Abstract:
BACKGROUND:Spinal cord injury (SCI) remains a huge medical problem nowadays as there is no hospital providing the versatile strategies for repairing central nervous system and restoring function. Herein, we focused on PC-12 cells as an important research tool and studied the potential role of resveratrol (RSV) in inflammation induced by LPS. RESULTS:RSV improved inflammatory injury and functional recovery in rat model of SCI. RSV inhibited LPS-induced inflammatory injury in PC-12 cells via increasing viability, decreasing apoptosis, and suppressing IL-1β, IL-6, and TNF-α expression. miR-132 was down-regulated after LPS treatment but up-regulated after RSV administration. miR-132 silence curbed the protective effect of RSV. The results including increase of cell growth, suppression of inflammatory response, and blocking of NF-κB and p38MAPK pathways produced by RSV were all reversed by miR-132 silence. CONCLUSION:RSV could up-regulate miR-132 and further ameliorate inflammatory response in PC-12 cells by inhibiting NF-κB and p38MAPK pathways.
journal_name
BMC Biotechnoljournal_title
BMC biotechnologyauthors
Zhang G,Liu Y,Xu L,Sha C,Zhang H,Xu Wdoi
10.1186/s12896-019-0502-1subject
Has Abstractpub_date
2019-01-28 00:00:00pages
10issue
1issn
1472-6750pii
10.1186/s12896-019-0502-1journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Domesticated einkorn (Triticum monococcum L.) is one of the oldest cultivated cereal crops in the world. Its small genome size (~ 5.7 GB), low ploidy (2n = 2x = 14, AmAm) and high genetic polymorphism make this species very attractive for use as a diploid model for understanding the genomics and proteomics o...
journal_title:BMC biotechnology
pub_type: 杂志文章
doi:10.1186/s12896-018-0477-3
更新日期:2018-10-23 00:00:00
abstract:BACKGROUND:Transformed cells of Escherichia coli DH5-alpha with pGFPuv, induced by IPTG (isopropyl-beta-d-thiogalactopyranoside), express the green fluorescent protein (gfpuv) during growth phases. E. coli subjected to the combination of selective permeation by freezing/thawing/sonication cycles followed by the three-p...
journal_title:BMC biotechnology
pub_type: 杂志文章
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更新日期:2002-04-24 00:00:00
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pub_type: 杂志文章
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更新日期:2012-09-11 00:00:00
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journal_title:BMC biotechnology
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更新日期:2017-05-12 00:00:00
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journal_title:BMC biotechnology
pub_type: 杂志文章
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更新日期:2015-08-04 00:00:00
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更新日期:2011-03-15 00:00:00
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journal_title:BMC biotechnology
pub_type: 杂志文章
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更新日期:2007-08-27 00:00:00
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journal_title:BMC biotechnology
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更新日期:2019-06-17 00:00:00
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更新日期:2012-08-23 00:00:00
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更新日期:2010-07-05 00:00:00
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journal_title:BMC biotechnology
pub_type: 杂志文章
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更新日期:2015-06-04 00:00:00
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journal_title:BMC biotechnology
pub_type: 杂志文章
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更新日期:2018-03-16 00:00:00
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更新日期:2011-06-02 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-09 00:00:00
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pub_type: 杂志文章
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更新日期:2015-02-13 00:00:00
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journal_title:BMC biotechnology
pub_type: 杂志文章
doi:10.1186/s12896-018-0472-8
更新日期:2018-10-03 00:00:00
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pub_type: 杂志文章
doi:10.1186/1472-6750-13-90
更新日期:2013-10-26 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12896-019-0507-9
更新日期:2019-03-08 00:00:00
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更新日期:2016-01-20 00:00:00
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pub_type: 杂志文章
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更新日期:2011-11-10 00:00:00
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更新日期:2016-04-14 00:00:00
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更新日期:2003-07-23 00:00:00
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更新日期:2015-05-28 00:00:00
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更新日期:2013-02-26 00:00:00
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