Potential thermodynamic and kinetic roles of phytate as an inhibitor of kidney stone formation: theoretical modelling and crystallization experiments.

Abstract:

:Kidney stone formation is governed by thermodynamic (supersaturation) and kinetic (crystal nucleation, growth, aggregation) mechanisms. We adopted a dual theoretical and experimental approach to investigate the potential role of urinary phytate in this regard. Thermodynamic constants for eight protonated phytate species and seven calcium-phytate complexes were determined by potentiometry and incorporated into the speciation program JESS. Urine was collected from 16 heathy males and their urine compositions were used as input for JESS. Phytate concentration was varied during modelling. No statistically significant decreases in Ca2+ concentrations or in supersaturation values were predicted by JESS. Crystallization experiments were then performed in pooled urine. Endogenous phytate concentration was determined using a metal-dye assay. The pool was dosed with various concentrations of phytate to achieve final concentrations equivalent to those used for modelling. Experiments showed that phytate had no effects on Ca2+ concentrations (as predicted by our theoretical modelling), metastable limits or crystal nucleation and growth kinetics. However, crystal aggregation kinetics was inhibited. We speculate that HPhy-11, small amounts of which were revealed by modelling, may bind to crystal surfaces and inhibit aggregation. We conclude that phytate exerts a kinetic, but not a thermodynamic inhibitory effect on crystallization in urine.

journal_name

Urolithiasis

journal_title

Urolithiasis

authors

Fakier S,Rodgers A,Jackson G

doi

10.1007/s00240-019-01117-1

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

493-502

issue

6

eissn

2194-7228

issn

2194-7236

pii

10.1007/s00240-019-01117-1

journal_volume

47

pub_type

杂志文章
  • A preliminary study: the role of preoperative procalcitonin in predicting postoperative fever after mini-percutaneous nephrolithotomy in patients with a negative baseline urine culture.

    abstract::To evaluate the role of preoperative procalcitonin (PCT) levels in predicting postoperative fever after mini-percutaneous nephrolithotomy (mini-PCNL) in patients with a negative baseline urine culture. Between January 2014 and October 2017, 329 patients with a negative baseline urine culture and who underwent mini-PCN...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-019-01115-3

    authors: Li D,Sha M,Chen L,Xiao Y,Lu J,Shao Y

    更新日期:2019-10-01 00:00:00

  • Race, ethnicity and urolithiasis: a critical review.

    abstract::Using combinations of the key words urolithiasis, kidney stones, race, ethnicity, population group in Google Scholar and Pubmed, a literature search identified 40 articles. Of these, 33 satisfied the principal inclusion criterion of studies involving comparison of at least two groups in which there is a perceived diff...

    journal_title:Urolithiasis

    pub_type: 杂志文章,评审

    doi:10.1007/s00240-012-0516-9

    authors: Rodgers AL

    更新日期:2013-04-01 00:00:00

  • Proposition for new terminologies in PCNL: what does 'ultra-mini-micro' actually mean?

    abstract::Ever smaller miniaturised techniques are being developed for percutaneous nephrolithotomy (PCNL), with access sheaths now as small as 4.8Fr being used in adults. With the ever expanding use of the terms "micro" "mini" or "ultra" techniques, the terminology can be somewhat confusing. We propose a simple classification ...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-014-0696-6

    authors: Wright AE,Somani BK,Rukin NJ

    更新日期:2014-12-01 00:00:00

  • Plasma oxalate: comparison of methodologies.

    abstract::Measurement of oxalate in the blood is essential for monitoring primary hyperoxaluria patients with progressive renal impairment and on dialysis prior to transplantation. As no external quality assurance scheme is available for this analyte, we conducted a sample exchange scheme between six laboratories specifically i...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-020-01197-4

    authors: Stokes F,Acquaviva-Bourdain C,Hoppe B,Lieske JC,Lindner E,Toulson G,Vaz FM,Rumsby G

