当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Analysis of repetitive element expression in the blood and skin of patients with Parkinson's disease identifies differential expression of satellite elements.

Analysis of repetitive element expression in the blood and skin of patients with Parkinson's disease identifies differential expression of satellite elements.

Abstract：

:Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mutagenic threat. Despite reports that associate RE expression with PD no study has comprehensively analysed the role of these elements in the disease. This study presents the first genome-wide analysis of RE expression in PD to date. Analysis of RNA-sequencing data of 12 PD patients and 12 healthy controls identified tissue-specific expression differences and more significantly, differential expression of four satellite elements; two simple satellite III (repName = CATTC_n and _GAATG_n) a high-copy satellite II (HSATII) and a centromeric satellite (ALR_Alpha) in the blood of PD patients. In support of the growing body of recent evidence associating REs with neurodegenerative disease, this study highlights the potential importance of characterization of RE expression in such diseases.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Billingsley KJ,Lättekivi F,Planken A,Reimann E,Kurvits L,Kadastik-Eerme L,Kasterpalu KM,Bubb VJ,Quinn JP,Kõks S,Taba P

doi

10.1038/s41598-019-40869-z

subject

Has Abstract

pub_date

2019-03-13 00:00:00

pages

4369

issue

1

issn

2045-2322

pii

10.1038/s41598-019-40869-z

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Linearly polarized photoluminescence of InGaN quantum disks embedded in GaN nanorods.

    abstract：:We have investigated the emission from InGaN/GaN quantum disks grown on the tip of GaN nanorods. The emission at 3.21 eV from the InGaN quantum disk doesn't show a Stark shift, and it is linearly polarized when excited perpendicular to the growth direction. The degree of linear polarization is about 39.3% due to the a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26642-8

    authors： Park Y,Chan CCS,Nuttall L,Puchtler TJ,Taylor RA,Kim N,Jo Y,Im H

    更新日期：2018-05-25 00:00:00

  • Molecular mechanism and functional significance of acid generation in the Drosophila midgut.

    abstract：:The gut of Drosophila melanogaster includes a proximal acidic region (~pH 2), however the genome lacks the H(+)/K(+) ATPase characteristic of the mammalian gastric parietal cell, and the molecular mechanisms of acid generation are poorly understood. Here, we show that maintenance of the low pH of the acidic region is ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27242

    authors： Overend G,Luo Y,Henderson L,Douglas AE,Davies SA,Dow JA

    更新日期：2016-06-02 00:00:00

  • Plasmonically Enhanced Schottky Photovoltaic Devices.

    abstract：:Solar-cells based on Schottky junctions between metals and semiconductors (without or with an intermediate insulator) are among the main possibilities towards economical photovoltaic conversion of the solar energy. This is mainly due to their structural simplicity and hence the ease of their realization. We propose he...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14528-0

    authors： Farhat M,Kais S,Alharbi FH

    更新日期：2017-10-27 00:00:00

  • D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation.

    abstract：:The prevalence of chronic kidney disease (CKD), characterized by progressive renal dysfunction with tubulointerstitial fibrosis, is increasing because of societal aging. Uremic toxins, accumulated during renal dysfunction, cause kidney damage, leading to renal deterioration. A recent metabolomic analysis revealed that...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11049-8

    authors： Okada A,Nangaku M,Jao TM,Maekawa H,Ishimono Y,Kawakami T,Inagi R

    更新日期：2017-09-11 00:00:00

  • RNA sequencing of cancer reveals novel splicing alterations.

    abstract：:Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to "tailor-make" specific functional transcripts. We systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing: TNBC, non-TNBC and HER2-positive breast cance...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01689

    authors： Eswaran J,Horvath A,Godbole S,Reddy SD,Mudvari P,Ohshiro K,Cyanam D,Nair S,Fuqua SA,Polyak K,Florea LD,Kumar R

    更新日期：2013-01-01 00:00:00

  • Controlled scalable synthesis of uniform, high-quality monolayer and few-layer MoS2 films.

