Abstract：
Background:We aimed to assess the frequency and structure of chromosomal abnormalities as well as the distribution of the indications of prenatal diagnosis in 4206 cases of high-risk pregnant women. Methods:A retrospective analysis of cytogenetic studies of 4206 pregnant women with indications of amniocentesis, referred to Linyi Women and Children's Hospital, Shandong Province, Linyi, China in 2016-2017, was performed. Among those, 4191 amniotic fluid specimens were successfully extracted and cultured, and received karyotype diagnosis. Results:A total of 358 abnormal karyotypes were detected and the abnormal rate was 8.54%. Among them, autosomal aneuploidy was the most common pattern occupied 64.53% and the detection rate was 5.51%, of which 173 (48.32%) cases were 21-trisomy, which was the main type of abnormal karyotypes, followed by 18-trisomy (14.25%). There were 38 cases with sex chromosome aneuploidy, including 47, XXY, 47, XXX, 47, XYY, 69, XXX and 45, X0, accounting for 10.61% of the total chromosome abnormalities and the detection rate was 0.91%. Chromosome structural disorders occupied 10.61% (38/358) of the chromosome abnormalities, including Robertson translocation (16 cases), balance translocation (14 cases), inversion (3 cases), deletion (3 cases), and so on. Chromosome polymorphism was 10.61% too. Other uncommon abnormal karyotypes included mosaicism (11/358), marker chromosome (1.3%). Advanced age and serological screening for high risk were the major prenatal diagnostic indications for pregnant women with chromosomal abnormalities. Conclusion:The karyotype analysis of amniotic fluid cells in pregnant women with different amniocentisis indications can effectively prevent the birth of fetuses with chromosomal diseases and reduce the risk of fetal malformation.
journal_name
Iran J Public Healthjournal_title
Iranian journal of public healthauthors
Li H,Li Y,Zhao R,Zhang Ysubject
Has Abstractpub_date
2019-01-01 00:00:00pages
126-131issue
1eissn
2251-6085issn
2251-6093journal_volume
48pub_type
杂志文章abstract：Background:There is no published study evaluating the performance of cumulative sum (CUSUM) algorithm on meningitis data with limited baseline period. This study aimed to evaluate the CUSUM performance in timely detection of 707 semi-synthetic outbreak days. Methods:Simulated outbreaks were generated using syndromic d...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Solving the dilemma of the organ shortage in Malaysia requires educating Malaysians about organ donation and transplantation. This paper aims at exploring the average Malaysian households ' preferred channels of campaigns and the preferred campaigners in a family setting, targeting at the dialysis family mem...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2019-10-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of public health
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abstract：BACKGROUND:Students emotional health and bullying behavior are receiving greater attention worldwide due to their long-term effects on students' health. The purpose of this study was to examine the relationships between perceived school climate, peer support, teacher support, school pressure and emotional health and bu...
journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-08-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2015-12-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2018-09-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2019-05-01 00:00:00
abstract：Background:We aimed to evaluate the efficacy of mineral trioxide aggregate (MTA) in the treatment of endodontic disease. Methods:Oversell, 384 patients with endodontic disease treated in Xuzhou Stomatological Hospital, Xuzhou, China, from June 2015 to June 2017 were selected, and randomly divided into four groups with...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2019-04-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2015-06-01 00:00:00
abstract：Background:One of the major causes of various work-related health problems among nurses is occupational stress. Hence, the main purpose of the present research was to find association between occupational stress of nurses and risk factors of cardiovascular disease. Methods:In this cross-sectional study, the Osipow job...
journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：10.18502/ijph.v49i10.4699
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of public health
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doi：
更新日期：2013-07-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2015-07-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2019-11-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-12-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
