Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota.

Abstract:

BACKGROUND:Disruption of the gut microbiota homeostasis may induce low-grade inflammation leading to obesity-associated diseases. A major protective mechanism is to use the multi-layered mucus structures to keep a safe distance between gut epithelial cells and microbiota. To investigate whether pesticides would induce insulin resistance/obesity through interfering with mucus-bacterial interactions, we conducted a study to determine how long-term exposure to chlorpyrifos affected C57Bl/6 and CD-1 (ICR) mice fed high- or normal-fat diets. To further investigate the effects of chlorpyrifos-altered microbiota, antibiotic treatment and microbiota transplantation experiments were conducted. RESULTS:The results showed that chlorpyrifos caused broken integrity of the gut barrier, leading to increased lipopolysaccharide entry into the body and finally low-grade inflammation, while genetic background and diet pattern have limited influence on the chlorpyrifos-induced results. Moreover, the mice given chlorpyrifos-altered microbiota had gained more fat and lower insulin sensitivity. CONCLUSIONS:Our results suggest that widespread use of pesticides may contribute to the worldwide epidemic of inflammation-related diseases.

journal_name

Microbiome

journal_title

Microbiome

authors

Liang Y,Zhan J,Liu D,Luo M,Han J,Liu X,Liu C,Cheng Z,Zhou Z,Wang P

doi

10.1186/s40168-019-0635-4

subject

Has Abstract

pub_date

2019-02-11 00:00:00

pages

19

issue

1

issn

2049-2618

pii

10.1186/s40168-019-0635-4

journal_volume

7

pub_type

杂志文章
  • Mentholation affects the cigarette microbiota by selecting for bacteria resistant to harsh environmental conditions and selecting against potential bacterial pathogens.

    abstract:BACKGROUND:There is a paucity of data regarding the microbial constituents of tobacco products and their impacts on public health. Moreover, there has been no comparative characterization performed on the bacterial microbiota associated with the addition of menthol, an additive that has been used by tobacco manufacture...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0235-0

    authors: Chopyk J,Chattopadhyay S,Kulkarni P,Claye E,Babik KR,Reid MC,Smyth EM,Hittle LE,Paulson JN,Cruz-Cano R,Pop M,Buehler SS,Clark PI,Sapkota AR,Mongodin EF

    更新日期:2017-02-15 00:00:00

  • A two-stage microbial association mapping framework with advanced FDR control.

    abstract:BACKGROUND:In microbiome studies, it is important to detect taxa which are associated with pathological outcomes at the lowest definable taxonomic rank, such as genus or species. Traditionally, taxa at the target rank are tested for individual association, followed by the Benjamini-Hochberg (BH) procedure to control fo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0517-1

    authors: Hu J,Koh H,He L,Liu M,Blaser MJ,Li H

    更新日期:2018-07-25 00:00:00

  • Bradymonabacteria, a novel bacterial predator group with versatile survival strategies in saline environments.

    abstract:BACKGROUND:Bacterial predation is an important selective force in microbial community structure and dynamics. However, only a limited number of predatory bacteria have been reported, and their predatory strategies and evolutionary adaptations remain elusive. We recently isolated a novel group of bacterial predators, Br...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00902-0

    authors: Mu DS,Wang S,Liang QY,Du ZZ,Tian R,Ouyang Y,Wang XP,Zhou A,Gong Y,Chen GJ,Van Nostrand J,Yang Y,Zhou J,Du ZJ

    更新日期:2020-08-31 00:00:00

  • Re-evaluating the relationship between missing heritability and the microbiome.

    abstract::Human genome-wide association studies (GWASs) have recurrently estimated lower heritability estimates than familial studies. Many explanations have been suggested to explain these lower estimates, including that a substantial proportion of genetic variation and gene-by-environment interactions are unmeasured in typica...

    journal_title:Microbiome

    pub_type: 信件

    doi:10.1186/s40168-020-00839-4

    authors: Douglas GM,Bielawski JP,Langille MGI

    更新日期:2020-06-08 00:00:00

  • Fine metagenomic profile of the Mediterranean stratified and mixed water columns revealed by assembly and recruitment.

    abstract:BACKGROUND:The photic zone of aquatic habitats is subjected to strong physicochemical gradients. To analyze the fine-scale variations in the marine microbiome, we collected seven samples from a single offshore location in the Mediterranean at 15 m depth intervals during a period of strong stratification, as well as two...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0513-5

    authors: Haro-Moreno JM,López-Pérez M,de la Torre JR,Picazo A,Camacho A,Rodriguez-Valera F

    更新日期:2018-07-10 00:00:00

  • Bacterial community composition of chronic periodontitis and novel oral sampling sites for detecting disease indicators.