    abstract：:Two dimensional (2D) materials with a monolayer of atoms represent an ultimate control of material dimension in the vertical direction. Molybdenum sulfide (MoS2) monolayers, with a direct bandgap of 1.8 eV, offer an unprecedented prospect of miniaturizing semiconductor science and technology down to a truly atomic sca...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01866

    authors： Yu Y,Li C,Liu Y,Su L,Zhang Y,Cao L

    更新日期：2013-01-01 00:00:00

  • A Triplet Parallelizing Spiral Microfluidic Chip for Continuous Separation of Tumor Cells.

    abstract：:Inertial and deformability- based particles separations gradually attract more significant attentions. In this work, we present a hybrid chip by combining the advantages of inertial and deformability -based principle. The chip is a triplet parallelizing spiral inertial microfluidic chip interconnected with numerable t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22348-z

    authors： Chen H

    更新日期：2018-03-06 00:00:00

  • Ultra sub-wavelength surface plasmon confinement using air-gap, sub-wavelength ring resonator arrays.

    abstract：:Arrays of sub-wavelength, sub-10 nm air-gap plasmonic ring resonators are fabricated using nanoimprinting. In near infra-red (NIR) range, the resonator supports a single dipole mode which is excited and identified via simple normal illumination and explored through transmission measurements. By controlling both latera...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22305

    authors： Lee J,Sung S,Choi JH,Eom SC,Mortensen NA,Shin JH

    更新日期：2016-02-29 00:00:00

  • Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.

    abstract：:The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29479

    authors： Liang Y,Zhu F,Zhang H,Chen D,Zhang X,Gao Q,Li Y

    更新日期：2016-07-05 00:00:00

  • Whales use distinct strategies to counteract solar ultraviolet radiation.

    abstract：:A current threat to the marine ecosystem is the high level of solar ultraviolet radiation (UV). Large whales have recently been shown to suffer sun-induced skin damage from continuous UV exposure. Genotoxic consequences of such exposure remain unknown for these long-lived marine species, as does their capacity to coun...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02386

    authors： Martinez-Levasseur LM,Birch-Machin MA,Bowman A,Gendron D,Weatherhead E,Knell RJ,Acevedo-Whitehouse K

    更新日期：2013-01-01 00:00:00

  • Nature and characteristics of temperature background effect for interactive respiration process.

    abstract：:Indoor air quality (IAQ) is much more crucial to human health than its atmospheric air quality counterpart. Improving indoor air environment requires investigating how different indoor air stability affects airflow trajectory. By presenting both manikin experiment and Computational Fluid Dynamics (CFD) simulation, we ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08871-5

    authors： Gong G,Deng X

    更新日期：2017-08-17 00:00:00

  • Automatic graphene transfer system for improved material quality and efficiency.

    abstract：:In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible su...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21676

    authors： Boscá A,Pedrós J,Martínez J,Palacios T,Calle F

    更新日期：2016-02-10 00:00:00

  • A critical role of toll-like receptor 2 (TLR2) and its' in vivo ligands in radio-resistance.

    abstract：:The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(-/-)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(-/-) mice. The cause of death in TLR2(-/-) mice may be severe a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13004

    authors： Gao F,Zhang C,Zhou C,Sun W,Liu X,Zhang P,Han J,Xian L,Bai D,Liu H,Cheng Y,Li B,Cui J,Cai J,Liu C

    更新日期：2015-08-13 00:00:00

  • Publisher Correction: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation.

    abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41598-017-14858-z

    authors： Hu C,Yu M,Ren Y,Li K,Maggio DM,Mei C,Ye L,Wei J,Jin J,Zhuang Z,Tong H

    更新日期：2017-11-07 00:00:00

  • Water: Promising Opportunities For Tunable All-dielectric Electromagnetic Metamaterials.

