Abstract:
BACKGROUND:Oral contrast preparation is fundamental to ensuring diagnostic examination quality for magnetic resonance enterography (MRE), yet little is known about the relative palatability and tolerability of various oral contrast agents in pediatric patients with known or suspected inflammatory bowel disease. OBJECTIVE:We prospectively compared three MRE oral preparations in pediatric patients with known or suspected Crohn disease with respect to patient-reported tolerability and radiologist-determined small-bowel distension and opacification. MATERIALS AND METHODS:Seventy-five pediatric patients (mean age 14.8 years, 55% female) with known or suspected Crohn disease referred for MRE were randomized to an oral preparation with a sugar alcohol-based flavored beverage (Breeza), polyethylene glycol preparation (MiraLAX), or low-concentration barium sulfate suspension (VoLumen). Patients were instructed to consume oral contrast agent (using a weight-based protocol) beginning 60 min prior to MRE imaging. Following MRE, patients completed a questionnaire regarding their oral preparation solution including: taste (1-5 scale), feeling of well-being (1-5 scale) and willingness to consume again (yes/no). Two radiologists reviewed all MRE exams and rated exams for global features (active disease, overall small-bowel distention [1-4 scale]) and features specific to individual small-bowel segments (extent of distention, maximal luminal diameter, opacification, and susceptibility artifact). Statistical methods included one-way analysis of variance (ANOVA) with Tukey honest difference and Fisher exact tests. RESULTS:The overall rate of completion of the entire prescribed contrast volume was 53% (40/75), with a significantly higher rate of completion for MiraLAX than for VoLumen (70% vs. 30%, P=0.007). Crossover to a different preparation occurred in nine patients (12%) and was significantly more frequent when the initial preparation was VoLumen versus MiraLAX (29% vs. 0%, P=0.005). Mean subjective taste ratings for both MiraLAX (3.4, P<0.0001) and Breeza (2.8, P=0.006) were superior to those of VoLumen (1.9), which persisted in the subset of patients with MRE evidence of active Crohn disease. Patients who consumed MiraLAX were more likely to be willing to drink it again compared to those consuming VoLumen (82% vs. 46%, P=0.009). Overall small-bowel distention and bowel-segment-specific metrics (distention, maximal diameter, opacification and susceptibility) did not significantly differ among groups. CONCLUSION:In pediatric patients with known or suspected Crohn disease, MiraLAX and Breeza were rated as more palatable than VoLumen, and all three preparations achieved a similar degree of small-bowel distension and opacification on MRE. Imaging centers performing MRE should stock multiple oral contrast preparations because a sizable proportion of children require more than one agent to ingest the requisite oral contrast volume.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Gottumukkala RV,LaPointe A,Sargent D,Gee MSdoi
10.1007/s00247-019-04378-5subject
Has Abstractpub_date
2019-06-01 00:00:00pages
889-896issue
7eissn
0301-0449issn
1432-1998pii
10.1007/s00247-019-04378-5journal_volume
49pub_type
杂志文章,随机对照试验abstract:BACKGROUND:No normal measurements or specific size criteria have been described for cervical lymph nodes in children. OBJECTIVE:To determine the normal measurements of cervical lymph nodes in children on CT. MATERIALS AND METHODS:We included 142 children (ages 1-17 years) who underwent cervical CT examination after h...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-019-04595-y
更新日期:2020-04-01 00:00:00
abstract::Part 1 of this series of two articles describes conventional and advanced MRI techniques that are useful for evaluating brainstem pathologies. In addition, it provides a review of the embryology, normal progression of myelination, and clinically and radiologically salient imaging anatomy of the normal brainstem. Final...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-020-04953-1
更新日期:2021-02-01 00:00:00
abstract::A retrospective study of the CT data of the brain was carried out in 48 newborns with neonatal subarachnoid hemorrhage. In addition to the posterior interhemispheric opacities generally accepted as an index of this type of bleeding, anterior interhemispheric, paravermian, cisternal and supratentorial hyperdensities mu...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02012955
更新日期:1990-01-01 00:00:00
abstract::Leigh syndrome by definition is (1) a neurodegenerative disease with variable symptoms, (2) caused by mitochondrial dysfunction from a hereditary genetic defect and (3) accompanied by bilateral central nervous system lesions. A genetic etiology is confirmed in approximately 50% of patients, with more than 60 identifie...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-015-3523-5