    abstract:BACKGROUND:Periodontitis is an infectious and inflammatory disease of polymicrobial etiology that can lead to the destruction of bones and tissues that support the teeth. The management of chronic periodontitis (CP) relies heavily on elimination or at least control of known pathogenic consortia associated with the dise...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-2-32

    authors: Galimanas V,Hall MW,Singh N,Lynch MD,Goldberg M,Tenenbaum H,Cvitkovitch DG,Neufeld JD,Senadheera DB

    更新日期:2014-08-26 00:00:00

  • A comparison of methods used to unveil the genetic and metabolic pool in the built environment.

    abstract:BACKGROUND:A majority of indoor residential microbes originate from humans, pets, and outdoor air and are not adapted to the built environment (BE). Consequently, a large portion of the microbes identified by DNA-based methods are either dead or metabolically inactive. Although many exceptions have been noted, the ribo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0453-0

    authors: Gomez-Silvan C,Leung MHY,Grue KA,Kaur R,Tong X,Lee PKH,Andersen GL

    更新日期:2018-04-16 00:00:00

  • Impact of investigational microbiota therapeutic RBX2660 on the gut microbiome and resistome revealed by a placebo-controlled clinical trial.

    abstract:BACKGROUND:Intestinal microbiota restoration can be achieved by complementing a subject's perturbed microbiota with that of a healthy donor. Recurrent Clostridioides difficile infection (rCDI) is one key application of such treatment. Another emerging application of interest is reducing antibiotic-resistant genes (ARGs...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00907-9

    authors: Kwak S,Choi J,Hink T,Reske KA,Blount K,Jones C,Bost MH,Sun X,Burnham CD,Dubberke ER,Dantas G,CDC Prevention Epicenter Program.

    更新日期:2020-08-31 00:00:00

  • CloVR-ITS: Automated internal transcribed spacer amplicon sequence analysis pipeline for the characterization of fungal microbiota.

    abstract:BACKGROUND:Besides the development of comprehensive tools for high-throughput 16S ribosomal RNA amplicon sequence analysis, there exists a growing need for protocols emphasizing alternative phylogenetic markers such as those representing eukaryotic organisms. RESULTS:Here we introduce CloVR-ITS, an automated pipeline ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-1-6

    authors: White JR,Maddox C,White O,Angiuoli SV,Fricke WF

    更新日期:2013-02-04 00:00:00

  • Encrustations on ureteral stents from patients without urinary tract infection reveal distinct urotypes and a low bacterial load.

    abstract:BACKGROUND:Current knowledge of the urinary tract microbiome is limited to urine analysis and analysis of biofilms formed on Foley catheters. Bacterial biofilms on ureteral stents have rarely been investigated, and no cultivation-independent data are available on the microbiome of the encrustations on the stents. RESU...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0674-x

    authors: Buhmann MT,Abt D,Nolte O,Neu TR,Strempel S,Albrich WC,Betschart P,Zumstein V,Neels A,Maniura-Weber K,Ren Q

    更新日期:2019-04-13 00:00:00

  • Antimicrobial-specific response from resistance gene carriers studied in a natural, highly diverse microbiome.

    abstract:BACKGROUND:Antimicrobial resistance (AMR) is a major threat to public health. Microorganisms equipped with AMR genes are suggested to have partially emerged from natural habitats; however, this hypothesis remains inconclusive so far. To understand the consequences of the introduction of exogenic antimicrobials into nat...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00982-y

    authors: Wicaksono WA,Kusstatscher P,Erschen S,Reisenhofer-Graber T,Grube M,Cernava T,Berg G

    更新日期:2021-01-27 00:00:00

  • Ruminal microbiome-host crosstalk stimulates the development of the ruminal epithelium in a lamb model.

    abstract:BACKGROUND:The development of the rumen is an important physiological challenge for young ruminants. Previous studies have shown that starter feeding can effectively facilitate the growth and development of the rumen in ruminants. However, the mechanism through which starter feeding stimulates the development of the ru...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0701-y

    authors: Lin L,Xie F,Sun D,Liu J,Zhu W,Mao S

    更新日期:2019-06-03 00:00:00

  • Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent model.

    abstract:BACKGROUND:This proof-of-principle study examines whether postnatal, low-dose exposure to environmental chemicals modifies the composition of gut microbiome. Three chemicals that are widely used in personal care products-diethyl phthalate (DEP), methylparaben (MPB), triclosan (TCS)-and their mixture (MIX) were administ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0173-2

    authors: Hu J,Raikhel V,Gopalakrishnan K,Fernandez-Hernandez H,Lambertini L,Manservisi F,Falcioni L,Bua L,Belpoggi F,L Teitelbaum S,Chen J

