Abstract:
BACKGROUND:Rs189037 (G > A) is a functional single nucleotide polymorphism (SNP) in the Ataxia-telangiectasia mutated (ATM) gene that may be associated with the risk of cancer. We performed a meta-analysis to determine whether rs189037 polymorphism influences the occurrence of cancer and examined the relationship between this SNP and the etiology of cancer. METHODS:Case-control studies were retrieved from literature databases in accordance with established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between rs189037 and cancer. Subgroup analysis and sensitivity analysis also were performed. RESULTS:After inclusion criteria were met, fifteen studies-comprising 8660 patients with cancer (cases) and 9259 controls-were included in this meta-analysis. Summary results indicated that an association was found between rs189037 and cancer risk. In the dominant model, the pooled OR using a random effects model was 1.207 (95% CI, 1.090-1.337; P < 0.001). The A allele of rs189037 increased the risk of lung cancer, breast cancer, and oral cancer. Results of subgroup analysis by ethnicity indicated that the SNP was associated with the risk of cancer among East Asian and Latino, but not Caucasian. CONCLUSIONS:Results of this meta-analysis suggest that rs189037 is associated with the occurrence of lung cancer, breast cancer, and oral cancer as the risk factor. These data provide possible avenues for future case-control studies related to cancer.
journal_name
BMC Med Genetjournal_title
BMC medical geneticsauthors
Zhao ZL,Xia L,Zhao C,Yao Jdoi
10.1186/s12881-019-0760-8subject
Has Abstractpub_date
2019-02-01 00:00:00pages
28issue
1issn
1471-2350pii
10.1186/s12881-019-0760-8journal_volume
20pub_type
杂志文章,meta分析abstract:BACKGROUND:Left ventricular (LV) mass and wall thickness are closely associated with measures of body size and blood pressure and also correlated with systolic and diastolic function, suggesting a contribution of common physiologic mechanisms, including pleiotropic genes, to their covariation. METHODS:Doppler echocard...
journal_title:BMC medical genetics
pub_type: 杂志文章
doi:10.1186/1471-2350-10-40
更新日期:2009-05-09 00:00:00
abstract:BACKGROUND:Observational studies and randomized trials have suggested that estrogens and/or progesterone may lower the risk for colorectal cancer. Inherited variation in the sex-hormone genes may be one mechanism by which sex hormones affect colorectal cancer, although data are limited. METHOD:We conducted a comprehen...
journal_title:BMC medical genetics
pub_type: 杂志文章
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更新日期:2011-05-31 00:00:00
abstract:BACKGROUND:Two important aspects for the development of anxiety disorders are genetic predisposition and alterations in the hypothalamic-pituitary-adrenal (HPA) axis. In order to identify genetic risk-factors for anxiety, the aim of this exploratory study was to investigate possible relationships between genetic polymo...
journal_title:BMC medical genetics
pub_type: 杂志文章
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更新日期:2020-09-21 00:00:00
abstract:BACKGROUND:Mutations in the FKBP10 gene were first described in patients with Osteogenesis imperfecta type III. Two follow up reports found FKBP10 mutations to be associated with Bruck syndrome type 1, a rare disorder characterized by congenital contractures and bone fragility. This raised the question if the patients ...
journal_title:BMC medical genetics
pub_type: 杂志文章
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更新日期:2011-11-22 00:00:00
abstract:BACKGROUND:Chronic kidney disease progression has been linked to pro-inflammatory cytokines and markers of inflammation. These markers are also elevated in end-stage renal disease (ESRD), which constitutes a serious public health problem. OBJECTIVE:To investigate whether single nucleotide polymorphisms (SNPs) located ...
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pub_type: 杂志文章
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更新日期:2012-07-20 00:00:00
abstract:BACKGROUND:Congenital cataract is the leading cause of blindness in children worldwide. Approximately half of all congenital cataracts have a genetic basis. Protein aggregation is the single most important factor in cataract formation. METHODS:A four-generation Chinese family diagnosed with autosomal dominant congenit...
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更新日期:2018-10-19 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2020-08-25 00:00:00
abstract:BACKGROUND:Primary ciliary dyskinesia (PCD) is a highly heterogeneous genetic disorder caused by defects in motile cilia. The hallmark features of PCD are the chronic infections of the respiratory tract, moreover, clinical manifestations include also laterality defects and risk of male infertility. Clinical phenotypes ...
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pub_type: 杂志文章
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更新日期:2020-11-10 00:00:00
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pub_type: 杂志文章
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更新日期:2018-06-18 00:00:00
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journal_title:BMC medical genetics
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更新日期:2002-10-11 00:00:00
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journal_title:BMC medical genetics
pub_type: 杂志文章
doi:10.1186/1471-2350-9-46
更新日期:2008-05-22 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12881-019-0765-3
更新日期:2019-02-19 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2350-11-4
更新日期:2010-01-12 00:00:00
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pub_type: 杂志文章
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更新日期:2011-12-20 00:00:00
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journal_title:BMC medical genetics
pub_type: 杂志文章
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更新日期:2011-02-04 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12881-017-0400-0
更新日期:2017-03-23 00:00:00
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journal_title:BMC medical genetics
pub_type: 杂志文章
doi:10.1186/1471-2350-2-7
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12881-016-0299-x
更新日期:2016-04-30 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-11-21 00:00:00
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pub_type: 杂志文章
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更新日期:2019-12-16 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12881-017-0507-3
更新日期:2017-12-15 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1186/1471-2350-14-98
更新日期:2013-09-25 00:00:00
abstract:BACKGROUND:Omphalocele is a congenital midline ventral body wall defect that can exist as isolated malformation or as part of a syndrome. It can be considered one of the major and most frequent clinical manifestation of Beckwith-Wiedemann Syndrome (BWS) in case of loss of methylation at KCNQ1OT1: Transcription Star Sit...
journal_title:BMC medical genetics
pub_type: 杂志文章
doi:10.1186/s12881-017-0470-z
更新日期:2017-10-18 00:00:00
abstract:BACKGROUND:A large number of distinct mutations in the BRCA1 and BRCA2 genes have been reported worldwide, but little is known regarding the role of these inherited susceptibility genes in breast cancer risk among Indian women. We investigated the distribution and the nature of BRCA1 and BRCA2 germline mutations and po...
journal_title:BMC medical genetics
pub_type: 杂志文章
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更新日期:2006-10-04 00:00:00
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pub_type: 杂志文章
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更新日期:2019-09-05 00:00:00
abstract:BACKGROUND:Because they are a closed founder population, the Old Order Amish (OOA) of Lancaster County have been the subject of many medical genetics studies. We constructed four versions of Anabaptist Genealogy Database (AGDB) using three sources of genealogies and multiple updates. In addition, we developed PedHunter...
journal_title:BMC medical genetics
pub_type: 杂志文章
doi:10.1186/1471-2350-11-68
更新日期:2010-05-02 00:00:00
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pub_type: 杂志文章
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更新日期:2012-11-29 00:00:00