    abstract：:We reveal an outstanding potential of water as an inexpensive, abundant and bio-friendly high-refractive-index material for creating tunable all-dielectric photonic structures and metamaterials. Specifically, we demonstrate thermal, mechanical and gravitational tunability of magnetic and electric resonances in a metam...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13535

    authors： Andryieuski A,Kuznetsova SM,Zhukovsky SV,Kivshar YS,Lavrinenko AV

    更新日期：2015-08-27 00:00:00

  • Geographical variation in morphology of Chaetosiphella stipae stipae Hille Ris Lambers, 1947 (Hemiptera: Aphididae: Chaitophorinae).

    abstract：:Chaetosiphella stipae stipae is a xerothermophilous aphid, associated with Palaearctic temperate steppe zones or dry mountain valleys, where there are grasses from the genus Stipa. Its geographical distribution shows several populations that are spread from Spain, across Europe and Asia Minor, to Mongolia and China. G...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43988

    authors： Wieczorek K,Bugaj-Nawrocka A,Kanturski M,Miller GL

    更新日期：2017-03-08 00:00:00

  • Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography.

    abstract：:Extracellular vesicles (EVs) have important roles in physiology, pathology, and more recently have been identified as efficient carriers of therapeutic cargoes. For efficient study of EVs, a single-step, rapid and scalable isolation strategy is necessary. Chromatography techniques are widely used for isolation of biol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24163-y

    authors： Heath N,Grant L,De Oliveira TM,Rowlinson R,Osteikoetxea X,Dekker N,Overman R

    更新日期：2018-04-10 00:00:00

  • Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood.

    abstract：:Corline Heparin Conjugate (CHC), a compound of multiple unfractionated heparin chains, coats cells with a glycocalyx-like layer and may inhibit (xeno)transplant-associated activation of the plasma cascade systems. Here, we investigated the use of CHC to protect WT and genetically modified (GTKO.hCD46.hTBM) pig aortic ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04898-w

    authors： Bongoni AK,Salvaris E,Nordling S,Klymiuk N,Wolf E,Ayares DL,Rieben R,Magnusson PU,Cowan PJ

    更新日期：2017-06-30 00:00:00

  • Effect of high pressure treatment and short term storage on changes in main volatile compounds of Chinese liquor.

    abstract：:Changes in main volatile compounds of Chinese liquor after high pressure (HP) treatment and following short term storage were investigated. 400 MPa-15 min & 400 MPa-30 min were applied to young liquor. Results from gas chromatography (GC) analysis revealed decreasing trends in alcohols, aldehydes and ethyl acetate imm...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17549-x

    authors： Xu M,Zhu S,Ramaswamy HS,Yu Y

    更新日期：2017-12-08 00:00:00

  • Forms and Lability of Phosphorus in Algae and Aquatic Macrophytes Characterized by Solution 31P NMR Coupled with Enzymatic Hydrolysis.

    abstract：:Solution Phosphorus-31 nuclear magnetic resonance (31P NMR) spectroscopy coupled with enzymatic hydrolysis (EH) with commercially available phosphatases was used to characterize phosphorus (P) compounds in extracts of the dominant aquatic macrophytes and algae in a eutrophic lake. Total extractable organic P (Po) conc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37164

    authors： Feng W,Zhu Y,Wu F,He Z,Zhang C,Giesy JP

    更新日期：2016-11-16 00:00:00

  • Loss of maternal annexin A5 increases the likelihood of placental platelet thrombosis and foetal loss.

    abstract：:Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy. We found significant reductions in litter size and foetal weight in Anxa5-null...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00827

    authors： Ueki H,Mizushina T,Laoharatchatathanin T,Terashima R,Nishimura Y,Rieanrakwong D,Yonezawa T,Kurusu S,Hasegawa Y,Brachvogel B,Pöschl E,Kawaminami M

    更新日期：2012-01-01 00:00:00

  • An embryo of protocells: The capsule of graphene with selective ion channels.

    abstract：:The synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating that graphene might be an embryo of protocell membrane. Firstly, we found that the highly oxidized graphene and phospholipid-graphene oxide ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10258

    authors： Li Z,Wang C,Tian L,Bai J,Yao H,Zhao Y,Zhang X,Cao S,Qi W,Wang S,Shi K,Xu Y,Mingliang Z,Liu B,Qiu H,Liu J,Wu W,Wang X,Wenzhen A