    更新日期:2016-06-14 00:00:00

  • Shifts among Eukaryota, Bacteria, and Archaea define the vertical organization of a lake sediment.

    abstract:BACKGROUND:Lake sediments harbor diverse microbial communities that cycle carbon and nutrients while being constantly colonized and potentially buried by organic matter sinking from the water column. The interaction of activity and burial remained largely unexplored in aquatic sediments. We aimed to relate taxonomic co...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0255-9

    authors: Wurzbacher C,Fuchs A,Attermeyer K,Frindte K,Grossart HP,Hupfer M,Casper P,Monaghan MT

    更新日期:2017-04-08 00:00:00

  • Consistent responses of soil microbial taxonomic and functional attributes to mercury pollution across China.

    abstract:BACKGROUND:The ecological consequences of mercury (Hg) pollution-one of the major pollutants worldwide-on microbial taxonomic and functional attributes remain poorly understood and largely unexplored. Using soils from two typical Hg-impacted regions across China, here, we evaluated the role of Hg pollution in regulatin...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0572-7

    authors: Liu YR,Delgado-Baquerizo M,Bi L,Zhu J,He JZ

    更新日期:2018-10-18 00:00:00

  • Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms.

    abstract:BACKGROUND:The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution, and development of both players. These interdependencies inspired a new view of multicellular organisms as "metaorganisms." The goal of the Collaborative Research Center "Origin and...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0743-1

    authors: Rausch P,Rühlemann M,Hermes BM,Doms S,Dagan T,Dierking K,Domin H,Fraune S,von Frieling J,Hentschel U,Heinsen FA,Höppner M,Jahn MT,Jaspers C,Kissoyan KAB,Langfeldt D,Rehman A,Reusch TBH,Roeder T,Schmitz RA,Schulenb

    更新日期:2019-09-14 00:00:00

  • Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1 month.

    abstract:BACKGROUND:Early disruption of the microbial community may influence life-long health. Environmental toxicants can contaminate breast milk and the developing infant gut microbiome is directly exposed. We investigated whether environmental toxicants in breastmilk affect the composition and function of the infant gut mic...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0645-2

    authors: Iszatt N,Janssen S,Lenters V,Dahl C,Stigum H,Knight R,Mandal S,Peddada S,González A,Midtvedt T,Eggesbø M

    更新日期:2019-02-27 00:00:00

  • Bloom and bust: intestinal microbiota dynamics in response to hospital exposures and Clostridium difficile colonization or infection.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) is the leading infectious cause of nosocomial diarrhea. Hospitalized patients are at increased risk of developing CDI because they are exposed to C. difficile spores through contact with the hospital environment and often receive antibiotics and other medications that ca...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0156-3

    authors: Vincent C,Miller MA,Edens TJ,Mehrotra S,Dewar K,Manges AR

    更新日期:2016-03-14 00:00:00

  • Two sampling methods yield distinct microbial signatures in the nasopharynges of asthmatic children.

    abstract:BACKGROUND:The nasopharynx is a reservoir for pathogens associated with respiratory illnesses, such as asthma. Next-generation sequencing (NGS) has been used to characterize the nasopharyngeal microbiome during health and disease. Most studies so far have surveyed the nasopharynx as a whole; however, less is known abou...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0170-5

    authors: Pérez-Losada M,Crandall KA,Freishtat RJ

    更新日期:2016-06-16 00:00:00

  • Direct and indirect effects of a pH gradient bring insights into the mechanisms driving prokaryotic community structures.

    abstract:BACKGROUND:pH is frequently reported as the main driver for prokaryotic community structure in soils. However, pH changes are also linked to "spillover effects" on other chemical parameters (e.g., availability of Al, Fe, Mn, Zn, and Cu) and plant growth, but these indirect effects on the microbial communities are rarel...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0482-8

    authors: Lammel DR,Barth G,Ovaskainen O,Cruz LM,Zanatta JA,Ryo M,de Souza EM,Pedrosa FO

    更新日期:2018-06-11 00:00:00

  • Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission.

    abstract:BACKGROUND:The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother's fecal/vaginal microbiota and human milk. RESULTS:The composition of bifidobacterial c...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0282-6

    authors: Duranti S,Lugli GA,Mancabelli L,Armanini F,Turroni F,James K,Ferretti P,Gorfer V,Ferrario C,Milani C,Mangifesta M,Anzalone R,Zolfo M,Viappiani A,Pasolli E,Bariletti I,Canto R,Clementi R,Cologna M,Crifò T,Cusumano

    更新日期:2017-06-26 00:00:00

  • Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants.

