056/jnm15186
更新日期:2016-04-30 00:00:00
abstract:Background/Aims:Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO) mouse model to investigate the changes of interstitial cells and the correl...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19136
更新日期:2019-10-30 00:00:00
abstract:BACKGROUND/AIMS:In isolated guinea-pig colon, we investigated regional differences in peristalsis evoked by intrinsic electrical nerve stimulation. METHODS:Four colonic segments from mid and distal colon of Hartley guinea pigs, were mounted horizontally in an organ bath. Measurement of pellet propulsion time, intralum...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2013.19.2.192
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND/AIMS:Rome criteria classifying functional gastrointestinal disorder (FGID) were updated. The aims of this study were to assess the spectra of FGID and to evaluate the applicability of Rome III criteria in Korea. METHODS:New patients who visited 2 primary clinics and 2 tertiary care hospitals were consecutiv...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2011.17.3.279
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND/AIMS:Approximately one-third of non-erosive reflux disease (NERD) patients are refractory to proton pump inhibitors (PPI) and face a therapeutic challenge. Therefore, it is important to differentiate between pathological and non-pathological reflux utilizing multichannel intraluminal impedance-pH (MII-pH) to...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm14038
更新日期:2014-10-30 00:00:00
abstract:BACKGROUND/AIMS:Irritable bowel syndrome (IBS) is a widespread chronic health condition which is significantly more prevalent in women. We conducted a gender difference analysis by comparing findings of men and women to determine whether any significant differences exist or not. METHODS:This single-center study was co...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2012.18.1.70
更新日期:2012-01-01 00:00:00
abstract::Patients with dyspepsia/functional dyspepsia (FD) show frequent overlapping of other gastrointestinal (GI) diseases, such as irri-table bowel syndrome, and non-GI diseases, in addition to internal subgroup overlapping. These overlap patients have more frequent or more severe symptoms, poorer health-related quality of ...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm14080
更新日期:2014-10-30 00:00:00
abstract:Background/Aims:Since the use of dexlansoprazole in Asian subjects with gastroesophageal reflux disease (GERD) has not been adequately characterized, this study was conducted to evaluate the efficacy and safety of dexlansoprazole modified-release in Asian subjects with non-erosive reflux disease (NERD) and erosive esop...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19031
更新日期:2020-01-30 00:00:00
abstract::Radiofrequency catheter ablation (RFCA) is a potentially curative method for treatment of highly symptomatic and drug-refractory atrial fibrillation (AF). However, this technique can provoke esophageal and nerve lesion, due to thermal injury. To our knowledge, there have been no reported cases of a newly described mot...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15034
更新日期:2015-10-01 00:00:00
abstract::Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent episodes of incapacitating nausea and vomiting interspersed with symptom free periods. Common triggers of cyclic vomiting include noxious stress, excitement, fatigue and menstrual period. Here, we report a case of cyclic vomiting syndrome in adult...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm.2010.16.1.77
更新日期:2010-01-01 00:00:00
abstract:Background/Aims:High-resolution manometry (HRM) has broadened the awareness of minor esophageal peristaltic disorders. However, the treatments for these minor disorders are limited and the role of prokinetics has been controversial. This study evaluates the effect of mosapride in patients with minor peristaltic disorde...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm19062
更新日期:2020-04-30 00:00:00
abstract::Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. It also leads to a significant economic burden due to workdays lost and reduced productivity. Further, long-term use of non-specific medications is also associated with side effects aff...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm15026
更新日期:2015-03-30 00:00:00
abstract:Background/Aims:Self-reported lactose intolerance (LI) is frequent in patients with functional bowel disorders (FBD) that could be interpreted as irritable bowel syndrome (IBS). The present study aims to characterize the responses of FBD patients without small intestinal bacterial overgrowth (SIBO), and LI, in terms of...
journal_title:Journal of neurogastroenterology and motility
pub_type: 杂志文章
doi:10.5056/jnm20094
更新日期:2020-12-28 00:00:00