Abstract:
PURPOSE OF REVIEW:The last 40 years of clinical research in interventional cardiology were extraordinarily innovative. This article will review the most promising up and coming interventional cardiovascular therapies, with a primary focus on the treatment of coronary artery disease. RECENT FINDINGS:From the first stent, to the first transcatheter aortic valve implantation (TAVI), and the left appendage closure technique, percutaneous interventions revolutionized the treatment of multiple diseases and dramatically improved the prognosis of many patients. While these advances have decreased the risk of mortality in some patients (such as ST-elevation myocardial infarction), 15% of acute coronary syndrome (ACS) patients still experience recurrent ischemic events within the first year, challenging us to develop new pharmaceutical targets and new devices. The continued emergence of data supporting inflammation as a risk factor and pharmacologic target as well as data supporting the importance of cholesterol efflux have identified novel therapeutic targets that may play a major role in the improvement of prognosis of patients with coronary artery disease. In addition, novel medical devices are being developed to allow even earlier detection of acute cardiac events and to support high-risk percutaneous coronary interventions. Advances in computing and the ability to analyze large datasets will allow us to use artificial intelligence to augment the clinician patient experience, both in and out of the catheterization laboratory, with live procedural guidance as well as pre- and post-operative prognostication tools.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
Kerneis M,Nafee T,Yee MK,Kazmi HA,Datta S,Zeitouni M,Afzal MK,Jafarizade M,Walia SS,Qamar I,Pitliya A,Kalayci A,Al Khalfan F,Gibson CMdoi
10.1007/s11886-019-1108-xsubject
Has Abstractpub_date
2019-03-13 00:00:00pages
26issue
4eissn
1523-3782issn
1534-3170pii
10.1007/s11886-019-1108-xjournal_volume
21pub_type
杂志文章,评审abstract::As more and more patients receive complex implantable cardioverter-defibrillators (ICDs), profound knowledge about the incidence of inappropriate device therapy, the reasons it happens, and the possibilities for prevention is crucial. In this article, the most important prevention algorithms incorporated in current IC...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-000-0092-4
更新日期:2000-07-01 00:00:00
abstract::It has been known for many decades that multiple abnormalities of the autonomic nervous system (ANS) are present in heart failure (HF). Moreover, many of the effective therapies currently used to treat HF have either direct or indirect effects on the ANS. While therapies that block over-activity of the sympathetic ner...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-015-0652-2
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review methodological and logistical aspects of CT myocardial perfusion, current clinical evidence and possible future directions, with specific focus on use in patients with coronary artery disease (CAD). RECENT FINDINGS:CT myocardial perfusion imaging may be performed as an add-on to standard co...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0937-8
更新日期:2017-10-25 00:00:00
abstract::Spontaneous coronary artery dissection is an important etiology of nonatherosclerotic acute coronary syndrome, myocardial infarction, and sudden death. Innovations in the catheterization laboratory including optical coherence tomography and intravascular ultrasound have enhanced the ability to visualize intimal disrup...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0737-6
更新日期:2016-07-01 00:00:00
abstract::Cardiovascular magnetic resonance (CMR) is widely regarded as capable of providing a cornucopia of detailed diagnostic information. However, of that information, very little is truly unique, and can be obtained by a combination of alternate diagnostic modalities. Given this, it is anticipated that in the short term (1...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-004-0067-y
更新日期:2004-01-01 00:00:00
abstract::Medical management of patients with atrial fibrillation (AF) at high risk for stroke is limited by problems of imperfect tools for assessment of thromboembolism and bleeding risks. Improved instruments, such as the CHA₂DS₂VASc and HAS-BLED risk stratification scores, have been incorporated into European practice guide...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-010-0148-z
更新日期:2011-02-01 00:00:00
abstract::Basic and animal research implicate inflammatory mechanisms in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers, particularly high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2, have been identified as potential predictors...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-009-0003-2
更新日期:2009-01-01 00:00:00
abstract::True aneurysms of the pulmonary artery are rare, and are most often due to pulmonary hypertension arising from congenital heart defects. We report the case of a 40-year-old man with an uncorrected patent ductus arteriosus who presented with pulmonary infarction and pneumonia, and subsequently died of cardiac arrest. A...