    更新日期:2020-12-01 00:00:00

  • Multiple tracts percutaneous nephrolithotomy assisted by LithoClast master in one session for staghorn calculi: report of 117 cases.

    abstract::The objective of the study is to evaluate the safety, efficacy and outcome of multiple tracts percutaneous nephrolithotomy (PCNL) assisted by LithoClast master (the third-generation Electro Medical System) in one session for the treatment of staghorn calculi. From October 2011 to March 2013, 117 patients with staghorn...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-013-0632-1

    authors: Chen J,Zhou X,Chen Z,Liu L,Jiang L,Chen C,Qi L,Zu X,Chen H

    更新日期:2014-04-01 00:00:00

  • Comparison of silodosin to tamsulosin for medical expulsive treatment of ureteral stones: a systematic review and meta-analysis.

    abstract::This study aimed at comparing the success rates of silodosin to the most commonly used for medical expulsive therapy (MET) tamsulosin for the management of ureteral stones. A systematic review using the search string: "silodosin AND (ston* OR calcu* OR expul*)" was conducted on Pubmed, SCOPUS, Web of Science, Cochrane...

    journal_title:Urolithiasis

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00240-016-0872-y

    authors: Özsoy M,Liatsikos E,Scheffbuch N,Kallidonis P

    更新日期:2016-11-01 00:00:00

  • Comparing non contrast computerized tomography criteria versus dual X-ray absorptiometry as predictors of radio-opaque upper urinary tract stone fragmentation after electromagnetic shockwave lithotripsy.

    abstract::The objective of this study was to assess the value of dual X-ray absorptiometry (DXA) in comparison to non contrast computed tomography (NCCT) density as possible predictors of upper urinary tract stone disintegration by shock wave lithotripsy (SWL). This study included 100 consecutive patients, with solitary renal s...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-013-0596-1

    authors: Hameed DA,Elgammal MA,ElGanainy EO,Hageb A,Mohammed K,El-Taher AM,Mostafa MM,Ahmed AI

    更新日期:2013-11-01 00:00:00

  • Early ureteral catheter removal after ureteroscopic lithotripsy using ureteral access sheath.

    abstract::A ureteral access sheath (UAS) can facilitate ureteroscopy (URS) and the retrieval of stone fragments while reducing the intrarenal pressure, thereby improving irrigate flow and decreasing the length of an operation. Ureteral stenting after URS is unnecessary for uncomplicated cases. This study examined the early remo...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-012-0518-7

    authors: Kawahara T,Ito H,Terao H,Kakizoe M,Kato Y,Uemura H,Kubota Y,Matsuzaki J

    更新日期:2013-02-01 00:00:00

  • The surgical experience influences the safety of retrograde intrarenal surgery for kidney stones: a propensity score analysis.

    abstract::The aim of this study is to evaluate if surgical experience could influence the outcomes of retrograde intrarenal surgery (RIRS) in terms of stone clearance and complication rate. Patients from five institutions were included in this study. Patients were divided into two groups. Group 1: patients treated by three surg...

    journal_title:Urolithiasis

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00240-016-0919-0

    authors: Berardinelli F,Cindolo L,De Francesco P,Proietti S,Hennessey D,Dalpiaz O,Cracco CM,Pellegrini F,Scoffone CM,Schips L,Giusti G

    更新日期:2017-08-01 00:00:00

  • Bone mineral density in adolescent urinary stone formers: is sex important?

    abstract::Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This pilot study was undertaken to assess an adolescent kidney stone cohort'...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-020-01183-w

    authors: Kusumi K,Schwaderer AL,Clark C,Budge K,Hussein N,Raina R,Denburg M,Safadi F

    更新日期:2020-08-01 00:00:00

  • Genetics of common complex kidney stone disease: insights from genome-wide association studies.

    abstract::Kidney stone disease is a common disorder in Western countries that is associated with significant suffering, morbidity, and cost for the healthcare system. Numerous studies have demonstrated familial aggregation of nephrolithiasis and a twin study estimated the heritability to be 56%. Over the past decade, genome-wid...