    更新日期：2015-05-19 00:00:00

  • Gellan sulfate inhibits Plasmodium falciparum growth and invasion of red blood cells in vitro.

    abstract：:Here, we assessed the sulfated derivative of the microbial polysaccharide gellan gum and derivatives of λ and κ-carrageenans for their ability to inhibit Plasmodium falciparum 3D7 and Dd2 growth and invasion of red blood cells in vitro. Growth inhibition was assessed by means of flow cytometry after a 96-h exposure to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04723

    authors： Recuenco FC,Kobayashi K,Ishiwa A,Enomoto-Rogers Y,Fundador NG,Sugi T,Takemae H,Iwanaga T,Murakoshi F,Gong H,Inomata A,Horimoto T,Iwata T,Kato K

    更新日期：2014-04-17 00:00:00

  • Publisher Correction: Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2.

    abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41598-017-18751-7

    authors： Ruskamo S,Nieminen T,Kristiansen CK,Vatne GH,Baumann A,Hallin EI,Raasakka A,Joensuu P,Bergmann U,Vattulainen I,Kursula P

    更新日期：2018-01-08 00:00:00

  • Author Correction: Pattern invariance for reaction-diffusion systems on complex networks.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-60111-5

    authors： Cencetti G,Clusella P,Fanelli D

    更新日期：2020-02-18 00:00:00

  • Key role of 15-LO/15-HETE in angiogenesis and functional recovery in later stages of post-stroke mice.

    abstract：:This study sought to clarify the effects of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in angiogenesis and neurological functional recovery after cerebral ischaemic stroke in mice. In vivo, we performed behavioural tests to determine functional recovery after stroke. Double immunofluorescence staining of CD31 and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46698

    authors： Wang D,Liu Y,Chen L,Li P,Qu Y,Zhu Y,Zhu Y

    更新日期：2017-04-24 00:00:00

  • Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study.

    abstract：:The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80812-1

    authors： Khor BH,Sahathevan S,Sualeheen A,Ali MSM,Narayanan SS,Chinna K,Gafor AHA,Goh BL,Ahmad G,Morad Z,Daud ZAM,Khosla P,Sundram K,Karupaiah T,PaTCH Investigators.

    更新日期：2021-01-14 00:00:00

  • Projecting groundwater storage changes in California's Central Valley.

    abstract：:Accurate and detailed knowledge of California's groundwater is of paramount importance for statewide water resources planning and management, and to sustain a multi-billion-dollar agriculture industry during prolonged droughts. In this study, we use water supply and demand information from California's Department of W...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31210-1

    authors： Massoud EC,Purdy AJ,Miro ME,Famiglietti JS

    更新日期：2018-08-27 00:00:00

  • Magnetic inhomogeneity on a triangular lattice: the magnetic-exchange versus the elastic energy and the role of disorder.

    abstract：:Inhomogeneity in the ground state is an intriguing, emergent phenomenon in magnetism. Recently, it has been observed in the magnetostructural channel of the geometrically frustrated α-NaMnO2, for the first time in the absence of active charge degrees of freedom. Here we report an in-depth numerical and local-probe exp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09272

    authors： Zorko A,Kokalj J,Komelj M,Adamopoulos O,Luetkens H,Arčon D,Lappas A

    更新日期：2015-03-19 00:00:00

  • Multivariate analysis reveals significant diuron-related changes in the soil composition of different Brazilian regions.

    abstract：:Sorption and desorption determine the amount of an herbicide in soil solution. Therefore, knowledge of the sorption and desorption coefficients in different soils is an essential factor to estimate the potential for environmental contamination by herbicides. We evaluated the feasibility of multivariate and linear disc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44405-x

    authors： Chagas PSFD,Souza MF,Dombroski JLD,Junior RSO,Nunes GHS,Pereira GAM,Silva TS,Passos ABRJ,Santos JBD,Silva DV

    更新日期：2019-05-27 00:00:00