journal_title:Current cardiology reports
pub_type: 杂志文章
doi:10.1007/s11886-005-0054-y
更新日期:2005-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Comprehensive discussion of alternative techniques in imaging coronary artery anomalies (CAAs) in different diagnostic scenarios. RECENT FINDINGS:At primary screening, intramural course essentially correlates with stenosis and clinical repercussion in some types of CAAs. Potential clinical aims in im...
journal_title:Current cardiology reports
pub_type: 杂志文章
doi:10.1007/s11886-019-1188-7
更新日期:2019-07-29 00:00:00
abstract::The risk of stroke associated with carotid artery stenosis can be reduced with carotid endarterectomy or carotid artery stenting in carefully selected patients. While surgery has been the traditional treatment there have been many trials comparing carotid endarterectomy with carotid artery stenting, and stenting has s...
journal_title:Current cardiology reports
pub_type: 杂志文章
doi:10.1007/s11886-012-0250-5
更新日期:2012-02-05 00:00:00
abstract::In STEMI, primary PCI restores macrovascular coronary blood flow effectively but microvascular perfusion remains a challenge. Thrombus has the potential to embolize to the microvasculature limiting effective coronary blood flow. Thrombus burden is associated with a higher mortality and manual aspiration thrombectomy h...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-016-0707-z
更新日期:2016-03-01 00:00:00
abstract::The burgeoning ranks of patients with heart failure, the limited number of organs available for heart transplant, and technological improvements have made ventricular assist devices (VADs) important therapeutic options for patients with acute and chronic cardiac decompensation. The increased use of VADs is paralleled ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-010-0102-0
更新日期:2010-05-01 00:00:00
abstract::Patients with advanced peripheral arterial disease may develop critical limb ischemia with rest pain, non-healing ulcerations, and eventually may require major amputation despite currently available revascularization technologies. Stem cell therapies hold promise as novel therapeutics to promote vasculogenesis and imp...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-013-0447-2
更新日期:2014-02-01 00:00:00
abstract::Angiotensin-converting enzyme (ACE) inhibitors have become the cornerstone of therapy for congestive heart failure (CHF). Because ischemic heart disease is the most common cause of CHF, aspirin is frequently given concomitantly with ACE inhibitors in patients with CHF. Increased bradykinin levels, with the consequent ...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-001-0030-0
更新日期:2001-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Ebstein's anomaly (EA) is a rare, but complex form of congenital heart disease consisting of a right ventricular myopathy and morphologic tricuspid valve disease leading to a high incidence of right ventricular dysfunction and arrhythmias. This review offers an updated overview of the current understa...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01412-z
更新日期:2020-10-09 00:00:00
abstract::While pulmonary arterial hypertension is a disease primarily affecting the pulmonary vasculature, the right ventricle plays an integral part in the disease process. Although widely used, two-dimensional echocardiography is limited in visualizing the right ventricle and, therefore, assessment of its structure and funct...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-012-0253-2
更新日期:2012-06-01 00:00:00
abstract::Atherosclerosis is the proximate cause of arterial thrombosis, leading to acute occlusive cardiovascular syndromes. Thrombosis in atherosclerosis usually results from rupture of the fibrous cap of atherosclerotic plaques with a smaller proportion resulting from superficial endothelial erosion. Ruptured plaques are oft...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-014-0547-7
更新日期:2014-12-01 00:00:00
abstract::Innate differences in gender physiology result in unique exposures, risk, and protection that are specific to women. Recognition and appreciation of these differences results in better treatment adaptations for women and better outcomes. Disparities between genders in the treatment of major cardiovascular risk factors...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-010-0135-4
更新日期:2010-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Machine learning (ML) and deep learning (DL) are two important categories of AI algorithms. Nowadays, AI technology has been gradually applied to cardiac magnetic resonance imaging (CMRI), covering the fields of myocardial contrast enhancement (MCE) pattern and automatic ventricular segmentation. This...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01306-0