    abstract:BACKGROUND:Polycyclic aromatic hydrocarbons (PAHs) are of environmental and public health concerns and contribute to adverse skin attributes such as premature skin aging and pigmentary disorder. However, little information is available on the potential roles of chronic urban PAH pollutant exposure on the cutaneous micr...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00874-1

    authors: Leung MHY,Tong X,Bastien P,Guinot F,Tenenhaus A,Appenzeller BMR,Betts RJ,Mezzache S,Li J,Bourokba N,Breton L,Clavaud C,Lee PKH

    更新日期:2020-06-26 00:00:00

  • Context and the human microbiome.

    abstract::Human microbiome reference datasets provide epidemiological context for researchers, enabling them to uncover new insights into their own data through meta-analyses. In addition, large and comprehensive reference sets offer a means to develop or test hypotheses and can pave the way for addressing practical study desig...

    journal_title:Microbiome

    pub_type: 杂志文章,评审

    doi:10.1186/s40168-015-0117-2

    authors: McDonald D,Birmingham A,Knight R

    更新日期:2015-11-04 00:00:00

  • The unsolved problem of otitis media in indigenous populations: a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media.

    abstract:BACKGROUND:Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence. We conducted a systematic ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0577-2

    authors: Coleman A,Wood A,Bialasiewicz S,Ware RS,Marsh RL,Cervin A

    更新日期:2018-11-05 00:00:00

  • Differential dynamics of microbial community networks help identify microorganisms interacting with residue-borne pathogens: the case of Zymoseptoria tritici in wheat.

    abstract:BACKGROUND:Wheat residues are a crucial determinant of the epidemiology of Septoria tritici blotch, as they support the sexual reproduction of the causal agent Zymoseptoria tritici. We aimed to characterize the effect of infection with this fungal pathogen on the microbial communities present on wheat residues and to i...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0736-0

    authors: Kerdraon L,Barret M,Laval V,Suffert F

    更新日期:2019-08-30 00:00:00

  • The gut mycobiome of the Human Microbiome Project healthy cohort.

    abstract:BACKGROUND:Most studies describing the human gut microbiome in healthy and diseased states have emphasized the bacterial component, but the fungal microbiome (i.e., the mycobiome) is beginning to gain recognition as a fundamental part of our microbiome. To date, human gut mycobiome studies have primarily been disease c...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0373-4

    authors: Nash AK,Auchtung TA,Wong MC,Smith DP,Gesell JR,Ross MC,Stewart CJ,Metcalf GA,Muzny DM,Gibbs RA,Ajami NJ,Petrosino JF

    更新日期:2017-11-25 00:00:00

  • Clustering co-abundant genes identifies components of the gut microbiome that are reproducibly associated with colorectal cancer and inflammatory bowel disease.

    abstract:BACKGROUND:Whole-genome "shotgun" (WGS) metagenomic sequencing is an increasingly widely used tool for analyzing the metagenomic content of microbiome samples. While WGS data contains gene-level information, it can be challenging to analyze the millions of microbial genes which are typically found in microbiome experim...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0722-6

    authors: Minot SS,Willis AD

    更新日期:2019-08-01 00:00:00

  • Mobile antibiotic resistome in wastewater treatment plants revealed by Nanopore metagenomic sequencing.

    abstract:BACKGROUND:Wastewater treatment plants (WWTPs) are recognized as hotspots for horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs). Despite our understanding of the composition and distribution of ARGs in WWTPs, the genetic location, host, and fate of ARGs remain largely unknown. RESULTS:In this study,...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0663-0

    authors: Che Y,Xia Y,Liu L,Li AD,Yang Y,Zhang T

    更新日期:2019-03-21 00:00:00

  • A metagenomic approach from aphid's hemolymph sheds light on the potential roles of co-existing endosymbionts.

    abstract:BACKGROUND:Aphids are known to live in symbiosis with specific bacteria, called endosymbionts which can be classified as obligate or accessory. Buchnera aphidicola is generally the only obligatory symbiont present in aphids, supplying essential nutrients that are missing in the plants phloem to its host. Pentalonia nig...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-015-0130-5

    authors: De Clerck C,Fujiwara A,Joncour P,Léonard S,Félix ML,Francis F,Jijakli MH,Tsuchida T,Massart S

    更新日期:2015-12-15 00:00:00

  • Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.

    abstract:BACKGROUND:The degree to which host genetic variation can modulate microbial communities in humans remains an open question. Here, we performed a genetic mapping study of the microbiome in two accessible upper airway sites, the nasopharynx and the nasal vestibule, during two seasons in 144 adult members of a founder po...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0227-5

    authors: Igartua C,Davenport ER,Gilad Y,Nicolae DL,Pinto J,Ober C

    更新日期:2017-02-01 00:00:00