Usefulness of continuous probability distributions of rates for modelling radionuclide biokinetics in humans and animals.

Abstract:

:Modelling the biokinetics of radionuclide excretion or retention is important in nuclear medicine and following accidental/malicious radioactivity releases. Sums of discrete exponential decay rates are often used, but we hypothesized that continuous probability distributions (CPD) of decay rates can describe the data more parsimoniously and robustly. We tested this hypothesis on diverse human and animal data sets involving various radionuclides (including plutonium, strontium, caesium) measured in the laboratory and in regions contaminated by the Fukushima and Chernobyl nuclear accidents. We used four models on each data set: mono-exponential (ME) with one discrete decay rate, bi-exponential (BE) with two rates, gamma-exponential (GE) with a Gamma distribution of stretched-exponential rates, and power-decay (PD) with a Gamma distribution of power-decay rates. Information-theoretic model selection suggested that radionuclide biokinetics, e.g. for plutonium in humans, are often better described by CPD models like GE and PD, than by discrete rates (ME and BE). Extrapolation of models fitted to data at short times to longer times was frequently more robust for CPD formalisms. We suggest that using a set of several CPD and discrete-rate models, and comparing them by information-theoretic methods, is a promising strategy to enhance the analysis of radionuclide excretion and retention kinetics.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Shuryak I,Dadachova E

doi

10.1038/s41598-018-38046-9

subject

Has Abstract

pub_date

2019-02-04 00:00:00

pages

1218

issue

1

issn

2045-2322

pii

10.1038/s41598-018-38046-9

journal_volume

9

pub_type

杂志文章
  • Electronic Health Record Driven Prediction for Gestational Diabetes Mellitus in Early Pregnancy.

    abstract::Gestational diabetes mellitus (GDM) is conventionally confirmed with oral glucose tolerance test (OGTT) in 24 to 28 weeks of gestation, but it is still uncertain whether it can be predicted with secondary use of electronic health records (EHRs) in early pregnancy. To this purpose, the cost-sensitive hybrid model (CSHM...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16665-y

    authors: Qiu H,Yu HY,Wang LY,Yao Q,Wu SN,Yin C,Fu B,Zhu XJ,Zhang YL,Xing Y,Deng J,Yang H,Lei SD

    更新日期:2017-11-27 00:00:00

  • Predictive value of cervical cytokine, antimicrobial and microflora levels for pre-term birth in high-risk women.

    abstract::Spontaneous preterm birth (sPTB, delivery <37 weeks gestation), accounts for approximately 10% of births worldwide; the aetiology is multifactorial with intra-amniotic infection being one contributing factor. This study aimed to determine whether asymptomatic women with a history of sPTB or cervical surgery have alter...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47756-7

    authors: Manning R,James CP,Smith MC,Innes BA,Stamp E,Peebles D,Bajaj-Elliott M,Klein N,Bulmer JN,Robson SC,Lash GE

    更新日期:2019-08-02 00:00:00

  • 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained.

    abstract::The potential of a spheroid tumor model composed of cells in different proliferative and metabolic states for the development of new anticancer strategies has been amply demonstrated. However, there is little or no information in the literature on the problems of reproducibility of data originating from experiments us...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19103

    authors: Zanoni M,Piccinini F,Arienti C,Zamagni A,Santi S,Polico R,Bevilacqua A,Tesei A

    更新日期:2016-01-11 00:00:00

  • Septin 9_i2 is downregulated in tumors, impairs cancer cell migration and alters subnuclear actin filaments.

    abstract::Functions of septin cytoskeletal polymers in tumorigenesis are still poorly defined. Their role in the regulation of cytokinesis and cell migration were proposed to contribute to cancer associated aneuploidy and metastasis. Overexpression of Septin 9 (Sept9) promotes migration of cancer cell lines. SEPT9 mRNA and prot...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44976

    authors: Verdier-Pinard P,Salaun D,Bouguenina H,Shimada S,Pophillat M,Audebert S,Agavnian E,Coslet S,Charafe-Jauffret E,Tachibana T,Badache A

    更新日期:2017-03-24 00:00:00

  • Quantum Engineering of Atomically Smooth Single-Crystalline Silver Films.

    abstract::There is a demand for ultra low-loss metal films with high-quality single crystals and perfect surface for nanophotonics and quantum information processing. Many researches are devoted to alternative materials, but silver is by far theoretically the most preferred low-loss material at optical and near-IR frequencies. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48508-3

    authors: Rodionov IA,Baburin AS,Gabidullin AR,Maklakov SS,Peters S,Ryzhikov IA,Andriyash AV