    journal_title:Urolithiasis

    pub_type: 杂志文章,评审

    doi:10.1007/s00240-018-1094-2

    authors: Palsson R,Indridason OS,Edvardsson VO,Oddsson A

    更新日期:2019-02-01 00:00:00

  • A preliminary survey of practice patterns across several European kidney stone centers and a call for action in developing shared practice.

    abstract::Currently an evidence-based approach to nephrolithiasis is hampered by a lack of randomized controlled trials. Thus, there is a need for common platforms for data sharing and recruitment of patients to interventional studies. A first step in achieving this objective would be to share practice methods and protocols for...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-019-01119-z

    authors: Ferraro PM,Arrabal-Polo MÁ,Capasso G,Croppi E,Cupisti A,Ernandez T,Fuster DG,Galan JA,Grases F,Hoorn EJ,Knauf F,Letavernier E,Mohebbi N,Moochhala S,Petkova K,Pozdzik A,Sayer J,Seitz C,Strazzullo P,Trinchieri A,Vez

    更新日期:2019-06-01 00:00:00

  • Correction to: Recent advances in the identification and management of inherited hyperoxalurias.

    abstract::The original version of this article unfortunately contained a mistake. On page 84, the dose for oral potassium citrate is incorrectly written as "0.1 mg/kg/day divided BID-QID for children, 30-60 mg per day divided BID-QID for adults". ...

    journal_title:Urolithiasis

    pub_type: 已发布勘误

    doi:10.1007/s00240-019-01166-6

    authors: Sas DJ,Harris PC,Milliner DS

    更新日期:2020-02-01 00:00:00

  • Transient renal impairment in the absence of pre-existing chronic kidney disease in patients with unilateral ureteric stone impaction.

    abstract::This study aims to describe the rate and characteristics of transient renal impairment in unilateral ureteric stone patients without chronic kidney disease (CKD) and to identify factors that may have influenced renal function of these patients. Unilateral ureteric stone patients who visited our hospital's emergency de...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-016-0904-7

    authors: Kim HY,Choe HS,Lee DS,Yoo JM,Lee SJ

    更新日期:2017-06-01 00:00:00

  • Metabolic risk-evaluation and prevention of recurrence in stone disease: does it make sense?

    abstract::In this review, aspects on the importance of information on urine composition and selection of the most appropriate regimen for prevention of recurrence are discussed. For patients with urolithiasis the treatment is facilitated by urine analysis with estimates of supersaturation levels. Despite lack of strong scientif...

    journal_title:Urolithiasis

    pub_type: 杂志文章,评审

    doi:10.1007/s00240-015-0840-y

    authors: Tiselius HG

    更新日期:2016-02-01 00:00:00

  • What is the fate of insignificant residual fragment following percutaneous nephrolithotomy in pediatric patients with anomalous kidney? A comparison with normal kidney.

    abstract::Pediatric population has increasing incidence of renal calculus and it is estimated to be around 50/10,000 population. The treatment of choice for large and complex stone in anomalous kidney is percutaneous nephrolithotomy (PCNL). The fate of insignificant residual fragment after PCNL in pediatric patients is not well...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-017-0980-3

    authors: Purkait B,Sinha RJ,Bansal A,Sokhal AK,Singh K,Singh V

    更新日期:2018-06-01 00:00:00

  • Comparative evaluation of efficacy of use of naftopidil and/or celecoxib for medical treatment of distal ureteral stones.

    abstract::We performed a randomized, prospective study to assess the possible role of combined a1D-receptor antagonist naftopidil and nonsteroidal anti-inflammatory hormones celecoxib for the spontaneous expulsion of distal ureteral stones. Patients were randomized to one of the three treatment groups. Treatment group 1 patient...

    journal_title:Urolithiasis

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00240-014-0708-6

    authors: Lv JL,Tang QL

    更新日期:2014-12-01 00:00:00

  • The effect of climate variability on urinary stone attacks: increased incidence associated with temperature over 18 °C: a population-based study.

