Abstract:
:Longitudinal genomics data and survival outcome are common in biomedical studies, where the genomics data are often of high dimension. It is of great interest to select informative longitudinal biomarkers (e.g. genes) related to the survival outcome. In this paper, we develop a computationally efficient tool, LCox, for selecting informative biomarkers related to the survival outcome using the longitudinal genomics data. LCox is powerful to detect different forms of dependence between the longitudinal biomarkers and the survival outcome. We show that LCox has improved performance compared to existing methods through extensive simulation studies. In addition, by applying LCox to a dataset of patients with idiopathic pulmonary fibrosis, we are able to identify biologically meaningful genes while all other methods fail to make any discovery. An R package to perform LCox is freely available at https://CRAN.R-project.org/package=LCox.
journal_name
Stat Appl Genet Mol Biolauthors
Sun J,Herazo-Maya JD,Wang JL,Kaminski N,Zhao Hdoi
10.1515/sagmb-2017-0060subject
Has Abstractpub_date
2019-02-13 00:00:00issue
2eissn
2194-6302issn
1544-6115pii
/j/sagmb.ahead-of-print/sagmb-2017-0060/sagmb-2017journal_volume
18pub_type
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