更新日期:2020-07-07 00:00:00
abstract::Imaging with radionuclides has historically played an important role in detection of cardiovascular disease as well as in risk stratification and prognostication. With the growth of molecular biology have come new therapeutic interventions and the requirement for new diagnostic imaging approaches. Noninvasive targeted...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-005-0025-3
更新日期:2005-03-01 00:00:00
abstract::The excess risk of hypertension in black Americans continues to be a major health concern. Although there is considerable information regarding these disease trends, much of the major underpinnings of the etiology of hypertension remain unclear. The excess mortality in blacks due to heart disease, renal failure, and s...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-004-0048-1
更新日期:2004-11-01 00:00:00
abstract:PURPOSE OF REVIEW:There is a broad spectrum of coronary artery anomalies that cardiologists may encounter either incidentally or during evaluation for cardiac symptoms. These anomalies include anomalous coronary arteries arising from the opposite sinus of Valsalva (ACAOS), coronary fistulae, and coronary artery aneurys...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0854-x
更新日期:2017-05-01 00:00:00
abstract::The appropriateness of coronary revascularization for various clinical scenarios has been reviewed formally by several specialty and subspecialty societies resulting in the formulation of scored appropriateness criteria. The goal of the appropriateness criteria is to guide physician decision-making and future research...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-013-0379-x
更新日期:2013-07-01 00:00:00
abstract::Viable treatment options for advanced heart failure have not emerged as the number of people afflicted with this condition has grown. Although heart transplantation is the only curative strategy for patients with end-stage heart failure, the relative shortage of donors has led to a worldwide plateau of this option ove...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-014-0468-5
更新日期:2014-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The pathogenesis and progression of coronary artery disease (CAD) is now known to be largely driven by inflammation on top of the well-accepted role for the disequilibrium between cholesterol deposition and removal from the arterial wall. Recent clinical trials have supported the inflammatory hypothes...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-020-01439-2
更新日期:2021-01-06 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses the benefits of a completely percutaneous approach to endovascular aortic aneurysm repair (EVAR), and provides an outline as to how this is performed by a multidisciplinary team of cardiologists and cardiovascular surgeons at a quaternary care community hospital. RECENT FINDINGS...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-1023-6
更新日期:2018-07-26 00:00:00
abstract::Controlled clinical trials, performed in more than 13,000 patients, have consistently shown the beneficial effects of long-term beta-blocker therapy in patients with chronic heart failure. However, it is not clear whether this is a class effect or if it is specific only for some agents. Beneficial effects on the progn...
journal_title:Current cardiology reports
pub_type: 杂志文章
doi:10.1007/s11886-000-0076-4
更新日期:2000-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Ocular perfusion pressure (OPP) is defined as the difference between BP and intraocular pressure (IOP). With low BP comes low OPP and resultant ischemic damage to the optic nerve, leading to glaucoma progression. The purpose of this article is to review the literature on BP as it relates to glaucoma a...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-017-0927-x
更新日期:2017-09-19 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to clarify the cardiovascular risk of white coat hypertension (WCH). RECENT FINDINGS:Cardiovascular risk of WCH has been evaluated in multiple meta-analyses and population-based studies. International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outc...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/s11886-018-0964-0
更新日期:2018-03-08 00:00:00
abstract::Since 1971, the Fontan operation has been performed for the repair of single-ventricle physiology. This ingenious operation commits a single ventricle to the systemic circulation and takes advantage of cardiovascular and respiratory physiology to propel deoxygenated blood to the lungs, thus minimizing right-to-left sh...
journal_title:Current cardiology reports
pub_type: 杂志文章,评审
doi:10.1007/BF02938382
更新日期:2007-07-01 00:00:00