更新日期:2016-04-01 00:00:00
abstract::Four children with Type I hepatorenal glycogen storage have been studied by barium enema. All showed strikingly similar changes of a smooth-walled, slightly narrow but normal length colon without any haustration. The findings simulated colitis but the patients had either mild diarrhea or no gastrointestinal complaints...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01000116
更新日期:1975-03-20 00:00:00
abstract::Abdominal trauma is a leading cause of death in children older than 1 year of age. The spleen is the most common organ injured following blunt abdominal trauma. Pediatric trauma patients present unique clinical challenges as compared to adults, including different mechanisms of injury, physiologic responses, and indic...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-009-1336-0
更新日期:2009-09-01 00:00:00
abstract::Part 1 of this series of two articles describes conventional and advanced MRI techniques that are useful for evaluating brainstem pathologies. In addition, it provides a review of the embryology, normal progression of myelination, and clinically and radiologically salient imaging anatomy of the normal brainstem. Final...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-020-04954-0
更新日期:2021-02-01 00:00:00
abstract::Most pediatric malignancies require some form of cross-sectional imaging, either for staging or response assessment. The majority of these are solid tumors and this review addresses the role of MRI, as well as other cross-sectional and functional imaging techniques, for evaluating the most common pediatric solid tumor...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-018-4162-4
更新日期:2018-08-01 00:00:00
abstract::Mid-cervical kyphosis in diastrophic dysplasia (DD) with cord compression and weakness has been recognized for the last three decades. A strikingly similar situation exists in Larsen's syndrome (LS), an otherwise unrelated problem of weakness with lay joints and dislocations with typical facies. Forty patients with DD...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02010328
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Radiologic reports of "normal" chest are not uncommon when there clearly are irregularities of sternal ossification and maturation. Analysis of imaging studies of sternal deformities for growth disturbances is not common in the literature and is addressed in this manuscript. OBJECTIVE:To determine the influ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050602
更新日期:1999-05-01 00:00:00
abstract::Common systemic disorders that cause cerebral venous thrombosis (CVT) in children include dehydration, trauma, infection and haematological diseases. No cause for CVT is identified in one quarter of all cases. We report a child with thalamic infarcts due to internal CVT who had congenital heterozygous protein-C defici...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050776
更新日期:2000-06-01 00:00:00
abstract::Intravesical catheter knotting during micturating cystourethrography is a rare but recognized complication of the procedure. We were able to untangle a knot utilizing a fluoroscopically guided vascular guidewire. Following this success, a small study was performed using a model. Various types of guidewires and techniq...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-007-0426-0
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Paediatric non-accidental injury is a considerable health problem, and imaging plays a fundamental role in its assessment. Since the introduction of joint guidelines published by the Royal College of Radiologists (RCR) and Royal College of Paediatrics and Child Health (RCPCH) in 2008, there has been a concer...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-014-3063-4
更新日期:2014-12-01 00:00:00
abstract::We present a case of neonatal acute gastric outlet obstruction related to prostaglandin-induced gastric foveolar hyperplasia, which developed following infusion of prostaglandin E1 (PGE1) for treatment of hypoplastic left heart syndrome. Abdominal distension occurred after administration of PGE1 in a cumulative dose o...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050064
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Lymphatic malformations (LMs) are congenital lesions of the lymphatic system and consist of lymphatic channels and cystic spaces of varying sizes. Recent evidence has shown that LMs respond well to intralesional sclerotherapy. OBJECTIVE:The purpose of this retrospective study is to evaluate the outcome and ...
