TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps.

abstract：:Non-pial neocortical astrocytes have historically been thought to comprise largely a nondiverse population of protoplasmic astrocytes. Here we show that astrocytes of the mouse somatosensory cortex manifest layer-specific morphological and molecular differences. Two- and three-dimensional observations revealed that as...

journal_title：Nature communications

authors： Lanjakornsiripan D,Pior BJ,Kawaguchi D,Furutachi S,Tahara T,Katsuyama Y,Suzuki Y,Fukazawa Y,Gotoh Y

更新日期：2018-04-24 00:00:00

abstract：:Multiferroic bismuth ferrite, BiFeO3, offers a vast landscape to study the interplay between different ferrroic orders. Another aspect which is equally exciting, and yet underutilized, is the possibility of large-scale ordering of domains. Along with symmetry-driven bulk photovoltaic effect, BiFeO3 presents opportunit...

journal_title：Nature communications

authors： Knoche DS,Steimecke M,Yun Y,Mühlenbein L,Bhatnagar A

更新日期：2021-01-12 00:00:00

abstract：:Compared with noble metals, semiconductors with surface plasmon resonance effect are another type of SERS substrate materials. The main obstacles so far are that the semiconducting materials are often unstable and easy to be further oxidized or decomposed by laser irradiating or contacting with corrosive substances. H...

journal_title：Nature communications

authors： Zhang Q,Li X,Ma Q,Zhang Q,Bai H,Yi W,Liu J,Han J,Xi G

更新日期：2017-04-24 00:00:00

abstract：:Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2....

journal_title：Nature communications

authors： van Ingen G,Li J,Goedegebure A,Pandey R,Li YR,March ME,Jaddoe VW,Bakay M,Mentch FD,Thomas K,Wei Z,Chang X,Hain HS,Uitterlinden AG,Moll HA,van Duijn CM,Rivadeneira F,Raat H,Baatenburg de Jong RJ,Sleiman PM,van der

更新日期：2016-09-28 00:00:00

abstract：:Autophagy cargo recognition and clearance are essential for intracellular protein quality control. SQSTM1/p62 sequesters intracellular aberrant proteins and mediates cargo delivery for their selective autophagic degradation. The formation of p62 non-membrane-bound liquid compartments is critical for its function as a ...

journal_title：Nature communications

authors： Yang Y,Willis TL,Button RW,Strang CJ,Fu Y,Wen X,Grayson PRC,Evans T,Sipthorpe RJ,Roberts SL,Hu B,Zhang J,Lu B,Luo S

更新日期：2019-08-21 00:00:00

abstract：:In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the spec...

journal_title：Nature communications

authors： Adhikari H,Counter CM

更新日期：2018-09-07 00:00:00

abstract：:Inelastic collisions involving molecular species are key to energy transfer in gaseous environments. They are commonly governed by an energy gap law, which dictates that transitions are dominated by those between initial and final states with roughly the same ro-vibrational energy. Transitions involving rotational ine...

journal_title：Nature communications

authors： Yang D,Huang J,Hu X,Guo H,Xie D

更新日期：2019-10-11 00:00:00

abstract：:Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cancer cells. Here, we report a lipid membrane-coated silica-carbon (LSC) hybrid nanoparticle that targets ...

journal_title：Nature communications

authors： Wang H,Gao Z,Liu X,Agarwal P,Zhao S,Conroy DW,Ji G,Yu J,Jaroniec CP,Liu Z,Lu X,Li X,He X

更新日期：2018-02-08 00:00:00

abstract：:Osteoderms are bones embedded within the dermis, and are common to select members of most major tetrapod lineages. The largest known animals that bear osteoderms are members of Titanosauria, a diverse clade of sauropod dinosaurs. Here we report on two titanosaur osteoderms recovered from the Upper Cretaceous Maevarano...

journal_title：Nature communications

authors： Curry Rogers K,D'Emic M,Rogers R,Vickaryous M,Cagan A

更新日期：2011-11-29 00:00:00

abstract：:RNA has emerged as a promising material for nanostructure and microstructure engineering. Although rare, some macroscopic RNA structures have also been constructed using lipid or polymer materials. Here, we report the first example of an enzymatically generated RNA membrane. This robust and free-standing RNA membrane ...

