Abstract:
:The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combined blood cell counts and their ratios. Several large observational studies have demonstrated the value of shifts in PLR in evaluating the severity of systemic inflammation and predicting infections and other comorbidities, in inflammatory rheumatic diseases. The value of PLR as an inflammatory marker increases when its fluctuations are interpreted along with other complementary hematologic indices, particularly the neutrophil-to-lymphocyte ratio (NLR), which provides additional information about the disease activity, presence of neutrophilic inflammation, infectious complications, and severe organ damage in systemic lupus erythematosus. PLR and NLR have high predictive value in rheumatic diseases with predominantly neutrophilic inflammation (e.g., Behçet disease and familial Mediterranean fever). High PLR, along with elevated platelet count, is potentially useful in diagnosing some systemic vasculitides, particularly giant-cell arteritis. A few longitudinal studies on rheumatic diseases have demonstrated a decrease in PLR in response to anti-inflammatory therapies. The main limitations of PLR studies are preanalytical faults, inadequate standardization of laboratory measurements, and inappropriate subject selection. Nonetheless, accumulating evidence suggests that PLR can provide valuable information to clinicians who encounter multisystem manifestations of rheumatic diseases, which are reflected in shifts in platelet, lymphocyte, neutrophil, or monocyte counts. Interpretation of PLR combined with complementary hematologic indices is advisable to more accurately diagnose inflammatory rheumatic diseases and predict related comorbidities.
journal_name
Ann Lab Medjournal_title
Annals of laboratory medicineauthors
Gasparyan AY,Ayvazyan L,Mukanova U,Yessirkepov M,Kitas GDdoi
10.3343/alm.2019.39.4.345subject
Has Abstractpub_date
2019-07-01 00:00:00pages
345-357issue
4eissn
2234-3806issn
2234-3814pii
39.345journal_volume
39pub_type
杂志文章,评审abstract:BACKGROUND:Clarithromycin, amoxicillin, metronidazole, tetracycline, and levofloxacin have been commonly used for the eradication of Helicobacter pylori. We compared the change in antibiotic resistance of H. pylori strains during two separate periods and investigated the effect of antibiotic resistance on H. pylori era...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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journal_title:Annals of laboratory medicine
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更新日期:2015-07-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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journal_title:Annals of laboratory medicine
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更新日期:2017-11-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2014.34.6.446
更新日期:2014-11-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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更新日期:2018-01-01 00:00:00