    abstract::The aim of this study was to evaluate the effect of seasonal variation and climate parameters on urinary tract stone attack and investigate whether stone attack is increased sharply at a specific point. Nationwide data of total urinary tract stone attack numbers per month between January 2006 and December 2010 were ob...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-014-0741-5

    authors: Park HK,Bae SR,Kim SE,Choi WS,Paick SH,Ho K,Kim HG,Lho YS

    更新日期:2015-02-01 00:00:00

  • Metabolic disturbances in Chinese children with urolithiasis: a single center report.

    abstract::Urinary stones and urine composition are the first steps in the process of recurrence prevention, but data concerning the association between the two compositions are scarce in Chinese children with urolithiasis. We retrospectively analyzed the records of children (age range 0-18 years) with urolithiasis in our center...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-016-0910-9

    authors: Yang D,Tiselius HG,Lan C,Chen D,Chen K,Ou L,Liu Y,Xu S,Zeng G,Lei M,Wu W

    更新日期:2017-06-01 00:00:00

  • Effect of mechanical percussion combined with patient position change on the elimination of upper urinary stones/fragments: a systematic review and meta-analysis.

    abstract::The objective of this study is to explore the efficacy and safety of mechanical percussion combined with changed patient position (MPPP) on elimination of residual stones/fragments in the upper urinary tract. The study was a systematic review and meta-analysis. A systematic literature review using Pubmed, Embase, Medl...

    journal_title:Urolithiasis

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00240-019-01140-2

    authors: Zeng T,Tiselius HG,Huang J,Deng T,Zeng G,Wu W

    更新日期:2020-04-01 00:00:00

  • Mutation analysis of SLC3A1 and SLC7A9 genes in patients with cystinuria.

    abstract::Cystinuria is an autosomal inherited disorder of renal reabsorption of cystine, arginine, lysine, and ornithine. Increased urinary excretion of cystine results in the formation of kidney stones. Considering the few studies on the genetic basis of the cystinuria in the Middle East and the population-specific distributi...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-015-0794-0

    authors: Koulivand L,Mohammadi M,Ezatpour B,Salehi R,Markazi S,Dashti S,Kheirollahi M

    更新日期:2015-10-01 00:00:00

  • Tubeless procedure reduces hospitalization and pain after percutaneous nephrolithotomy: results of a multivariable analysis.

    abstract::The objective of the study was to assess the efficacy and safety of tubeless percutaneous nephrolithotomy (t-PCNL) in comparison with standard PCNL (s-PCNL). We retrospectively evaluated 317 consecutive PCNL and compared perioperative results, time of hospitalization and analgesic requirement of t-PCNL (114; 36.0 %) t...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-013-0565-8

    authors: Garofalo M,Pultrone CV,Schiavina R,Brunocilla E,Sanguedolce F,Borghesi M,Rocca C,Del Prete C,Morselli-Labate AM,Paccapelo A,Martorana G

    更新日期:2013-08-01 00:00:00

  • Limitation of apoptotic changes and crystal deposition by Tutukon following hyperoxaluria-induced tubular cell injury in rat model.

    abstract::This study aimed at evaluating the protective effects of a herbal medication (Tutukon) on the hyperoxaluria induced apoptotic changes and crystal deposition in renal tubular epithelium in rat model. 60 male wistar rats were divided into three different groups (each group n: 20). In Group I severe hyperoxaluria was ind...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-015-0777-1

    authors: Sahin C,Sarikaya S,Basak K,Cetinel CA,Narter F,Eryildirim B,Saglam E,Sarica K

    更新日期:2015-08-01 00:00:00

  • Predictive value of ureteral wall thickness (UWT) assessment on the success of internal ureteral stent insertion in cases with obstructing ureteral calculi.