journal_title:Pediatric radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00247-012-2406-2
更新日期:2012-09-01 00:00:00
abstract::We report a case of eosinophilic granuloma at the fourth cervical vertebra in a 10-year-old girl presenting with a 1-month history of cervical pain and stiffness. This lesion was histologically diagnosed by needle biopsy and then treated by percutaneous vertebroplasty. After the procedure, the cervical pain and stiffn...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-007-0575-1
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Stress fractures of many etiologies are found not infrequently in various tarsal bones but are less commonly recognized in carpal bones. OBJECTIVE:To assess the distribution of tarsal and carpal stress fractures. MATERIALS AND METHODS:During the last three decades, the senior author collected locations of ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-010-1577-y
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Sonography has been used to predict pneumatic reduction outcome in children with intussusception. OBJECTIVE:To assess the prognostic significance of fluid between the intussusceptum and intussuscepiens with respect to reduction outcome, lead point or necrosis. MATERIALS AND METHODS:Sonograms of children wi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-010-1931-0
更新日期:2011-06-01 00:00:00
abstract::In a group of 70 premature and newborn infants, treated with artificial ventilation, 24.3% developed bronchopulmonary dysplasia (BPD). Only in a very few cases did the typical radiological stages, as described by Northway, succeed each other in a chronological order. It is impossible to differentiate BPD stage I or II...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00973978
更新日期:1977-03-17 00:00:00
abstract::Peripheral primitive neuroectodermal tumour in the kidney is a rare entity with high malignant potential. The distinctive demographic, clinical and radiological findings, as described in the present case, should suggest this aggressive tumour in the differential diagnosis of renal neoplasms in adolescents. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470000392
更新日期:2001-02-01 00:00:00
abstract:: ...
journal_title:Pediatric radiology
pub_type: 评论,信件
doi:10.1007/s00247-018-4234-5
更新日期:2019-01-01 00:00:00
abstract::Prenatal imaging with high-resolution US and rapid acquisition MRI plays a key role in the accurate diagnosis of congenital chest masses. Imaging has enhanced our understanding of the natural history of fetal lung masses, allowing for accurate prediction of outcome, parental counseling, and planning of pregnancy and n...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-011-2171-7
更新日期:2012-01-01 00:00:00
abstract::This multicenter collaborative study was undertaken to review the types and complications of femoral neck fractures in children. It is a retrospective clinical and radiological review of 108 femoral neck fractures. Cases originated from four different pediatric hospitals. All the patients had plain radiographs. Fractu...
journal_title:Pediatric radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/BF02012436
更新日期:1993-01-01 00:00:00
abstract::In hypertrophic pyloric stenosis (HPS), prompt pyloromyotomy is, in general, the treatment of choice. There has been no information available as to the natural history of the pyloric tumour. We present four infants with medically treated HPS who were followed by sonography to observe the anatomical changes that occur ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050325
更新日期:1998-03-01 00:00:00
abstract::Previous studies have suggested that CT examinations of the brain in children soon after near-drowning incidents are not helpful in predicting clinical outcome and are not necessary. The clinical and CT findings of 19 pediatric near-drowning victims were reviewed for correlation with clinical and neurologic outcome. A...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02010911
更新日期:1993-01-01 00:00:00
abstract::Perlman syndrome is a rare autosomal recessive syndrome of macrosomia and nephromegaly associated with a significant predisposition to Wilms tumor. We report a premature infant with Perlman syndrome to demonstrate additional manifestations of this condition: large cisterna magna, intestinal malrotation, and skeletal a...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::We review our experience with unusual ocular pathologies, some mimicking retinoblastoma, that were referred to our institution during the past two decades. After presenting the imaging anatomy of the normal eye, we discuss pertinent clinical and pathological features, and illustrate the US and MRI appearance of retino...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-012-2374-6
更新日期:2012-06-01 00:00:00
abstract::Three very low birth weight infants, treated with frusemide for broncho-pulmonary dysplasia are described. They all developed medullary nephrocalcinosis identifiable by real time ultrasound. The sonographic findings of diffuse medullary hyper-echogenicity appears to be specific for nephrocalcinosis. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02389002
更新日期:1988-01-01 00:00:00
abstract::In infants and children the association of paravertebral widening and abdominal tumour has been regarded as typical of neuroblastoma. However, a paraspinal mass may develop in other malignant tumours too, but seems to be extremely rare in nephroblastoma. The fourth case so far on record is reported. Microscopically th...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00971775
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Phalangeal microgeodic syndrome is an uncommon benign self-limiting condition that often occurs during cold weather. The etiology and the pathogenesis of the disease remain unclear. OBJECTIVE:To report a series of children with phalangeal microgeodic syndrome. MATERIALS AND METHODS:Twenty children with pha...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-018-4137-5
更新日期:2018-08-01 00:00:00