journal_title：Nature communications

authors： Han D,Park Y,Kim H,Lee JB

更新日期：2014-07-04 00:00:00

abstract：:Biomolecular X-ray structures typically provide a static, time- and ensemble-averaged view of molecular ensembles in crystals. In the absence of rigid-body motions and lattice defects, B-factors are thought to accurately reflect the structural heterogeneity of such ensembles. In order to study the effects of averaging...

journal_title：Nature communications

authors： Kuzmanic A,Pannu NS,Zagrovic B

更新日期：2014-01-01 00:00:00

abstract：:One of the fundamental challenges in nanophotonics is to gain full control over nanoscale optical elements. The precise spatiotemporal arrangement determines their interactions and collective behavior. To this end, DNA nanotechnology is employed as an unprecedented tool to create nanophotonic devices with excellent sp...

journal_title：Nature communications

authors： Xin L,Zhou C,Duan X,Liu N

更新日期：2019-11-27 00:00:00

abstract：:Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch's reaction, high-throughput methods and polymer chemistry. A ...

journal_title：Nature communications

authors： Liu G,Zeng Y,Lv T,Mao T,Wei Y,Jia S,Gou Y,Tao L

更新日期：2020-12-04 00:00:00

abstract：:Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous f...

journal_title：Nature communications

authors： Brina D,Miluzio A,Ricciardi S,Clarke K,Davidsen PK,Viero G,Tebaldi T,Offenhäuser N,Rozman J,Rathkolb B,Neschen S,Klingenspor M,Wolf E,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Quattrone A,Falciani F,Biffo S

更新日期：2015-09-18 00:00:00

abstract：:Twisted Laguerre-Gaussian lasers, with orbital angular momentum and characterized by doughnut-shaped intensity profiles, provide a transformative set of tools and research directions in a growing range of fields and applications, from super-resolution microcopy and ultra-fast optical communications to quantum computin...

journal_title：Nature communications

authors： Vieira J,Trines RM,Alves EP,Fonseca RA,Mendonça JT,Bingham R,Norreys P,Silva LO

更新日期：2016-01-28 00:00:00

abstract：:Large igneous province subduction is a rare process on Earth. A modern example is the subduction of the oceanic Hikurangi Plateau beneath the southern Kermadec arc, offshore New Zealand. This segment of the arc has the largest total lava volume erupted and the highest volcano density of the entire Kermadec arc. Here w...

journal_title：Nature communications

authors： Timm C,Davy B,Haase K,Hoernle KA,Graham IJ,de Ronde CE,Woodhead J,Bassett D,Hauff F,Mortimer N,Seebeck HC,Wysoczanski RJ,Caratori-Tontini F,Gamble JA

更新日期：2014-09-17 00:00:00

abstract：:Circulating tumor cells (CTCs) have become an established biomarker for prognosis in patients with various carcinomas. However, current ex vivo CTC isolation technologies rely on small blood volumes from a single venipuncture limiting the number of captured CTCs. This produces statistical variability and inaccurate re...

journal_title：Nature communications

authors： Kim TH,Wang Y,Oliver CR,Thamm DH,Cooling L,Paoletti C,Smith KJ,Nagrath S,Hayes DF

更新日期：2019-04-01 00:00:00

abstract：:Non-symmorphic chiral topological crystals host exotic multifold fermions, and their associated Fermi arcs helically wrap around and expand throughout the Brillouin zone between the high-symmetry center and surface-corner momenta. However, Fermi-arc splitting and realization of the theoretically proposed maximal Chern...

journal_title：Nature communications

authors： Yao M,Manna K,Yang Q,Fedorov A,Voroshnin V,Valentin Schwarze B,Hornung J,Chattopadhyay S,Sun Z,Guin SN,Wosnitza J,Borrmann H,Shekhar C,Kumar N,Fink J,Sun Y,Felser C

更新日期：2020-04-27 00:00:00

abstract：:Replicating biological patterns is promising for designing materials with multifaceted properties. Twisted cholesteric liquid crystal patterns are found in the iridescent tessellated cuticles of many insects and a few fruits. Their accurate replication is extremely difficult since discontinuous patterns and colors mus...

journal_title：Nature communications

authors： Scarangella A,Soldan V,Mitov M

更新日期：2020-08-14 00:00:00

abstract：:The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent ste...