    更新日期:2019-08-22 00:00:00

  • The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery.

    abstract::Lipofectamine reagents are widely accepted as "gold-standard" for the safe delivery of exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based explanation of their superior efficacy has remained mostly elusive thus far. Here we apply a straightforward combination of live cell imaging, single-part...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25879

    authors: Cardarelli F,Digiacomo L,Marchini C,Amici A,Salomone F,Fiume G,Rossetta A,Gratton E,Pozzi D,Caracciolo G

    更新日期:2016-05-11 00:00:00

  • Impacts of manure application on soil environment, rainfall use efficiency and crop biomass under dryland farming.

    abstract::Because of inadequate nutrient and water supply, soils are often unproductive in Northwest China. We studied the effects of manure application at low (LM 7.5  t ha(-1)), medium (MM 15 t ha(-1)), and high (HM 22.5 t ha(-1)) rates combined with fixed levels of chemical fertilizers on maize growth and rainfall use effici...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20994

    authors: Wang X,Jia Z,Liang L,Yang B,Ding R,Nie J,Wang J

    更新日期:2016-02-12 00:00:00

  • Characterization of H7N2 Avian Influenza Virus in Wild Birds and Pikas in Qinghai-Tibet Plateau Area.

    abstract::Qinghai Lake is a major migrating bird breeding site that has experienced several recent highly pathogenic avian influenza virus (HPAIV) epizootics. From 2006 to 2009 we studied Qinghai's wild birds and pikas for evidence of AIV infections. We sampled 941 healthy wild animals and isolated seventeen H7N2 viruses (eight...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30974

    authors: Su S,Xing G,Wang J,Li Z,Gu J,Yan L,Lei J,Ji S,Hu B,Gray GC,Yan Y,Zhou J

    更新日期:2016-08-24 00:00:00

  • The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway.

    abstract::The nuclear receptor, farnesoid X receptor (FXR), has been recently considered as a tumor suppressor in HCC. IL-6/Janus kinase 2 (Jak-2)/signal transducer and activator of transcription 3 (STAT3) pathway has been implicated as a key player in many cancer types. This study aimed at investigating the potential effect of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12629-4

    authors: Attia YM,Tawfiq RA,Ali AA,Elmazar MM

    更新日期:2017-10-02 00:00:00

  • HIV-infected sex workers with beneficial HLA-variants are potential hubs for selection of HIV-1 recombinants that may affect disease progression.

    abstract::Cytotoxic T lymphocyte (CTL) responses against the HIV Gag protein are associated with lowering viremia; however, immune control is undermined by viral escape mutations. The rapid viral mutation rate is a key factor, but recombination may also contribute. We hypothesized that CTL responses drive the outgrowth of uniqu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11253

    authors: Chang CH,Kist NC,Stuart Chester TL,Sreenu VB,Herman M,Luo M,Lunn D,Bell J,Plummer FA,Ball TB,Katzourakis A,Iversen AK

    更新日期:2015-06-17 00:00:00

  • Total Knee Arthroplasty with a Ti6Al4V/PEEK Prosthesis on an Osteoarthritis Rat Model: Behavioral and Neurophysiological Analysis.

    abstract::Arthroplasty is a surgical procedure to restore the function of the joint of patient suffering from knee osteoarthritis. However, postoperative functional deficits are reported even after a rehabilitation program. In order to determine the origin of functional deficits of patient suffering from knee osteoarthritis and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62146-0

    authors: Lecocq M,Linares JM,Chaves-Jacob J,Coyle T,Roffino S,Eyraud M,Gigmes D,Decherchi P,Dousset E

    更新日期:2020-03-24 00:00:00

  • Author Correction: Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-31948-8

    authors: Brilha S,Ong CWM,Weksler B,Romero N,Couraud PO,Friedland JS

    更新日期:2018-09-12 00:00:00

  • Author Correction: Anthropometric measures and HbA1c to detect dysglycemia in young Asian women planning conception: The S-PRESTO cohort.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-69653-0

    authors: Chu AHY,Aris IM,Ng S,Loy SL,Bernard JY,Tint MT,Yuan WL,Godfrey KM,Chan JKY,Shek LP,Chong YS,Tan KH,Ang SB,Tan HH,Chern BSM,Yap F,Lee YS,Lek N,Leow MK,Khoo CM,Chan SY

