Abstract：
:Pressure-induced deep tissue injury is a form of pressure ulcer which is difficult to detect and diagnose at an early stage, before the wound has severely progressed and becomes visible at the skin surface. At the present time, no such detection technique is available. To test the hypothesis that muscle damage biomarkers can be indicative of the development of deep tissue injury after sustained mechanical loading, an indentation test was performed for 2 h on the tibialis anterior muscle of rats. Myoglobin and troponin were analysed in blood plasma and urine over a period of 5 days. The damage as detected by the biomarkers was compared to damage as observed with T2 MRI to validate the response. We found that myoglobin and troponin levels in blood increased due to the damage. Myoglobin was also increased in urine. The amount of damage observed with MRI immediately after loading had a strong correlation with the maximal biomarker levels: troponin in blood rs = 0.94; myoglobin in blood rs = 0.75; and myoglobin in urine rs = 0.57. This study suggests that muscle damage markers measured in blood and urine could serve as early diagnosis for pressure induced deep tissue injury.
journal_name
J Mech Behav Biomed Materauthors
Traa WA,Strijkers GJ,Bader DL,Oomens CWJdoi
10.1016/j.jmbbm.2018.12.026subject
Has Abstractpub_date
2019-04-01 00:00:00pages
50-57eissn
1751-6161issn
1878-0180pii
S1751-6161(18)31435-8journal_volume
92pub_type
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
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