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NATURE文献大全abstract::Methane-oxidizing bacteria (methanotrophs) require large quantities of copper for the membrane-bound (particulate) methane monooxygenase. Certain methanotrophs are also able to switch to using the iron-containing soluble methane monooxygenase to catalyse methane oxidation, with this switchover regulated by copper. Met...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14854
更新日期:2015-09-03 00:00:00
abstract::The generation of a double-strand break in the Saccharomyces cerevisiae genome is a potentially catastrophic event that can induce cell-cycle arrest or ultimately result in loss of cell viability. The repair of such lesions is strongly dependent on proteins encoded by the RAD52 epistasis group of genes (RAD50-55, RAD5...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/34950
更新日期:1998-01-22 00:00:00
abstract::XX female mammals undergo transcriptional silencing of most genes on one of their two X chromosomes to equalize X-linked gene dosage with XY males in a process referred to as X-chromosome inactivation (XCI). XCI is an example of epigenetic regulation. Once enacted in individual cells of the early female embryo, XCI is...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08161
更新日期:2009-07-30 00:00:00
abstract::In 2001 the Intergovernmental Panel on Climate Change projected the contribution to sea level rise from the Greenland ice sheet to be between -0.02 and +0.09 m from 1990 to 2100 (ref. 1). However, recent work has suggested that the ice sheet responds more quickly to climate perturbations than previously thought, parti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05168
更新日期:2006-09-21 00:00:00
abstract::Eukaryotic structural gene mutations occurring spontaneously in a mouse myeloma cell line offer the opportunity to study somatic mutation in animal cells at the molecular level. Studies on the myeloma protein and on mRNA have enabled us to characterise four such mutants representing four different mutation mechanisms....
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/265299a0
更新日期:1977-01-27 00:00:00
abstract::Oligomerization of membrane proteins in response to lipid binding has a critical role in many cell-signalling pathways but is often difficult to define or predict. Here we report the development of a mass spectrometry platform to determine simultaneously the presence of interfacial lipids and oligomeric stability and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20820
更新日期:2017-01-19 00:00:00
abstract::Eukaryotes and archaea use a protease called the proteasome that has an integral role in maintaining cellular function through the selective degradation of proteins. Proteolysis occurs in a barrel-shaped 20S core particle, which in Thermoplasma acidophilum is built from four stacked homoheptameric rings of subunits, α...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09444
更新日期:2010-10-14 00:00:00
abstract::The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs). Although hundreds of ISGs have been identified since their discovery more than 25 years ago, only a few have been characterized with res...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09907
更新日期:2011-04-28 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-019-00710-z
更新日期:2019-03-01 00:00:00
abstract::In order to direct a movement towards a visual stimulus, visual spatial information must be combined with postural information. For example, directing gaze (eye plus head) towards a visible target requires the combination of retinal image location with eye and head position to determine the location of the target rela...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/29777
更新日期:1998-08-27 00:00:00
abstract::Magnetic compass information has a key role in bird orientation, but the physiological mechanisms enabling birds to sense the Earth's magnetic field remain one of the unresolved mysteries in biology. Two biophysical mechanisms have become established as the most promising magnetodetection candidates. The iron-mineral-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08528
更新日期:2009-10-29 00:00:00
abstract::Ultrafast time-resolved optical spectroscopy has revealed new classes of physical, chemical and biological reactions, in which directed, deterministic motions of atoms have a key role. This contrasts with the random, diffusive motion of atoms across activation barriers that typically determines kinetic rates on slower...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35065045
更新日期:2001-03-01 00:00:00
abstract::Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature24050
更新日期:2017-10-19 00:00:00
abstract::An alphabeta T-cell response depends on the recognition of antigen plus major histocompatibility complex (MHC) proteins by its antigen receptor (TCR). The ability of peripheral alphabeta T cells to recognize MHC is at least partly determined by MHC-dependent thymic selection, by which an immature T cell survives only ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07812
更新日期:2009-04-23 00:00:00
abstract::Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances i...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature03723
更新日期:2005-06-02 00:00:00
abstract::The human nose is often considered something of a luxury, but in the rest of the animal world, from bacteria to mammals, detecting chemicals in the environment has been critical to the successful organism. An indication of the importance of olfactory systems is the significant proportion - as much as 4% - of the genom...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35093026
更新日期:2001-09-13 00:00:00
abstract::Recognition of an avirulent pathogen triggers the rapid production of the reactive oxygen intermediates superoxide (O2-) and hydrogen peroxide (H2O2). This oxidative burst drives crosslinking of the cell wall, induces several plant genes involved in cellular protection and defence, and is necessary for the initiation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/29087
更新日期:1998-08-06 00:00:00
abstract::On 12 May 2008, the devastating magnitude 7.9 (Wenchuan) earthquake struck the eastern edge of the Tibetan plateau, collapsing buildings and killing thousands in major cities aligned along the western Sichuan basin in China. After such a large-magnitude earthquake, rearrangement of stresses in the crust commonly leads...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07177
更新日期:2008-07-24 00:00:00
abstract::Quantum mechanical experiments in ring geometries have long fascinated physicists. Open rings connected to leads, for example, allow the observation of the Aharonov-Bohm effect, one of the best examples of quantum mechanical phase coherence. The phase coherence of electrons travelling through a quantum dot embedded in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35101552
更新日期:2001-10-25 00:00:00
abstract::The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NA...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314592a0
更新日期:1985-04-18 00:00:00
abstract::Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/310138a0
更新日期:1984-07-12 00:00:00
abstract::It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313678a0
更新日期:1985-02-21 00:00:00
abstract::Transformation of the well-studied maize transposable elements into other plant species should enable transposon tagging methodology to be used for the isolation of interesting genes in the heterologous host. Here we describe the isolation of a transposon-tagged male sterile mutant in Arabidopsis thaliana using the ma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363715a0
更新日期:1993-06-24 00:00:00
abstract::The global burden of malaria has been substantially reduced over the past two decades. Future efforts to reduce malaria further will require moving beyond the treatment of clinical infections to targeting malaria transmission more broadly in the community. As such, the accurate identification of asymptomatic human inf...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16039
更新日期:2015-12-03 00:00:00
abstract::Processes such as the scattering of alpha particles ((4)He), the triple-alpha reaction, and alpha capture play a major role in stellar nucleosynthesis. In particular, alpha capture on carbon determines the ratio of carbon to oxygen during helium burning, and affects subsequent carbon, neon, oxygen, and silicon burning...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16067
更新日期:2015-12-03 00:00:00
abstract::The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields informatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16949
更新日期:2016-02-11 00:00:00
abstract::Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25168
更新日期:2018-01-11 00:00:00
abstract::Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease suscep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329599a0
更新日期:1987-10-15 00:00:00
abstract::The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy. However, the existence of these multipotent MaSCs remains controversial and the nature of such cells is unknown. Here we demonstrate that protein C receptor (Proc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13851
更新日期:2015-01-01 00:00:00
abstract::RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a central control point for cellular function. Here we investigate the transcription dynamics of single RNAP II molecules from S...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05701
更新日期:2007-04-12 00:00:00