    更新日期:2020-07-24 00:00:00

  • Author Correction: Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-73065-5

    authors: Del Carmen Asensio Lopez M,Lax A,Hernandez Vicente A,Saura Guillen E,Hernandez-Martinez A,Fernandez Del Palacio MJ,Bayes-Genis A,Pascual Figal DA

    更新日期:2020-10-09 00:00:00

  • The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease.

    abstract::Globally breast cancer is the leading cause of cancer death among women. The breast consists of epithelium, stroma and a mucosal immune system that make up a complex microenvironment. Growing awareness of the role of microbes in the microenvironment recently has led to a series of findings important for human health. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30751

    authors: Hieken TJ,Chen J,Hoskin TL,Walther-Antonio M,Johnson S,Ramaker S,Xiao J,Radisky DC,Knutson KL,Kalari KR,Yao JZ,Baddour LM,Chia N,Degnim AC

    更新日期:2016-08-03 00:00:00

  • The RNA-binding protein CsrA plays a central role in positively regulating virulence factors in Erwinia amylovora.

    abstract::The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates non-coding small regulatory RNA csrB, which in turn binds to the RNA-binding protein CsrA. However, how GacS/GacA-Csr system regulates virulenc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37195

    authors: Ancona V,Lee JH,Zhao Y

    更新日期:2016-11-15 00:00:00

  • Effects of Compound Sand Barrier for Habitat Restoration on Sediment Grain-size Distribution in Ulan Buh Desert.

    abstract::Wind erosion is a huge challenge for ecologists to stabilize sand dunes and to change them into stable productive ecosystems. In order to better understand its role in the process of ecological restoration, the sediment grain-size characteristics of compound sand barrier were evaluated through field experimental obser...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59538-7

    authors: Pan X,Wang Z,Gao Y

    更新日期:2020-02-13 00:00:00

  • Impact of Body Mass Index on Oncological Outcomes of Prostate Cancer Patients after Radical Prostatectomy.

    abstract::Obesity, often represented by higher body mass index (BMI), is not yet fully understood as a potential risk factor for poor clinical outcomes of prostate cancer (PCa) after radical prostatectomy (RP). This study aimed to evaluate the relationship between BMI and biochemical recurrence (BCR)-free survival in RP patient...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30473-y

    authors: Yu YD,Byun SS,Lee SE,Hong SK

    更新日期:2018-08-10 00:00:00

  • Quantitative 3-D morphometric analysis of individual dendritic spines.

    abstract::The observation and analysis of dendritic spines morphological changes poses a major challenge in neuroscience studies. The alterations of their density and/or morphology are indicators of the cellular processes involved in neural plasticity underlying learning and memory, and are symptomatic in neuropsychiatric disor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21753-8

    authors: Basu S,Saha PK,Roszkowska M,Magnowska M,Baczynska E,Das N,Plewczynski D,Wlodarczyk J

    更新日期:2018-02-23 00:00:00

  • Gender-related differences in heart failure with preserved ejection fraction.

    abstract::Heart failure with preserved ejection fraction (HFpEF) affects more women than men, suggesting gender to play a major role in disease evolution. However, studies investigating gender differences in HFpEF are limited. In the present study we aimed to describe gender differences in a well-characterized HFpEF cohort. Con...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19507-7

    authors: Duca F,Zotter-Tufaro C,Kammerlander AA,Aschauer S,Binder C,Mascherbauer J,Bonderman D

    更新日期:2018-01-18 00:00:00

  • Forward genetic screen for auxin-deficient mutants by cytokinin.

    abstract::Identification of mutants with impairments in auxin biosynthesis and dynamics by forward genetic screening is hindered by the complexity, redundancy and necessity of the pathways involved. Furthermore, although a few auxin-deficient mutants have been recently identified by screening for altered responses to shade, eth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11923

    authors: Wu L,Luo P,Di DW,Wang L,Wang M,Lu CK,Wei SD,Zhang L,Zhang TZ,Amakorová P,Strnad M,Novák O,Guo GQ

    更新日期:2015-07-06 00:00:00

  • Unsupervised Hebbian learning experimentally realized with analogue memristive crossbar arrays.

