Abstract:
:Subjective cognitive decline (SCD) is frequently reported in diabetic patients. Diabetes mellitus (DM) is associated with changes in the microstructure of the brain arise in diabetic patients, including changes in gray matter volume (GMV). However, the underlying mechanisms of changes in GMV in DM patients with cognitive impairment remain uncertain. Here, we present an overview of amyloid-β-dependent cognitive impairment in DM patients with SCD. Moreover, we review the evolving insights from studies on the GMV changes in GMV and cognitive dysfunction to which provide the mechanisms of cognitive impairment in T2DM. Ultimately, the novel structural magnetic resonance imaging (MRI) protocol was used for detecting neuroimaging biomarkers that can predict the clinical outcomes in diabetic patients with SCD. A reliable MRI protocol would be helpful to detect neurobiomarkers, and to understand the pathological mechanisms of preclinical cognitive impairment in diabetic patients.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Dong Y,Wang Q,Yao H,Xiao Y,Wei J,Xie P,Hu J,Chen W,Tang Y,Zhou H,Liu Jdoi
10.1002/jcp.28359subject
Has Abstractpub_date
2019-08-01 00:00:00pages
16838-16846issue
10eissn
0021-9541issn
1097-4652journal_volume
234pub_type
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