journal_title：Nature communications

authors： Pisco AO,Brock A,Zhou J,Moor A,Mojtahedi M,Jackson D,Huang S

更新日期：2013-01-01 00:00:00

abstract：:Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populations retaining or l...

journal_title：Nature communications

authors： Muzumdar MD,Dorans KJ,Chung KM,Robbins R,Tammela T,Gocheva V,Li CM,Jacks T

更新日期：2016-09-02 00:00:00

abstract：:Despite the pursuit of quantum advantages in various applications, the power of quantum computers in executing neural network has mostly remained unknown, primarily due to a missing tool that effectively designs a neural network suitable for quantum circuit. Here, we present a neural network and quantum circuit co-des...

journal_title：Nature communications

authors： Jiang W,Xiong J,Shi Y

更新日期：2021-01-25 00:00:00

abstract：:Saccharomyces cerevisiae is a Crabtree-positive eukaryal model organism. It is believed that the Crabtree effect has evolved as a competition mechanism by allowing for rapid growth and production of ethanol at aerobic glucose excess conditions. This inherent property of yeast metabolism and the multiple mechanisms und...

journal_title：Nature communications

authors： Dai Z,Huang M,Chen Y,Siewers V,Nielsen J

更新日期：2018-08-03 00:00:00

abstract：:The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function. Whether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis drives DNA unwinding remain open questions. Here we use cryo-electron ...

journal_title：Nature communications

authors： Abid Ali F,Renault L,Gannon J,Gahlon HL,Kotecha A,Zhou JC,Rueda D,Costa A

更新日期：2016-02-18 00:00:00

abstract：:Laboratory spectroscopy of atomic hydrogen in a magnetic flux density of 10(5) T (1 gigagauss), the maximum observed on high-field magnetic white dwarfs, is impossible because practically available fields are about a thousand times less. In this regime, the cyclotron and binding energies become equal. Here we demonstr...

journal_title：Nature communications

authors： Murdin BN,Li J,Pang ML,Bowyer ET,Litvinenko KL,Clowes SK,Engelkamp H,Pidgeon CR,Galbraith I,Abrosimov NV,Riemann H,Pavlov SG,Hübers HW,Murdin PG

更新日期：2013-01-01 00:00:00

abstract：:Hallmarks of criticality, such as power-laws and scale invariance, have been empirically found in cortical-network dynamics and it has been conjectured that operating at criticality entails functional advantages, such as optimal computational capabilities, memory and large dynamical ranges. As critical behaviour requi...

journal_title：Nature communications

authors： Moretti P,Muñoz MA

更新日期：2013-01-01 00:00:00

abstract：:Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by the lysosome. Maturation of autophagosomes requires their transport towards the perinuclear region of the cell, with key factors underlying both processes still poorly understood. Here we show that transport and positioning of lat...

journal_title：Nature communications

authors： Wijdeven RH,Janssen H,Nahidiazar L,Janssen L,Jalink K,Berlin I,Neefjes J

更新日期：2016-06-10 00:00:00

abstract：:Understanding the dynamics of ring polymers is a particularly challenging yet interesting problem in soft materials. Despite recent progress, a complete understanding of the nonequilibrium behavior of ring polymers has not yet been achieved. In this work, we directly observe the flow dynamics of DNA-based rings in sem...

journal_title：Nature communications

authors： Zhou Y,Hsiao KW,Regan KE,Kong D,McKenna GB,Robertson-Anderson RM,Schroeder CM

更新日期：2019-04-15 00:00:00

abstract：:Ocean ventilation is the integrated effect of various processes that exchange surface properties with the ocean interior and is essential for oxygen supply, storage of anthropogenic carbon and the heat budget of the ocean, for instance. Current observational methods utilise transient tracers, e.g. tritium, SF6, CFCs a...

journal_title：Nature communications

authors： Ebser S,Kersting A,Stöven T,Feng Z,Ringena L,Schmidt M,Tanhua T,Aeschbach W,Oberthaler MK

更新日期：2018-11-28 00:00:00

abstract：:Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aimi...

journal_title：Nature communications

authors： Huang J,Howie B,McCarthy S,Memari Y,Walter K,Min JL,Danecek P,Malerba G,Trabetti E,Zheng HF,UK10K Consortium.,Gambaro G,Richards JB,Durbin R,Timpson NJ,Marchini J,Soranzo N

更新日期：2015-09-14 00:00:00