    abstract::Conventional transistor electronics are reaching their limits in terms of scalability, power dissipation, and the underlying Boolean system architecture. To overcome this obstacle neuromorphic analogue systems are recently highly investigated. Particularly, the use of memristive devices in VLSI analogue concepts provi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27033-9

    authors: Hansen M,Zahari F,Kohlstedt H,Ziegler M

    更新日期:2018-06-11 00:00:00

  • Elevation of autophagy markers in Sjögren syndrome dry eye.

    abstract::Autophagy is known to be implicated in the pathogenesis of Sjögren syndrome (SS), but evidences are limited. We aimed to examine the levels of autophagy markers in tear film and conjunctival epithelial cells from SS dry eye patients, and analyze their correlations with clinical features. Patients with SS dry eye exhib...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17128-0

    authors: Byun YS,Lee HJ,Shin S,Chung SH

    更新日期:2017-12-08 00:00:00

  • Anxiety and depression in diabetes care: longitudinal associations with health-related quality of life.

    abstract::Anxiety and depression are commonly found in patients with diabetes, but little is known about how the anxiety and depression symptoms of diabetes patients and the health-related quality of life (HRQoL) over time influence each other. Therefore, we conducted a survey among patients with diabetes (T1) and repeated the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57647-x

    authors: Liu X,Haagsma J,Sijbrands E,Buijks H,Boogaard L,Mackenbach JP,Erasmus V,Polinder S

    更新日期:2020-05-20 00:00:00

  • A horizontally acquired expansin gene increases virulence of the emerging plant pathogen Erwinia tracheiphila.

    abstract::Erwinia tracheiphila is a bacterial plant pathogen that causes a fatal wilt infection in some cucurbit crop plants. Wilt symptoms are thought to be caused by systemic bacterial colonization through xylem that impedes sap flow. However, the genetic determinants of within-plant movement are unknown for this pathogen spe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78157-w

    authors: Rocha J,Shapiro LR,Kolter R

    更新日期:2020-12-10 00:00:00

  • The understanding of congruent and incongruent referential gaze in 17-month-old infants: an eye-tracking study comparing human and robot.

    abstract::Several studies have shown that the human gaze, but not the robot gaze, has significant effects on infant social cognition and facilitate social engagement. The present study investigates early understanding of the referential nature of gaze by comparing-through the eye-tracking technique-infants' response to human an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69140-6

    authors: Manzi F,Ishikawa M,Di Dio C,Itakura S,Kanda T,Ishiguro H,Massaro D,Marchetti A

    更新日期:2020-07-17 00:00:00

  • The presence of microplastics in commercial salts from different countries.

    abstract::The occurrence of microplastics (MPs) in saltwater bodies is relatively well studied, but nothing is known about their presence in most of the commercial salts that are widely consumed by humans across the globe. Here, we extracted MP-like particles larger than 149 μm from 17 salt brands originating from 8 different c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46173

    authors: Karami A,Golieskardi A,Keong Choo C,Larat V,Galloway TS,Salamatinia B

    更新日期:2017-04-06 00:00:00

  • Partially spatially coherent digital holographic microscopy and machine learning for quantitative analysis of human spermatozoa under oxidative stress condition.

    abstract::Semen quality assessed by sperm count and sperm cell characteristics such as morphology and motility, is considered to be the main determinant of men's reproductive health. Therefore, sperm cell selection is vital in assisted reproductive technology (ART) used for the treatment of infertility. Conventional bright fiel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39523-5

    authors: Dubey V,Popova D,Ahmad A,Acharya G,Basnet P,Mehta DS,Ahluwalia BS

    更新日期:2019-03-05 00:00:00

  • Multiple uprising invasions of Pelophylax water frogs, potentially inducing a new hybridogenetic complex.

    abstract::The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to reconstruct the scenario of an uprising invasion of the famous water frogs (Pelophylax) in southern France, through a fine-s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06655-5

    authors: Dufresnes C,Denoël M,di Santo L,Dubey S

    更新日期:2017-07-26 00:00:00

  • Genetic diversity and population structure of the rockpool shrimp Palaemon elegans based on microsatellites: evidence for a cryptic species and differentiation across the Atlantic-Mediterranean transition.

    abstract::The rockpool shrimp Palaemon elegans is an ecologically important crustacean species within the European coastline fauna. In the present study, genetic diversity and population structure and connectivity were assessed by examining 21 polymorphic microsatellite loci at 13 sampling sites located along the natural distri...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67824-7

    authors: González-Castellano I,González-López J,González-Tizón AM,Martínez-Lage A

    更新日期:2020-07-01 00:00:00