    abstract::To evaluate the possible role of ureteral wall thickness (UWT) assessment in the prediction of the success for stent placement in cases with obstructing ureteric stones. 227 adult patients with a single unilateral obstructing ureteral stone requiring internal ureteral stent placement were included. In addition to ston...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-020-01233-3

    authors: Sarica K,Eryildirim B,Akdere H,Karagoz MA,Karaca Y,Sahan A

    更新日期:2021-01-02 00:00:00

  • Does extracorporeal shock wave lithotripsy-related pain get affected by menstrual cycle and menopause?

    abstract::The objective of the study was to investigate the effect of the menstrual cycle and menopause on extracorporeal shock wave lithotripsy (ESWL)-related pain outcome. Since March 2017, we evaluated a total of 145 women who underwent the first session of ESWL for renal or ureteral stones. Patients were divided into two gr...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-018-1084-4

    authors: Islamoglu E,Tas S,Karamik K,Yalcinkaya S,Tokgoz H,Savas M

    更新日期:2019-12-01 00:00:00

  • Dietary recommendations and treatment of patients with recurrent idiopathic calcium stone disease.

    abstract::This review describes the various dietary regimens that have been used to advise patients on how to prevent the recurrence of their calcium-containing kidney stones. The conclusion is that although there is some general advice that may be useful to many patients, it is more efficacious to screen each patient individua...

    journal_title:Urolithiasis

    pub_type: 杂志文章,评审

    doi:10.1007/s00240-015-0849-2

    authors: Robertson WG

    更新日期:2016-02-01 00:00:00

  • Comparison of microperc and mini-percutaneous nephrolithotomy for medium-sized lower calyx stones.

    abstract::The objective of this study was to present the outcomes of comparative clinical study of microperc versus mini-percutaneous nephrolithotomy (mini-PNL) in the treatment of lower calyx stones of 10-20 mm. Patients with lower calyx stones treated with microperc (Group-1) or mini-PNL (Group-2) between 2011 and 2014 were r...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-015-0804-2

    authors: Tok A,Akbulut F,Buldu I,Karatag T,Kucuktopcu O,Gurbuz G,Istanbulluoglu O,Armagan A,Tepeler A,Tasci AI

    更新日期:2016-04-01 00:00:00

  • Transurethral holmium-YAG laser lithotripsy for large symptomatic prostatic calculi: initial experience.

    abstract::Symptomatic prostatic calculi are a rare clinical entity with wide range of management options, however, there is no agreement about the preferred method for treating these symptomatic calculi. In this study we describe our experience of transurethral management of symptomatic prostatic calculi using holmium-YAG laser...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-013-0571-x

    authors: Goyal NK,Goel A,Sankhwar S

    更新日期:2013-08-01 00:00:00

  • Site of impaction of ureteric calculi requiring surgical intervention.

    abstract::Textbooks describe three narrowest anatomic sites in the ureter as the most likely places for ureteral calculi to lodge, these are: the pelvi-ureteric junction (PUJ), the point where the ureters cross over the iliac vessels and the ureterovesical junction (UVJ). The purpose of this study is to determine whether calcul...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-013-0605-4

    authors: El-Barky E,Ali Y,Sahsah M,Terra AA,Kehinde EO

    更新日期:2014-02-01 00:00:00

  • Ureteral wall volume at ureteral stone site is a critical predictor for shock wave lithotripsy outcomes: comparison with ureteral wall thickness and area.

    abstract::Our objectives were to compare measurements of ureteral wall area, ureteral wall volume and ureteral wall thickness for their use in prediction of shock wave lithotripsy outcomes. We retrospectively identified 218 patients that underwent shock wave lithotripsy for ureteral calculi with pretreatment non-contrast comput...

    journal_title:Urolithiasis

    pub_type: 杂志文章

    doi:10.1007/s00240-019-01154-w

    authors: Yamashita S,Kohjimoto Y,Iguchi T,Nishizawa S,Kikkawa K,Hara I

    更新日期:2020-08-01 00:00:00