Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice.

Abstract:

:The germ line provides the cellular link between generations of multicellular organisms, its cells entering the meiotic cell cycle only once each generation. However, the mechanisms governing this initiation of meiosis remain poorly understood. Here, we examined cells undergoing meiotic initiation in mice, and we found that initiation involves the dramatic upregulation of a transcriptional network of thousands of genes whose expression is not limited to meiosis. This broad gene expression program is directly upregulated by STRA8, encoded by a germ cell-specific gene required for meiotic initiation. STRA8 binds its own promoter and those of thousands of other genes, including meiotic prophase genes, factors mediating DNA replication and the G1-S cell-cycle transition, and genes that promote the lengthy prophase unique to meiosis I. We conclude that, in mice, the robust amplification of this extraordinarily broad transcription program by a common factor triggers initiation of meiosis.

journal_name

Elife

journal_title

eLife

authors

Kojima ML,de Rooij DG,Page DC

doi

10.7554/eLife.43738

subject

Has Abstract

pub_date

2019-02-27 00:00:00

issn

2050-084X

pii

43738

journal_volume

8

pub_type

杂志文章

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